Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NDRG1_HUMAN

Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in NDRG1_HUMAN
GO:0043168 anion binding 35.3535 4 no
GO:0000166 nucleotide binding 34.3434 4 no
GO:0017076 purine nucleotide binding 33.3333 5 no
GO:0032555 purine ribonucleotide binding 31.3131 4 no
GO:0035639 purine ribonucleoside triphosphate binding 30.3030 4 no
GO:0003723 RNA binding 27.2727 4 no
GO:0016462 pyrophosphatase activity 23.2323 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 23.2323 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 23.2323 6 no
GO:0019900 kinase binding 20.2020 4 no
GO:0019901 protein kinase binding 20.2020 5 no
GO:0045296 cadherin binding 15.1515 4 yes
GO:0015631 tubulin binding 9.0909 4 yes
GO:0008017 microtubule binding 7.0707 5 yes
GO:0051020 GTPase binding 5.0505 4 yes
GO:0031267 small GTPase binding 3.0303 5 yes
GO:0043015 gamma-tubulin binding 3.0303 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NDRG1_HUMAN
GO:0048522 positive regulation of cellular process 54.5455 4 no
GO:0060255 regulation of macromolecule metabolic process 45.4545 4 no
GO:0080090 regulation of primary metabolic process 42.4242 4 no
GO:0031323 regulation of cellular metabolic process 40.4040 4 no
GO:0008104 protein localization 39.3939 4 no
GO:0048523 negative regulation of cellular process 38.3838 4 yes
GO:0009889 regulation of biosynthetic process 37.3737 4 no
GO:0031326 regulation of cellular biosynthetic process 36.3636 5 no
GO:0010556 regulation of macromolecule biosynthetic process 34.3434 5 no
GO:0051128 regulation of cellular component organization 33.3333 4 no
GO:0051246 regulation of protein metabolic process 32.3232 5 no
GO:0071702 organic substance transport 32.3232 4 no
GO:0010646 regulation of cell communication 32.3232 4 no
GO:0071705 nitrogen compound transport 31.3131 4 no
GO:0010468 regulation of gene expression 31.3131 6 no
GO:0006996 organelle organization 30.3030 4 no
GO:0009893 positive regulation of metabolic process 29.2929 4 no
GO:0051049 regulation of transport 29.2929 4 no
GO:0010604 positive regulation of macromolecule metabolic process 28.2828 5 no
GO:0009966 regulation of signal transduction 28.2828 4 no
GO:0015031 protein transport 27.2727 4 no
GO:0022607 cellular component assembly 27.2727 4 no
GO:0031325 positive regulation of cellular metabolic process 26.2626 5 no
GO:0060341 regulation of cellular localization 25.2525 4 no
GO:0009891 positive regulation of biosynthetic process 24.2424 5 no
GO:0031328 positive regulation of cellular biosynthetic process 23.2323 6 no
GO:0032880 regulation of protein localization 23.2323 5 no
GO:0009892 negative regulation of metabolic process 22.2222 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 22.2222 6 no
GO:0048584 positive regulation of response to stimulus 22.2222 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 22.2222 5 no
GO:0031324 negative regulation of cellular metabolic process 21.2121 5 no
GO:0051247 positive regulation of protein metabolic process 20.2020 6 no
GO:0010605 negative regulation of macromolecule metabolic process 20.2020 5 no
GO:0042981 regulation of apoptotic process 20.2020 5 no
GO:0043067 regulation of programmed cell death 20.2020 4 no
GO:0071310 cellular response to organic substance 20.2020 4 no
GO:1902531 regulation of intracellular signal transduction 20.2020 5 no
GO:0006886 intracellular protein transport 20.2020 4 no
GO:0042127 regulation of cell population proliferation 18.1818 4 yes
GO:0061024 membrane organization 15.1515 4 yes
GO:0006974 DNA damage response 9.0909 4 yes
GO:0008285 negative regulation of cell population proliferation 7.0707 5 yes
GO:0010038 response to metal ion 7.0707 4 yes
GO:0007009 plasma membrane organization 3.0303 5 yes
GO:0036293 response to decreased oxygen levels 3.0303 4 yes
GO:0072331 signal transduction by p53 class mediator 3.0303 4 yes
GO:0030330 DNA damage response, signal transduction by p53 class mediator 2.0202 5 yes
GO:0032287 peripheral nervous system myelin maintenance 2.0202 7 yes
GO:0036294 cellular response to decreased oxygen levels 2.0202 5 yes
GO:0042770 signal transduction in response to DNA damage 2.0202 4 yes
GO:0043217 myelin maintenance 2.0202 6 yes
GO:0045576 mast cell activation 2.0202 4 yes
GO:0071453 cellular response to oxygen levels 2.0202 4 yes
GO:0071456 cellular response to hypoxia 2.0202 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SGK1_HUMAN [view interactions] Low throughput no yes
NDRG1_HUMAN [view entry] [view interactions] Low throughput yes yes
RAB4A_HUMAN [view entry] [view interactions] Low throughput yes no
HS90A_HUMAN [view entry] [view interactions] Low throughput yes yes
CADH1_HUMAN [view entry] [view interactions] Low throughput yes no
RTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
APOA1_HUMAN [view interactions] Low throughput no no
APOA2_HUMAN [view interactions] Low throughput no no
PRAF1_HUMAN [view interactions] Low throughput no yes
AR6P1_HUMAN [view interactions] Low throughput no yes
S100B_HUMAN [view entry] [view interactions] Low throughput yes yes
B2L11_HUMAN [view interactions] Low throughput no yes
HSP74_HUMAN [view entry] [view interactions] Low throughput yes yes
CUL2_HUMAN [view interactions] Low throughput no yes
ERBB3_HUMAN [view interactions] Low throughput no yes
MYC_HUMAN [view interactions] Low throughput no yes
SKP2_HUMAN [view interactions] Low throughput no yes
GSK3B_HUMAN [view entry] [view interactions] Low throughput yes yes
NR4A1_HUMAN [view interactions] Low throughput no yes
PPM1F_HUMAN [view interactions] Low throughput no yes
TIDC1_HUMAN [view interactions] High throughput no yes
CEP19_HUMAN [view interactions] High throughput no no
MBNL1_HUMAN [view interactions] High throughput no yes
RPC9_HUMAN [view interactions] High throughput no yes
PINK1_HUMAN [view interactions] High throughput no yes
NRSN1_HUMAN [view interactions] High throughput no yes
WASC3_HUMAN [view interactions] High throughput no yes
SSUH2_HUMAN [view interactions] High throughput no no
DNJB6_HUMAN [view entry] [view interactions] High throughput yes yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOF_HUMAN [view interactions] High throughput no no
LAT1_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
ANDR_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
UBP48_HUMAN [view interactions] High throughput no yes
TET5C_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
ANXA5_HUMAN [view entry] [view interactions] High throughput yes no
ICLN_HUMAN [view interactions] High throughput no yes
IGBP1_HUMAN [view interactions] High throughput no yes
JIP4_HUMAN [view interactions] High throughput no yes
BACH_HUMAN [view entry] [view interactions] High throughput yes yes
DX39B_HUMAN [view interactions] High throughput no no
GSHR_HUMAN [view interactions] High throughput no yes
DPP3_HUMAN [view interactions] High throughput no no
IF4H_HUMAN [view interactions] High throughput no yes
FTO_HUMAN [view interactions] High throughput no yes
KYNU_HUMAN [view interactions] High throughput no no
MVD1_HUMAN [view interactions] High throughput no yes
NAMPT_HUMAN [view interactions] High throughput no no
PEPD_HUMAN [view interactions] High throughput no yes
6PGD_HUMAN [view entry] [view interactions] High throughput yes no
DHX15_HUMAN [view interactions] High throughput no yes
G6PD_HUMAN [view entry] [view interactions] High throughput yes no
PUR2_HUMAN [view interactions] High throughput no yes
HIP1R_HUMAN [view entry] [view interactions] High throughput yes yes
CCD22_HUMAN [view entry] [view interactions] High throughput yes no
CLIC4_HUMAN [view interactions] High throughput no no
NAA50_HUMAN [view interactions] High throughput no yes
RTCB_HUMAN [view interactions] High throughput no yes
SH24A_HUMAN [view interactions] High throughput no no
THUM1_HUMAN [view interactions] High throughput no yes
TIM13_HUMAN [view interactions] High throughput no yes
TS101_HUMAN [view entry] [view interactions] High throughput yes yes
UBP14_HUMAN [view entry] [view interactions] High throughput yes yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
NIF3L_HUMAN [view interactions] High throughput no yes
NTM1A_HUMAN [view interactions] High throughput no yes
TADBP_HUMAN [view interactions] High throughput no yes
UFM1_HUMAN [view interactions] High throughput no yes
PEDF_HUMAN [view interactions] High throughput no no
CUTA_HUMAN [view interactions] High throughput no yes
SBP1_HUMAN [view interactions] High throughput no no
TAGL_HUMAN [view interactions] High throughput no no
VPS51_HUMAN [view interactions] High throughput no yes
PARVA_HUMAN [view interactions] High throughput no yes
MP2K6_HUMAN [view interactions] High throughput no yes
5NT3B_HUMAN [view interactions] High throughput no yes
PTGDS_HUMAN [view interactions] High throughput no yes
TYB4_HUMAN [view interactions] High throughput no yes
TPRGL_HUMAN [view interactions] High throughput no no
ZER1_HUMAN [view interactions] High throughput no no
RFFL_HUMAN [view interactions] High throughput no yes
DC1I2_HUMAN [view entry] [view interactions] High throughput yes yes
RN183_HUMAN [view interactions] High throughput no no
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
CK052_HUMAN [view interactions] High throughput no no
CAV1_HUMAN [view interactions] High throughput no no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
OCLN_HUMAN [view interactions] High throughput no no
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RAB9A_HUMAN [view interactions] High throughput no yes
STX4_HUMAN [view entry] [view interactions] High throughput yes no
STX6_HUMAN [view interactions] High throughput no yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
ZFPL1_HUMAN [view interactions] High throughput no yes
NAA40_HUMAN [view interactions] High throughput no no
CNTP2_HUMAN [view entry] [view interactions] High throughput yes yes
RAB18_HUMAN [view entry] [view interactions] High throughput yes yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
MUC18_HUMAN [view interactions] High throughput no yes
SSR3_HUMAN [view interactions] High throughput no yes
MLH1_HUMAN [view interactions] High throughput no yes
S1PR2_HUMAN [view entry] [view interactions] High throughput yes no
SHCAF_HUMAN [view interactions] High throughput no yes
PLM_HUMAN [view interactions] High throughput no no
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
SH2D3_HUMAN [view interactions] High throughput no no
KPCB_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
CUL4A_HUMAN [view interactions] High throughput no no
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
SIM26_HUMAN [view interactions] High throughput no no
APBB1_HUMAN [view entry] [view interactions] High throughput yes yes
HTRA4_HUMAN [view interactions] High throughput no no
MYLK4_HUMAN [view interactions] High throughput no no
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
PRS6A_HUMAN [view entry] [view interactions] High throughput yes yes
PRS7_HUMAN [view interactions] High throughput no yes
PSMD2_HUMAN [view entry] [view interactions] High throughput yes yes
XRCC6_HUMAN [view interactions] High throughput no yes
RUVB2_HUMAN [view interactions] High throughput no yes
SC23A_HUMAN [view entry] [view interactions] High throughput yes yes
COPB2_HUMAN [view entry] [view interactions] High throughput yes yes
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
AP2M1_HUMAN [view entry] [view interactions] High throughput yes yes
AP1M2_HUMAN [view interactions] High throughput no no
NEP_HUMAN [view interactions] High throughput no no
KINH_HUMAN [view entry] [view interactions] High throughput yes no
2ABA_HUMAN [view interactions] High throughput no yes
DHB4_HUMAN [view entry] [view interactions] High throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
TLE3_HUMAN [view interactions] High throughput no yes
CNDP2_HUMAN [view entry] [view interactions] High throughput yes yes
SYDC_HUMAN [view interactions] High throughput no yes
ODO2_HUMAN [view entry] [view interactions] High throughput yes yes
ACSL3_HUMAN [view entry] [view interactions] High throughput yes yes
FAS_HUMAN [view entry] [view interactions] High throughput yes no
AOFA_HUMAN [view entry] [view interactions] High throughput yes yes
LDHA_HUMAN [view entry] [view interactions] High throughput yes yes
KPYM_HUMAN [view interactions] High throughput no yes
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
SYTC_HUMAN [view interactions] High throughput no yes
GLYM_HUMAN [view entry] [view interactions] High throughput yes yes
ADT3_HUMAN [view entry] [view interactions] High throughput yes yes
AT1A1_HUMAN [view entry] [view interactions] High throughput yes no
EF2_HUMAN [view entry] [view interactions] High throughput yes yes
EF1G_HUMAN [view entry] [view interactions] High throughput yes yes
IF2G_HUMAN [view interactions] High throughput no yes
EIF3E_HUMAN [view entry] [view interactions] High throughput yes yes
PABP1_HUMAN [view entry] [view interactions] High throughput yes yes
RS3_HUMAN [view entry] [view interactions] High throughput yes yes
RS6_HUMAN [view entry] [view interactions] High throughput yes yes
RL24_HUMAN [view entry] [view interactions] High throughput yes yes
RL3_HUMAN [view entry] [view interactions] High throughput yes yes
RS16_HUMAN [view entry] [view interactions] High throughput yes yes
RS8_HUMAN [view entry] [view interactions] High throughput yes no
RS20_HUMAN [view entry] [view interactions] High throughput yes yes
RS9_HUMAN [view entry] [view interactions] High throughput yes yes
RL4_HUMAN [view entry] [view interactions] High throughput yes yes
RS26_HUMAN [view entry] [view interactions] High throughput yes yes
NUCL_HUMAN [view interactions] High throughput no yes
HNRPF_HUMAN [view interactions] High throughput no yes
HNRPU_HUMAN [view interactions] High throughput no yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
DDX1_HUMAN [view entry] [view interactions] High throughput yes yes
DDX5_HUMAN [view entry] [view interactions] High throughput yes yes
RENT1_HUMAN [view entry] [view interactions] High throughput yes yes
EWS_HUMAN [view interactions] High throughput no yes
KCMA1_HUMAN [view entry] [view interactions] High throughput yes no
SAP30_HUMAN [view interactions] High throughput no yes
MSRB2_HUMAN [view interactions] High throughput no no
RYBP_HUMAN [view interactions] High throughput no no
TTC33_HUMAN [view interactions] High throughput no yes
DCR1B_HUMAN [view interactions] High throughput no no
MED28_HUMAN [view interactions] High throughput no yes
LDH6B_HUMAN [view interactions] High throughput no no
SPA2L_HUMAN [view entry] [view interactions] High throughput yes yes
ZMAT2_HUMAN [view interactions] High throughput no yes
FX4L6_HUMAN [view interactions] High throughput no no
PHYIP_HUMAN [view entry] [view interactions] High throughput yes yes
ARL4D_HUMAN [view interactions] High throughput no no
ETS2_HUMAN [view interactions] High throughput no no
TMM17_HUMAN [view interactions] High throughput no yes
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
CFTR_HUMAN [view interactions] High throughput no no
KCNK3_HUMAN [view interactions] High throughput no no
TAF9_HUMAN [view interactions] High throughput no yes
ILF3_HUMAN [view interactions] High throughput no yes
SUZ12_HUMAN [view interactions] High throughput no no
EED_HUMAN [view interactions] High throughput no yes
NDRG2_HUMAN [view entry] [view interactions] High throughput yes yes
LNX1_HUMAN [view entry] [view interactions] High throughput yes yes
MYOME_HUMAN [view interactions] High throughput no no
CDK15_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
YAP1_HUMAN [view interactions] High throughput no yes
ZBT38_HUMAN [view interactions] High throughput no no
CTBP2_HUMAN [view interactions] High throughput no no
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
SIA7F_HUMAN [view interactions] High throughput no yes
OR2A4_HUMAN [view interactions] High throughput no no
HXC5_HUMAN [view interactions] High throughput no no
RL35A_HUMAN [view entry] [view interactions] High throughput yes no
FXYD3_HUMAN [view interactions] High throughput no yes
SRRT_HUMAN [view interactions] High throughput no yes
2ABB_HUMAN [view interactions] High throughput no yes
NAA11_HUMAN [view interactions] High throughput no no
AATC_HUMAN [view entry] [view interactions] High throughput yes yes
STX17_HUMAN [view interactions] High throughput no yes
WIF1_HUMAN [view entry] [view interactions] High throughput yes no
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
AT1B1_HUMAN [view entry] [view interactions] High throughput yes no
COAA1_HUMAN [view interactions] High throughput no no
CERS3_HUMAN [view interactions] High throughput no no
OPTN_HUMAN [view interactions] High throughput no yes
SSBP2_HUMAN [view interactions] High throughput no yes
AT1B3_HUMAN [view interactions] High throughput no yes
CB073_HUMAN [view interactions] High throughput no no
NTNG1_HUMAN [view interactions] High throughput no no
FGF12_HUMAN [view interactions] High throughput no no
OSGEP_HUMAN [view interactions] High throughput no yes
CCR1_HUMAN [view interactions] High throughput no no