VPS18_HUMAN
Evidence for PS localization
Functions
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed, PubMed, PubMed, PubMed). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed). Involved in dendrite development of Pukinje cells . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in VPS18_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 30.9524 | 4 | no |
| GO:0043168 | anion binding | 30.9524 | 4 | no |
| GO:0017076 | purine nucleotide binding | 28.5714 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 28.5714 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 28.5714 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 21.4286 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 21.4286 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 21.4286 | 6 | no |
| GO:0043169 | cation binding | 19.0476 | 4 | yes |
| GO:0046872 | metal ion binding | 19.0476 | 5 | yes |
| GO:0003779 | actin binding | 14.2857 | 4 | yes |
| GO:0019905 | syntaxin binding | 11.9048 | 4 | yes |
| GO:0004842 | ubiquitin-protein transferase activity | 4.7619 | 4 | yes |
| GO:0016755 | aminoacyltransferase activity | 4.7619 | 4 | yes |
| GO:0061630 | ubiquitin protein ligase activity | 4.7619 | 5 | yes |
| GO:0061659 | ubiquitin-like protein ligase activity | 4.7619 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in VPS18_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 69.0476 | 4 | yes |
| GO:0006996 | organelle organization | 66.6667 | 4 | yes |
| GO:0071702 | organic substance transport | 64.2857 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 64.2857 | 4 | yes |
| GO:0015031 | protein transport | 61.9048 | 4 | yes |
| GO:0006886 | intracellular protein transport | 54.7619 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 54.7619 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 52.3810 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 45.2381 | 4 | yes |
| GO:0016050 | vesicle organization | 42.8571 | 5 | yes |
| GO:0010646 | regulation of cell communication | 40.4762 | 4 | yes |
| GO:0007034 | vacuolar transport | 38.0952 | 4 | yes |
| GO:0061024 | membrane organization | 38.0952 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 35.7143 | 4 | no |
| GO:0009966 | regulation of signal transduction | 35.7143 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 35.7143 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 33.3333 | 4 | no |
| GO:0022607 | cellular component assembly | 33.3333 | 4 | no |
| GO:0007041 | lysosomal transport | 33.3333 | 5 | yes |
| GO:0043254 | regulation of protein-containing complex assembly | 33.3333 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 30.9524 | 5 | no |
| GO:0006906 | vesicle fusion | 30.9524 | 6 | yes |
| GO:0048284 | organelle fusion | 30.9524 | 5 | yes |
| GO:0051049 | regulation of transport | 30.9524 | 4 | yes |
| GO:0061025 | membrane fusion | 30.9524 | 5 | yes |
| GO:0090174 | organelle membrane fusion | 30.9524 | 6 | yes |
| GO:0009893 | positive regulation of metabolic process | 30.9524 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.9524 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 30.9524 | 5 | no |
| GO:0023056 | positive regulation of signaling | 30.9524 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 30.9524 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 28.5714 | 6 | no |
| GO:0009967 | positive regulation of signal transduction | 26.1905 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 23.8095 | 4 | no |
| GO:0033365 | protein localization to organelle | 23.8095 | 5 | no |
| GO:0032880 | regulation of protein localization | 23.8095 | 5 | no |
| GO:0060341 | regulation of cellular localization | 23.8095 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 23.8095 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 21.4286 | 4 | no |
| GO:0043933 | protein-containing complex organization | 21.4286 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 21.4286 | 5 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 21.4286 | 4 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 21.4286 | 4 | yes |
| GO:0009894 | regulation of catabolic process | 21.4286 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 21.4286 | 5 | no |
| GO:0035542 | regulation of SNARE complex assembly | 19.0476 | 6 | yes |
| GO:0007033 | vacuole organization | 16.6667 | 5 | yes |
| GO:0010648 | negative regulation of cell communication | 16.6667 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 16.6667 | 4 | yes |
| GO:0034058 | endosomal vesicle fusion | 16.6667 | 7 | yes |
| GO:0048278 | vesicle docking | 16.6667 | 4 | yes |
| GO:0048585 | negative regulation of response to stimulus | 16.6667 | 4 | yes |
| GO:0007032 | endosome organization | 14.2857 | 6 | yes |
| GO:0036211 | protein modification process | 14.2857 | 4 | yes |
| GO:0043412 | macromolecule modification | 14.2857 | 4 | yes |
| GO:0009968 | negative regulation of signal transduction | 11.9048 | 5 | yes |
| GO:0017157 | regulation of exocytosis | 11.9048 | 5 | yes |
| GO:0051046 | regulation of secretion | 11.9048 | 5 | yes |
| GO:1903530 | regulation of secretion by cell | 11.9048 | 4 | yes |
| GO:0032446 | protein modification by small protein conjugation | 9.5238 | 7 | yes |
| GO:0043687 | post-translational protein modification | 9.5238 | 5 | yes |
| GO:0046928 | regulation of neurotransmitter secretion | 9.5238 | 5 | yes |
| GO:0051588 | regulation of neurotransmitter transport | 9.5238 | 5 | yes |
| GO:0070647 | protein modification by small protein conjugation or removal | 9.5238 | 6 | yes |
| GO:1903305 | regulation of regulated secretory pathway | 9.5238 | 6 | yes |
| GO:0007040 | lysosome organization | 7.1429 | 7 | yes |
| GO:0016567 | protein ubiquitination | 7.1429 | 8 | yes |
| GO:0080171 | lytic vacuole organization | 7.1429 | 6 | yes |
| GO:0033143 | regulation of intracellular steroid hormone receptor signaling pathway | 4.7619 | 5 | yes |
| GO:0033144 | negative regulation of intracellular steroid hormone receptor signaling pathway | 4.7619 | 6 | yes |
| GO:0033146 | regulation of intracellular estrogen receptor signaling pathway | 4.7619 | 6 | yes |
| GO:0033147 | negative regulation of intracellular estrogen receptor signaling pathway | 4.7619 | 7 | yes |
| GO:2000300 | regulation of synaptic vesicle exocytosis | 4.7619 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MON1B_HUMAN | [view interactions] | Low throughput | no | yes |
| VPS16_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VPS11_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| VPS41_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SPE39_HUMAN | [view interactions] | Low throughput | no | yes |
| VP33A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| STX7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VP33B_HUMAN | [view interactions] | Low throughput | no | yes |
| STX17_HUMAN | [view interactions] | Low throughput | no | yes |
| PKHM1_HUMAN | [view interactions] | Low throughput | no | yes |
| RILP_HUMAN | [view interactions] | Low throughput | no | no |
| RAB5C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PLK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYNP2_HUMAN | [view interactions] | Low throughput | no | yes |
| GGA1_HUMAN | [view interactions] | Low throughput | no | yes |
| GGA2_HUMAN | [view interactions] | Low throughput | no | yes |
| GGA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VPS8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UB2D2_HUMAN | [view interactions] | Low throughput | no | yes |
| COPB_HUMAN | [view interactions] | High throughput | no | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| UVRAG_HUMAN | [view interactions] | High throughput | no | yes |
| MK06_HUMAN | [view interactions] | High throughput | no | yes |
| TGO1_HUMAN | [view interactions] | High throughput | no | yes |
| TGFA1_HUMAN | [view interactions] | High throughput | no | no |
| ALDOA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SERC1_HUMAN | [view interactions] | High throughput | no | yes |
| DNJB5_HUMAN | [view interactions] | High throughput | no | yes |
| SCLY_HUMAN | [view interactions] | High throughput | no | yes |
| UPP1_HUMAN | [view interactions] | High throughput | no | no |
| ELMO3_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZGRF1_HUMAN | [view interactions] | High throughput | no | no |
| CT55_HUMAN | [view interactions] | High throughput | no | no |
| VIPR2_HUMAN | [view interactions] | High throughput | no | no |
| TCPR2_HUMAN | [view interactions] | High throughput | no | yes |
| XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEK4_HUMAN | [view interactions] | High throughput | no | yes |
| VPS39_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HTRA2_HUMAN | [view interactions] | High throughput | no | yes |
| IMP1L_HUMAN | [view interactions] | High throughput | no | yes |
| IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARL8B_HUMAN | [view interactions] | High throughput | no | yes |
| ARGL1_HUMAN | [view interactions] | High throughput | no | yes |
| MED23_HUMAN | [view interactions] | High throughput | no | no |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CCNA1_HUMAN | [view interactions] | High throughput | no | no |
| HOOK1_HUMAN | [view interactions] | High throughput | no | no |
| VPS45_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| VTI1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAMP8_HUMAN | [view interactions] | High throughput | no | no |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKTIP_HUMAN | [view interactions] | High throughput | no | yes |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX8_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| LRAD4_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| BIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUV3_HUMAN | [view interactions] | High throughput | no | yes |
| TRY1_HUMAN | [view interactions] | High throughput | no | no |
| MTA1_HUMAN | [view interactions] | High throughput | no | yes |
| SRRM1_HUMAN | [view interactions] | High throughput | no | yes |
| RSRC1_HUMAN | [view interactions] | High throughput | no | yes |
| SEN2_HUMAN | [view interactions] | High throughput | no | yes |
| OBSCN_HUMAN | [view interactions] | High throughput | no | yes |
| TJAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP3D1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| UXS1_HUMAN | [view interactions] | High throughput | no | yes |
| LYPD4_HUMAN | [view interactions] | High throughput | no | no |
| ZUP1_HUMAN | [view interactions] | High throughput | no | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| EDEM1_HUMAN | [view interactions] | High throughput | no | yes |
| HYPM_HUMAN | [view interactions] | High throughput | no | no |
| EFNA4_HUMAN | [view interactions] | High throughput | no | no |
| SEM4C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KRT38_HUMAN | [view interactions] | High throughput | no | no |
| DUS16_HUMAN | [view interactions] | High throughput | no | yes |
| K22E_HUMAN | [view interactions] | High throughput | no | no |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GR6_HUMAN | [view interactions] | High throughput | no | no |
| CCD96_HUMAN | [view interactions] | High throughput | no | no |
| GHC2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IFT20_HUMAN | [view interactions] | High throughput | no | yes |
| TCPQM_HUMAN | [view interactions] | High throughput | no | no |
| CCG8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CC018_HUMAN | [view interactions] | High throughput | no | yes |
| CIA2A_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| PMM1_HUMAN | [view interactions] | High throughput | no | yes |
| DYR_HUMAN | [view interactions] | High throughput | no | yes |
| PKHG7_HUMAN | [view interactions] | High throughput | no | no |
| D2HDH_HUMAN | [view interactions] | High throughput | no | no |
| B4GT2_HUMAN | [view interactions] | High throughput | no | no |
| ST1C4_HUMAN | [view interactions] | High throughput | no | no |
| CI163_HUMAN | [view interactions] | High throughput | no | no |
| F167A_HUMAN | [view interactions] | High throughput | no | yes |
| CRBB3_HUMAN | [view interactions] | High throughput | no | no |
| LSG1_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| SRPK1_HUMAN | [view interactions] | High throughput | no | yes |
| FITM2_HUMAN | [view interactions] | High throughput | no | no |
| SPRNG_HUMAN | [view interactions] | High throughput | no | yes |
| ATG7_HUMAN | [view interactions] | High throughput | no | yes |
| ATG10_HUMAN | [view interactions] | High throughput | no | yes |
| ATG3_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| MERL_HUMAN | [view interactions] | High throughput | no | yes |
| SPPL3_HUMAN | [view interactions] | High throughput | no | no |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UTP20_HUMAN | [view interactions] | High throughput | no | no |
| RPC1_HUMAN | [view interactions] | High throughput | no | no |
| IF4G1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STK4_HUMAN | [view interactions] | High throughput | no | yes |
| EEA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HOOK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| ATG9A_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |