EEA1_HUMAN
Evidence for PS localization
Functions
Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in EEA1_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 33.9286 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 33.9286 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 33.9286 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 21.4286 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 21.4286 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 21.4286 | 6 | no |
| GO:0046872 | metal ion binding | 19.6429 | 4 | yes |
| GO:0042803 | protein homodimerization activity | 14.2857 | 4 | yes |
| GO:0046914 | transition metal ion binding | 12.5000 | 5 | yes |
| GO:0008270 | zinc ion binding | 10.7143 | 6 | yes |
| GO:0035091 | phosphatidylinositol binding | 8.9286 | 4 | yes |
| GO:0005545 | 1-phosphatidylinositol binding | 3.5714 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in EEA1_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 53.5714 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 51.7857 | 4 | no |
| GO:0006996 | organelle organization | 50.0000 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 44.6429 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 44.6429 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 42.8571 | 4 | no |
| GO:0015031 | protein transport | 42.8571 | 4 | no |
| GO:0071702 | organic substance transport | 42.8571 | 4 | no |
| GO:0071705 | nitrogen compound transport | 42.8571 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 39.2857 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 37.5000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 35.7143 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.9286 | 5 | no |
| GO:0006886 | intracellular protein transport | 33.9286 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 33.9286 | 4 | no |
| GO:0051049 | regulation of transport | 33.9286 | 4 | no |
| GO:0010646 | regulation of cell communication | 32.1429 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 30.3571 | 5 | no |
| GO:0022607 | cellular component assembly | 30.3571 | 4 | no |
| GO:0009966 | regulation of signal transduction | 28.5714 | 4 | no |
| GO:0016050 | vesicle organization | 26.7857 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 26.7857 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 26.7857 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 26.7857 | 4 | no |
| GO:0023056 | positive regulation of signaling | 26.7857 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 25.0000 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.0000 | 4 | no |
| GO:0006897 | endocytosis | 23.2143 | 5 | yes |
| GO:0010468 | regulation of gene expression | 23.2143 | 5 | no |
| GO:0032880 | regulation of protein localization | 23.2143 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 23.2143 | 6 | no |
| GO:0060341 | regulation of cellular localization | 23.2143 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 23.2143 | 5 | no |
| GO:0061024 | membrane organization | 21.4286 | 4 | yes |
| GO:0030030 | cell projection organization | 21.4286 | 4 | no |
| GO:0033043 | regulation of organelle organization | 21.4286 | 5 | no |
| GO:0036211 | protein modification process | 21.4286 | 4 | no |
| GO:0043412 | macromolecule modification | 21.4286 | 4 | no |
| GO:0051050 | positive regulation of transport | 21.4286 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 21.4286 | 5 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 21.4286 | 4 | no |
| GO:0061025 | membrane fusion | 16.0714 | 5 | yes |
| GO:0007032 | endosome organization | 14.2857 | 6 | yes |
| GO:0016482 | cytosolic transport | 14.2857 | 4 | yes |
| GO:0006906 | vesicle fusion | 12.5000 | 6 | yes |
| GO:0048284 | organelle fusion | 12.5000 | 5 | yes |
| GO:0090174 | organelle membrane fusion | 12.5000 | 6 | yes |
| GO:0045022 | early endosome to late endosome transport | 8.9286 | 5 | yes |
| GO:0098927 | vesicle-mediated transport between endosomal compartments | 8.9286 | 5 | yes |
| GO:0016189 | synaptic vesicle to endosome fusion | 3.5714 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in EEA1_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 3.5714 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SNX27_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| IGF1R_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RABE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TERA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| P53_HUMAN | [view interactions] | Low throughput | no | no |
| STX12_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAD_HUMAN | [view interactions] | Low throughput | no | yes |
| PXK_HUMAN | [view interactions] | Low throughput | no | yes |
| ACK1_HUMAN | [view interactions] | Low throughput | no | yes |
| WASH1_HUMAN | [view interactions] | Low throughput | no | yes |
| VPS35_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBP8_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| 1433S_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PROM1_HUMAN | [view interactions] | Low throughput | no | no |
| MBP_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MYPR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ADRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NSF_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PDC6I_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NICA_HUMAN | [view interactions] | Low throughput | no | yes |
| RB22A_HUMAN | [view interactions] | Low throughput | no | yes |
| STX6_HUMAN | [view interactions] | Low throughput | no | yes |
| RAB5B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SAM9L_HUMAN | [view interactions] | Low throughput | no | yes |
| SAMD9_HUMAN | [view interactions] | Low throughput | no | yes |
| RAB31_HUMAN | [view interactions] | Low throughput | no | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | Low throughput | no | no |
| RAB14_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MPRI_HUMAN | [view interactions] | Low throughput | no | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KI16B_HUMAN | [view interactions] | Low throughput | no | yes |
| EGF_HUMAN | [view interactions] | Low throughput | no | no |
| TM1L1_HUMAN | [view interactions] | Low throughput | no | yes |
| ALS2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RSPO3_HUMAN | [view interactions] | Low throughput | no | yes |
| LRP2_HUMAN | [view interactions] | Low throughput | no | no |
| EGFR_HUMAN | [view interactions] | Low throughput | no | no |
| VAC14_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RN167_HUMAN | [view interactions] | Low throughput | no | yes |
| OLR1_HUMAN | [view interactions] | Low throughput | no | no |
| TCPA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CAN7_HUMAN | [view interactions] | Low throughput | no | no |
| EEA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| OPSD_HUMAN | [view interactions] | Low throughput | no | no |
| ZFYV9_HUMAN | [view interactions] | Low throughput | no | yes |
| GRAB_HUMAN | [view interactions] | Low throughput | no | no |
| RABX5_HUMAN | [view interactions] | Low throughput | no | no |
| TGFA1_HUMAN | [view interactions] | Low throughput | no | no |
| ZFY16_HUMAN | [view interactions] | Low throughput | no | yes |
| TOM1_HUMAN | [view interactions] | Low throughput | no | yes |
| CY24B_HUMAN | [view interactions] | Low throughput | no | no |
| ITB2_HUMAN | [view interactions] | Low throughput | no | no |
| RASF5_HUMAN | [view interactions] | Low throughput | no | yes |
| STK4_HUMAN | [view interactions] | Low throughput | no | yes |
| VGFR1_HUMAN | [view interactions] | Low throughput | no | no |
| VGFR2_HUMAN | [view interactions] | Low throughput | no | no |
| MRTFB_HUMAN | [view interactions] | High throughput | no | yes |
| PDGFC_HUMAN | [view interactions] | High throughput | no | no |
| DBLOH_HUMAN | [view interactions] | High throughput | no | no |
| CK049_HUMAN | [view interactions] | High throughput | no | yes |
| GTPB4_HUMAN | [view interactions] | High throughput | no | yes |
| DVL3_HUMAN | [view interactions] | High throughput | no | yes |
| LRC49_HUMAN | [view interactions] | High throughput | no | no |
| HAUS6_HUMAN | [view interactions] | High throughput | no | yes |
| TPGS1_HUMAN | [view interactions] | High throughput | no | no |
| RRP12_HUMAN | [view interactions] | High throughput | no | no |
| PCM1_HUMAN | [view interactions] | High throughput | no | yes |
| GAPD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KEAP1_HUMAN | [view interactions] | High throughput | no | yes |
| RS29_HUMAN | [view interactions] | High throughput | no | yes |
| LRBA_HUMAN | [view interactions] | High throughput | no | yes |
| LSM8_HUMAN | [view interactions] | High throughput | no | yes |
| IF4G3_HUMAN | [view interactions] | High throughput | no | yes |
| DVL2_HUMAN | [view interactions] | High throughput | no | yes |
| PDLI1_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
| PIBF1_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRQ_HUMAN | [view interactions] | High throughput | no | no |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| FCG2A_HUMAN | [view interactions] | High throughput | no | no |
| PPR3C_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RBCC1_HUMAN | [view interactions] | High throughput | no | no |
| IL24_HUMAN | [view interactions] | High throughput | no | no |
| CAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| E41L5_HUMAN | [view interactions] | High throughput | no | no |
| BCORL_HUMAN | [view interactions] | High throughput | no | no |
| NUP58_HUMAN | [view interactions] | High throughput | no | yes |
| WDR76_HUMAN | [view interactions] | High throughput | no | no |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| H2A1B_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| ZNRF2_HUMAN | [view interactions] | High throughput | no | yes |
| CEA16_HUMAN | [view interactions] | High throughput | no | no |
| KRT38_HUMAN | [view interactions] | High throughput | no | no |
| HSBP1_HUMAN | [view interactions] | High throughput | no | no |
| BRK1_HUMAN | [view interactions] | High throughput | no | no |
| KRT37_HUMAN | [view interactions] | High throughput | no | no |
| BET1_HUMAN | [view interactions] | High throughput | no | no |
| MYCB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYCE1_HUMAN | [view interactions] | High throughput | no | no |
| FBSP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| FBX43_HUMAN | [view interactions] | High throughput | no | no |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RANG_HUMAN | [view interactions] | High throughput | no | no |
| SMCA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2B1C_HUMAN | [view interactions] | High throughput | no | yes |
| PDLI7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AIF1L_HUMAN | [view interactions] | High throughput | no | yes |
| H2A2A_HUMAN | [view interactions] | High throughput | no | yes |
| ATG9A_HUMAN | [view interactions] | High throughput | no | yes |
| SORT_HUMAN | [view interactions] | High throughput | no | yes |
| SYMC_HUMAN | [view interactions] | High throughput | no | yes |
| OCRL_HUMAN | [view interactions] | High throughput | no | yes |
| USO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| ANFY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IRAK1_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RGAP1_HUMAN | [view interactions] | High throughput | no | no |
| TNKS2_HUMAN | [view interactions] | High throughput | no | no |
| ABL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSPC1_HUMAN | [view interactions] | High throughput | no | yes |
| ASF1B_HUMAN | [view interactions] | High throughput | no | yes |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| NEUL_HUMAN | [view interactions] | High throughput | no | yes |
| CNDG2_HUMAN | [view interactions] | High throughput | no | yes |
| APC4_HUMAN | [view interactions] | High throughput | no | yes |
| BEGIN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FN3K_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OAS3_HUMAN | [view interactions] | High throughput | no | no |
| IRGQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OSBL1_HUMAN | [view interactions] | High throughput | no | yes |
| NPHP4_HUMAN | [view interactions] | High throughput | no | yes |
| TPIS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| TRIPB_HUMAN | [view interactions] | High throughput | no | yes |
| SNR27_HUMAN | [view interactions] | High throughput | no | yes |
| AF17_HUMAN | [view interactions] | High throughput | no | yes |
| PAI2_HUMAN | [view interactions] | High throughput | no | no |
| UBP47_HUMAN | [view interactions] | High throughput | no | yes |
| BMP1_HUMAN | [view interactions] | High throughput | no | yes |
| TMA16_HUMAN | [view interactions] | High throughput | no | yes |
| FUCM_HUMAN | [view interactions] | High throughput | no | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAZ_HUMAN | [view interactions] | High throughput | no | yes |
| RBM33_HUMAN | [view interactions] | High throughput | no | yes |
| SEC13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIMT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC16A_HUMAN | [view interactions] | High throughput | no | yes |
| RT12_HUMAN | [view interactions] | High throughput | no | yes |
| TENS3_HUMAN | [view interactions] | High throughput | no | no |
| RUVB1_HUMAN | [view interactions] | High throughput | no | yes |
| IMB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| AXIN1_HUMAN | [view interactions] | High throughput | no | yes |
| FZD5_HUMAN | [view interactions] | High throughput | no | yes |
| LRP6_HUMAN | [view interactions] | High throughput | no | yes |
| NISCH_HUMAN | [view interactions] | High throughput | no | yes |
| DP13A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F135A_HUMAN | [view interactions] | High throughput | no | yes |
| VPS45_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRPE1_HUMAN | [view interactions] | High throughput | no | yes |
| PTN23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S6A15_HUMAN | [view interactions] | High throughput | no | yes |
| RUFY1_HUMAN | [view interactions] | High throughput | no | yes |
| GLO2_HUMAN | [view interactions] | High throughput | no | yes |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| KIF5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RUFY2_HUMAN | [view interactions] | High throughput | no | yes |
| ECM29_HUMAN | [view interactions] | High throughput | no | no |
| VIP2_HUMAN | [view interactions] | High throughput | no | yes |
| OCLN_HUMAN | [view interactions] | Computational | no | no |
| PK3C3_HUMAN | [view interactions] | Computational | no | yes |
| LAMP1_HUMAN | [view interactions] | Computational | no | yes |
| RAB7B_HUMAN | [view interactions] | Computational | no | no |
| RB11A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ELAF_HUMAN | [view interactions] | Computational | no | no |
| TFR1_HUMAN | [view interactions] | Computational | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |