Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AQP1_HUMAN

GO
G2C
SynGO

Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in AQP1_HUMAN
GO:0008324 cation transmembrane transporter activity 16.0000 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 12.0000 4 yes
GO:0046873 metal ion transmembrane transporter activity 12.0000 5 yes
GO:0005216 ion channel activity 8.0000 4 yes
GO:0005217 intracellular ligand-gated ion channel activity 8.0000 6 yes
GO:0005221 intracellular cyclic nucleotide activated cation channel activity 8.0000 7 yes
GO:0005223 intracellular cGMP-activated cation channel activity 8.0000 8 yes
GO:0005261 cation channel activity 8.0000 5 yes
GO:0005267 potassium channel activity 8.0000 6 yes
GO:0005372 water transmembrane transporter activity 8.0000 4 yes
GO:0008519 ammonium transmembrane transporter activity 8.0000 6 yes
GO:0015079 potassium ion transmembrane transporter activity 8.0000 6 yes
GO:0015166 polyol transmembrane transporter activity 8.0000 4 yes
GO:0015168 glycerol transmembrane transporter activity 8.0000 4 yes
GO:0015250 water channel activity 8.0000 5 yes
GO:0015267 channel activity 8.0000 4 yes
GO:0015276 ligand-gated ion channel activity 8.0000 5 yes
GO:0022834 ligand-gated channel activity 8.0000 6 yes
GO:0022836 gated channel activity 8.0000 5 yes
GO:0030184 nitric oxide transmembrane transporter activity 8.0000 4 yes
GO:0043855 cyclic nucleotide-gated ion channel activity 8.0000 6 yes
GO:0099094 ligand-gated cation channel activity 8.0000 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in AQP1_HUMAN
GO:0048522 positive regulation of cellular process 52.0000 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 48.0000 4 yes
GO:0080090 regulation of primary metabolic process 48.0000 4 yes
GO:0048523 negative regulation of cellular process 44.0000 4 yes
GO:0060255 regulation of macromolecule metabolic process 44.0000 4 yes
GO:0071702 organic substance transport 44.0000 4 yes
GO:0051246 regulation of protein metabolic process 40.0000 5 yes
GO:0031323 regulation of cellular metabolic process 40.0000 4 no
GO:0051049 regulation of transport 36.0000 4 yes
GO:0071705 nitrogen compound transport 36.0000 4 yes
GO:0022607 cellular component assembly 36.0000 4 no
GO:0009966 regulation of signal transduction 36.0000 4 no
GO:0010646 regulation of cell communication 36.0000 4 no
GO:0009892 negative regulation of metabolic process 36.0000 4 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 32.0000 5 yes
GO:0008104 protein localization 32.0000 4 no
GO:0009889 regulation of biosynthetic process 32.0000 4 no
GO:0010468 regulation of gene expression 32.0000 5 no
GO:0010556 regulation of macromolecule biosynthetic process 32.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 32.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 32.0000 5 no
GO:0071310 cellular response to organic substance 28.0000 4 yes
GO:0031399 regulation of protein modification process 28.0000 6 no
GO:0051128 regulation of cellular component organization 28.0000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 28.0000 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 28.0000 4 yes
GO:0048878 chemical homeostasis 24.0000 4 yes
GO:0051248 negative regulation of protein metabolic process 24.0000 6 yes
GO:1901701 cellular response to oxygen-containing compound 24.0000 4 yes
GO:0006355 regulation of DNA-templated transcription 24.0000 6 no
GO:0051252 regulation of RNA metabolic process 24.0000 5 no
GO:1903506 regulation of nucleic acid-templated transcription 24.0000 7 no
GO:2001141 regulation of RNA biosynthetic process 24.0000 6 no
GO:0009893 positive regulation of metabolic process 24.0000 4 no
GO:0031324 negative regulation of cellular metabolic process 24.0000 5 no
GO:0031325 positive regulation of cellular metabolic process 24.0000 5 no
GO:1902531 regulation of intracellular signal transduction 24.0000 5 no
GO:0010243 response to organonitrogen compound 24.0000 4 yes
GO:0010941 regulation of cell death 24.0000 4 yes
GO:0036293 response to decreased oxygen levels 24.0000 4 yes
GO:0042127 regulation of cell population proliferation 24.0000 4 yes
GO:0051050 positive regulation of transport 20.0000 4 yes
GO:0051094 positive regulation of developmental process 20.0000 4 yes
GO:0051240 positive regulation of multicellular organismal process 20.0000 4 yes
GO:0060548 negative regulation of cell death 20.0000 5 yes
GO:0071407 cellular response to organic cyclic compound 20.0000 5 yes
GO:0071453 cellular response to oxygen levels 20.0000 4 yes
GO:1901699 cellular response to nitrogen compound 20.0000 4 yes
GO:0006811 ion transport 20.0000 4 yes
GO:0006996 organelle organization 20.0000 4 yes
GO:0014070 response to organic cyclic compound 20.0000 4 yes
GO:0036294 cellular response to decreased oxygen levels 20.0000 5 yes
GO:0043086 negative regulation of catalytic activity 20.0000 4 yes
GO:0044057 regulation of system process 20.0000 4 yes
GO:0071417 cellular response to organonitrogen compound 16.0000 4 yes
GO:0071456 cellular response to hypoxia 16.0000 4 yes
GO:1901342 regulation of vasculature development 16.0000 5 yes
GO:2000026 regulation of multicellular organismal development 16.0000 4 yes
GO:0006812 cation transport 16.0000 5 yes
GO:0007010 cytoskeleton organization 16.0000 5 yes
GO:0008284 positive regulation of cell population proliferation 16.0000 5 yes
GO:0008643 carbohydrate transport 16.0000 5 yes
GO:0030001 metal ion transport 16.0000 6 yes
GO:0033993 response to lipid 16.0000 4 yes
GO:0042981 regulation of apoptotic process 16.0000 6 yes
GO:0043066 negative regulation of apoptotic process 16.0000 7 yes
GO:0043067 regulation of programmed cell death 16.0000 5 yes
GO:0043069 negative regulation of programmed cell death 16.0000 6 yes
GO:0045765 regulation of angiogenesis 16.0000 5 yes
GO:0046903 secretion 16.0000 4 yes
GO:0048145 regulation of fibroblast proliferation 12.0000 5 yes
GO:0051336 regulation of hydrolase activity 12.0000 4 yes
GO:0051346 negative regulation of hydrolase activity 12.0000 5 yes
GO:0062197 cellular response to chemical stress 12.0000 4 yes
GO:0071260 cellular response to mechanical stimulus 12.0000 4 yes
GO:0071396 cellular response to lipid 12.0000 5 yes
GO:0071470 cellular response to osmotic stress 12.0000 4 yes
GO:0071474 cellular hyperosmotic response 12.0000 5 yes
GO:0098655 cation transmembrane transport 12.0000 4 yes
GO:0098660 inorganic ion transmembrane transport 12.0000 4 yes
GO:0098662 inorganic cation transmembrane transport 12.0000 5 yes
GO:0006813 potassium ion transport 12.0000 7 yes
GO:0006972 hyperosmotic response 12.0000 4 yes
GO:0007589 body fluid secretion 12.0000 4 yes
GO:0008361 regulation of cell size 12.0000 5 yes
GO:0032535 regulation of cellular component size 12.0000 4 yes
GO:0042476 odontogenesis 12.0000 4 yes
GO:0048146 positive regulation of fibroblast proliferation 8.0000 6 yes
GO:0048545 response to steroid hormone 8.0000 4 yes
GO:0050829 defense response to Gram-negative bacterium 8.0000 5 yes
GO:0051046 regulation of secretion 8.0000 5 yes
GO:0051047 positive regulation of secretion 8.0000 5 yes
GO:0051384 response to glucocorticoid 8.0000 6 yes
GO:0051591 response to cAMP 8.0000 4 yes
GO:0052547 regulation of peptidase activity 8.0000 5 yes
GO:0052548 regulation of endopeptidase activity 8.0000 6 yes
GO:0060456 positive regulation of digestive system process 8.0000 5 yes
GO:0070301 cellular response to hydrogen peroxide 8.0000 5 yes
GO:0070633 transepithelial transport 8.0000 4 yes
GO:0071241 cellular response to inorganic substance 8.0000 4 yes
GO:0071248 cellular response to metal ion 8.0000 5 yes
GO:0071280 cellular response to copper ion 8.0000 6 yes
GO:0071288 cellular response to mercury ion 8.0000 6 yes
GO:0071300 cellular response to retinoic acid 8.0000 5 yes
GO:0071320 cellular response to cAMP 8.0000 5 yes
GO:0071383 cellular response to steroid hormone stimulus 8.0000 5 yes
GO:0071384 cellular response to corticosteroid stimulus 8.0000 6 yes
GO:0071385 cellular response to glucocorticoid stimulus 8.0000 7 yes
GO:0071472 cellular response to salt stress 8.0000 5 yes
GO:0071478 cellular response to radiation 8.0000 4 yes
GO:0071482 cellular response to light stimulus 8.0000 5 yes
GO:0071548 response to dexamethasone 8.0000 5 yes
GO:0071549 cellular response to dexamethasone stimulus 8.0000 6 yes
GO:0071731 response to nitric oxide 8.0000 4 yes
GO:0071732 cellular response to nitric oxide 8.0000 5 yes
GO:0072488 ammonium transmembrane transport 8.0000 5 yes
GO:1901654 response to ketone 8.0000 4 yes
GO:1901655 cellular response to ketone 8.0000 5 yes
GO:1902170 cellular response to reactive nitrogen species 8.0000 5 yes
GO:1904018 positive regulation of vasculature development 8.0000 5 yes
GO:2000116 regulation of cysteine-type endopeptidase activity 8.0000 7 yes
GO:2000117 negative regulation of cysteine-type endopeptidase activity 8.0000 8 yes
GO:0000302 response to reactive oxygen species 8.0000 4 yes
GO:0003091 renal water homeostasis 8.0000 4 yes
GO:0003097 renal water transport 8.0000 4 yes
GO:0006833 water transport 8.0000 5 yes
GO:0009411 response to UV 8.0000 5 yes
GO:0009416 response to light stimulus 8.0000 4 yes
GO:0009651 response to salt stress 8.0000 4 yes
GO:0009992 cellular water homeostasis 8.0000 4 yes
GO:0010038 response to metal ion 8.0000 4 yes
GO:0010466 negative regulation of peptidase activity 8.0000 6 yes
GO:0010951 negative regulation of endopeptidase activity 8.0000 7 yes
GO:0014074 response to purine-containing compound 8.0000 5 yes
GO:0015669 gas transport 8.0000 4 yes
GO:0015670 carbon dioxide transport 8.0000 5 yes
GO:0015793 glycerol transmembrane transport 8.0000 4 yes
GO:0015850 organic hydroxy compound transport 8.0000 5 yes
GO:0019755 one-carbon compound transport 8.0000 5 yes
GO:0019932 second-messenger-mediated signaling 8.0000 4 yes
GO:0019934 cGMP-mediated signaling 8.0000 6 yes
GO:0019935 cyclic-nucleotide-mediated signaling 8.0000 5 yes
GO:0030104 water homeostasis 8.0000 5 yes
GO:0030162 regulation of proteolysis 8.0000 6 yes
GO:0030185 nitric oxide transport 8.0000 5 yes
GO:0030950 establishment or maintenance of actin cytoskeleton polarity 8.0000 4 yes
GO:0031960 response to corticosteroid 8.0000 5 yes
GO:0032526 response to retinoic acid 8.0000 4 yes
GO:0032870 cellular response to hormone stimulus 8.0000 4 yes
GO:0034599 cellular response to oxidative stress 8.0000 4 yes
GO:0034614 cellular response to reactive oxygen species 8.0000 5 yes
GO:0034644 cellular response to UV 8.0000 6 yes
GO:0035377 transepithelial water transport 8.0000 6 yes
GO:0042044 fluid transport 8.0000 4 yes
GO:0042045 epithelial fluid transport 8.0000 5 yes
GO:0042542 response to hydrogen peroxide 8.0000 4 yes
GO:0042742 defense response to bacterium 8.0000 4 yes
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 8.0000 8 yes
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 8.0000 8 yes
GO:0044058 regulation of digestive system process 8.0000 5 yes
GO:0045766 positive regulation of angiogenesis 8.0000 6 yes
GO:0045861 negative regulation of proteolysis 8.0000 7 yes
GO:0046683 response to organophosphorus 8.0000 4 yes
GO:0046688 response to copper ion 8.0000 5 yes
GO:0046689 response to mercury ion 8.0000 5 yes
GO:0046877 regulation of saliva secretion 8.0000 4 yes
GO:0046878 positive regulation of saliva secretion 8.0000 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
EFNB2_HUMAN [view entry] [view interactions] Low throughput yes yes
AQP1_HUMAN [view entry] [view interactions] Low throughput yes no
ZIM2_HUMAN [view interactions] High throughput no no
MKRN3_HUMAN [view interactions] High throughput no yes
TRIM7_HUMAN [view interactions] High throughput no yes
LDOC1_HUMAN [view interactions] High throughput no no
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes
KRA44_HUMAN [view interactions] High throughput no no
MYF5_HUMAN [view interactions] High throughput no no
KHDR3_HUMAN [view interactions] High throughput no yes
CRTP1_HUMAN [view interactions] High throughput no yes
ZBT39_HUMAN [view interactions] High throughput no yes
KRA98_HUMAN [view interactions] High throughput no no
RBAK_HUMAN [view interactions] High throughput no no
BEGIN_HUMAN [view entry] [view interactions] High throughput yes no
KRT37_HUMAN [view interactions] High throughput no no
ZN792_HUMAN [view interactions] High throughput no yes
KRA32_HUMAN [view interactions] High throughput no no
LRAD1_HUMAN [view interactions] High throughput no no
KR124_HUMAN [view interactions] High throughput no no
CDR2_HUMAN [view interactions] High throughput no yes
TNS2_HUMAN [view interactions] High throughput no no
NT2NC_HUMAN [view interactions] High throughput no no
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
SPRE2_HUMAN [view interactions] High throughput no yes
LPXN_HUMAN [view interactions] High throughput no yes
CCDB1_HUMAN [view interactions] High throughput no yes
COMP_HUMAN [view interactions] High throughput no no
GO45_HUMAN [view interactions] High throughput no yes
ZN398_HUMAN [view interactions] High throughput no no
GLI1_HUMAN [view interactions] High throughput no no
TRI41_HUMAN [view interactions] High throughput no yes
PRDM6_HUMAN [view interactions] High throughput no no
KRA11_HUMAN [view interactions] High throughput no no
ZNF16_HUMAN [view interactions] High throughput no no
KLH26_HUMAN [view interactions] High throughput no no
BMF_HUMAN [view interactions] High throughput no yes
PA2GX_HUMAN [view interactions] High throughput no no
SPRE1_HUMAN [view interactions] High throughput no yes
S15A2_HUMAN [view interactions] High throughput no no
PRD14_HUMAN [view interactions] High throughput no no
TRI42_HUMAN [view interactions] High throughput no no
KR108_HUMAN [view interactions] High throughput no no
LRC59_HUMAN [view entry] [view interactions] High throughput yes yes
F161A_HUMAN [view interactions] High throughput no no
LCE1A_HUMAN [view interactions] High throughput no no
B2L13_HUMAN [view interactions] High throughput no no
SPY3_HUMAN [view interactions] High throughput no no
KRA15_HUMAN [view interactions] High throughput no no
BHLH9_HUMAN [view interactions] High throughput no no
FNDC9_HUMAN [view interactions] High throughput no no
G37L1_HUMAN [view interactions] High throughput no yes
LIME1_HUMAN [view entry] [view interactions] High throughput yes yes
KCNK5_HUMAN [view interactions] High throughput no yes
TMM80_HUMAN [view interactions] High throughput no yes
IL21R_HUMAN [view interactions] High throughput no no
ESM1_HUMAN [view interactions] High throughput no no
SPDYA_HUMAN [view interactions] High throughput no no
CXB5_HUMAN [view interactions] High throughput no no
SAR1A_HUMAN [view entry] [view interactions] High throughput yes yes
GET1_HUMAN [view interactions] High throughput no yes
MRM1_HUMAN [view interactions] High throughput no no
MGST3_HUMAN [view entry] [view interactions] High throughput yes yes
S39A2_HUMAN [view interactions] High throughput no yes
F209A_HUMAN [view interactions] High throughput no no
CPLX4_HUMAN [view interactions] High throughput no no
TM45B_HUMAN [view interactions] High throughput no yes
KRA62_HUMAN [view interactions] High throughput no no
SSMM1_HUMAN [view interactions] High throughput no no
GPX8_HUMAN [view interactions] High throughput no no
RN122_HUMAN [view interactions] High throughput no yes
CD79A_HUMAN [view interactions] High throughput no no
AQP6_HUMAN [view interactions] High throughput no no
IBP6_HUMAN [view interactions] High throughput no yes
PLS2_HUMAN [view interactions] High throughput no no
TM38B_HUMAN [view interactions] High throughput no yes
CLD5_HUMAN [view interactions] High throughput no no
CACO2_HUMAN [view interactions] High throughput no yes
TRI54_HUMAN [view interactions] High throughput no no
FBLN4_HUMAN [view interactions] High throughput no no
KCD17_HUMAN [view interactions] High throughput no yes
KR412_HUMAN [view interactions] High throughput no no
CC85B_HUMAN [view interactions] High throughput no yes
PCNA_HUMAN [view interactions] High throughput no no
FOS_HUMAN [view interactions] High throughput no yes
TRIM1_HUMAN [view interactions] High throughput no no
CC136_HUMAN [view interactions] High throughput no yes
KR103_HUMAN [view interactions] High throughput no no
LMNA_HUMAN [view entry] [view interactions] High throughput yes yes
IFT20_HUMAN [view interactions] High throughput no yes
SPRY7_HUMAN [view interactions] High throughput no yes
MI4GD_HUMAN [view interactions] High throughput no yes
AMOT_HUMAN [view interactions] High throughput no no
PGPI_HUMAN [view interactions] High throughput no yes
TM237_HUMAN [view interactions] High throughput no no
REL_HUMAN [view interactions] High throughput no yes
TSC1_HUMAN [view entry] [view interactions] High throughput yes yes
TMPS2_HUMAN [view interactions] High throughput no no
NUTM1_HUMAN [view interactions] High throughput no no
SIVA_HUMAN [view interactions] High throughput no no
MUC1_HUMAN [view interactions] High throughput no no
EVI2B_HUMAN [view interactions] High throughput no no
NBPF6_HUMAN [view interactions] High throughput no no
PPARA_HUMAN [view interactions] High throughput no yes
RN166_HUMAN [view interactions] High throughput no no
VPP2_HUMAN [view interactions] High throughput no yes
CREB3_HUMAN [view interactions] High throughput no no
AP2C_HUMAN [view interactions] High throughput no no
ALDOA_HUMAN [view entry] [view interactions] High throughput yes no
AT2B4_HUMAN [view entry] [view interactions] High throughput yes yes
B3AT_HUMAN [view entry] [view interactions] High throughput yes no
EPB42_HUMAN [view entry] [view interactions] High throughput yes no
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
FLOT2_HUMAN [view entry] [view interactions] High throughput yes yes
GTR1_HUMAN [view entry] [view interactions] High throughput yes no
ICAM4_HUMAN [view interactions] High throughput no no
S29A1_HUMAN [view entry] [view interactions] High throughput yes yes
S40A1_HUMAN [view interactions] High throughput no no
STOM_HUMAN [view entry] [view interactions] High throughput yes yes
CD47_HUMAN [view interactions] High throughput no no
CAV3_HUMAN [view interactions] High throughput no no
ATL4_HUMAN [view interactions] High throughput no yes
MDFI_HUMAN [view interactions] High throughput no no
FSD2_HUMAN [view interactions] High throughput no no
SPY2_HUMAN [view interactions] High throughput no yes
RGS20_HUMAN [view interactions] High throughput no no
ITF2_HUMAN [view interactions] High throughput no yes
TRI23_HUMAN [view interactions] High throughput no yes
KR107_HUMAN [view interactions] High throughput no no
ACK1_HUMAN [view interactions] High throughput no yes
TRAF2_HUMAN [view interactions] High throughput no yes
TRAF1_HUMAN [view interactions] High throughput no no
KT33B_HUMAN [view interactions] High throughput no no
K1H1_HUMAN [view interactions] High throughput no no
TRIP6_HUMAN [view interactions] High throughput no yes
CCD57_HUMAN [view interactions] High throughput no yes
MTUS2_HUMAN [view interactions] High throughput no yes
K1C40_HUMAN [view interactions] High throughput no no
KCTD9_HUMAN [view interactions] High throughput no no
NT2NA_HUMAN [view interactions] High throughput no no
SIAH1_HUMAN [view interactions] High throughput no yes
IHO1_HUMAN [view interactions] High throughput no no
K1958_HUMAN [view interactions] High throughput no yes
CSRN1_HUMAN [view interactions] High throughput no no
KRA92_HUMAN [view interactions] High throughput no no
KRA42_HUMAN [view interactions] High throughput no no
CEP44_HUMAN [view interactions] High throughput no yes
CRAC1_HUMAN [view entry] [view interactions] High throughput yes yes
RIM3A_HUMAN [view interactions] High throughput no no
RGS17_HUMAN [view entry] [view interactions] High throughput yes yes
IKZF2_HUMAN [view interactions] High throughput no no
IKZF3_HUMAN [view interactions] High throughput no no
AQP11_HUMAN [view interactions] Computational no no
CTNB1_HUMAN [view entry] [view interactions] Computational yes yes
LIN7A_HUMAN [view entry] [view interactions] Computational yes yes