Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AK1C2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids (PubMed). Most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentrations of NADPH (PubMed). Displays a broad positional specificity acting on positions 3, 17 and 20 of steroids and regulates the metabolism of hormones like estrogens and androgens (PubMed). Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol) (PubMed, PubMed, PubMed, PubMed). Also specifically able to produce 17beta-hydroxy-5alpha-androstan-3-one/5alphaDHT (PubMed). May also reduce conjugated steroids such as 5alpha-dihydrotestosterone sulfate (PubMed). Displays affinity for bile acids (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in AK1C2_HUMAN
GO:0004032 alditol:NADP+ 1-oxidoreductase activity 33.3333 7 yes
GO:0004033 aldo-keto reductase (NADP) activity 33.3333 5 yes
GO:0004303 estradiol 17-beta-dehydrogenase activity 33.3333 5 yes
GO:0008106 alcohol dehydrogenase (NADP+) activity 33.3333 6 yes
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 33.3333 4 yes
GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 33.3333 4 yes
GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 33.3333 4 yes
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 33.3333 4 yes
GO:0018636 phenanthrene 9,10-monooxygenase activity 33.3333 5 yes
GO:0031406 carboxylic acid binding 33.3333 4 yes
GO:0032052 bile acid binding 33.3333 6 yes
GO:0033293 monocarboxylic acid binding 33.3333 5 yes
GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 33.3333 4 yes
GO:0044594 17-beta-hydroxysteroid dehydrogenase (NAD+) activity 33.3333 6 yes
GO:0047023 androsterone dehydrogenase activity 33.3333 5 yes
GO:0047044 androstan-3-alpha,17-beta-diol dehydrogenase activity 33.3333 5 yes
GO:0047086 ketosteroid monooxygenase activity 33.3333 5 yes
GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity 33.3333 5 yes
GO:0047718 indanol dehydrogenase activity 33.3333 5 yes
GO:0047834 D-threo-aldose 1-dehydrogenase activity 33.3333 5 yes
GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 33.3333 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in AK1C2_HUMAN
GO:0048522 positive regulation of cellular process 66.6667 4 yes
GO:0009966 regulation of signal transduction 55.5556 4 yes
GO:0010646 regulation of cell communication 55.5556 4 yes
GO:0019752 carboxylic acid metabolic process 55.5556 5 yes
GO:0043436 oxoacid metabolic process 55.5556 4 yes
GO:0006631 fatty acid metabolic process 44.4444 4 yes
GO:0006690 icosanoid metabolic process 44.4444 6 yes
GO:0006692 prostanoid metabolic process 44.4444 6 yes
GO:0006693 prostaglandin metabolic process 44.4444 7 yes
GO:0009967 positive regulation of signal transduction 44.4444 5 yes
GO:0010647 positive regulation of cell communication 44.4444 5 yes
GO:0023056 positive regulation of signaling 44.4444 4 yes
GO:0032787 monocarboxylic acid metabolic process 44.4444 6 yes
GO:0032870 cellular response to hormone stimulus 44.4444 4 yes
GO:0033559 unsaturated fatty acid metabolic process 44.4444 5 yes
GO:0033993 response to lipid 44.4444 4 yes
GO:0048584 positive regulation of response to stimulus 44.4444 4 yes
GO:0071310 cellular response to organic substance 44.4444 4 yes
GO:1901701 cellular response to oxygen-containing compound 44.4444 4 yes
GO:1902531 regulation of intracellular signal transduction 44.4444 5 yes
GO:1902533 positive regulation of intracellular signal transduction 44.4444 6 yes
GO:0008202 steroid metabolic process 33.3333 4 yes
GO:0008207 C21-steroid hormone metabolic process 33.3333 4 yes
GO:0008284 positive regulation of cell population proliferation 33.3333 5 yes
GO:0009753 response to jasmonic acid 33.3333 4 yes
GO:0016137 glycoside metabolic process 33.3333 5 yes
GO:0030647 aminoglycoside antibiotic metabolic process 33.3333 6 yes
GO:0030855 epithelial cell differentiation 33.3333 4 yes
GO:0034308 primary alcohol metabolic process 33.3333 4 yes
GO:0042127 regulation of cell population proliferation 33.3333 4 yes
GO:0042448 progesterone metabolic process 33.3333 4 yes
GO:0070542 response to fatty acid 33.3333 4 yes
GO:0071395 cellular response to jasmonic acid stimulus 33.3333 5 yes
GO:0071396 cellular response to lipid 33.3333 5 yes
GO:0071398 cellular response to fatty acid 33.3333 5 yes
GO:1901657 glycosyl compound metabolic process 33.3333 4 yes
GO:1901661 quinone metabolic process 33.3333 4 yes
GO:1902644 tertiary alcohol metabolic process 33.3333 4 yes
GO:0048523 negative regulation of cellular process 33.3333 4 no
GO:0071702 organic substance transport 33.3333 4 no
GO:0034694 response to prostaglandin 22.2222 4 yes
GO:0051896 regulation of protein kinase B signaling 22.2222 6 yes
GO:0051897 positive regulation of protein kinase B signaling 22.2222 7 yes
GO:0071379 cellular response to prostaglandin stimulus 22.2222 5 yes
GO:0071798 response to prostaglandin D 22.2222 5 yes
GO:0071799 cellular response to prostaglandin D stimulus 22.2222 6 yes
GO:0097305 response to alcohol 22.2222 4 yes
GO:0097306 cellular response to alcohol 22.2222 5 yes
GO:1901654 response to ketone 22.2222 4 yes
GO:1901655 cellular response to ketone 22.2222 5 yes
GO:0008104 protein localization 22.2222 4 no
GO:0009892 negative regulation of metabolic process 22.2222 4 no
GO:0010605 negative regulation of macromolecule metabolic process 22.2222 5 no
GO:0015031 protein transport 22.2222 4 no
GO:0016192 vesicle-mediated transport 22.2222 4 no
GO:0051049 regulation of transport 22.2222 4 no
GO:0051171 regulation of nitrogen compound metabolic process 22.2222 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 22.2222 5 no
GO:0051246 regulation of protein metabolic process 22.2222 5 no
GO:0051248 negative regulation of protein metabolic process 22.2222 6 no
GO:0060255 regulation of macromolecule metabolic process 22.2222 4 no
GO:0071705 nitrogen compound transport 22.2222 4 no
GO:0080090 regulation of primary metabolic process 22.2222 4 no
GO:0016053 organic acid biosynthetic process 22.2222 4 no
GO:0046394 carboxylic acid biosynthetic process 22.2222 5 no
GO:0048878 chemical homeostasis 22.2222 4 no
GO:0055088 lipid homeostasis 22.2222 5 no
GO:0009893 positive regulation of metabolic process 22.2222 4 no
GO:0031323 regulation of cellular metabolic process 22.2222 4 no
GO:0031325 positive regulation of cellular metabolic process 22.2222 5 no
GO:0010941 regulation of cell death 22.2222 4 no
GO:0042981 regulation of apoptotic process 22.2222 6 no
GO:0043066 negative regulation of apoptotic process 22.2222 7 no
GO:0043067 regulation of programmed cell death 22.2222 5 no
GO:0043069 negative regulation of programmed cell death 22.2222 6 no
GO:0043408 regulation of MAPK cascade 22.2222 6 no
GO:0043410 positive regulation of MAPK cascade 22.2222 7 no
GO:0060548 negative regulation of cell death 22.2222 5 no
GO:0080134 regulation of response to stress 22.2222 4 no
GO:0080135 regulation of cellular response to stress 22.2222 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
AK1C2_HUMAN [view entry] [view interactions] Low throughput yes no
AK1C1_HUMAN [view entry] [view interactions] High throughput yes yes
AK1C3_HUMAN [view interactions] High throughput no yes
AK1C4_HUMAN [view interactions] High throughput no no
IPO8_HUMAN [view interactions] High throughput no no
LTOR5_HUMAN [view interactions] High throughput no yes
ZFP1_HUMAN [view interactions] High throughput no no
AGR2_HUMAN [view interactions] High throughput no no
TISD_HUMAN [view interactions] High throughput no no
DYR1A_HUMAN [view interactions] High throughput no yes
BRD4_HUMAN [view interactions] High throughput no yes
ISG15_HUMAN [view interactions] High throughput no no
PXL2A_HUMAN [view interactions] High throughput no yes
SRRT_HUMAN [view interactions] High throughput no yes
AATC_HUMAN [view entry] [view interactions] High throughput yes yes
JIP3_HUMAN [view entry] [view interactions] High throughput yes yes
CCR1_HUMAN [view interactions] High throughput no no
PINK1_HUMAN [view interactions] High throughput no yes
BAG1_HUMAN [view interactions] High throughput no yes
SHIP2_HUMAN [view interactions] High throughput no yes
P3C2A_HUMAN [view interactions] High throughput no yes
PUR2_HUMAN [view interactions] High throughput no yes
PIMT_HUMAN [view entry] [view interactions] High throughput yes yes
SNX3_HUMAN [view entry] [view interactions] High throughput yes no
SODC_HUMAN [view interactions] High throughput no yes
TKT_HUMAN [view entry] [view interactions] High throughput yes yes
CK054_HUMAN [view interactions] High throughput no no
MIF_HUMAN [view entry] [view interactions] High throughput yes yes
S5A2_HUMAN [view interactions] Computational no no
DHRS9_HUMAN [view interactions] Computational no yes
PORED_HUMAN [view interactions] Computational no yes
CP2AD_HUMAN [view interactions] Computational no no
S5A1_HUMAN [view interactions] Computational no yes
CP2A6_HUMAN [view interactions] Computational no no
UDB15_HUMAN [view interactions] Computational no no
DHDH_HUMAN [view interactions] Computational no no