SEM4C_HUMAN
Evidence for PS localization
Functions
Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at Tyr-1248. Required for normal brain development, axon guidance and cell migration . Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SEM4C_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 34.0909 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 34.0909 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 34.0909 | 4 | no |
| GO:0003924 | GTPase activity | 25.0000 | 7 | no |
| GO:0005525 | GTP binding | 25.0000 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 25.0000 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 25.0000 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 25.0000 | 6 | no |
| GO:0019001 | guanyl nucleotide binding | 25.0000 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 25.0000 | 5 | no |
| GO:0019003 | GDP binding | 22.7273 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SEM4C_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 63.6364 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 61.3636 | 4 | yes |
| GO:0071702 | organic substance transport | 61.3636 | 4 | no |
| GO:0071705 | nitrogen compound transport | 61.3636 | 4 | no |
| GO:0015031 | protein transport | 52.2727 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 50.0000 | 4 | no |
| GO:0051049 | regulation of transport | 47.7273 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 47.7273 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 45.4545 | 4 | yes |
| GO:0010646 | regulation of cell communication | 45.4545 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 43.1818 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 40.9091 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 40.9091 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 40.9091 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 40.9091 | 4 | no |
| GO:0006886 | intracellular protein transport | 40.9091 | 4 | no |
| GO:0006996 | organelle organization | 40.9091 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 38.6364 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 36.3636 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 34.0909 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 31.8182 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 31.8182 | 5 | no |
| GO:2000145 | regulation of cell motility | 29.5455 | 4 | yes |
| GO:0010468 | regulation of gene expression | 29.5455 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 29.5455 | 5 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 29.5455 | 4 | no |
| GO:0022607 | cellular component assembly | 29.5455 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 29.5455 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 29.5455 | 4 | yes |
| GO:0030334 | regulation of cell migration | 29.5455 | 5 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 27.2727 | 5 | yes |
| GO:0042127 | regulation of cell population proliferation | 27.2727 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 27.2727 | 5 | yes |
| GO:0040017 | positive regulation of locomotion | 25.0000 | 4 | yes |
| GO:2000147 | positive regulation of cell motility | 25.0000 | 5 | yes |
| GO:0031399 | regulation of protein modification process | 25.0000 | 6 | no |
| GO:0051046 | regulation of secretion | 25.0000 | 5 | no |
| GO:0071310 | cellular response to organic substance | 25.0000 | 4 | no |
| GO:0046903 | secretion | 25.0000 | 4 | no |
| GO:0030335 | positive regulation of cell migration | 25.0000 | 6 | yes |
| GO:0048585 | negative regulation of response to stimulus | 22.7273 | 4 | yes |
| GO:0010243 | response to organonitrogen compound | 22.7273 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 22.7273 | 5 | no |
| GO:0023057 | negative regulation of signaling | 22.7273 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 22.7273 | 6 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.7273 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 22.7273 | 7 | no |
| GO:0043085 | positive regulation of catalytic activity | 22.7273 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.7273 | 5 | no |
| GO:0008284 | positive regulation of cell population proliferation | 22.7273 | 5 | no |
| GO:0030030 | cell projection organization | 22.7273 | 4 | yes |
| GO:0031344 | regulation of cell projection organization | 22.7273 | 5 | yes |
| GO:0045595 | regulation of cell differentiation | 20.4545 | 4 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 20.4545 | 6 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 20.4545 | 5 | yes |
| GO:2000026 | regulation of multicellular organismal development | 20.4545 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 20.4545 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 20.4545 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 20.4545 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 20.4545 | 5 | no |
| GO:0006897 | endocytosis | 20.4545 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 20.4545 | 7 | no |
| GO:0033043 | regulation of organelle organization | 20.4545 | 5 | no |
| GO:0033365 | protein localization to organelle | 20.4545 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 20.4545 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 20.4545 | 4 | no |
| GO:1903530 | regulation of secretion by cell | 20.4545 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 18.1818 | 4 | yes |
| GO:0051093 | negative regulation of developmental process | 15.9091 | 4 | yes |
| GO:1902533 | positive regulation of intracellular signal transduction | 15.9091 | 6 | yes |
| GO:0040013 | negative regulation of locomotion | 13.6364 | 4 | yes |
| GO:0043408 | regulation of MAPK cascade | 13.6364 | 6 | yes |
| GO:0045596 | negative regulation of cell differentiation | 13.6364 | 5 | yes |
| GO:0050767 | regulation of neurogenesis | 13.6364 | 6 | yes |
| GO:0051129 | negative regulation of cellular component organization | 13.6364 | 5 | yes |
| GO:0051960 | regulation of nervous system development | 13.6364 | 5 | yes |
| GO:0060284 | regulation of cell development | 13.6364 | 5 | yes |
| GO:0080134 | regulation of response to stress | 13.6364 | 4 | yes |
| GO:0001558 | regulation of cell growth | 13.6364 | 4 | yes |
| GO:0031175 | neuron projection development | 13.6364 | 6 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 11.3636 | 4 | yes |
| GO:0080135 | regulation of cellular response to stress | 11.3636 | 4 | yes |
| GO:0010975 | regulation of neuron projection development | 11.3636 | 7 | yes |
| GO:0032101 | regulation of response to external stimulus | 9.0909 | 4 | yes |
| GO:0043410 | positive regulation of MAPK cascade | 9.0909 | 7 | yes |
| GO:0048638 | regulation of developmental growth | 9.0909 | 4 | yes |
| GO:0050920 | regulation of chemotaxis | 9.0909 | 4 | yes |
| GO:0032102 | negative regulation of response to external stimulus | 6.8182 | 5 | yes |
| GO:0045926 | negative regulation of growth | 6.8182 | 4 | yes |
| GO:0050768 | negative regulation of neurogenesis | 6.8182 | 6 | yes |
| GO:0050770 | regulation of axonogenesis | 6.8182 | 5 | yes |
| GO:0051961 | negative regulation of nervous system development | 6.8182 | 5 | yes |
| GO:0061387 | regulation of extent of cell growth | 6.8182 | 5 | yes |
| GO:0070302 | regulation of stress-activated protein kinase signaling cascade | 6.8182 | 5 | yes |
| GO:0070304 | positive regulation of stress-activated protein kinase signaling cascade | 6.8182 | 6 | yes |
| GO:0001667 | ameboidal-type cell migration | 6.8182 | 4 | yes |
| GO:0010721 | negative regulation of cell development | 6.8182 | 6 | yes |
| GO:0010977 | negative regulation of neuron projection development | 6.8182 | 7 | yes |
| GO:0030308 | negative regulation of cell growth | 6.8182 | 5 | yes |
| GO:0030516 | regulation of axon extension | 6.8182 | 5 | yes |
| GO:0031345 | negative regulation of cell projection organization | 6.8182 | 6 | yes |
| GO:0032872 | regulation of stress-activated MAPK cascade | 4.5455 | 6 | yes |
| GO:0032874 | positive regulation of stress-activated MAPK cascade | 4.5455 | 7 | yes |
| GO:0042692 | muscle cell differentiation | 4.5455 | 4 | yes |
| GO:0048640 | negative regulation of developmental growth | 4.5455 | 5 | yes |
| GO:0048841 | regulation of axon extension involved in axon guidance | 4.5455 | 6 | yes |
| GO:0048843 | negative regulation of axon extension involved in axon guidance | 4.5455 | 6 | yes |
| GO:0050771 | negative regulation of axonogenesis | 4.5455 | 6 | yes |
| GO:0050922 | negative regulation of chemotaxis | 4.5455 | 5 | yes |
| GO:0060606 | tube closure | 4.5455 | 4 | yes |
| GO:0071526 | semaphorin-plexin signaling pathway | 4.5455 | 4 | yes |
| GO:0090497 | mesenchymal cell migration | 4.5455 | 5 | yes |
| GO:0097485 | neuron projection guidance | 4.5455 | 7 | yes |
| GO:0001755 | neural crest cell migration | 4.5455 | 6 | yes |
| GO:0001843 | neural tube closure | 4.5455 | 5 | yes |
| GO:0007411 | axon guidance | 4.5455 | 8 | yes |
| GO:0030517 | negative regulation of axon extension | 4.5455 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in SEM4C_HUMAN |
|---|---|---|---|---|
| DOID:0050155 | sensory system disease | 4.5455 | 3 | no |
| DOID:0050563 | nonsyndromic deafness | 4.5455 | 5 | no |
| DOID:0050564 | autosomal dominant nonsyndromic deafness | 4.5455 | 6 | no |
| DOID:2742 | auditory system disease | 4.5455 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GIPC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GIPC2_HUMAN | [view interactions] | Low throughput | no | yes |
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CC50B_HUMAN | [view interactions] | High throughput | no | yes |
| I13R2_HUMAN | [view interactions] | High throughput | no | no |
| TNFL8_HUMAN | [view interactions] | High throughput | no | no |
| SACA1_HUMAN | [view interactions] | High throughput | no | no |
| K1H1_HUMAN | [view interactions] | High throughput | no | no |
| K1C40_HUMAN | [view interactions] | High throughput | no | no |
| NT2NA_HUMAN | [view interactions] | High throughput | no | no |
| PNMA1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN363_HUMAN | [view interactions] | High throughput | no | yes |
| USBP1_HUMAN | [view interactions] | High throughput | no | no |
| NT2NC_HUMAN | [view interactions] | High throughput | no | no |
| HSF2B_HUMAN | [view interactions] | High throughput | no | yes |
| K1C27_HUMAN | [view interactions] | High throughput | no | no |
| CRTP1_HUMAN | [view interactions] | High throughput | no | yes |
| KRT34_HUMAN | [view interactions] | High throughput | no | no |
| K1C16_HUMAN | [view interactions] | High throughput | no | no |
| PEX1_HUMAN | [view interactions] | High throughput | no | no |
| WFS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| TRI54_HUMAN | [view interactions] | High throughput | no | no |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| TGON2_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| AT1B3_HUMAN | [view interactions] | High throughput | no | yes |
| MCLN3_HUMAN | [view interactions] | High throughput | no | no |
| CC50A_HUMAN | [view interactions] | High throughput | no | yes |
| AT1B4_HUMAN | [view interactions] | High throughput | no | no |
| VSIG4_HUMAN | [view interactions] | High throughput | no | no |
| TNFA_HUMAN | [view interactions] | High throughput | no | no |
| 5HT3C_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| ATR_HUMAN | [view interactions] | High throughput | no | no |
| EXOC7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRBA_HUMAN | [view interactions] | High throughput | no | yes |
| MTOR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SARM1_HUMAN | [view interactions] | High throughput | no | yes |
| FCERA_HUMAN | [view interactions] | High throughput | no | yes |
| FIGL1_HUMAN | [view interactions] | High throughput | no | yes |
| DAAF5_HUMAN | [view interactions] | High throughput | no | no |
| TTC28_HUMAN | [view interactions] | High throughput | no | no |
| MSTO1_HUMAN | [view interactions] | High throughput | no | yes |
| GSH0_HUMAN | [view interactions] | High throughput | no | yes |
| HEAT3_HUMAN | [view interactions] | High throughput | no | yes |
| NF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VPS18_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TX264_HUMAN | [view interactions] | High throughput | no | no |
| SEM4A_HUMAN | [view interactions] | High throughput | no | no |
| COG2_HUMAN | [view interactions] | High throughput | no | no |
| BIG1_HUMAN | [view interactions] | High throughput | no | yes |
| TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IKKA_HUMAN | [view interactions] | High throughput | no | yes |
| EXOC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEX19_HUMAN | [view interactions] | High throughput | no | yes |
| SNX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NBEL2_HUMAN | [view interactions] | High throughput | no | no |
| EXOC6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLH42_HUMAN | [view interactions] | High throughput | no | yes |
| HXK2_HUMAN | [view interactions] | High throughput | no | yes |
| BTAF1_HUMAN | [view interactions] | High throughput | no | no |
| GCP3_HUMAN | [view interactions] | High throughput | no | yes |
| CKAP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLXB2_HUMAN | [view interactions] | High throughput | no | yes |
| WAPL_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| DPS1_HUMAN | [view interactions] | High throughput | no | yes |
| PLAP_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
| CIP2A_HUMAN | [view interactions] | High throughput | no | yes |
| ARVC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LEG1_HUMAN | [view interactions] | High throughput | no | yes |
| NEMO_HUMAN | [view interactions] | High throughput | no | yes |
| SYMPK_HUMAN | [view interactions] | High throughput | no | yes |
| TGFA1_HUMAN | [view interactions] | High throughput | no | no |
| CAND2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATP7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BTBD1_HUMAN | [view interactions] | High throughput | no | yes |
| DYHC2_HUMAN | [view interactions] | High throughput | no | yes |
| ELMO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| XPO4_HUMAN | [view interactions] | High throughput | no | no |
| TBC9B_HUMAN | [view interactions] | High throughput | no | yes |
| MRPP3_HUMAN | [view interactions] | High throughput | no | yes |
| MZT2B_HUMAN | [view interactions] | High throughput | no | yes |
| TNPO3_HUMAN | [view interactions] | High throughput | no | yes |
| HELLS_HUMAN | [view interactions] | High throughput | no | yes |
| COG4_HUMAN | [view interactions] | High throughput | no | no |
| CNDD3_HUMAN | [view interactions] | High throughput | no | no |
| TSC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BUB1B_HUMAN | [view interactions] | High throughput | no | no |
| STAG2_HUMAN | [view interactions] | High throughput | no | yes |
| UBE4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPS16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| STAT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F1142_HUMAN | [view interactions] | High throughput | no | yes |
| SMC2_HUMAN | [view interactions] | High throughput | no | yes |
| NUB1_HUMAN | [view interactions] | High throughput | no | no |
| TYY1_HUMAN | [view interactions] | High throughput | no | yes |
| FLCN_HUMAN | [view interactions] | High throughput | no | yes |
| TNPO2_HUMAN | [view interactions] | High throughput | no | yes |
| ZFN2A_HUMAN | [view interactions] | High throughput | no | yes |
| LRN4L_HUMAN | [view interactions] | High throughput | no | yes |
| RAMP3_HUMAN | [view interactions] | High throughput | no | no |
| PCDB3_HUMAN | [view interactions] | High throughput | no | no |
| TYRP2_HUMAN | [view interactions] | High throughput | no | no |
| PSPC_HUMAN | [view interactions] | High throughput | no | no |
| APOM_HUMAN | [view interactions] | High throughput | no | no |
| DQA1_HUMAN | [view interactions] | High throughput | no | yes |
| FBX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UPK2_HUMAN | [view interactions] | High throughput | no | no |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPRNG_HUMAN | [view interactions] | High throughput | no | yes |
| NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLXB1_HUMAN | [view interactions] | High throughput | no | yes |
| PLXB3_HUMAN | [view interactions] | High throughput | no | yes |
| PLXD1_HUMAN | [view interactions] | High throughput | no | yes |
| MYO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OTULL_HUMAN | [view interactions] | High throughput | no | no |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| ELOV5_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MET7A_HUMAN | [view interactions] | High throughput | no | no |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB3B_HUMAN | [view interactions] | High throughput | no | no |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| SEC62_HUMAN | [view interactions] | High throughput | no | yes |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |