ARVC_HUMAN
Evidence for PS localization
Functions
Involved in protein-protein interactions at adherens junctions. [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 46%

Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
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ARVC_HUMAN has binary interactions with 21 proteins
Isoforms
Interacting regions
Canonical [ARVC_HUMAN]
Isoform [C9JJX6] alignment
Isoform [E9PDC3] alignment
Isoform [O00192-2] alignment
LOADING 56%

Disease-causing germline mutations
No data found.
Linear motifs
ELM instance | Name | Type | Start | End | Partner |
---|---|---|---|---|---|
ELMI003528 | LIG_PDZ_Wminus1_1 | LIG | 960 | 962 | - |
ELMI003528 | LIG_PDZ_Wminus1_1 | LIG | 960 | 962 | - |
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Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in ARVC_HUMAN |
---|---|---|---|---|
GO:0045296 | cadherin binding | 27.2727 | 4 | yes |
GO:0019900 | kinase binding | 27.2727 | 4 | no |
GO:0019901 | protein kinase binding | 27.2727 | 5 | no |
GO:0043169 | cation binding | 27.2727 | 4 | no |
GO:0046872 | metal ion binding | 27.2727 | 5 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in ARVC_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 63.6364 | 4 | no |
GO:0048523 | negative regulation of cellular process | 63.6364 | 4 | no |
GO:0010646 | regulation of cell communication | 59.0909 | 4 | no |
GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | no |
GO:0009966 | regulation of signal transduction | 45.4545 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 45.4545 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 40.9091 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 40.9091 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 40.9091 | 5 | no |
GO:0022607 | cellular component assembly | 36.3636 | 4 | yes |
GO:0034330 | cell junction organization | 36.3636 | 4 | yes |
GO:0008104 | protein localization | 36.3636 | 4 | no |
GO:0010647 | positive regulation of cell communication | 36.3636 | 5 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 36.3636 | 4 | no |
GO:0050804 | modulation of chemical synaptic transmission | 36.3636 | 5 | no |
GO:0051049 | regulation of transport | 36.3636 | 4 | no |
GO:0099177 | regulation of trans-synaptic signaling | 36.3636 | 4 | no |
GO:2000026 | regulation of multicellular organismal development | 36.3636 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 36.3636 | 4 | no |
GO:0010468 | regulation of gene expression | 36.3636 | 6 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 36.3636 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 36.3636 | 5 | no |
GO:0023056 | positive regulation of signaling | 31.8182 | 4 | no |
Disease
No data found.
All partners
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
AAKG3_HUMAN | [view interactions] | High throughput | no | no |
ACK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ANK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ANLN_HUMAN | [view interactions] | High throughput | no | yes |
ARGL1_HUMAN | [view interactions] | High throughput | no | yes |
CAD12_HUMAN | [view interactions] | High throughput | no | no |
CAD15_HUMAN | [view interactions] | Low throughput | no | no |
CADH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
CADH2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
CADH5_HUMAN | [view interactions] | High throughput | no | yes |
CADH8_HUMAN | [view interactions] | High throughput | no | no |
CAV1_HUMAN | [view interactions] | High throughput | no | no |
CBPA5_HUMAN | [view interactions] | High throughput | no | no |
CC85A_HUMAN | [view interactions] | High throughput | no | yes |
CCNF_HUMAN | [view interactions] | High throughput | no | no |
CERS2_HUMAN | [view interactions] | High throughput | no | no |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
CK052_HUMAN | [view interactions] | High throughput | no | no |
CP2S1_HUMAN | [view interactions] | High throughput | no | no |
CTDSL_HUMAN | [view interactions] | High throughput | no | no |
CTNA3_HUMAN | [view interactions] | High throughput | no | no |
CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CTND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CXB7_HUMAN | [view interactions] | High throughput | no | no |
CYTM1_HUMAN | [view interactions] | High throughput | no | no |