Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AK1C1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids (PubMed). Most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentrations of NADPH (PubMed). Displays a broad positional specificity acting on positions 3, 17 and 20 of steroids and regulates the metabolism of hormones like estrogens and androgens (PubMed). May also reduce conjugated steroids such as 5alpha-dihydrotestosterone sulfate (PubMed). Displays affinity for bile acids (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in AK1C1_HUMAN
GO:0043168 anion binding 83.3333 4 yes
GO:0000166 nucleotide binding 50.0000 4 no
GO:0005524 ATP binding 50.0000 5 no
GO:0017076 purine nucleotide binding 50.0000 5 no
GO:0030554 adenyl nucleotide binding 50.0000 6 no
GO:0032555 purine ribonucleotide binding 50.0000 4 no
GO:0032559 adenyl ribonucleotide binding 50.0000 5 no
GO:0035639 purine ribonucleoside triphosphate binding 50.0000 4 no
GO:0004032 aldose reductase (NADPH) activity 33.3333 7 yes
GO:0004033 aldo-keto reductase (NADPH) activity 33.3333 5 yes
GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)] activity 33.3333 5 yes
GO:0008106 alcohol dehydrogenase (NADP+) activity 33.3333 6 yes
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 33.3333 4 yes
GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 33.3333 4 yes
GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 33.3333 4 yes
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 33.3333 4 yes
GO:0018636 phenanthrene 9,10-monooxygenase activity 33.3333 5 yes
GO:0031406 carboxylic acid binding 33.3333 4 yes
GO:0032052 bile acid binding 33.3333 6 yes
GO:0033293 monocarboxylic acid binding 33.3333 5 yes
GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 33.3333 4 yes
GO:0047023 androsterone dehydrogenase activity 33.3333 5 yes
GO:0047044 androstan-3-alpha,17-beta-diol dehydrogenase activity 33.3333 5 yes
GO:0047086 ketosteroid monooxygenase activity 33.3333 5 yes
GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity 33.3333 5 yes
GO:0047718 indanol dehydrogenase activity 33.3333 5 yes
GO:0002020 protease binding 33.3333 4 no
GO:1990381 ubiquitin-specific protease binding 33.3333 5 no
GO:0004674 protein serine/threonine kinase activity 33.3333 4 no
GO:0016301 kinase activity 33.3333 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 33.3333 4 no
GO:0106310 protein serine kinase activity 33.3333 4 no
GO:0019902 phosphatase binding 33.3333 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in AK1C1_HUMAN
GO:0048522 positive regulation of cellular process 100.0000 4 yes
GO:0009893 positive regulation of metabolic process 83.3333 4 yes
GO:0031323 regulation of cellular metabolic process 83.3333 4 yes
GO:0009966 regulation of signal transduction 83.3333 4 no
GO:0009967 positive regulation of signal transduction 83.3333 5 no
GO:0010646 regulation of cell communication 83.3333 4 no
GO:0010647 positive regulation of cell communication 83.3333 5 no
GO:0023056 positive regulation of signaling 83.3333 4 no
GO:0048584 positive regulation of response to stimulus 83.3333 4 no
GO:0031325 positive regulation of cellular metabolic process 66.6667 5 yes
GO:1901701 cellular response to oxygen-containing compound 66.6667 4 yes
GO:0006796 phosphate-containing compound metabolic process 66.6667 4 no
GO:0009889 regulation of biosynthetic process 66.6667 4 no
GO:0009968 negative regulation of signal transduction 66.6667 5 no
GO:0010604 positive regulation of macromolecule metabolic process 66.6667 5 no
GO:0010648 negative regulation of cell communication 66.6667 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 66.6667 5 no
GO:0023057 negative regulation of signaling 66.6667 4 no
GO:0036211 protein modification process 66.6667 4 no
GO:0042127 regulation of cell population proliferation 66.6667 4 no
GO:0043085 positive regulation of catalytic activity 66.6667 4 no
GO:0043412 macromolecule modification 66.6667 4 no
GO:0048523 negative regulation of cellular process 66.6667 4 no
GO:0048585 negative regulation of response to stimulus 66.6667 4 no
GO:0051128 regulation of cellular component organization 66.6667 4 no
GO:0060255 regulation of macromolecule metabolic process 66.6667 4 no
GO:0080090 regulation of primary metabolic process 66.6667 4 no
GO:1902531 regulation of intracellular signal transduction 66.6667 5 no
GO:0071310 cellular response to organic substance 50.0000 4 yes
GO:0071702 organic substance transport 50.0000 4 yes
GO:0006355 regulation of DNA-templated transcription 50.0000 7 no
GO:0006915 apoptotic process 50.0000 4 no
GO:0006996 organelle organization 50.0000 4 no
GO:0007010 cytoskeleton organization 50.0000 5 no
GO:0008284 positive regulation of cell population proliferation 50.0000 5 no
GO:0009894 regulation of catabolic process 50.0000 4 no
GO:0009896 positive regulation of catabolic process 50.0000 5 no
GO:0010468 regulation of gene expression 50.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 50.0000 5 no
GO:0019220 regulation of phosphate metabolic process 50.0000 6 no
GO:0022607 cellular component assembly 50.0000 4 no
GO:0030162 regulation of proteolysis 50.0000 6 no
GO:0031326 regulation of cellular biosynthetic process 50.0000 5 no
GO:0031399 regulation of protein modification process 50.0000 6 no
GO:0031401 positive regulation of protein modification process 50.0000 7 no
GO:0044087 regulation of cellular component biogenesis 50.0000 4 no
GO:0051174 regulation of phosphorus metabolic process 50.0000 5 no
GO:0051246 regulation of protein metabolic process 50.0000 5 no
GO:0051247 positive regulation of protein metabolic process 50.0000 6 no
GO:0051252 regulation of RNA metabolic process 50.0000 5 no
GO:0141124 intracellular signaling cassette 50.0000 4 no
GO:2000145 regulation of cell motility 50.0000 4 no
GO:2001141 regulation of RNA biosynthetic process 50.0000 6 no
GO:0009891 positive regulation of biosynthetic process 50.0000 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 50.0000 5 no
GO:1902533 positive regulation of intracellular signal transduction 50.0000 6 no
GO:0006631 fatty acid metabolic process 33.3333 4 yes
GO:0006690 icosanoid metabolic process 33.3333 6 yes
GO:0006692 prostanoid metabolic process 33.3333 6 yes
GO:0006693 prostaglandin metabolic process 33.3333 7 yes
GO:0008202 steroid metabolic process 33.3333 4 yes
GO:0009753 response to jasmonic acid 33.3333 4 yes
GO:0016137 glycoside metabolic process 33.3333 5 yes
GO:0019752 carboxylic acid metabolic process 33.3333 5 yes
GO:0030647 aminoglycoside antibiotic metabolic process 33.3333 6 yes
GO:0030855 epithelial cell differentiation 33.3333 4 yes
GO:0032787 monocarboxylic acid metabolic process 33.3333 6 yes
GO:0032870 cellular response to hormone stimulus 33.3333 4 yes
GO:0033559 unsaturated fatty acid metabolic process 33.3333 5 yes
GO:0033993 response to lipid 33.3333 4 yes
GO:0034308 primary alcohol metabolic process 33.3333 4 yes
GO:0043436 oxoacid metabolic process 33.3333 4 yes
GO:0044597 daunorubicin metabolic process 33.3333 4 yes
GO:0044598 doxorubicin metabolic process 33.3333 4 yes
GO:0070542 response to fatty acid 33.3333 4 yes
GO:0071395 cellular response to jasmonic acid stimulus 33.3333 5 yes
GO:0071396 cellular response to lipid 33.3333 5 yes
GO:0071398 cellular response to fatty acid 33.3333 5 yes
GO:1901657 glycosyl compound metabolic process 33.3333 4 yes
GO:1902644 tertiary alcohol metabolic process 33.3333 4 yes
GO:0001932 regulation of protein phosphorylation 33.3333 7 no
GO:0008285 negative regulation of cell population proliferation 33.3333 5 no
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0010605 negative regulation of macromolecule metabolic process 33.3333 5 no
GO:0030334 regulation of cell migration 33.3333 5 no
GO:0032101 regulation of response to external stimulus 33.3333 4 no
GO:0033135 regulation of peptidyl-serine phosphorylation 33.3333 8 no
GO:0042325 regulation of phosphorylation 33.3333 7 no
GO:0043086 negative regulation of catalytic activity 33.3333 4 no
GO:0045595 regulation of cell differentiation 33.3333 4 no
GO:0045862 positive regulation of proteolysis 33.3333 7 no
GO:0050804 modulation of chemical synaptic transmission 33.3333 5 no
GO:0050807 regulation of synapse organization 33.3333 5 no
GO:0051049 regulation of transport 33.3333 4 no
GO:0051129 negative regulation of cellular component organization 33.3333 5 no
GO:0051248 negative regulation of protein metabolic process 33.3333 6 no
GO:0051338 regulation of transferase activity 33.3333 4 no
GO:0051347 positive regulation of transferase activity 33.3333 5 no
GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 33.3333 6 no
GO:0080134 regulation of response to stress 33.3333 4 no
GO:0099177 regulation of trans-synaptic signaling 33.3333 4 no
GO:1901873 regulation of post-translational protein modification 33.3333 7 no
GO:1901875 positive regulation of post-translational protein modification 33.3333 8 no
GO:1902532 negative regulation of intracellular signal transduction 33.3333 6 no
GO:1903050 regulation of proteolysis involved in protein catabolic process 33.3333 7 no
GO:1903052 positive regulation of proteolysis involved in protein catabolic process 33.3333 8 no
GO:1903320 regulation of protein modification by small protein conjugation or removal 33.3333 8 no
GO:1903322 positive regulation of protein modification by small protein conjugation or removal 33.3333 9 no
GO:2000058 regulation of ubiquitin-dependent protein catabolic process 33.3333 5 no
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process 33.3333 6 no
GO:0000165 MAPK cascade 33.3333 5 no
GO:0006357 regulation of transcription by RNA polymerase II 33.3333 8 no
GO:0006468 protein phosphorylation 33.3333 5 no
GO:0007167 enzyme-linked receptor protein signaling pathway 33.3333 4 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 33.3333 5 no
GO:0008104 protein localization 33.3333 4 no
GO:0008286 insulin receptor signaling pathway 33.3333 6 no
GO:0010557 positive regulation of macromolecule biosynthetic process 33.3333 6 no
GO:0010562 positive regulation of phosphorus metabolic process 33.3333 6 no
GO:0014044 Schwann cell development 33.3333 5 no
GO:0015031 protein transport 33.3333 4 no
GO:0016310 phosphorylation 33.3333 5 no
GO:0019221 cytokine-mediated signaling pathway 33.3333 4 no
GO:0021782 glial cell development 33.3333 4 no
GO:0030878 thyroid gland development 33.3333 5 no
GO:0031279 regulation of cyclase activity 33.3333 4 no
GO:0031281 positive regulation of cyclase activity 33.3333 5 no
GO:0031328 positive regulation of cellular biosynthetic process 33.3333 6 no
GO:0038127 ERBB signaling pathway 33.3333 6 no
GO:0038128 ERBB2 signaling pathway 33.3333 7 no
GO:0038129 ERBB3 signaling pathway 33.3333 7 no
GO:0038133 ERBB2-ERBB3 signaling pathway 33.3333 8 no
GO:0042552 myelination 33.3333 4 no
GO:0042981 regulation of apoptotic process 33.3333 5 no
GO:0043067 regulation of programmed cell death 33.3333 4 no
GO:0043254 regulation of protein-containing complex assembly 33.3333 5 no
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 33.3333 8 no
GO:0043408 regulation of MAPK cascade 33.3333 6 no
GO:0043410 positive regulation of MAPK cascade 33.3333 7 no
GO:0043933 protein-containing complex organization 33.3333 4 no
GO:0045893 positive regulation of DNA-templated transcription 33.3333 8 no
GO:0045937 positive regulation of phosphate metabolic process 33.3333 7 no
GO:0045944 positive regulation of transcription by RNA polymerase II 33.3333 9 no
GO:0048009 insulin-like growth factor receptor signaling pathway 33.3333 6 no
GO:0048534 hematopoietic or lymphoid organ development 33.3333 4 no
GO:0048538 thymus development 33.3333 5 no
GO:0048732 gland development 33.3333 4 no
GO:0051254 positive regulation of RNA metabolic process 33.3333 6 no
GO:0051336 regulation of hydrolase activity 33.3333 4 no
GO:0052547 regulation of peptidase activity 33.3333 5 no
GO:0052548 regulation of endopeptidase activity 33.3333 6 no
GO:0071705 nitrogen compound transport 33.3333 4 no
GO:1902680 positive regulation of RNA biosynthetic process 33.3333 7 no
GO:2000116 regulation of cysteine-type endopeptidase activity 33.3333 7 no
GO:0006974 DNA damage response 33.3333 4 no
GO:0009059 macromolecule biosynthetic process 33.3333 4 no
GO:0016236 macroautophagy 33.3333 4 no
GO:0034654 nucleobase-containing compound biosynthetic process 33.3333 4 no
GO:0051130 positive regulation of cellular component organization 33.3333 5 no
GO:0060341 regulation of cellular localization 33.3333 4 no
GO:0090304 nucleic acid metabolic process 33.3333 4 no
GO:0141187 nucleic acid biosynthetic process 33.3333 5 no
GO:1901362 organic cyclic compound biosynthetic process 33.3333 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TFF3_HUMAN [view interactions] Low throughput no no
MK03_HUMAN [view entry] [view interactions] High throughput yes yes
COMD8_HUMAN [view interactions] High throughput no yes
AK1C2_HUMAN [view entry] [view interactions] High throughput yes no
AK1C3_HUMAN [view interactions] High throughput no yes
AK1D1_HUMAN [view interactions] High throughput no no
ANR16_HUMAN [view interactions] High throughput no yes
FINC_HUMAN [view interactions] High throughput no yes
PTN3_HUMAN [view interactions] High throughput no yes
SPRE1_HUMAN [view interactions] High throughput no yes
AGR2_HUMAN [view interactions] High throughput no no
BRD4_HUMAN [view interactions] High throughput no yes
FNDC5_HUMAN [view interactions] High throughput no no
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes