Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PIMT_HUMAN

Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin carboxyl-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein. [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in PIMT_HUMAN
GO:0043168 anion binding 30.0000 4 no
GO:0000166 nucleotide binding 26.6667 4 no
GO:0043169 cation binding 26.6667 4 no
GO:0046872 metal ion binding 26.6667 5 no
GO:0017076 purine nucleotide binding 25.0000 5 no
GO:0044389 ubiquitin-like protein ligase binding 25.0000 4 no
GO:0032555 purine ribonucleotide binding 23.3333 4 no
GO:0035639 purine ribonucleoside triphosphate binding 23.3333 4 no
GO:0031625 ubiquitin protein ligase binding 23.3333 5 no
GO:0030554 adenyl nucleotide binding 21.6667 6 no
GO:0045296 cadherin binding 16.6667 4 yes
GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity 3.3333 5 yes
GO:0008168 methyltransferase activity 3.3333 4 yes
GO:0008171 O-methyltransferase activity 3.3333 5 yes
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 3.3333 5 yes
GO:0010340 carboxyl-O-methyltransferase activity 3.3333 6 yes
GO:0051998 protein carboxyl O-methyltransferase activity 3.3333 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PIMT_HUMAN
GO:0048522 positive regulation of cellular process 61.6667 4 no
GO:0031323 regulation of cellular metabolic process 58.3333 4 no
GO:0060255 regulation of macromolecule metabolic process 55.0000 4 no
GO:0048523 negative regulation of cellular process 55.0000 4 no
GO:0010646 regulation of cell communication 53.3333 4 no
GO:0080090 regulation of primary metabolic process 53.3333 4 no
GO:0009966 regulation of signal transduction 46.6667 4 no
GO:0009893 positive regulation of metabolic process 43.3333 4 no
GO:0051128 regulation of cellular component organization 43.3333 4 no
GO:0009889 regulation of biosynthetic process 43.3333 4 no
GO:0010468 regulation of gene expression 43.3333 6 no
GO:0010556 regulation of macromolecule biosynthetic process 43.3333 5 no
GO:0031326 regulation of cellular biosynthetic process 43.3333 5 no
GO:0010604 positive regulation of macromolecule metabolic process 41.6667 5 no
GO:0009892 negative regulation of metabolic process 41.6667 4 no
GO:0006996 organelle organization 40.0000 4 no
GO:0022607 cellular component assembly 40.0000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 40.0000 5 no
GO:0031325 positive regulation of cellular metabolic process 38.3333 5 no
GO:0051246 regulation of protein metabolic process 38.3333 5 no
GO:0031324 negative regulation of cellular metabolic process 36.6667 5 no
GO:0043412 macromolecule modification 35.0000 4 yes
GO:0008104 protein localization 35.0000 4 no
GO:1902531 regulation of intracellular signal transduction 35.0000 5 no
GO:0042981 regulation of apoptotic process 35.0000 5 no
GO:0043067 regulation of programmed cell death 35.0000 4 no
GO:0036211 protein modification process 33.3333 4 yes
GO:0048584 positive regulation of response to stimulus 33.3333 4 no
GO:0009890 negative regulation of biosynthetic process 33.3333 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 33.3333 5 no
GO:0009894 regulation of catabolic process 33.3333 4 no
GO:0006796 phosphate-containing compound metabolic process 31.6667 4 no
GO:0010647 positive regulation of cell communication 31.6667 5 no
GO:0023056 positive regulation of signaling 31.6667 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 31.6667 6 no
GO:0031327 negative regulation of cellular biosynthetic process 31.6667 6 no
GO:0043933 protein-containing complex organization 31.6667 4 no
GO:0048585 negative regulation of response to stimulus 31.6667 4 no
GO:0051247 positive regulation of protein metabolic process 30.0000 6 no
GO:0010648 negative regulation of cell communication 30.0000 5 no
GO:0023057 negative regulation of signaling 30.0000 4 no
GO:0043066 negative regulation of apoptotic process 30.0000 6 no
GO:0043069 negative regulation of programmed cell death 30.0000 5 no
GO:0006355 regulation of DNA-templated transcription 30.0000 7 no
GO:0051252 regulation of RNA metabolic process 30.0000 5 no
GO:2001141 regulation of RNA biosynthetic process 30.0000 6 no
GO:0009967 positive regulation of signal transduction 28.3333 5 no
GO:0009891 positive regulation of biosynthetic process 28.3333 5 no
GO:0009968 negative regulation of signal transduction 28.3333 5 no
GO:0031328 positive regulation of cellular biosynthetic process 28.3333 6 no
GO:0080134 regulation of response to stress 28.3333 4 no
GO:0031399 regulation of protein modification process 26.6667 6 no
GO:0010557 positive regulation of macromolecule biosynthetic process 26.6667 6 no
GO:0051049 regulation of transport 26.6667 4 no
GO:0033043 regulation of organelle organization 26.6667 5 no
GO:0060341 regulation of cellular localization 26.6667 4 no
GO:0051130 positive regulation of cellular component organization 25.0000 5 no
GO:0032880 regulation of protein localization 25.0000 5 no
GO:0010629 negative regulation of gene expression 23.3333 7 no
GO:0042127 regulation of cell population proliferation 23.3333 4 no
GO:0065003 protein-containing complex assembly 23.3333 5 no
GO:0044087 regulation of cellular component biogenesis 23.3333 4 no
GO:0051129 negative regulation of cellular component organization 23.3333 5 no
GO:0019220 regulation of phosphate metabolic process 21.6667 6 no
GO:0051174 regulation of phosphorus metabolic process 21.6667 5 no
GO:0006357 regulation of transcription by RNA polymerase II 21.6667 8 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 21.6667 5 no
GO:0051094 positive regulation of developmental process 21.6667 4 no
GO:0006479 protein methylation 3.3333 4 yes
GO:0008213 protein alkylation 3.3333 5 yes
GO:0030091 protein repair 3.3333 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
M4K2_HUMAN [view interactions] High throughput no yes
M4K5_HUMAN [view interactions] High throughput no no
DPP4_HUMAN [view interactions] High throughput no no
BAG1_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
FBX43_HUMAN [view interactions] High throughput no no
SOX2_HUMAN [view interactions] High throughput no yes
TRI31_HUMAN [view interactions] High throughput no no
ANM1_HUMAN [view interactions] High throughput no yes
FOLR1_HUMAN [view interactions] High throughput no no
MYCN_HUMAN [view interactions] High throughput no no
ZRAN1_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
CCNF_HUMAN [view interactions] High throughput no no
RUFY1_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
FBW1A_HUMAN [view interactions] High throughput no yes
PIAS1_HUMAN [view entry] [view interactions] High throughput yes yes
MOB3C_HUMAN [view interactions] High throughput no no
EZH2_HUMAN [view interactions] High throughput no no
MIDN_HUMAN [view interactions] High throughput no no
B3GN2_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
TNIP1_HUMAN [view interactions] High throughput no yes
ZRAB2_HUMAN [view interactions] High throughput no yes
PPIH_HUMAN [view interactions] High throughput no yes
TPM4_HUMAN [view entry] [view interactions] High throughput yes yes
VATB2_HUMAN [view entry] [view interactions] High throughput yes yes
PSB7_HUMAN [view interactions] High throughput no yes
RD23A_HUMAN [view interactions] High throughput no yes
RIR2_HUMAN [view interactions] High throughput no no
PFD2_HUMAN [view interactions] High throughput no yes
SC24A_HUMAN [view interactions] High throughput no no
GDIA_HUMAN [view entry] [view interactions] High throughput yes yes
SVIL_HUMAN [view interactions] High throughput no yes
NOTC2_HUMAN [view entry] [view interactions] High throughput yes yes
UCHL3_HUMAN [view interactions] High throughput no yes
SDHF2_HUMAN [view interactions] High throughput no yes
SIAS_HUMAN [view interactions] High throughput no yes
UBE2C_HUMAN [view interactions] High throughput no yes
ALDR_HUMAN [view interactions] High throughput no no
AK1C2_HUMAN [view entry] [view interactions] High throughput yes no
COX17_HUMAN [view interactions] High throughput no yes
CYTB_HUMAN [view interactions] High throughput no no
ENOA_HUMAN [view entry] [view interactions] High throughput yes yes
ENOG_HUMAN [view entry] [view interactions] High throughput yes yes
ETFA_HUMAN [view interactions] High throughput no yes
LDH6A_HUMAN [view interactions] High throughput no no
LDHB_HUMAN [view entry] [view interactions] High throughput yes yes
MIF_HUMAN [view entry] [view interactions] High throughput yes yes
CK054_HUMAN [view interactions] High throughput no no
CRIP1_HUMAN [view interactions] High throughput no yes
MTAP_HUMAN [view interactions] High throughput no no
SCYL2_HUMAN [view interactions] High throughput no yes
SPRE_HUMAN [view interactions] High throughput no yes
TKT_HUMAN [view entry] [view interactions] High throughput yes yes
PRDX2_HUMAN [view entry] [view interactions] High throughput yes yes
TRAP1_HUMAN [view entry] [view interactions] High throughput yes yes
UFC1_HUMAN [view interactions] High throughput no yes
YKT6_HUMAN [view interactions] High throughput no yes
RFIP5_HUMAN [view entry] [view interactions] High throughput yes yes
SNX3_HUMAN [view entry] [view interactions] High throughput yes no
SH3L1_HUMAN [view interactions] High throughput no yes
GLO2_HUMAN [view interactions] High throughput no yes
NB5R4_HUMAN [view interactions] High throughput no yes
FUBP2_HUMAN [view interactions] High throughput no yes
F136A_HUMAN [view interactions] High throughput no yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
BICD2_HUMAN [view interactions] High throughput no yes
RN183_HUMAN [view interactions] High throughput no no
NAA40_HUMAN [view interactions] High throughput no no
T106B_HUMAN [view interactions] High throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
KBTB4_HUMAN [view interactions] High throughput no yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
RAB25_HUMAN [view interactions] High throughput no no
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
WWTR1_HUMAN [view interactions] High throughput no yes
MLP3A_HUMAN [view entry] [view interactions] High throughput yes yes
MLP3B_HUMAN [view interactions] High throughput no yes
GBRL2_HUMAN [view entry] [view interactions] High throughput yes yes
KLC3_HUMAN [view interactions] High throughput no no
ATX1_HUMAN [view interactions] High throughput no yes
RHGBB_HUMAN [view interactions] High throughput no no
ZBT18_HUMAN [view interactions] High throughput no yes
VCAM1_HUMAN [view interactions] High throughput no no
DLDH_HUMAN [view entry] [view interactions] High throughput yes yes
ODO2_HUMAN [view entry] [view interactions] High throughput yes yes
DNM1L_HUMAN [view entry] [view interactions] High throughput yes yes
HCD2_HUMAN [view entry] [view interactions] High throughput yes yes
SODC_HUMAN [view interactions] High throughput no yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
2ABB_HUMAN [view interactions] High throughput no yes
PTPRB_HUMAN [view interactions] High throughput no yes
EEA1_HUMAN [view entry] [view interactions] High throughput yes yes
LMNA_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
SNF5_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
VHL_HUMAN [view entry] [view interactions] High throughput yes yes
TRAF6_HUMAN [view entry] [view interactions] High throughput yes yes
PIMT_HUMAN [view entry] [view interactions] High throughput yes yes
CRCM_HUMAN [view interactions] High throughput no no
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
ATG5_HUMAN [view entry] [view interactions] High throughput yes no
TNR5_HUMAN [view interactions] High throughput no no
RIPK2_HUMAN [view interactions] High throughput no yes
PAK2_HUMAN [view entry] [view interactions] High throughput yes no
EIF1B_HUMAN [view interactions] High throughput no no
DEGS1_HUMAN [view interactions] High throughput no no
TIMP2_HUMAN [view interactions] High throughput no no
HLAB_HUMAN [view interactions] High throughput no yes
IKKE_HUMAN [view interactions] High throughput no yes
EPB41_HUMAN [view entry] [view interactions] High throughput yes no
MK03_HUMAN [view entry] [view interactions] High throughput yes yes
JUN_HUMAN [view interactions] High throughput no yes
ANGI_HUMAN [view interactions] High throughput no no
HDAC5_HUMAN [view interactions] High throughput no yes
BMI1_HUMAN [view interactions] High throughput no yes
RPIA_HUMAN [view interactions] High throughput no yes
AIMP2_HUMAN [view interactions] High throughput no yes
CHD3_HUMAN [view interactions] High throughput no yes
APOA1_HUMAN [view interactions] High throughput no no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
AGTR1_HUMAN [view interactions] High throughput no no
CCR2_HUMAN [view interactions] High throughput no yes
CLTR2_HUMAN [view interactions] High throughput no no
TAAR1_HUMAN [view interactions] High throughput no yes
CAND1_HUMAN [view entry] [view interactions] High throughput yes no
CUL1_HUMAN [view interactions] High throughput no yes
CSN5_HUMAN [view interactions] High throughput no yes
CUL2_HUMAN [view interactions] High throughput no yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
NFKB1_HUMAN [view interactions] High throughput no yes
PCNA_HUMAN [view interactions] High throughput no no
DYRK2_HUMAN [view interactions] High throughput no yes
HEN1_HUMAN [view interactions] High throughput no no
HME1_HUMAN [view interactions] High throughput no no
HNF1B_HUMAN [view interactions] High throughput no no
HNF4A_HUMAN [view interactions] High throughput no no
MYOD1_HUMAN [view interactions] High throughput no no
NFYC_HUMAN [view interactions] High throughput no no
PAX6_HUMAN [view interactions] High throughput no no
SWAP1_HUMAN [view interactions] High throughput no no
APOE_HUMAN [view entry] [view interactions] High throughput yes yes
VKOR1_HUMAN [view interactions] High throughput no yes
CLP1_HUMAN [view interactions] High throughput no yes
IQCB1_HUMAN [view interactions] High throughput no no
TERF1_HUMAN [view interactions] High throughput no no
TERF2_HUMAN [view interactions] High throughput no yes
POTE1_HUMAN [view interactions] High throughput no no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
CDK2_HUMAN [view interactions] High throughput no yes
TP53B_HUMAN [view entry] [view interactions] High throughput yes yes
FINC_HUMAN [view interactions] High throughput no yes
ITA4_HUMAN [view interactions] High throughput no no
SH3R2_HUMAN [view interactions] High throughput no yes
AURKA_HUMAN [view entry] [view interactions] High throughput yes no
P53_HUMAN [view interactions] High throughput no no
HUWE1_HUMAN [view interactions] High throughput no yes
CUL7_HUMAN [view interactions] High throughput no yes
OBSL1_HUMAN [view interactions] High throughput no yes
KLH20_HUMAN [view interactions] High throughput no yes
A16A1_HUMAN [view entry] [view interactions] High throughput yes no
TM102_HUMAN [view interactions] High throughput no no
DEOC_HUMAN [view interactions] High throughput no no
PDPR_HUMAN [view interactions] High throughput no yes
KTHY_HUMAN [view interactions] High throughput no yes
RAB3I_HUMAN [view interactions] High throughput no no
RMC1_HUMAN [view interactions] High throughput no no
KC1E_HUMAN [view entry] [view interactions] High throughput yes yes
KLH24_HUMAN [view interactions] High throughput no no
KLH42_HUMAN [view interactions] High throughput no yes
KBTB7_HUMAN [view interactions] High throughput no yes
KBTB6_HUMAN [view interactions] High throughput no yes
P5CR3_HUMAN [view interactions] High throughput no no
KCTD3_HUMAN [view interactions] High throughput no yes
SHKB1_HUMAN [view interactions] High throughput no yes
ABI2_HUMAN [view entry] [view interactions] High throughput yes yes
ABI1_HUMAN [view entry] [view interactions] High throughput yes yes
KLH26_HUMAN [view interactions] High throughput no no
YDJC_HUMAN [view interactions] High throughput no no
KLH18_HUMAN [view interactions] High throughput no yes
MA2C1_HUMAN [view interactions] High throughput no no
KS6B2_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
MCM2_HUMAN [view interactions] High throughput no no
PCGF1_HUMAN [view interactions] High throughput no yes
DPPA4_HUMAN [view interactions] High throughput no no
BCOR_HUMAN [view interactions] High throughput no no
NANOG_HUMAN [view interactions] High throughput no no
PO5F1_HUMAN [view interactions] High throughput no yes
DS13A_HUMAN [view interactions] High throughput no no
PTPC1_HUMAN [view interactions] High throughput no yes
PTN1_HUMAN [view entry] [view interactions] High throughput yes yes
SSH3_HUMAN [view interactions] High throughput no yes
CSN7B_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
BRCA1_HUMAN [view interactions] High throughput no yes
HDAC6_HUMAN [view interactions] High throughput no yes
PTPRE_HUMAN [view interactions] High throughput no no
PRP8_HUMAN [view interactions] High throughput no yes
U5S1_HUMAN [view interactions] High throughput no yes
AAR2_HUMAN [view interactions] High throughput no no
PIHD1_HUMAN [view interactions] High throughput no yes
UBC12_HUMAN [view entry] [view interactions] High throughput yes yes
RELB_HUMAN [view interactions] High throughput no yes
UB2R1_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
HEXI1_HUMAN [view interactions] High throughput no yes
LARP7_HUMAN [view interactions] High throughput no yes
RN123_HUMAN [view interactions] High throughput no yes
PPT1_HUMAN [view interactions] High throughput no yes
SNAI1_HUMAN [view interactions] High throughput no yes
RECQ4_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
RNF41_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
RC3H1_HUMAN [view interactions] High throughput no yes
TET2_HUMAN [view interactions] High throughput no yes
ATX3_HUMAN [view interactions] High throughput no yes
DYR1A_HUMAN [view interactions] High throughput no yes
TIP_HUMAN [view entry] [view interactions] High throughput yes yes
RBP56_HUMAN [view interactions] High throughput no yes
MATR3_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
NFX1_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
YAP1_HUMAN [view interactions] High throughput no yes
TFCP2_HUMAN [view interactions] High throughput no no
DOCK8_HUMAN [view interactions] High throughput no yes
AKP13_HUMAN [view interactions] High throughput no yes
RHG24_HUMAN [view interactions] High throughput no yes
RHG29_HUMAN [view interactions] High throughput no yes
ARGAL_HUMAN [view interactions] High throughput no yes
ITSN1_HUMAN [view entry] [view interactions] High throughput yes yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
KIF23_HUMAN [view interactions] High throughput no yes
PRC1_HUMAN [view interactions] High throughput no yes
AGR2_HUMAN [view interactions] High throughput no no
BRD4_HUMAN [view interactions] High throughput no yes
CTIP_HUMAN [view interactions] High throughput no no
RIN3_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
UFL1_HUMAN [view interactions] High throughput no yes
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes