BEGIN_HUMAN
Evidence for PS localization
Functions
May sustain the structure of the postsynaptic density (PSD). [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 46%
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
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BEGIN_HUMAN has binary interactions with 22 proteins
Isoforms
Interacting regions
Canonical [BEGIN_HUMAN]
Isoform [G3V536] alignment
Isoform [A0A1B0GTT1] alignment
Isoform [G3V3R5] alignment
Isoform [G3V3S3] alignment
Isoform [G3V3A2] alignment
Isoform [A0A1B0GVM0] alignment
Isoform [G3V2K4] alignment
LOADING 30%
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in BEGIN_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 30.4348 | 4 | no |
| GO:0046872 | metal ion binding | 30.4348 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in BEGIN_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 56.5217 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 47.8261 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 47.8261 | 4 | no |
| GO:0006996 | organelle organization | 43.4783 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 43.4783 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 43.4783 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 43.4783 | 4 | no |
| GO:0010646 | regulation of cell communication | 34.7826 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 34.7826 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 34.7826 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 34.7826 | 5 | no |
| GO:0051049 | regulation of transport | 30.4348 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 30.4348 | 4 | no |
| GO:0010468 | regulation of gene expression | 30.4348 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.4348 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 30.4348 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 30.4348 | 5 | no |
| GO:0031399 | regulation of protein modification process | 30.4348 | 6 | no |
| GO:0008104 | protein localization | 26.0870 | 4 | no |
| GO:0009966 | regulation of signal transduction | 26.0870 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 26.0870 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 26.0870 | 5 | no |
| GO:0050890 | cognition | 26.0870 | 4 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 26.0870 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 26.0870 | 7 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABLM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AQP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATPF2_HUMAN | [view interactions] | High throughput | no | yes |
| BAHD1_HUMAN | [view interactions] | High throughput | no | no |
| BEGIN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| BMP7_HUMAN | [view interactions] | High throughput | no | no |
| C170L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC23_HUMAN | [view interactions] | High throughput | no | yes |
| CE170_HUMAN | [view interactions] | High throughput | no | yes |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTSR1_HUMAN | [view interactions] | High throughput | no | no |
| DDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DEFI6_HUMAN | [view interactions] | High throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DTNB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EEA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENKD1_HUMAN | [view interactions] | High throughput | no | yes |
| F107A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| F161A_HUMAN | [view interactions] | High throughput | no | no |
| F90A1_HUMAN | [view interactions] | High throughput | no | no |
| GEM_HUMAN | [view interactions] | High throughput | no | yes |
| GFI1B_HUMAN | [view interactions] | High throughput | no | no |
| GFOD2_HUMAN | [view interactions] | High throughput | no | yes |