Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

S1PR2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P) (PubMed). S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues (PubMed). When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis (PubMed). Receptor for the chemokine-like protein FAM19A5 (PubMed). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
108 Arg Pro Deafness,autosomalrecessive,68(DFNB68) -
140 Tyr Cys Deafness,autosomalrecessive,68(DFNB68) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in S1PR2_HUMAN
GO:0043169 cation binding 38.8889 4 no
GO:0046872 metal ion binding 38.8889 5 no
GO:0043168 anion binding 27.7778 4 no
GO:0031625 ubiquitin protein ligase binding 27.7778 5 no
GO:0044389 ubiquitin-like protein ligase binding 27.7778 4 no
GO:0001664 G protein-coupled receptor binding 22.2222 4 yes
GO:0045296 cadherin binding 22.2222 4 no
GO:0004930 G protein-coupled receptor activity 11.1111 4 yes
GO:0045125 bioactive lipid receptor activity 11.1111 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in S1PR2_HUMAN
GO:0009966 regulation of signal transduction 44.4444 4 yes
GO:0010646 regulation of cell communication 44.4444 4 yes
GO:0022607 cellular component assembly 38.8889 4 yes
GO:0030030 cell projection organization 38.8889 4 yes
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 33.3333 4 yes
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 33.3333 5 yes
GO:0048522 positive regulation of cellular process 33.3333 4 yes
GO:0120036 plasma membrane bounded cell projection organization 33.3333 5 yes
GO:0048523 negative regulation of cellular process 33.3333 4 no
GO:1902531 regulation of intracellular signal transduction 33.3333 5 no
GO:0036211 protein modification process 33.3333 4 no
GO:0043412 macromolecule modification 33.3333 4 no
GO:0006996 organelle organization 27.7778 4 yes
GO:0042127 regulation of cell population proliferation 27.7778 4 yes
GO:0051246 regulation of protein metabolic process 27.7778 5 yes
GO:0060255 regulation of macromolecule metabolic process 27.7778 4 yes
GO:0080090 regulation of primary metabolic process 27.7778 4 yes
GO:0009967 positive regulation of signal transduction 27.7778 5 no
GO:0010647 positive regulation of cell communication 27.7778 5 no
GO:0023056 positive regulation of signaling 27.7778 4 no
GO:0048584 positive regulation of response to stimulus 27.7778 4 no
GO:1902533 positive regulation of intracellular signal transduction 27.7778 6 no
GO:0006508 proteolysis 27.7778 4 no
GO:0009057 macromolecule catabolic process 27.7778 4 no
GO:0016567 protein ubiquitination 27.7778 8 no
GO:0019941 modification-dependent protein catabolic process 27.7778 6 no
GO:0032446 protein modification by small protein conjugation 27.7778 7 no
GO:0043632 modification-dependent macromolecule catabolic process 27.7778 5 no
GO:0043687 post-translational protein modification 27.7778 5 no
GO:0051603 proteolysis involved in protein catabolic process 27.7778 5 no
GO:0070647 protein modification by small protein conjugation or removal 27.7778 6 no
GO:0009893 positive regulation of metabolic process 22.2222 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 22.2222 5 yes
GO:0030031 cell projection assembly 22.2222 5 yes
GO:0031323 regulation of cellular metabolic process 22.2222 4 yes
GO:0031399 regulation of protein modification process 22.2222 6 yes
GO:0051094 positive regulation of developmental process 22.2222 4 yes
GO:0120031 plasma membrane bounded cell projection assembly 22.2222 6 yes
GO:0022603 regulation of anatomical structure morphogenesis 22.2222 4 no
GO:0030334 regulation of cell migration 22.2222 5 no
GO:0031344 regulation of cell projection organization 22.2222 5 no
GO:0032101 regulation of response to external stimulus 22.2222 4 no
GO:0033993 response to lipid 22.2222 4 no
GO:0042981 regulation of apoptotic process 22.2222 5 no
GO:0043067 regulation of programmed cell death 22.2222 4 no
GO:0051056 regulation of small GTPase mediated signal transduction 22.2222 6 no
GO:0051128 regulation of cellular component organization 22.2222 4 no
GO:0071310 cellular response to organic substance 22.2222 4 no
GO:0071396 cellular response to lipid 22.2222 5 no
GO:0071453 cellular response to oxygen levels 22.2222 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 22.2222 6 no
GO:1901701 cellular response to oxygen-containing compound 22.2222 4 no
GO:2000145 regulation of cell motility 22.2222 4 no
GO:0001932 regulation of protein phosphorylation 16.6667 7 yes
GO:0008284 positive regulation of cell population proliferation 16.6667 5 yes
GO:0019220 regulation of phosphate metabolic process 16.6667 6 yes
GO:0031325 positive regulation of cellular metabolic process 16.6667 5 yes
GO:0031401 positive regulation of protein modification process 16.6667 7 yes
GO:0042325 regulation of phosphorylation 16.6667 7 yes
GO:0046847 filopodium assembly 16.6667 7 yes
GO:0051174 regulation of phosphorus metabolic process 16.6667 5 yes
GO:0051247 positive regulation of protein metabolic process 16.6667 6 yes
GO:0001934 positive regulation of protein phosphorylation 11.1111 8 yes
GO:0007010 cytoskeleton organization 11.1111 5 yes
GO:0010562 positive regulation of phosphorus metabolic process 11.1111 6 yes
GO:0042327 positive regulation of phosphorylation 11.1111 8 yes
GO:0044057 regulation of system process 11.1111 4 yes
GO:0045595 regulation of cell differentiation 11.1111 4 yes
GO:0045937 positive regulation of phosphate metabolic process 11.1111 7 yes
GO:0050804 modulation of chemical synaptic transmission 11.1111 5 yes
GO:0060284 regulation of cell development 11.1111 5 yes
GO:0099177 regulation of trans-synaptic signaling 11.1111 4 yes
GO:2000026 regulation of multicellular organismal development 11.1111 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RTN4_HUMAN [view entry] [view interactions] Low throughput yes yes
ITB4_HUMAN [view entry] [view interactions] Low throughput yes yes
UBB_HUMAN [view entry] [view interactions] Low throughput yes yes
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
RS27A_HUMAN [view entry] [view interactions] Low throughput yes yes
RL40_HUMAN [view entry] [view interactions] Low throughput yes yes
S1PR1_HUMAN [view interactions] Low throughput no no
GBB1_HUMAN [view entry] [view interactions] Low throughput yes yes
GBG2_HUMAN [view entry] [view interactions] Low throughput yes yes
GNA13_HUMAN [view entry] [view interactions] Low throughput yes yes
LPAR1_HUMAN [view entry] [view interactions] High throughput yes no
PALM3_HUMAN [view interactions] High throughput no no
PRAF3_HUMAN [view interactions] High throughput no yes
ATPB_HUMAN [view interactions] High throughput no yes
CO8G_HUMAN [view interactions] High throughput no no
LEG1_HUMAN [view interactions] High throughput no yes
PPAL_HUMAN [view interactions] High throughput no no
NEUM_HUMAN [view entry] [view interactions] High throughput yes yes
HPCL1_HUMAN [view interactions] High throughput no yes
GNAQ_HUMAN [view entry] [view interactions] High throughput yes yes
WDFY1_HUMAN [view interactions] High throughput no yes
NDRG1_HUMAN [view entry] [view interactions] High throughput yes yes
REEP6_HUMAN [view interactions] High throughput no no
FKB14_HUMAN [view interactions] High throughput no yes
PHAG1_HUMAN [view interactions] High throughput no yes
TRADD_HUMAN [view interactions] High throughput no yes
FADD_HUMAN [view interactions] High throughput no yes
SHRPN_HUMAN [view entry] [view interactions] High throughput yes yes
TNAP3_HUMAN [view interactions] High throughput no yes
SG196_HUMAN [view interactions] High throughput no yes
SRC_HUMAN [view entry] [view interactions] High throughput yes no
KC1G3_HUMAN [view interactions] High throughput no yes
PTER_HUMAN [view interactions] High throughput no yes
ARVC_HUMAN [view entry] [view interactions] High throughput yes yes
MFSD8_HUMAN [view interactions] High throughput no yes
TTYH1_HUMAN [view entry] [view interactions] High throughput yes no
TNF18_HUMAN [view interactions] High throughput no no
TSN15_HUMAN [view interactions] High throughput no yes
ARL5A_HUMAN [view interactions] High throughput no yes
SPPL3_HUMAN [view interactions] High throughput no no