Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ARVC_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Involved in protein-protein interactions at adherens junctions. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI003528 LIG_PDZ_Wminus1_1 LIG 960 962 -
ELMI003528 LIG_PDZ_Wminus1_1 LIG 960 962 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ARVC_HUMAN
GO:0045296 cadherin binding 27.2727 4 yes
GO:0019900 kinase binding 27.2727 4 no
GO:0019901 protein kinase binding 27.2727 5 no
GO:0043169 cation binding 27.2727 4 no
GO:0046872 metal ion binding 27.2727 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in ARVC_HUMAN
GO:0048522 positive regulation of cellular process 63.6364 4 no
GO:0048523 negative regulation of cellular process 63.6364 4 no
GO:0010646 regulation of cell communication 59.0909 4 no
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0009966 regulation of signal transduction 45.4545 4 no
GO:0080090 regulation of primary metabolic process 45.4545 4 no
GO:0009893 positive regulation of metabolic process 40.9091 4 no
GO:0010604 positive regulation of macromolecule metabolic process 40.9091 5 no
GO:0031325 positive regulation of cellular metabolic process 40.9091 5 no
GO:0022607 cellular component assembly 36.3636 4 yes
GO:0034330 cell junction organization 36.3636 4 yes
GO:0008104 protein localization 36.3636 4 no
GO:0010647 positive regulation of cell communication 36.3636 5 no
GO:0022603 regulation of anatomical structure morphogenesis 36.3636 4 no
GO:0050804 modulation of chemical synaptic transmission 36.3636 5 no
GO:0051049 regulation of transport 36.3636 4 no
GO:0099177 regulation of trans-synaptic signaling 36.3636 4 no
GO:2000026 regulation of multicellular organismal development 36.3636 4 no
GO:0009889 regulation of biosynthetic process 36.3636 4 no
GO:0010468 regulation of gene expression 36.3636 6 no
GO:0010556 regulation of macromolecule biosynthetic process 36.3636 5 no
GO:0031326 regulation of cellular biosynthetic process 36.3636 5 no
GO:0023056 positive regulation of signaling 31.8182 4 no
GO:0031344 regulation of cell projection organization 31.8182 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 31.8182 6 no
GO:0045595 regulation of cell differentiation 31.8182 4 no
GO:0060284 regulation of cell development 31.8182 5 no
GO:0141124 intracellular signaling cassette 31.8182 4 no
GO:0051246 regulation of protein metabolic process 31.8182 5 no
GO:0034329 cell junction assembly 27.2727 5 yes
GO:0009967 positive regulation of signal transduction 27.2727 5 no
GO:0010975 regulation of neuron projection development 27.2727 7 no
GO:0042127 regulation of cell population proliferation 27.2727 4 no
GO:0048584 positive regulation of response to stimulus 27.2727 4 no
GO:0048585 negative regulation of response to stimulus 27.2727 4 no
GO:0050808 synapse organization 27.2727 5 no
GO:1902531 regulation of intracellular signal transduction 27.2727 5 no
GO:0006996 organelle organization 27.2727 4 no
GO:0030030 cell projection organization 27.2727 4 no
GO:0042981 regulation of apoptotic process 27.2727 5 no
GO:0043067 regulation of programmed cell death 27.2727 4 no
GO:0050767 regulation of neurogenesis 27.2727 6 no
GO:0051960 regulation of nervous system development 27.2727 5 no
GO:0009891 positive regulation of biosynthetic process 27.2727 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 27.2727 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 27.2727 5 no
GO:0030334 regulation of cell migration 27.2727 5 no
GO:0031328 positive regulation of cellular biosynthetic process 27.2727 6 no
GO:0031399 regulation of protein modification process 27.2727 6 no
GO:0051240 positive regulation of multicellular organismal process 27.2727 4 no
GO:0051247 positive regulation of protein metabolic process 27.2727 6 no
GO:0051252 regulation of RNA metabolic process 27.2727 5 no
GO:2000145 regulation of cell motility 27.2727 4 no
GO:0007043 cell-cell junction assembly 22.7273 6 yes
GO:0045216 cell-cell junction organization 22.7273 5 yes
GO:0009968 negative regulation of signal transduction 22.7273 5 no
GO:0010648 negative regulation of cell communication 22.7273 5 no
GO:0023057 negative regulation of signaling 22.7273 4 no
GO:0032880 regulation of protein localization 22.7273 5 no
GO:0033043 regulation of organelle organization 22.7273 5 no
GO:0043408 regulation of MAPK cascade 22.7273 6 no
GO:0050807 regulation of synapse organization 22.7273 5 no
GO:0051050 positive regulation of transport 22.7273 4 no
GO:0060341 regulation of cellular localization 22.7273 4 no
GO:0072657 protein localization to membrane 22.7273 4 no
GO:1902533 positive regulation of intracellular signal transduction 22.7273 6 no
GO:0006915 apoptotic process 22.7273 4 no
GO:0007264 small GTPase-mediated signal transduction 22.7273 5 no
GO:0043523 regulation of neuron apoptotic process 22.7273 6 no
GO:0045596 negative regulation of cell differentiation 22.7273 5 no
GO:0051093 negative regulation of developmental process 22.7273 4 no
GO:0051241 negative regulation of multicellular organismal process 22.7273 4 no
GO:0120036 plasma membrane bounded cell projection organization 22.7273 5 no
GO:0001932 regulation of protein phosphorylation 22.7273 7 no
GO:0001934 positive regulation of protein phosphorylation 22.7273 8 no
GO:0006355 regulation of DNA-templated transcription 22.7273 7 no
GO:0008284 positive regulation of cell population proliferation 22.7273 5 no
GO:0009892 negative regulation of metabolic process 22.7273 4 no
GO:0010562 positive regulation of phosphorus metabolic process 22.7273 6 no
GO:0010605 negative regulation of macromolecule metabolic process 22.7273 5 no
GO:0019220 regulation of phosphate metabolic process 22.7273 6 no
GO:0031324 negative regulation of cellular metabolic process 22.7273 5 no
GO:0031401 positive regulation of protein modification process 22.7273 7 no
GO:0042325 regulation of phosphorylation 22.7273 7 no
GO:0042327 positive regulation of phosphorylation 22.7273 8 no
GO:0045937 positive regulation of phosphate metabolic process 22.7273 7 no
GO:0051174 regulation of phosphorus metabolic process 22.7273 5 no
GO:2001141 regulation of RNA biosynthetic process 22.7273 6 no
GO:0051094 positive regulation of developmental process 22.7273 4 no
GO:0016070 RNA metabolic process 13.6364 5 yes
GO:0090304 nucleic acid metabolic process 13.6364 4 yes
GO:0006396 RNA processing 9.0909 6 yes
GO:0006397 mRNA processing 9.0909 7 yes
GO:0008380 RNA splicing 9.0909 7 yes
GO:0016071 mRNA metabolic process 9.0909 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ERBIN_HUMAN [view entry] [view interactions] Low throughput yes yes
CAD15_HUMAN [view interactions] Low throughput no no
CADH1_HUMAN [view entry] [view interactions] Low throughput yes no
CADH2_HUMAN [view entry] [view interactions] Low throughput yes no
ARGL1_HUMAN [view interactions] High throughput no yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
CTDSL_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
KCNK3_HUMAN [view interactions] High throughput no no
LNX1_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK1_HUMAN [view interactions] High throughput no yes
CADH8_HUMAN [view interactions] High throughput no no
CADH5_HUMAN [view interactions] High throughput no yes
CTNA3_HUMAN [view interactions] High throughput no no
NK1R_HUMAN [view entry] [view interactions] High throughput yes no
SDC1_HUMAN [view interactions] High throughput no no
CP2S1_HUMAN [view interactions] High throughput no no
CXB7_HUMAN [view interactions] High throughput no no
S1PR2_HUMAN [view entry] [view interactions] High throughput yes no
CBPA5_HUMAN [view interactions] High throughput no no
P4HA2_HUMAN [view interactions] High throughput no no
PROZ_HUMAN [view interactions] High throughput no no
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
ESR2_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
ACK1_HUMAN [view entry] [view interactions] High throughput yes yes
AAKG3_HUMAN [view interactions] High throughput no no
ANLN_HUMAN [view interactions] High throughput no yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
INS_HUMAN [view interactions] High throughput no no
CYTM1_HUMAN [view interactions] High throughput no no
TX1B3_HUMAN [view interactions] High throughput no no
EFNA4_HUMAN [view interactions] High throughput no no
CERS2_HUMAN [view interactions] High throughput no no
SEM4C_HUMAN [view entry] [view interactions] High throughput yes no
CAD12_HUMAN [view interactions] High throughput no no
SCML1_HUMAN [view interactions] High throughput no no
CC85A_HUMAN [view interactions] High throughput no yes
S10A2_HUMAN [view interactions] High throughput no no
SLIRP_HUMAN [view interactions] High throughput no yes
PRSR2_HUMAN [view interactions] High throughput no yes
GPR45_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
CCNF_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
TOP3B_HUMAN [view interactions] High throughput no no
CTND1_HUMAN [view entry] [view interactions] High throughput yes no
EZH2_HUMAN [view interactions] High throughput no no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
ANK3_HUMAN [view entry] [view interactions] High throughput yes yes
CK052_HUMAN [view interactions] High throughput no no
CAV1_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
GBB2_HUMAN [view entry] [view interactions] High throughput yes yes
SSR3_HUMAN [view interactions] High throughput no yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no