Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

MRTFB_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in MRTFB_HUMAN
GO:0000166 nucleotide binding 45.0000 4 no
GO:0017076 purine nucleotide binding 45.0000 5 no
GO:0032555 purine ribonucleotide binding 45.0000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 45.0000 4 no
GO:0043168 anion binding 45.0000 4 no
GO:0005524 ATP binding 40.0000 5 no
GO:0030554 adenyl nucleotide binding 40.0000 6 no
GO:0032559 adenyl ribonucleotide binding 40.0000 5 no
GO:0031625 ubiquitin protein ligase binding 35.0000 5 no
GO:0044389 ubiquitin-like protein ligase binding 35.0000 4 no
GO:0045296 cadherin binding 25.0000 4 yes
GO:0003723 RNA binding 25.0000 4 no
GO:0043169 cation binding 25.0000 4 no
GO:0046872 metal ion binding 25.0000 5 no
GO:0019900 kinase binding 25.0000 4 no
GO:0019901 protein kinase binding 25.0000 5 no
GO:0016462 pyrophosphatase activity 25.0000 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 25.0000 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 25.0000 6 no

Biological process

Term Name % Distance from top the of the tree Annotated in MRTFB_HUMAN
GO:0031323 regulation of cellular metabolic process 75.0000 4 yes
GO:0060255 regulation of macromolecule metabolic process 75.0000 4 yes
GO:0009889 regulation of biosynthetic process 70.0000 4 yes
GO:0080090 regulation of primary metabolic process 70.0000 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 65.0000 5 yes
GO:0031326 regulation of cellular biosynthetic process 65.0000 5 yes
GO:0048522 positive regulation of cellular process 65.0000 4 yes
GO:0051128 regulation of cellular component organization 60.0000 4 no
GO:0009891 positive regulation of biosynthetic process 60.0000 5 yes
GO:0009893 positive regulation of metabolic process 60.0000 4 yes
GO:0010468 regulation of gene expression 60.0000 6 yes
GO:0010604 positive regulation of macromolecule metabolic process 60.0000 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 60.0000 5 yes
GO:0031325 positive regulation of cellular metabolic process 60.0000 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 55.0000 6 yes
GO:0031328 positive regulation of cellular biosynthetic process 55.0000 6 yes
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0006355 regulation of DNA-templated transcription 50.0000 7 yes
GO:0051252 regulation of RNA metabolic process 50.0000 5 yes
GO:2001141 regulation of RNA biosynthetic process 50.0000 6 yes
GO:0008104 protein localization 50.0000 4 no
GO:0051246 regulation of protein metabolic process 45.0000 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 45.0000 5 yes
GO:0051049 regulation of transport 40.0000 4 no
GO:0060341 regulation of cellular localization 40.0000 4 no
GO:0022607 cellular component assembly 40.0000 4 no
GO:0071310 cellular response to organic substance 40.0000 4 no
GO:0048584 positive regulation of response to stimulus 40.0000 4 no
GO:0006996 organelle organization 40.0000 4 no
GO:0009894 regulation of catabolic process 40.0000 4 no
GO:0032880 regulation of protein localization 35.0000 5 no
GO:0042176 regulation of protein catabolic process 35.0000 5 no
GO:0071702 organic substance transport 35.0000 4 no
GO:0071705 nitrogen compound transport 35.0000 4 no
GO:0009892 negative regulation of metabolic process 35.0000 4 no
GO:0010646 regulation of cell communication 35.0000 4 no
GO:0014070 response to organic cyclic compound 35.0000 4 no
GO:0031399 regulation of protein modification process 35.0000 6 no
GO:0033043 regulation of organelle organization 35.0000 5 no
GO:0044087 regulation of cellular component biogenesis 35.0000 4 no
GO:0080134 regulation of response to stress 35.0000 4 no
GO:0043933 protein-containing complex organization 35.0000 4 no
GO:0051094 positive regulation of developmental process 35.0000 4 yes
GO:0051254 positive regulation of RNA metabolic process 35.0000 6 yes
GO:0030162 regulation of proteolysis 30.0000 6 no
GO:0061136 regulation of proteasomal protein catabolic process 30.0000 6 no
GO:1903050 regulation of proteolysis involved in protein catabolic process 30.0000 7 no
GO:0006796 phosphate-containing compound metabolic process 30.0000 4 no
GO:0031324 negative regulation of cellular metabolic process 30.0000 5 no
GO:0045595 regulation of cell differentiation 30.0000 4 no
GO:0071407 cellular response to organic cyclic compound 30.0000 5 no
GO:0009966 regulation of signal transduction 30.0000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 30.0000 5 no
GO:0010647 positive regulation of cell communication 30.0000 5 no
GO:0023056 positive regulation of signaling 30.0000 4 no
GO:0042981 regulation of apoptotic process 30.0000 5 no
GO:0043067 regulation of programmed cell death 30.0000 4 no
GO:0051247 positive regulation of protein metabolic process 30.0000 6 no
GO:0051493 regulation of cytoskeleton organization 30.0000 6 no
GO:0006357 regulation of transcription by RNA polymerase II 30.0000 8 yes
GO:0045893 positive regulation of DNA-templated transcription 30.0000 8 yes
GO:0051240 positive regulation of multicellular organismal process 30.0000 4 yes
GO:1902680 positive regulation of RNA biosynthetic process 30.0000 7 yes
GO:0006886 intracellular protein transport 30.0000 4 no
GO:0015031 protein transport 30.0000 4 no
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process 25.0000 6 no
GO:0051726 regulation of cell cycle 25.0000 4 no
GO:2000058 regulation of ubiquitin-dependent protein catabolic process 25.0000 5 no
GO:0036211 protein modification process 25.0000 4 no
GO:0043412 macromolecule modification 25.0000 4 no
GO:0051129 negative regulation of cellular component organization 25.0000 5 no
GO:0060284 regulation of cell development 25.0000 5 no
GO:1901701 cellular response to oxygen-containing compound 25.0000 4 no
GO:2000026 regulation of multicellular organismal development 25.0000 4 no
GO:0002684 positive regulation of immune system process 25.0000 4 no
GO:0009057 macromolecule catabolic process 25.0000 4 no
GO:0009890 negative regulation of biosynthetic process 25.0000 5 no
GO:0009896 positive regulation of catabolic process 25.0000 5 no
GO:0009967 positive regulation of signal transduction 25.0000 5 no
GO:0009968 negative regulation of signal transduction 25.0000 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0010628 positive regulation of gene expression 25.0000 7 no
GO:0010648 negative regulation of cell communication 25.0000 5 no
GO:0023057 negative regulation of signaling 25.0000 4 no
GO:0031327 negative regulation of cellular biosynthetic process 25.0000 6 no
GO:0045732 positive regulation of protein catabolic process 25.0000 6 no
GO:0045862 positive regulation of proteolysis 25.0000 7 no
GO:0048585 negative regulation of response to stimulus 25.0000 4 no
GO:0051130 positive regulation of cellular component organization 25.0000 5 no
GO:1901800 positive regulation of proteasomal protein catabolic process 25.0000 7 no
GO:1901873 regulation of post-translational protein modification 25.0000 7 no
GO:1902903 regulation of supramolecular fiber organization 25.0000 5 no
GO:1903052 positive regulation of proteolysis involved in protein catabolic process 25.0000 8 no
GO:1903320 regulation of protein modification by small protein conjugation or removal 25.0000 8 no
GO:0045944 positive regulation of transcription by RNA polymerase II 20.0000 9 yes
GO:0042692 muscle cell differentiation 15.0000 4 yes
GO:0051145 smooth muscle cell differentiation 15.0000 5 yes
GO:1902893 regulation of miRNA transcription 15.0000 7 yes
GO:1902895 positive regulation of miRNA transcription 15.0000 8 yes
GO:2000628 regulation of miRNA metabolic process 15.0000 6 yes
GO:2000630 positive regulation of miRNA metabolic process 15.0000 7 yes
GO:0007517 muscle organ development 10.0000 4 yes
GO:0016202 regulation of striated muscle tissue development 10.0000 5 yes
GO:0045844 positive regulation of striated muscle tissue development 10.0000 6 yes
GO:0048634 regulation of muscle organ development 10.0000 4 yes
GO:0048636 positive regulation of muscle organ development 10.0000 5 yes
GO:1901861 regulation of muscle tissue development 10.0000 4 yes
GO:1901863 positive regulation of muscle tissue development 10.0000 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SRF_HUMAN [view interactions] Low throughput no yes
MRTFB_HUMAN [view entry] [view interactions] Low throughput yes yes
MRTFA_HUMAN [view entry] [view interactions] Low throughput yes yes
NCOA3_HUMAN [view interactions] Low throughput no yes
KDM3A_HUMAN [view interactions] Low throughput no no
SMAD7_HUMAN [view interactions] High throughput no yes
SMAD1_HUMAN [view interactions] High throughput no yes
XPO7_HUMAN [view entry] [view interactions] High throughput yes yes
PRD16_HUMAN [view interactions] High throughput no no
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
H2B2E_HUMAN [view interactions] High throughput no yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
ST38L_HUMAN [view entry] [view interactions] High throughput yes yes
BMI1_HUMAN [view interactions] High throughput no yes
ODFP2_HUMAN [view interactions] High throughput no no
ESR1_HUMAN [view interactions] High throughput no no
IMA3_HUMAN [view interactions] High throughput no yes
EEA1_HUMAN [view entry] [view interactions] High throughput yes yes
NECD_HUMAN [view interactions] High throughput no no
DYRK2_HUMAN [view interactions] High throughput no yes
SVIL_HUMAN [view interactions] High throughput no yes
NPHP4_HUMAN [view interactions] High throughput no yes
HUWE1_HUMAN [view interactions] High throughput no yes
FHL3_HUMAN [view interactions] High throughput no no
BCL7A_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
ACTC_HUMAN [view interactions] High throughput no no
FHL2_HUMAN [view interactions] High throughput no yes
BAG2_HUMAN [view entry] [view interactions] High throughput yes no
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
CLCA_HUMAN [view entry] [view interactions] High throughput yes no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
SMG1_HUMAN [view interactions] High throughput no yes
FRG1_HUMAN [view interactions] High throughput no yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
RNF41_HUMAN [view interactions] High throughput no yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
LTN1_HUMAN [view interactions] High throughput no no
GBF1_HUMAN [view interactions] High throughput no yes
XRCC6_HUMAN [view interactions] High throughput no yes
HOOK1_HUMAN [view interactions] High throughput no no
NHLC2_HUMAN [view interactions] High throughput no yes
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
SEC62_HUMAN [view interactions] High throughput no yes
RN183_HUMAN [view interactions] High throughput no no
IMDH2_HUMAN [view interactions] High throughput no yes
NAA40_HUMAN [view interactions] High throughput no no
CCNF_HUMAN [view interactions] High throughput no no
NUP43_HUMAN [view interactions] High throughput no yes
KDM1A_HUMAN [view interactions] High throughput no yes
HDAC1_HUMAN [view interactions] High throughput no no
PF21A_HUMAN [view interactions] High throughput no yes
RCOR1_HUMAN [view interactions] High throughput no yes
KBTB4_HUMAN [view interactions] High throughput no yes
RAB18_HUMAN [view entry] [view interactions] High throughput yes yes
YAP1_HUMAN [view interactions] High throughput no yes