LIME1_HUMAN
Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in LIME1_HUMAN |
---|---|---|---|---|
GO:0005524 | ATP binding | 37.5000 | 5 | no |
GO:0016462 | pyrophosphatase activity | 37.5000 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 37.5000 | 4 | no |
GO:0016887 | ATP hydrolysis activity | 37.5000 | 7 | no |
GO:0017076 | purine nucleotide binding | 37.5000 | 4 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 37.5000 | 6 | no |
GO:0030554 | adenyl nucleotide binding | 37.5000 | 5 | no |
GO:0032555 | purine ribonucleotide binding | 37.5000 | 4 | no |
GO:0032559 | adenyl ribonucleotide binding | 37.5000 | 5 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 37.5000 | 4 | no |
GO:0003723 | RNA binding | 31.2500 | 4 | no |
GO:0031625 | ubiquitin protein ligase binding | 31.2500 | 5 | no |
GO:0044389 | ubiquitin-like protein ligase binding | 31.2500 | 4 | no |
GO:0019900 | kinase binding | 12.5000 | 4 | yes |
GO:0019901 | protein kinase binding | 12.5000 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in LIME1_HUMAN |
---|---|---|---|---|
GO:0016192 | vesicle-mediated transport | 62.5000 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 56.2500 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 56.2500 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 56.2500 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 56.2500 | 4 | no |
GO:0006996 | organelle organization | 50.0000 | 4 | no |
GO:0071310 | cellular response to organic substance | 50.0000 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 43.7500 | 4 | yes |
GO:0051246 | regulation of protein metabolic process | 43.7500 | 5 | yes |
GO:0009893 | positive regulation of metabolic process | 43.7500 | 4 | no |
GO:0051128 | regulation of cellular component organization | 43.7500 | 4 | no |
GO:0071702 | organic substance transport | 43.7500 | 4 | no |
GO:0071705 | nitrogen compound transport | 43.7500 | 4 | no |
GO:0048523 | negative regulation of cellular process | 43.7500 | 4 | no |
GO:0010468 | regulation of gene expression | 37.5000 | 5 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 37.5000 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 37.5000 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 37.5000 | 5 | no |
GO:0061024 | membrane organization | 37.5000 | 4 | no |
GO:0006886 | intracellular protein transport | 37.5000 | 4 | no |
GO:0008104 | protein localization | 37.5000 | 4 | no |
GO:0015031 | protein transport | 37.5000 | 4 | no |
GO:0044087 | regulation of cellular component biogenesis | 37.5000 | 4 | no |
GO:0006986 | response to unfolded protein | 37.5000 | 4 | no |
GO:0034620 | cellular response to unfolded protein | 37.5000 | 5 | no |
GO:0035967 | cellular response to topologically incorrect protein | 37.5000 | 4 | no |
GO:0051084 | de novo post-translational protein folding | 37.5000 | 4 | no |
GO:0051085 | chaperone cofactor-dependent protein refolding | 37.5000 | 4 | no |
GO:0006355 | regulation of DNA-templated transcription | 31.2500 | 6 | yes |
GO:0009889 | regulation of biosynthetic process | 31.2500 | 4 | yes |
GO:0009966 | regulation of signal transduction | 31.2500 | 4 | yes |
GO:0010556 | regulation of macromolecule biosynthetic process | 31.2500 | 5 | yes |
GO:0010646 | regulation of cell communication | 31.2500 | 4 | yes |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 31.2500 | 5 | yes |
GO:0031326 | regulation of cellular biosynthetic process | 31.2500 | 5 | yes |
GO:0048584 | positive regulation of response to stimulus | 31.2500 | 4 | yes |
GO:0050776 | regulation of immune response | 31.2500 | 4 | yes |
GO:0051049 | regulation of transport | 31.2500 | 4 | yes |
GO:0051252 | regulation of RNA metabolic process | 31.2500 | 5 | yes |
GO:1902531 | regulation of intracellular signal transduction | 31.2500 | 5 | yes |
GO:1903506 | regulation of nucleic acid-templated transcription | 31.2500 | 7 | yes |
GO:2001141 | regulation of RNA biosynthetic process | 31.2500 | 6 | yes |
GO:0022607 | cellular component assembly | 31.2500 | 4 | no |
GO:0043254 | regulation of protein-containing complex assembly | 31.2500 | 5 | no |
GO:0009892 | negative regulation of metabolic process | 31.2500 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 31.2500 | 5 | no |
GO:0010941 | regulation of cell death | 31.2500 | 4 | no |
GO:0014070 | response to organic cyclic compound | 31.2500 | 4 | no |
GO:0033993 | response to lipid | 31.2500 | 4 | no |
GO:0042981 | regulation of apoptotic process | 31.2500 | 6 | no |
GO:0043066 | negative regulation of apoptotic process | 31.2500 | 7 | no |
GO:0043067 | regulation of programmed cell death | 31.2500 | 5 | no |
GO:0043069 | negative regulation of programmed cell death | 31.2500 | 6 | no |
GO:0051129 | negative regulation of cellular component organization | 31.2500 | 5 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 31.2500 | 5 | no |
GO:0060548 | negative regulation of cell death | 31.2500 | 5 | no |
GO:1902903 | regulation of supramolecular fiber organization | 31.2500 | 5 | no |
GO:0031399 | regulation of protein modification process | 25.0000 | 6 | yes |
GO:0043933 | protein-containing complex organization | 25.0000 | 4 | no |
GO:0009894 | regulation of catabolic process | 25.0000 | 4 | no |
GO:0030162 | regulation of proteolysis | 25.0000 | 6 | no |
GO:0032870 | cellular response to hormone stimulus | 25.0000 | 4 | no |
GO:0033043 | regulation of organelle organization | 25.0000 | 5 | no |
GO:0034599 | cellular response to oxidative stress | 25.0000 | 4 | no |
GO:0042127 | regulation of cell population proliferation | 25.0000 | 4 | no |
GO:0042176 | regulation of protein catabolic process | 25.0000 | 5 | no |
GO:0048545 | response to steroid hormone | 25.0000 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 25.0000 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 25.0000 | 6 | no |
GO:0051248 | negative regulation of protein metabolic process | 25.0000 | 6 | no |
GO:0051726 | regulation of cell cycle | 25.0000 | 4 | no |
GO:0062197 | cellular response to chemical stress | 25.0000 | 4 | no |
GO:0071383 | cellular response to steroid hormone stimulus | 25.0000 | 5 | no |
GO:0071396 | cellular response to lipid | 25.0000 | 5 | no |
GO:0071407 | cellular response to organic cyclic compound | 25.0000 | 5 | no |
GO:1902905 | positive regulation of supramolecular fiber organization | 25.0000 | 6 | no |
GO:2000026 | regulation of multicellular organismal development | 25.0000 | 4 | no |
GO:0006357 | regulation of transcription by RNA polymerase II | 18.7500 | 7 | yes |
GO:0001932 | regulation of protein phosphorylation | 12.5000 | 7 | yes |
GO:0002684 | positive regulation of immune system process | 12.5000 | 4 | yes |
GO:0010959 | regulation of metal ion transport | 12.5000 | 6 | yes |
GO:0019220 | regulation of phosphate metabolic process | 12.5000 | 6 | yes |
GO:0034762 | regulation of transmembrane transport | 12.5000 | 4 | yes |
GO:0034765 | regulation of ion transmembrane transport | 12.5000 | 5 | yes |
GO:0042325 | regulation of phosphorylation | 12.5000 | 7 | yes |
GO:0043269 | regulation of ion transport | 12.5000 | 5 | yes |
GO:0050778 | positive regulation of immune response | 12.5000 | 5 | yes |
GO:0051174 | regulation of phosphorus metabolic process | 12.5000 | 5 | yes |
GO:0051924 | regulation of calcium ion transport | 12.5000 | 7 | yes |
GO:1903169 | regulation of calcium ion transmembrane transport | 12.5000 | 7 | yes |
GO:1904062 | regulation of cation transmembrane transport | 12.5000 | 6 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
GRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
UPK2_HUMAN | [view interactions] | High throughput | no | no |
FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
NRAC_HUMAN | [view interactions] | High throughput | no | no |
LHPL5_HUMAN | [view interactions] | High throughput | no | no |
CIA2A_HUMAN | [view interactions] | High throughput | no | yes |
RTP2_HUMAN | [view interactions] | High throughput | no | no |
NINJ1_HUMAN | [view interactions] | High throughput | no | no |
FRMD8_HUMAN | [view interactions] | High throughput | no | yes |
SNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SC22C_HUMAN | [view interactions] | High throughput | no | no |
ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
ARFG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
T3JAM_HUMAN | [view interactions] | High throughput | no | no |
DCE2_HUMAN | [view interactions] | High throughput | no | yes |
SGMR2_HUMAN | [view interactions] | High throughput | no | no |
PNPO_HUMAN | [view interactions] | High throughput | no | yes |
TM86B_HUMAN | [view interactions] | High throughput | no | no |
PTN9_HUMAN | [view interactions] | High throughput | no | yes |
S41A2_HUMAN | [view interactions] | High throughput | no | yes |
SNP47_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EMD_HUMAN | [view interactions] | High throughput | no | yes |
LPAR3_HUMAN | [view interactions] | High throughput | no | no |
CLN6_HUMAN | [view interactions] | High throughput | no | no |
AGR3_HUMAN | [view interactions] | High throughput | no | no |
STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BI1_HUMAN | [view interactions] | High throughput | no | yes |
CABP8_HUMAN | [view interactions] | High throughput | no | yes |
TM143_HUMAN | [view interactions] | High throughput | no | yes |
TMM74_HUMAN | [view interactions] | High throughput | no | no |
UN93B_HUMAN | [view interactions] | High throughput | no | yes |
STX6_HUMAN | [view interactions] | High throughput | no | yes |
GOSR2_HUMAN | [view interactions] | High throughput | no | yes |
NDRG4_HUMAN | [view interactions] | High throughput | no | no |
PMYT1_HUMAN | [view interactions] | High throughput | no | no |
AIG1_HUMAN | [view interactions] | High throughput | no | no |
PBX3_HUMAN | [view interactions] | High throughput | no | yes |
MID49_HUMAN | [view interactions] | High throughput | no | yes |
TRAF7_HUMAN | [view interactions] | High throughput | no | yes |
EGFL8_HUMAN | [view interactions] | High throughput | no | no |
IDE_HUMAN | [view interactions] | High throughput | no | yes |
DX39A_HUMAN | [view interactions] | High throughput | no | yes |
HSP76_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HPCL1_HUMAN | [view interactions] | High throughput | no | yes |
ZY11B_HUMAN | [view interactions] | High throughput | no | yes |
D19L1_HUMAN | [view interactions] | High throughput | no | yes |
HSP72_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CANB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SNAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GPX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MEST_HUMAN | [view interactions] | High throughput | no | no |
AQP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
BNIP2_HUMAN | [view interactions] | High throughput | no | yes |
TM243_HUMAN | [view interactions] | High throughput | no | no |
MA2B2_HUMAN | [view interactions] | High throughput | no | no |