NDRG1_HUMAN
Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in NDRG1_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 33.6957 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 33.6957 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 32.6087 | 4 | no |
GO:0003723 | RNA binding | 29.3478 | 4 | no |
GO:0016462 | pyrophosphatase activity | 22.8261 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 22.8261 | 4 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 22.8261 | 6 | no |
GO:0045296 | cadherin binding | 16.3043 | 4 | yes |
GO:0015631 | tubulin binding | 8.6957 | 4 | yes |
GO:0008017 | microtubule binding | 7.6087 | 5 | yes |
GO:0051020 | GTPase binding | 5.4348 | 4 | yes |
GO:0031267 | small GTPase binding | 3.2609 | 5 | yes |
GO:0043015 | gamma-tubulin binding | 3.2609 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in NDRG1_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 52.1739 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 46.7391 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 44.5652 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 42.3913 | 4 | no |
GO:0048523 | negative regulation of cellular process | 41.3043 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 41.3043 | 4 | no |
GO:0008104 | protein localization | 38.0435 | 4 | no |
GO:0071702 | organic substance transport | 34.7826 | 4 | no |
GO:0010468 | regulation of gene expression | 34.7826 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 33.6957 | 5 | no |
GO:0010646 | regulation of cell communication | 32.6087 | 4 | no |
GO:0071705 | nitrogen compound transport | 32.6087 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 31.5217 | 4 | no |
GO:0051128 | regulation of cellular component organization | 31.5217 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 30.4348 | 4 | no |
GO:0031326 | regulation of cellular biosynthetic process | 30.4348 | 5 | no |
GO:0015031 | protein transport | 29.3478 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 29.3478 | 5 | no |
GO:0051049 | regulation of transport | 28.2609 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 28.2609 | 5 | no |
GO:0022607 | cellular component assembly | 28.2609 | 4 | no |
GO:0009966 | regulation of signal transduction | 28.2609 | 4 | no |
GO:0006996 | organelle organization | 27.1739 | 4 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 27.1739 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 25.0000 | 5 | no |
GO:0071310 | cellular response to organic substance | 23.9130 | 4 | no |
GO:0016192 | vesicle-mediated transport | 23.9130 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 22.8261 | 4 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 22.8261 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 21.7391 | 4 | no |
GO:0006886 | intracellular protein transport | 20.6522 | 4 | no |
GO:0010647 | positive regulation of cell communication | 20.6522 | 5 | no |
GO:0023056 | positive regulation of signaling | 20.6522 | 4 | no |
GO:0060341 | regulation of cellular localization | 20.6522 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 20.6522 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 20.6522 | 6 | no |
GO:0042127 | regulation of cell population proliferation | 17.3913 | 4 | yes |
GO:0061024 | membrane organization | 13.0435 | 4 | yes |
GO:0006974 | cellular response to DNA damage stimulus | 8.6957 | 4 | yes |
GO:0010038 | response to metal ion | 8.6957 | 4 | yes |
GO:0008285 | negative regulation of cell population proliferation | 7.6087 | 5 | yes |
GO:0036293 | response to decreased oxygen levels | 4.3478 | 4 | yes |
GO:0007009 | plasma membrane organization | 3.2609 | 5 | yes |
GO:0072331 | signal transduction by p53 class mediator | 3.2609 | 4 | yes |
GO:0030330 | DNA damage response, signal transduction by p53 class mediator | 2.1739 | 5 | yes |
GO:0032287 | peripheral nervous system myelin maintenance | 2.1739 | 7 | yes |
GO:0036294 | cellular response to decreased oxygen levels | 2.1739 | 5 | yes |
GO:0042770 | signal transduction in response to DNA damage | 2.1739 | 4 | yes |
GO:0043217 | myelin maintenance | 2.1739 | 6 | yes |
GO:0045576 | mast cell activation | 2.1739 | 4 | yes |
GO:0071453 | cellular response to oxygen levels | 2.1739 | 4 | yes |
GO:0071456 | cellular response to hypoxia | 2.1739 | 4 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
NDRG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RAB4A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
HS90A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CADH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
RTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
APOA1_HUMAN | [view interactions] | Low throughput | no | no |
APOA2_HUMAN | [view interactions] | Low throughput | no | no |
PRAF1_HUMAN | [view interactions] | Low throughput | no | yes |
AR6P1_HUMAN | [view interactions] | Low throughput | no | yes |
S100B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
B2L11_HUMAN | [view interactions] | Low throughput | no | yes |
HSP74_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CUL2_HUMAN | [view interactions] | Low throughput | no | yes |
ERBB3_HUMAN | [view interactions] | Low throughput | no | yes |
MYC_HUMAN | [view interactions] | Low throughput | no | yes |
SKP2_HUMAN | [view interactions] | Low throughput | no | yes |
GSK3B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NR4A1_HUMAN | [view interactions] | Low throughput | no | yes |
PPM1F_HUMAN | [view interactions] | Low throughput | no | yes |
SGK1_HUMAN | [view interactions] | Low throughput | no | yes |
MVD1_HUMAN | [view interactions] | High throughput | no | yes |
NAMPT_HUMAN | [view interactions] | High throughput | no | no |
PEPD_HUMAN | [view interactions] | High throughput | no | yes |
6PGD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DHX15_HUMAN | [view interactions] | High throughput | no | yes |
G6PD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PUR2_HUMAN | [view interactions] | High throughput | no | yes |
HIP1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CCD22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CLIC4_HUMAN | [view interactions] | High throughput | no | no |
NAA50_HUMAN | [view interactions] | High throughput | no | yes |
RTCB_HUMAN | [view interactions] | High throughput | no | yes |
SH24A_HUMAN | [view interactions] | High throughput | no | no |
THUM1_HUMAN | [view interactions] | High throughput | no | yes |
TIM13_HUMAN | [view interactions] | High throughput | no | yes |
TS101_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NIF3L_HUMAN | [view interactions] | High throughput | no | yes |
NTM1A_HUMAN | [view interactions] | High throughput | no | yes |
TADBP_HUMAN | [view interactions] | High throughput | no | yes |
UFM1_HUMAN | [view interactions] | High throughput | no | yes |
PEDF_HUMAN | [view interactions] | High throughput | no | no |
CUTA_HUMAN | [view interactions] | High throughput | no | yes |
SBP1_HUMAN | [view interactions] | High throughput | no | no |
TAGL_HUMAN | [view interactions] | High throughput | no | no |
VPS51_HUMAN | [view interactions] | High throughput | no | yes |
PARVA_HUMAN | [view interactions] | High throughput | no | yes |
MP2K6_HUMAN | [view interactions] | High throughput | no | yes |
5NT3B_HUMAN | [view interactions] | High throughput | no | yes |
PTGDS_HUMAN | [view interactions] | High throughput | no | yes |
TYB4_HUMAN | [view interactions] | High throughput | no | yes |
TPRGL_HUMAN | [view interactions] | High throughput | no | no |
ZER1_HUMAN | [view interactions] | High throughput | no | no |
RFFL_HUMAN | [view interactions] | High throughput | no | yes |
DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RN183_HUMAN | [view interactions] | High throughput | no | no |
ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CK052_HUMAN | [view interactions] | High throughput | no | no |
CAV1_HUMAN | [view interactions] | High throughput | no | no |
LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OCLN_HUMAN | [view interactions] | High throughput | no | no |
RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
STX6_HUMAN | [view interactions] | High throughput | no | yes |
STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
NAA40_HUMAN | [view interactions] | High throughput | no | no |
MLH1_HUMAN | [view interactions] | High throughput | no | yes |
S1PR2_HUMAN | [view interactions] | High throughput | no | no |
SHCAF_HUMAN | [view interactions] | High throughput | no | yes |
PLM_HUMAN | [view interactions] | High throughput | no | no |
1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SH2D3_HUMAN | [view interactions] | High throughput | no | no |
KPCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CUL4A_HUMAN | [view interactions] | High throughput | no | no |
APBB1_HUMAN | [view interactions] | High throughput | no | yes |
HTRA4_HUMAN | [view interactions] | High throughput | no | no |
MYLK4_HUMAN | [view interactions] | High throughput | no | no |
1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRS6A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRS7_HUMAN | [view interactions] | High throughput | no | yes |
PSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
XRCC6_HUMAN | [view interactions] | High throughput | no | yes |
RUVB2_HUMAN | [view interactions] | High throughput | no | yes |
SC23A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COPB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AP1M2_HUMAN | [view interactions] | High throughput | no | no |
NEP_HUMAN | [view interactions] | High throughput | no | no |
KINH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
2ABA_HUMAN | [view interactions] | High throughput | no | yes |
DHB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TLE3_HUMAN | [view interactions] | High throughput | no | yes |
CNDP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYDC_HUMAN | [view interactions] | High throughput | no | yes |
ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACSL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AOFA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LDHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KPYM_HUMAN | [view interactions] | High throughput | no | yes |
RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYTC_HUMAN | [view interactions] | High throughput | no | yes |
GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ADT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AT1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
EF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EF1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IF2G_HUMAN | [view interactions] | High throughput | no | yes |
EIF3E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PABP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RL24_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RS16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RS8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RS20_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RS9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RS26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NUCL_HUMAN | [view interactions] | High throughput | no | yes |
HNRPF_HUMAN | [view interactions] | High throughput | no | yes |
HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RENT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EWS_HUMAN | [view interactions] | High throughput | no | yes |
KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ZMAT2_HUMAN | [view interactions] | High throughput | no | yes |
SPA2L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LDH6B_HUMAN | [view interactions] | High throughput | no | no |
MED28_HUMAN | [view interactions] | High throughput | no | yes |
DCR1B_HUMAN | [view interactions] | High throughput | no | no |
TTC33_HUMAN | [view interactions] | High throughput | no | yes |
RYBP_HUMAN | [view interactions] | High throughput | no | no |
MSRB2_HUMAN | [view interactions] | High throughput | no | no |
SAP30_HUMAN | [view interactions] | High throughput | no | yes |
FX4L6_HUMAN | [view interactions] | High throughput | no | no |
PHYIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARL4D_HUMAN | [view interactions] | High throughput | no | no |
TMM17_HUMAN | [view interactions] | High throughput | no | yes |
EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TGON2_HUMAN | [view interactions] | High throughput | no | yes |
LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TAF9_HUMAN | [view interactions] | High throughput | no | yes |
ILF3_HUMAN | [view interactions] | High throughput | no | yes |
SUZ12_HUMAN | [view interactions] | High throughput | no | no |
EED_HUMAN | [view interactions] | High throughput | no | yes |
NDRG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LNX1_HUMAN | [view interactions] | High throughput | no | yes |
MYOME_HUMAN | [view interactions] | High throughput | no | no |
CDK15_HUMAN | [view interactions] | High throughput | no | no |
TRI25_HUMAN | [view interactions] | High throughput | no | yes |
HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
YAP1_HUMAN | [view interactions] | High throughput | no | yes |
ZBT38_HUMAN | [view interactions] | High throughput | no | no |
CTBP2_HUMAN | [view interactions] | High throughput | no | no |
MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SIA7F_HUMAN | [view interactions] | High throughput | no | yes |
OR2A4_HUMAN | [view interactions] | High throughput | no | no |
HXC5_HUMAN | [view interactions] | High throughput | no | no |
RL35A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FXYD3_HUMAN | [view interactions] | High throughput | no | yes |
SRRT_HUMAN | [view interactions] | High throughput | no | yes |
2ABB_HUMAN | [view interactions] | High throughput | no | yes |
NAA11_HUMAN | [view interactions] | High throughput | no | no |
AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STX17_HUMAN | [view interactions] | High throughput | no | yes |
WIF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
COAA1_HUMAN | [view interactions] | High throughput | no | no |
CERS3_HUMAN | [view interactions] | High throughput | no | no |
OPTN_HUMAN | [view interactions] | High throughput | no | yes |
SSBP2_HUMAN | [view interactions] | High throughput | no | yes |
AT1B3_HUMAN | [view interactions] | High throughput | no | yes |
CB073_HUMAN | [view interactions] | High throughput | no | no |
NTNG1_HUMAN | [view interactions] | High throughput | no | no |
FGF12_HUMAN | [view interactions] | High throughput | no | no |
OSGEP_HUMAN | [view interactions] | High throughput | no | yes |
CCR1_HUMAN | [view interactions] | High throughput | no | no |
TIDC1_HUMAN | [view interactions] | High throughput | no | yes |
CEP19_HUMAN | [view interactions] | High throughput | no | no |
MBNL1_HUMAN | [view interactions] | High throughput | no | yes |
RPC9_HUMAN | [view interactions] | High throughput | no | yes |
PINK1_HUMAN | [view interactions] | High throughput | no | yes |
NRSN1_HUMAN | [view interactions] | High throughput | no | yes |
WASC3_HUMAN | [view interactions] | High throughput | no | yes |
SSUH2_HUMAN | [view interactions] | High throughput | no | no |
DNJB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
RHOQ_HUMAN | [view interactions] | High throughput | no | no |
RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOF_HUMAN | [view interactions] | High throughput | no | no |
LAT1_HUMAN | [view interactions] | High throughput | no | yes |
ANXA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ICLN_HUMAN | [view interactions] | High throughput | no | yes |
IGBP1_HUMAN | [view interactions] | High throughput | no | yes |
JIP4_HUMAN | [view interactions] | High throughput | no | yes |
BACH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DX39B_HUMAN | [view interactions] | High throughput | no | no |
GSHR_HUMAN | [view interactions] | High throughput | no | yes |
DPP3_HUMAN | [view interactions] | High throughput | no | no |
IF4H_HUMAN | [view interactions] | High throughput | no | yes |
FTO_HUMAN | [view interactions] | High throughput | no | yes |
KYNU_HUMAN | [view interactions] | High throughput | no | no |
MYCN_HUMAN | [view interactions] | Computational | no | no |
P53_HUMAN | [view interactions] | Computational | no | no |
LRP6_HUMAN | [view interactions] | Computational | no | yes |
ST38L_HUMAN | [view entry] [view interactions] | Computational | yes | yes |