VPS18_HUMAN
Evidence for PS localization
Functions
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed, PubMed, PubMed, PubMed). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed). Involved in dendrite development of Pukinje cells . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in VPS18_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 27.0270 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 27.0270 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 27.0270 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 24.3243 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 24.3243 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 24.3243 | 6 | no |
| GO:0046872 | metal ion binding | 18.9189 | 4 | yes |
| GO:0003779 | actin binding | 16.2162 | 4 | yes |
| GO:0019905 | syntaxin binding | 13.5135 | 4 | yes |
| GO:0004842 | ubiquitin-protein transferase activity | 5.4054 | 4 | yes |
| GO:0061630 | ubiquitin protein ligase activity | 5.4054 | 5 | yes |
| GO:0061659 | ubiquitin-like protein ligase activity | 5.4054 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in VPS18_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 75.6757 | 4 | yes |
| GO:0071702 | organic substance transport | 70.2703 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 70.2703 | 4 | yes |
| GO:0015031 | protein transport | 67.5676 | 4 | yes |
| GO:0006996 | organelle organization | 64.8649 | 4 | yes |
| GO:0006886 | intracellular protein transport | 59.4595 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 56.7568 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 54.0541 | 4 | no |
| GO:0010646 | regulation of cell communication | 45.9459 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 45.9459 | 4 | no |
| GO:0009966 | regulation of signal transduction | 40.5405 | 4 | yes |
| GO:0007034 | vacuolar transport | 37.8378 | 4 | yes |
| GO:0016050 | vesicle organization | 37.8378 | 5 | yes |
| GO:0051049 | regulation of transport | 37.8378 | 4 | yes |
| GO:0022607 | cellular component assembly | 37.8378 | 4 | no |
| GO:0007041 | lysosomal transport | 35.1351 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 35.1351 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 35.1351 | 5 | no |
| GO:0023056 | positive regulation of signaling | 35.1351 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 35.1351 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 35.1351 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 35.1351 | 4 | no |
| GO:0008333 | endosome to lysosome transport | 32.4324 | 5 | yes |
| GO:0061024 | membrane organization | 32.4324 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 32.4324 | 4 | no |
| GO:0048284 | organelle fusion | 29.7297 | 5 | yes |
| GO:0009967 | positive regulation of signal transduction | 29.7297 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 29.7297 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 29.7297 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 29.7297 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 29.7297 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 29.7297 | 5 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 27.0270 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 27.0270 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 27.0270 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 27.0270 | 6 | no |
| GO:0006906 | vesicle fusion | 24.3243 | 6 | no |
| GO:0016197 | endosomal transport | 24.3243 | 4 | no |
| GO:0061025 | membrane fusion | 24.3243 | 5 | no |
| GO:0090174 | organelle membrane fusion | 24.3243 | 6 | no |
| GO:0045595 | regulation of cell differentiation | 24.3243 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 21.6216 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 21.6216 | 4 | yes |
| GO:0051050 | positive regulation of transport | 21.6216 | 4 | no |
| GO:0072657 | protein localization to membrane | 21.6216 | 4 | no |
| GO:0033365 | protein localization to organelle | 21.6216 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 21.6216 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 18.9189 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 18.9189 | 4 | yes |
| GO:0048278 | vesicle docking | 18.9189 | 4 | yes |
| GO:0007033 | vacuole organization | 16.2162 | 5 | yes |
| GO:0048585 | negative regulation of response to stimulus | 16.2162 | 4 | yes |
| GO:0009968 | negative regulation of signal transduction | 13.5135 | 5 | yes |
| GO:0017157 | regulation of exocytosis | 13.5135 | 5 | yes |
| GO:0036211 | protein modification process | 13.5135 | 4 | yes |
| GO:0043412 | macromolecule modification | 13.5135 | 4 | yes |
| GO:0051046 | regulation of secretion | 13.5135 | 5 | yes |
| GO:1903530 | regulation of secretion by cell | 13.5135 | 4 | yes |
| GO:0007032 | endosome organization | 10.8108 | 6 | yes |
| GO:0032446 | protein modification by small protein conjugation | 10.8108 | 6 | yes |
| GO:0046928 | regulation of neurotransmitter secretion | 10.8108 | 4 | yes |
| GO:0051588 | regulation of neurotransmitter transport | 10.8108 | 5 | yes |
| GO:0070647 | protein modification by small protein conjugation or removal | 10.8108 | 5 | yes |
| GO:1903305 | regulation of regulated secretory pathway | 10.8108 | 6 | yes |
| GO:0016567 | protein ubiquitination | 8.1081 | 7 | yes |
| GO:0007040 | lysosome organization | 5.4054 | 7 | yes |
| GO:0033143 | regulation of intracellular steroid hormone receptor signaling pathway | 5.4054 | 5 | yes |
| GO:0033144 | negative regulation of intracellular steroid hormone receptor signaling pathway | 5.4054 | 6 | yes |
| GO:0033146 | regulation of intracellular estrogen receptor signaling pathway | 5.4054 | 6 | yes |
| GO:0033147 | negative regulation of intracellular estrogen receptor signaling pathway | 5.4054 | 7 | yes |
| GO:0044000 | movement in host | 5.4054 | 4 | yes |
| GO:0080171 | lytic vacuole organization | 5.4054 | 6 | yes |
| GO:2000300 | regulation of synaptic vesicle exocytosis | 5.4054 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PLK2_HUMAN | [view interactions] | Low throughput | no | yes |
| SYNP2_HUMAN | [view interactions] | Low throughput | no | yes |
| GGA1_HUMAN | [view interactions] | Low throughput | no | yes |
| GGA2_HUMAN | [view interactions] | Low throughput | no | yes |
| GGA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VPS8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UB2D2_HUMAN | [view interactions] | Low throughput | no | yes |
| MON1B_HUMAN | [view interactions] | Low throughput | no | yes |
| VPS16_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VPS11_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VPS41_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SPE39_HUMAN | [view interactions] | Low throughput | no | yes |
| VP33A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| STX7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VP33B_HUMAN | [view interactions] | Low throughput | no | yes |
| STX17_HUMAN | [view interactions] | Low throughput | no | yes |
| PKHM1_HUMAN | [view interactions] | Low throughput | no | yes |
| RILP_HUMAN | [view interactions] | Low throughput | no | no |
| RAB5C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| STX12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VTI1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK1_HUMAN | [view interactions] | High throughput | no | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGON2_HUMAN | [view interactions] | High throughput | no | yes |
| AKTIP_HUMAN | [view interactions] | High throughput | no | yes |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX8_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| LRAD4_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| BIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUV3_HUMAN | [view interactions] | High throughput | no | yes |
| TRY1_HUMAN | [view interactions] | High throughput | no | no |
| MTA1_HUMAN | [view interactions] | High throughput | no | yes |
| SRRM1_HUMAN | [view interactions] | High throughput | no | yes |
| RSRC1_HUMAN | [view interactions] | High throughput | no | yes |
| SEN2_HUMAN | [view interactions] | High throughput | no | yes |
| OBSCN_HUMAN | [view interactions] | High throughput | no | yes |
| TJAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP3D1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| UXS1_HUMAN | [view interactions] | High throughput | no | yes |
| LYPD4_HUMAN | [view interactions] | High throughput | no | no |
| ZUP1_HUMAN | [view interactions] | High throughput | no | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| EDEM1_HUMAN | [view interactions] | High throughput | no | yes |
| HYPM_HUMAN | [view interactions] | High throughput | no | no |
| EFNA4_HUMAN | [view interactions] | High throughput | no | no |
| SEM4C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KRT38_HUMAN | [view interactions] | High throughput | no | no |
| DUS16_HUMAN | [view interactions] | High throughput | no | yes |
| K22E_HUMAN | [view interactions] | High throughput | no | no |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GR6_HUMAN | [view interactions] | High throughput | no | no |
| CCD96_HUMAN | [view interactions] | High throughput | no | no |
| GHC2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IFT20_HUMAN | [view interactions] | High throughput | no | yes |
| TCPQM_HUMAN | [view interactions] | High throughput | no | no |
| CCG8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CC018_HUMAN | [view interactions] | High throughput | no | yes |
| CIA2A_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| PMM1_HUMAN | [view interactions] | High throughput | no | yes |
| DYR_HUMAN | [view interactions] | High throughput | no | yes |
| PKHG7_HUMAN | [view interactions] | High throughput | no | no |
| D2HDH_HUMAN | [view interactions] | High throughput | no | no |
| B4GT2_HUMAN | [view interactions] | High throughput | no | no |
| ST1C4_HUMAN | [view interactions] | High throughput | no | no |
| CI163_HUMAN | [view interactions] | High throughput | no | no |
| F167A_HUMAN | [view interactions] | High throughput | no | yes |
| CRBB3_HUMAN | [view interactions] | High throughput | no | no |
| LSG1_HUMAN | [view interactions] | High throughput | no | yes |
| FITM2_HUMAN | [view interactions] | High throughput | no | no |
| SPRNG_HUMAN | [view interactions] | High throughput | no | yes |
| ATG7_HUMAN | [view interactions] | High throughput | no | yes |
| ATG10_HUMAN | [view interactions] | High throughput | no | yes |
| ATG3_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UTP20_HUMAN | [view interactions] | High throughput | no | no |
| RPC1_HUMAN | [view interactions] | High throughput | no | no |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| COPB_HUMAN | [view interactions] | High throughput | no | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| UVRAG_HUMAN | [view interactions] | High throughput | no | yes |
| MK06_HUMAN | [view interactions] | High throughput | no | yes |
| ALDOA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TGFA1_HUMAN | [view interactions] | High throughput | no | no |
| TGO1_HUMAN | [view interactions] | High throughput | no | yes |
| ZGRF1_HUMAN | [view interactions] | High throughput | no | no |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELMO3_HUMAN | [view interactions] | High throughput | no | yes |
| UPP1_HUMAN | [view interactions] | High throughput | no | no |
| SCLY_HUMAN | [view interactions] | High throughput | no | yes |
| DNJB5_HUMAN | [view interactions] | High throughput | no | yes |
| SERC1_HUMAN | [view interactions] | High throughput | no | yes |
| CT55_HUMAN | [view interactions] | High throughput | no | no |
| VIPR2_HUMAN | [view interactions] | High throughput | no | no |
| TCPR2_HUMAN | [view interactions] | High throughput | no | yes |
| XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEK4_HUMAN | [view interactions] | High throughput | no | yes |
| VPS39_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HTRA2_HUMAN | [view interactions] | High throughput | no | yes |
| IMP1L_HUMAN | [view interactions] | High throughput | no | yes |
| IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARL8B_HUMAN | [view interactions] | High throughput | no | yes |
| ARGL1_HUMAN | [view interactions] | High throughput | no | yes |
| MED23_HUMAN | [view interactions] | High throughput | no | no |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CCNA1_HUMAN | [view interactions] | High throughput | no | no |
| VAMP8_HUMAN | [view interactions] | High throughput | no | no |
| VPS45_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PK3C3_HUMAN | [view interactions] | Computational | no | yes |
| 3MG_HUMAN | [view interactions] | Computational | no | yes |
| VTI1A_HUMAN | [view interactions] | Computational | no | yes |
| RAB7B_HUMAN | [view interactions] | Computational | no | no |
| SNF8_HUMAN | [view interactions] | Computational | no | yes |
| STX10_HUMAN | [view interactions] | Computational | no | yes |