Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

MRTFA_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in MRTFA_HUMAN
GO:0043168 anion binding 47.6190 4 no
GO:0044389 ubiquitin-like protein ligase binding 38.0952 4 no
GO:0000166 nucleotide binding 38.0952 4 no
GO:0017076 purine nucleotide binding 38.0952 5 no
GO:0031625 ubiquitin protein ligase binding 38.0952 5 no
GO:0032555 purine ribonucleotide binding 38.0952 4 no
GO:0035639 purine ribonucleoside triphosphate binding 38.0952 4 no
GO:0005524 ATP binding 33.3333 5 no
GO:0030554 adenyl nucleotide binding 33.3333 6 no
GO:0032559 adenyl ribonucleotide binding 33.3333 5 no
GO:0045296 cadherin binding 28.5714 4 no
GO:0003723 RNA binding 23.8095 4 no
GO:0003779 actin binding 23.8095 4 yes
GO:0019900 kinase binding 23.8095 4 no
GO:0019901 protein kinase binding 23.8095 5 no
GO:0003785 actin monomer binding 14.2857 5 yes
GO:0030275 LRR domain binding 9.5238 4 yes
GO:0043522 leucine zipper domain binding 9.5238 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in MRTFA_HUMAN
GO:0060255 regulation of macromolecule metabolic process 76.1905 4 yes
GO:0031323 regulation of cellular metabolic process 71.4286 4 yes
GO:0048522 positive regulation of cellular process 71.4286 4 yes
GO:0080090 regulation of primary metabolic process 71.4286 4 yes
GO:0009889 regulation of biosynthetic process 61.9048 4 yes
GO:0009893 positive regulation of metabolic process 61.9048 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 61.9048 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 61.9048 5 yes
GO:0031325 positive regulation of cellular metabolic process 61.9048 5 yes
GO:0031326 regulation of cellular biosynthetic process 61.9048 5 yes
GO:0006996 organelle organization 57.1429 4 yes
GO:0009891 positive regulation of biosynthetic process 57.1429 5 yes
GO:0010468 regulation of gene expression 57.1429 6 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 57.1429 6 yes
GO:0031328 positive regulation of cellular biosynthetic process 57.1429 6 yes
GO:0051128 regulation of cellular component organization 52.3810 4 no
GO:0051246 regulation of protein metabolic process 52.3810 5 no
GO:0048523 negative regulation of cellular process 47.6190 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 42.8571 5 yes
GO:0031399 regulation of protein modification process 42.8571 6 no
GO:0006355 regulation of DNA-templated transcription 38.0952 7 yes
GO:0051252 regulation of RNA metabolic process 38.0952 5 yes
GO:2001141 regulation of RNA biosynthetic process 38.0952 6 yes
GO:0022607 cellular component assembly 38.0952 4 no
GO:0033043 regulation of organelle organization 38.0952 5 no
GO:0044087 regulation of cellular component biogenesis 38.0952 4 no
GO:0051247 positive regulation of protein metabolic process 38.0952 6 no
GO:0008104 protein localization 38.0952 4 no
GO:0006357 regulation of transcription by RNA polymerase II 33.3333 8 yes
GO:0007010 cytoskeleton organization 33.3333 5 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 33.3333 5 yes
GO:0051493 regulation of cytoskeleton organization 33.3333 6 no
GO:0010628 positive regulation of gene expression 33.3333 7 no
GO:0010646 regulation of cell communication 33.3333 4 no
GO:0045595 regulation of cell differentiation 33.3333 4 no
GO:0071310 cellular response to organic substance 33.3333 4 no
GO:0080134 regulation of response to stress 33.3333 4 no
GO:0051254 positive regulation of RNA metabolic process 28.5714 6 yes
GO:0010638 positive regulation of organelle organization 28.5714 6 no
GO:0043933 protein-containing complex organization 28.5714 4 no
GO:0051130 positive regulation of cellular component organization 28.5714 5 no
GO:0051094 positive regulation of developmental process 28.5714 4 no
GO:0051240 positive regulation of multicellular organismal process 28.5714 4 no
GO:0009892 negative regulation of metabolic process 28.5714 4 no
GO:0009894 regulation of catabolic process 28.5714 4 no
GO:0009966 regulation of signal transduction 28.5714 4 no
GO:0010605 negative regulation of macromolecule metabolic process 28.5714 5 no
GO:0031400 negative regulation of protein modification process 28.5714 7 no
GO:0042176 regulation of protein catabolic process 28.5714 5 no
GO:0051049 regulation of transport 28.5714 4 no
GO:0051248 negative regulation of protein metabolic process 28.5714 6 no
GO:0060284 regulation of cell development 28.5714 5 no
GO:0048584 positive regulation of response to stimulus 28.5714 4 no
GO:0045893 positive regulation of DNA-templated transcription 23.8095 8 yes
GO:1902680 positive regulation of RNA biosynthetic process 23.8095 7 yes
GO:0030030 cell projection organization 23.8095 4 no
GO:0031334 positive regulation of protein-containing complex assembly 23.8095 6 no
GO:0043254 regulation of protein-containing complex assembly 23.8095 5 no
GO:0044089 positive regulation of cellular component biogenesis 23.8095 5 no
GO:1902903 regulation of supramolecular fiber organization 23.8095 5 no
GO:0009968 negative regulation of signal transduction 23.8095 5 no
GO:0010648 negative regulation of cell communication 23.8095 5 no
GO:0019220 regulation of phosphate metabolic process 23.8095 6 no
GO:0023057 negative regulation of signaling 23.8095 4 no
GO:0030155 regulation of cell adhesion 23.8095 4 no
GO:0030162 regulation of proteolysis 23.8095 6 no
GO:0031324 negative regulation of cellular metabolic process 23.8095 5 no
GO:0042981 regulation of apoptotic process 23.8095 5 no
GO:0043067 regulation of programmed cell death 23.8095 4 no
GO:0045597 positive regulation of cell differentiation 23.8095 5 no
GO:0048585 negative regulation of response to stimulus 23.8095 4 no
GO:0051129 negative regulation of cellular component organization 23.8095 5 no
GO:0051174 regulation of phosphorus metabolic process 23.8095 5 no
GO:0051338 regulation of transferase activity 23.8095 4 no
GO:0060341 regulation of cellular localization 23.8095 4 no
GO:0061136 regulation of proteasomal protein catabolic process 23.8095 6 no
GO:1901701 cellular response to oxygen-containing compound 23.8095 4 no
GO:1901873 regulation of post-translational protein modification 23.8095 7 no
GO:1903050 regulation of proteolysis involved in protein catabolic process 23.8095 7 no
GO:1903320 regulation of protein modification by small protein conjugation or removal 23.8095 8 no
GO:0002684 positive regulation of immune system process 23.8095 4 no
GO:0014070 response to organic cyclic compound 23.8095 4 no
GO:0034599 cellular response to oxidative stress 23.8095 4 no
GO:0042127 regulation of cell population proliferation 23.8095 4 no
GO:0062197 cellular response to chemical stress 23.8095 4 no
GO:2000026 regulation of multicellular organismal development 23.8095 4 no
GO:0010564 regulation of cell cycle process 23.8095 5 no
GO:0015031 protein transport 23.8095 4 no
GO:0051726 regulation of cell cycle 23.8095 4 no
GO:0071702 organic substance transport 23.8095 4 no
GO:0071705 nitrogen compound transport 23.8095 4 no
GO:0045944 positive regulation of transcription by RNA polymerase II 19.0476 9 yes
GO:1902893 regulation of miRNA transcription 19.0476 7 yes
GO:1902895 positive regulation of miRNA transcription 19.0476 8 yes
GO:2000628 regulation of miRNA metabolic process 19.0476 6 yes
GO:2000630 positive regulation of miRNA metabolic process 19.0476 7 yes
GO:0042692 muscle cell differentiation 14.2857 4 yes
GO:0051145 smooth muscle cell differentiation 14.2857 5 yes
GO:0044319 wound healing, spreading of cells 9.5238 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
IMA4_HUMAN [view interactions] Low throughput no yes
SRF_HUMAN [view interactions] Low throughput no yes
MRTFB_HUMAN [view entry] [view interactions] Low throughput yes yes
ACTB_HUMAN [view entry] [view interactions] Low throughput yes no
IMA3_HUMAN [view interactions] Low throughput no yes
IMB1_HUMAN [view entry] [view interactions] Low throughput yes yes
NCOA3_HUMAN [view interactions] Low throughput no yes
SP16H_HUMAN [view interactions] Low throughput no yes
SSRP1_HUMAN [view interactions] Low throughput no yes
SMCA4_HUMAN [view interactions] Low throughput no yes
GSK3B_HUMAN [view entry] [view interactions] Low throughput yes yes
SMAD3_HUMAN [view interactions] Low throughput no yes
DNMT1_HUMAN [view interactions] Low throughput no no
EP300_HUMAN [view interactions] Low throughput no yes
TF65_HUMAN [view entry] [view interactions] Low throughput yes yes
UBP10_HUMAN [view interactions] Low throughput no yes
MYCD_HUMAN [view interactions] Low throughput no yes
KDM3A_HUMAN [view interactions] Low throughput no no
MRTFA_HUMAN [view entry] [view interactions] Low throughput yes yes
MLP3B_HUMAN [view interactions] High throughput no yes
MLP3A_HUMAN [view entry] [view interactions] High throughput yes yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
CUL4B_HUMAN [view interactions] High throughput no yes
FUND2_HUMAN [view interactions] High throughput no yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
LHX2_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
RAB1A_HUMAN [view entry] [view interactions] High throughput yes yes
MOONR_HUMAN [view interactions] High throughput no yes
TECT1_HUMAN [view interactions] High throughput no yes
LCA5_HUMAN [view interactions] High throughput no no
RPGR1_HUMAN [view interactions] High throughput no no
CEP19_HUMAN [view interactions] High throughput no no
CEP63_HUMAN [view interactions] High throughput no yes
MVP_HUMAN [view entry] [view interactions] High throughput yes yes
TRI54_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
BCL7A_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
ACTC_HUMAN [view interactions] High throughput no no
APEX1_HUMAN [view interactions] High throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
FHL2_HUMAN [view interactions] High throughput no yes
BAG2_HUMAN [view entry] [view interactions] High throughput yes no
HSP72_HUMAN [view entry] [view interactions] High throughput yes no
S10A2_HUMAN [view interactions] High throughput no no
SNX27_HUMAN [view entry] [view interactions] High throughput yes no
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
ATG7_HUMAN [view interactions] High throughput no yes
PEX14_HUMAN [view interactions] High throughput no yes
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
VASP_HUMAN [view entry] [view interactions] High throughput yes yes
VINC_HUMAN [view entry] [view interactions] High throughput yes no
ZYX_HUMAN [view interactions] High throughput no no
STING_HUMAN [view interactions] High throughput no yes
KDM1A_HUMAN [view interactions] High throughput no yes
HDAC1_HUMAN [view interactions] High throughput no no
PF21A_HUMAN [view interactions] High throughput no yes
RCOR1_HUMAN [view interactions] High throughput no yes
KBTB4_HUMAN [view interactions] High throughput no yes