Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

LIME1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in LIME1_HUMAN
GO:0000166 nucleotide binding 37.5000 4 no
GO:0005524 ATP binding 37.5000 5 no
GO:0016462 pyrophosphatase activity 37.5000 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 37.5000 4 no
GO:0016887 ATP hydrolysis activity 37.5000 7 no
GO:0017076 purine nucleotide binding 37.5000 5 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 37.5000 6 no
GO:0030554 adenyl nucleotide binding 37.5000 6 no
GO:0032555 purine ribonucleotide binding 37.5000 4 no
GO:0032559 adenyl ribonucleotide binding 37.5000 5 no
GO:0035639 purine ribonucleoside triphosphate binding 37.5000 4 no
GO:0043168 anion binding 37.5000 4 no
GO:0003723 RNA binding 31.2500 4 no
GO:0031625 ubiquitin protein ligase binding 31.2500 5 no
GO:0044389 ubiquitin-like protein ligase binding 31.2500 4 no
GO:0019900 kinase binding 12.5000 4 yes
GO:0019901 protein kinase binding 12.5000 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in LIME1_HUMAN
GO:0031323 regulation of cellular metabolic process 50.0000 4 yes
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 yes
GO:0080090 regulation of primary metabolic process 50.0000 4 yes
GO:0048522 positive regulation of cellular process 50.0000 4 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:0071702 organic substance transport 50.0000 4 no
GO:0071705 nitrogen compound transport 50.0000 4 no
GO:0006996 organelle organization 50.0000 4 no
GO:0048584 positive regulation of response to stimulus 43.7500 4 yes
GO:0006886 intracellular protein transport 43.7500 4 no
GO:0008104 protein localization 43.7500 4 no
GO:0015031 protein transport 43.7500 4 no
GO:0009889 regulation of biosynthetic process 37.5000 4 yes
GO:0009966 regulation of signal transduction 37.5000 4 yes
GO:0010468 regulation of gene expression 37.5000 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 37.5000 5 yes
GO:0010646 regulation of cell communication 37.5000 4 yes
GO:0031326 regulation of cellular biosynthetic process 37.5000 5 yes
GO:0050776 regulation of immune response 37.5000 4 yes
GO:0061024 membrane organization 37.5000 4 no
GO:0044087 regulation of cellular component biogenesis 37.5000 4 no
GO:0051084 de novo post-translational protein folding 37.5000 4 no
GO:0051085 chaperone cofactor-dependent protein refolding 37.5000 4 no
GO:0002684 positive regulation of immune system process 31.2500 4 yes
GO:0006355 regulation of DNA-templated transcription 31.2500 7 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 31.2500 5 yes
GO:0050778 positive regulation of immune response 31.2500 5 yes
GO:0051049 regulation of transport 31.2500 4 yes
GO:0051252 regulation of RNA metabolic process 31.2500 5 yes
GO:1902531 regulation of intracellular signal transduction 31.2500 5 yes
GO:2001141 regulation of RNA biosynthetic process 31.2500 6 yes
GO:0009893 positive regulation of metabolic process 31.2500 4 no
GO:0031325 positive regulation of cellular metabolic process 31.2500 5 no
GO:0022607 cellular component assembly 31.2500 4 no
GO:0043933 protein-containing complex organization 31.2500 4 no
GO:0051129 negative regulation of cellular component organization 31.2500 5 no
GO:0051246 regulation of protein metabolic process 31.2500 5 no
GO:0043254 regulation of protein-containing complex assembly 31.2500 5 no
GO:1902903 regulation of supramolecular fiber organization 31.2500 5 no
GO:0009892 negative regulation of metabolic process 31.2500 4 no
GO:0010605 negative regulation of macromolecule metabolic process 31.2500 5 no
GO:0014070 response to organic cyclic compound 31.2500 4 no
GO:0033993 response to lipid 31.2500 4 no
GO:0042981 regulation of apoptotic process 31.2500 5 no
GO:0043066 negative regulation of apoptotic process 31.2500 6 no
GO:0043067 regulation of programmed cell death 31.2500 4 no
GO:0043069 negative regulation of programmed cell death 31.2500 5 no
GO:0071310 cellular response to organic substance 31.2500 4 no
GO:0009967 positive regulation of signal transduction 25.0000 5 no
GO:0010604 positive regulation of macromolecule metabolic process 25.0000 5 no
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:0016050 vesicle organization 25.0000 5 no
GO:0006986 response to unfolded protein 25.0000 4 no
GO:0033043 regulation of organelle organization 25.0000 5 no
GO:0051130 positive regulation of cellular component organization 25.0000 5 no
GO:1902905 positive regulation of supramolecular fiber organization 25.0000 6 no
GO:0030162 regulation of proteolysis 25.0000 6 no
GO:0034599 cellular response to oxidative stress 25.0000 4 no
GO:0042127 regulation of cell population proliferation 25.0000 4 no
GO:0051248 negative regulation of protein metabolic process 25.0000 6 no
GO:0062197 cellular response to chemical stress 25.0000 4 no
GO:0032870 cellular response to hormone stimulus 25.0000 4 no
GO:0048545 response to steroid hormone 25.0000 4 no
GO:0071383 cellular response to steroid hormone stimulus 25.0000 5 no
GO:0071396 cellular response to lipid 25.0000 5 no
GO:0071407 cellular response to organic cyclic compound 25.0000 5 no
GO:2000026 regulation of multicellular organismal development 25.0000 4 no
GO:0006357 regulation of transcription by RNA polymerase II 18.7500 8 yes
GO:0002429 immune response-activating cell surface receptor signaling pathway 12.5000 4 yes
GO:0002768 immune response-regulating cell surface receptor signaling pathway 12.5000 4 yes
GO:0010959 regulation of metal ion transport 12.5000 6 yes
GO:0034762 regulation of transmembrane transport 12.5000 4 yes
GO:0034765 regulation of monoatomic ion transmembrane transport 12.5000 5 yes
GO:0043269 regulation of monoatomic ion transport 12.5000 5 yes
GO:0050851 antigen receptor-mediated signaling pathway 12.5000 5 yes
GO:0050853 B cell receptor signaling pathway 12.5000 6 yes
GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 12.5000 6 yes
GO:0051924 regulation of calcium ion transport 12.5000 7 yes
GO:1903169 regulation of calcium ion transmembrane transport 12.5000 7 yes
GO:1904062 regulation of monoatomic cation transmembrane transport 12.5000 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GRB2_HUMAN [view entry] [view interactions] Low throughput yes yes
MEST_HUMAN [view interactions] High throughput no no
AQP1_HUMAN [view entry] [view interactions] High throughput yes no
BNIP2_HUMAN [view interactions] High throughput no yes
TM243_HUMAN [view interactions] High throughput no no
MA2B2_HUMAN [view interactions] High throughput no no
UPK2_HUMAN [view interactions] High throughput no no
FAKD4_HUMAN [view interactions] High throughput no yes
NRAC_HUMAN [view interactions] High throughput no no
LHPL5_HUMAN [view interactions] High throughput no no
CIA2A_HUMAN [view interactions] High throughput no yes
RTP2_HUMAN [view interactions] High throughput no no
NINJ1_HUMAN [view interactions] High throughput no no
FRMD8_HUMAN [view interactions] High throughput no yes
SNX1_HUMAN [view entry] [view interactions] High throughput yes yes
SC22C_HUMAN [view interactions] High throughput no no
ZFPL1_HUMAN [view interactions] High throughput no yes
ARFG3_HUMAN [view entry] [view interactions] High throughput yes no
T3JAM_HUMAN [view interactions] High throughput no no
DCE2_HUMAN [view interactions] High throughput no yes
SGMR2_HUMAN [view interactions] High throughput no no
PNPO_HUMAN [view interactions] High throughput no yes
TM86B_HUMAN [view interactions] High throughput no no
PTN9_HUMAN [view interactions] High throughput no yes
S41A2_HUMAN [view interactions] High throughput no yes
SNP47_HUMAN [view entry] [view interactions] High throughput yes yes
EMD_HUMAN [view interactions] High throughput no yes
LPAR3_HUMAN [view interactions] High throughput no no
CLN6_HUMAN [view interactions] High throughput no no
AGR3_HUMAN [view interactions] High throughput no no
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
BI1_HUMAN [view interactions] High throughput no yes
CABP8_HUMAN [view interactions] High throughput no yes
TM143_HUMAN [view interactions] High throughput no yes
TMM74_HUMAN [view interactions] High throughput no no
UN93B_HUMAN [view interactions] High throughput no yes
STX6_HUMAN [view interactions] High throughput no yes
GOSR2_HUMAN [view interactions] High throughput no yes
NDRG4_HUMAN [view interactions] High throughput no no
PMYT1_HUMAN [view interactions] High throughput no no
AIG1_HUMAN [view interactions] High throughput no no
PBX3_HUMAN [view interactions] High throughput no yes
MID49_HUMAN [view interactions] High throughput no yes
TRAF7_HUMAN [view interactions] High throughput no yes
EGFL8_HUMAN [view interactions] High throughput no no
IDE_HUMAN [view interactions] High throughput no yes
DX39A_HUMAN [view interactions] High throughput no yes
HSP76_HUMAN [view entry] [view interactions] High throughput yes yes
GRP75_HUMAN [view entry] [view interactions] High throughput yes yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
HPCL1_HUMAN [view interactions] High throughput no yes
ZY11B_HUMAN [view interactions] High throughput no yes
D19L1_HUMAN [view interactions] High throughput no yes
HSP72_HUMAN [view entry] [view interactions] High throughput yes no
CANB1_HUMAN [view entry] [view interactions] High throughput yes yes
SNAA_HUMAN [view entry] [view interactions] High throughput yes yes
GPX1_HUMAN [view entry] [view interactions] High throughput yes yes
TOP3B_HUMAN [view interactions] High throughput no no