PIMT_HUMAN
Evidence for PS localization
Functions
Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin carboxyl-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PIMT_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 22.4490 | 4 | no |
| GO:0017076 | purine nucleotide binding | 22.4490 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 22.4490 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 22.4490 | 4 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 20.4082 | 4 | no |
| GO:0045296 | cadherin binding | 14.2857 | 4 | yes |
| GO:0004719 | protein-L-isoaspartate (D-aspartate) O-methyltransferase activity | 4.0816 | 5 | yes |
| GO:0008168 | methyltransferase activity | 4.0816 | 4 | yes |
| GO:0008171 | O-methyltransferase activity | 4.0816 | 5 | yes |
| GO:0008757 | S-adenosylmethionine-dependent methyltransferase activity | 4.0816 | 5 | yes |
| GO:0010340 | carboxyl-O-methyltransferase activity | 4.0816 | 6 | yes |
| GO:0051998 | protein carboxyl O-methyltransferase activity | 4.0816 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PIMT_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 55.1020 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 48.9796 | 4 | no |
| GO:0010646 | regulation of cell communication | 48.9796 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 44.8980 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 44.8980 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 44.8980 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 44.8980 | 4 | no |
| GO:0043412 | macromolecule modification | 42.8571 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 42.8571 | 4 | no |
| GO:0036211 | protein modification process | 40.8163 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 38.7755 | 4 | no |
| GO:0006996 | organelle organization | 36.7347 | 4 | no |
| GO:0022607 | cellular component assembly | 36.7347 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 36.7347 | 4 | no |
| GO:0010468 | regulation of gene expression | 36.7347 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 34.6939 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 34.6939 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 34.6939 | 5 | no |
| GO:0008104 | protein localization | 32.6531 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 32.6531 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 32.6531 | 5 | no |
| GO:0010941 | regulation of cell death | 30.6122 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 28.5714 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 28.5714 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 28.5714 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 28.5714 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 26.5306 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 26.5306 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 26.5306 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 26.5306 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 26.5306 | 5 | no |
| GO:0060548 | negative regulation of cell death | 26.5306 | 5 | no |
| GO:0033043 | regulation of organelle organization | 26.5306 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 26.5306 | 6 | no |
| GO:0006355 | regulation of DNA-templated transcription | 24.4898 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 24.4898 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 24.4898 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 24.4898 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 24.4898 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 24.4898 | 5 | no |
| GO:0023057 | negative regulation of signaling | 24.4898 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 24.4898 | 4 | no |
| GO:0060341 | regulation of cellular localization | 24.4898 | 4 | no |
| GO:0080134 | regulation of response to stress | 24.4898 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 24.4898 | 4 | no |
| GO:0043933 | protein-containing complex organization | 22.4490 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 22.4490 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 22.4490 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 22.4490 | 5 | no |
| GO:0043066 | negative regulation of apoptotic process | 22.4490 | 7 | no |
| GO:0043069 | negative regulation of programmed cell death | 22.4490 | 6 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 22.4490 | 5 | no |
| GO:0032880 | regulation of protein localization | 22.4490 | 5 | no |
| GO:0051049 | regulation of transport | 22.4490 | 4 | no |
| GO:0009894 | regulation of catabolic process | 22.4490 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 22.4490 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 22.4490 | 5 | no |
| GO:0023056 | positive regulation of signaling | 22.4490 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 20.4082 | 5 | no |
| GO:0016310 | phosphorylation | 20.4082 | 5 | no |
| GO:0031399 | regulation of protein modification process | 20.4082 | 6 | no |
| GO:0019220 | regulation of phosphate metabolic process | 20.4082 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 20.4082 | 5 | no |
| GO:0006479 | protein methylation | 4.0816 | 4 | yes |
| GO:0008213 | protein alkylation | 4.0816 | 5 | yes |
| GO:0030091 | protein repair | 4.0816 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in PIMT_HUMAN |
|---|---|---|---|---|
| DOID:574 | peripheral nervous system disease | 4.0816 | 3 | no |
| DOID:870 | neuropathy | 4.0816 | 4 | no |
| DOID:1289 | neurodegenerative disease | 4.0816 | 4 | no |
| DOID:331 | central nervous system disease | 4.0816 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLC3_HUMAN | [view interactions] | High throughput | no | no |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| RHGBB_HUMAN | [view interactions] | High throughput | no | no |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNM1L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2ABB_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRB_HUMAN | [view interactions] | High throughput | no | yes |
| EEA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNF5_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| VHL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRAF6_HUMAN | [view interactions] | High throughput | no | yes |
| PIMT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRCM_HUMAN | [view interactions] | High throughput | no | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATG5_HUMAN | [view interactions] | High throughput | no | no |
| TNR5_HUMAN | [view interactions] | High throughput | no | no |
| RIPK2_HUMAN | [view interactions] | High throughput | no | yes |
| PAK2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EIF1B_HUMAN | [view interactions] | High throughput | no | no |
| DEGS1_HUMAN | [view interactions] | High throughput | no | no |
| TIMP2_HUMAN | [view interactions] | High throughput | no | no |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| IKKE_HUMAN | [view interactions] | High throughput | no | yes |
| EPB41_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| ANGI_HUMAN | [view interactions] | High throughput | no | no |
| HDAC5_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| RPIA_HUMAN | [view interactions] | High throughput | no | yes |
| AIMP2_HUMAN | [view interactions] | High throughput | no | yes |
| CHD3_HUMAN | [view interactions] | High throughput | no | yes |
| APOA1_HUMAN | [view interactions] | High throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGTR1_HUMAN | [view interactions] | High throughput | no | no |
| CCR2_HUMAN | [view interactions] | High throughput | no | yes |
| CLTR2_HUMAN | [view interactions] | High throughput | no | no |
| TAAR1_HUMAN | [view interactions] | High throughput | no | yes |
| CAND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CUL1_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| CUL2_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| DYRK2_HUMAN | [view interactions] | High throughput | no | yes |
| HEN1_HUMAN | [view interactions] | High throughput | no | no |
| HME1_HUMAN | [view interactions] | High throughput | no | no |
| HNF1B_HUMAN | [view interactions] | High throughput | no | no |
| HNF4A_HUMAN | [view interactions] | High throughput | no | no |
| MYOD1_HUMAN | [view interactions] | High throughput | no | no |
| NFYC_HUMAN | [view interactions] | High throughput | no | no |
| PAX6_HUMAN | [view interactions] | High throughput | no | no |
| APOE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VKOR1_HUMAN | [view interactions] | High throughput | no | yes |
| CLP1_HUMAN | [view interactions] | High throughput | no | yes |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| TERF1_HUMAN | [view interactions] | High throughput | no | no |
| TERF2_HUMAN | [view interactions] | High throughput | no | yes |
| POTE1_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| TP53B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| SH3R2_HUMAN | [view interactions] | High throughput | no | yes |
| AURKA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| KLH20_HUMAN | [view interactions] | High throughput | no | yes |
| A16A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TM102_HUMAN | [view interactions] | High throughput | no | no |
| DEOC_HUMAN | [view interactions] | High throughput | no | no |
| PDPR_HUMAN | [view interactions] | High throughput | no | yes |
| KTHY_HUMAN | [view interactions] | High throughput | no | yes |
| RAB3I_HUMAN | [view interactions] | High throughput | no | no |
| RMC1_HUMAN | [view interactions] | High throughput | no | no |
| KC1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLH24_HUMAN | [view interactions] | High throughput | no | no |
| KLH42_HUMAN | [view interactions] | High throughput | no | yes |
| KBTB7_HUMAN | [view interactions] | High throughput | no | yes |
| KBTB6_HUMAN | [view interactions] | High throughput | no | yes |
| P5CR3_HUMAN | [view interactions] | High throughput | no | no |
| KCTD3_HUMAN | [view interactions] | High throughput | no | yes |
| SHKB1_HUMAN | [view interactions] | High throughput | no | yes |
| ABI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLH26_HUMAN | [view interactions] | High throughput | no | no |
| YDJC_HUMAN | [view interactions] | High throughput | no | no |
| KLH18_HUMAN | [view interactions] | High throughput | no | yes |
| MA2C1_HUMAN | [view interactions] | High throughput | no | no |
| KS6B2_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| PCGF1_HUMAN | [view interactions] | High throughput | no | yes |
| DPPA4_HUMAN | [view interactions] | High throughput | no | no |
| BCOR_HUMAN | [view interactions] | High throughput | no | no |
| NANOG_HUMAN | [view interactions] | High throughput | no | no |
| PO5F1_HUMAN | [view interactions] | High throughput | no | yes |
| PTPC1_HUMAN | [view interactions] | High throughput | no | yes |
| PTN1_HUMAN | [view interactions] | High throughput | no | yes |
| SSH3_HUMAN | [view interactions] | High throughput | no | yes |
| CSN7B_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRE_HUMAN | [view interactions] | High throughput | no | no |
| PRP8_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RELB_HUMAN | [view interactions] | High throughput | no | yes |
| UB2R1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| RN123_HUMAN | [view interactions] | High throughput | no | yes |
| PPT1_HUMAN | [view interactions] | High throughput | no | yes |
| SNAI1_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| RNF41_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| RC3H1_HUMAN | [view interactions] | High throughput | no | yes |
| TET2_HUMAN | [view interactions] | High throughput | no | yes |
| ATX3_HUMAN | [view interactions] | High throughput | no | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| TIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBP56_HUMAN | [view interactions] | High throughput | no | yes |
| MATR3_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| NFX1_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| DOCK8_HUMAN | [view interactions] | High throughput | no | yes |
| AKP13_HUMAN | [view interactions] | High throughput | no | yes |
| RHG24_HUMAN | [view interactions] | High throughput | no | yes |
| RHG29_HUMAN | [view interactions] | High throughput | no | yes |
| ARGAL_HUMAN | [view interactions] | High throughput | no | yes |
| ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| CTIP_HUMAN | [view interactions] | High throughput | no | no |
| RIN3_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M4K2_HUMAN | [view interactions] | High throughput | no | yes |
| M4K5_HUMAN | [view interactions] | High throughput | no | no |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| FBX43_HUMAN | [view interactions] | High throughput | no | no |
| ZRAB2_HUMAN | [view interactions] | High throughput | no | yes |
| PPIH_HUMAN | [view interactions] | High throughput | no | yes |
| TPM4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSB7_HUMAN | [view interactions] | High throughput | no | yes |
| RD23A_HUMAN | [view interactions] | High throughput | no | yes |
| RIR2_HUMAN | [view interactions] | High throughput | no | no |
| PFD2_HUMAN | [view interactions] | High throughput | no | yes |
| SC24A_HUMAN | [view interactions] | High throughput | no | no |
| GDIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SVIL_HUMAN | [view interactions] | High throughput | no | yes |
| NOTC2_HUMAN | [view interactions] | High throughput | no | yes |
| UCHL3_HUMAN | [view interactions] | High throughput | no | yes |
| SDHF2_HUMAN | [view interactions] | High throughput | no | yes |
| SIAS_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2C_HUMAN | [view interactions] | High throughput | no | yes |
| ALDR_HUMAN | [view interactions] | High throughput | no | no |
| AK1C2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COX17_HUMAN | [view interactions] | High throughput | no | yes |
| CYTB_HUMAN | [view interactions] | High throughput | no | no |
| ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENOG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ETFA_HUMAN | [view interactions] | High throughput | no | yes |
| LDH6A_HUMAN | [view interactions] | High throughput | no | no |
| LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK054_HUMAN | [view interactions] | High throughput | no | no |
| CRIP1_HUMAN | [view interactions] | High throughput | no | yes |
| MTAP_HUMAN | [view interactions] | High throughput | no | no |
| SCYL2_HUMAN | [view interactions] | High throughput | no | yes |
| SPRE_HUMAN | [view interactions] | High throughput | no | yes |
| TKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UFC1_HUMAN | [view interactions] | High throughput | no | yes |
| YKT6_HUMAN | [view interactions] | High throughput | no | yes |
| RFIP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| T106B_HUMAN | [view interactions] | High throughput | no | yes |