Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SPA2L_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

[View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SPA2L_HUMAN
GO:0019900 kinase binding 50.0000 4 no
GO:0046872 metal ion binding 35.7143 4 no
GO:0019901 protein kinase binding 28.5714 5 no
GO:0003723 RNA binding 21.4286 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in SPA2L_HUMAN
GO:0031323 regulation of cellular metabolic process 64.2857 4 no
GO:0048522 positive regulation of cellular process 64.2857 4 no
GO:0051128 regulation of cellular component organization 64.2857 4 no
GO:0010646 regulation of cell communication 57.1429 4 no
GO:0048523 negative regulation of cellular process 57.1429 4 no
GO:0051171 regulation of nitrogen compound metabolic process 57.1429 4 no
GO:0060255 regulation of macromolecule metabolic process 57.1429 4 no
GO:0080090 regulation of primary metabolic process 57.1429 4 no
GO:0009966 regulation of signal transduction 50.0000 4 no
GO:0010647 positive regulation of cell communication 50.0000 5 no
GO:0023056 positive regulation of signaling 50.0000 4 no
GO:0044087 regulation of cellular component biogenesis 50.0000 4 no
GO:0051246 regulation of protein metabolic process 50.0000 5 no
GO:1902531 regulation of intracellular signal transduction 50.0000 5 no
GO:0006996 organelle organization 50.0000 4 no
GO:0009967 positive regulation of signal transduction 42.8571 5 no
GO:0031325 positive regulation of cellular metabolic process 42.8571 5 no
GO:0048584 positive regulation of response to stimulus 42.8571 4 no
GO:0048585 negative regulation of response to stimulus 42.8571 4 no
GO:0051049 regulation of transport 42.8571 4 no
GO:0009893 positive regulation of metabolic process 42.8571 4 no
GO:0009894 regulation of catabolic process 35.7143 4 no
GO:0009968 negative regulation of signal transduction 35.7143 5 no
GO:0010648 negative regulation of cell communication 35.7143 5 no
GO:0010941 regulation of cell death 35.7143 4 no
GO:0010942 positive regulation of cell death 35.7143 5 no
GO:0019220 regulation of phosphate metabolic process 35.7143 6 no
GO:0023057 negative regulation of signaling 35.7143 4 no
GO:0031329 regulation of cellular catabolic process 35.7143 5 no
GO:0031344 regulation of cell projection organization 35.7143 5 no
GO:0031399 regulation of protein modification process 35.7143 6 no
GO:0033043 regulation of organelle organization 35.7143 5 no
GO:0042325 regulation of phosphorylation 35.7143 7 no
GO:0042981 regulation of apoptotic process 35.7143 6 no
GO:0043067 regulation of programmed cell death 35.7143 5 no
GO:0043549 regulation of kinase activity 35.7143 5 no
GO:0044089 positive regulation of cellular component biogenesis 35.7143 5 no
GO:0045859 regulation of protein kinase activity 35.7143 6 no
GO:0051130 positive regulation of cellular component organization 35.7143 5 no
GO:0051174 regulation of phosphorus metabolic process 35.7143 5 no
GO:0051338 regulation of transferase activity 35.7143 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 35.7143 6 no
GO:0009892 negative regulation of metabolic process 35.7143 4 no
GO:0010605 negative regulation of macromolecule metabolic process 35.7143 5 no
GO:0043254 regulation of protein-containing complex assembly 35.7143 5 no
GO:0080134 regulation of response to stress 35.7143 4 no
GO:0001932 regulation of protein phosphorylation 35.7143 7 no
GO:0010638 positive regulation of organelle organization 28.5714 6 no
GO:0016192 vesicle-mediated transport 28.5714 4 no
GO:0043065 positive regulation of apoptotic process 28.5714 7 no
GO:0043068 positive regulation of programmed cell death 28.5714 6 no
GO:2001233 regulation of apoptotic signaling pathway 28.5714 5 no
GO:0001933 negative regulation of protein phosphorylation 28.5714 8 no
GO:0010563 negative regulation of phosphorus metabolic process 28.5714 6 no
GO:0010604 positive regulation of macromolecule metabolic process 28.5714 5 no
GO:0031324 negative regulation of cellular metabolic process 28.5714 5 no
GO:0031400 negative regulation of protein modification process 28.5714 7 no
GO:0032880 regulation of protein localization 28.5714 5 no
GO:0042326 negative regulation of phosphorylation 28.5714 8 no
GO:0045936 negative regulation of phosphate metabolic process 28.5714 7 no
GO:0051172 negative regulation of nitrogen compound metabolic process 28.5714 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 28.5714 5 no
GO:0051223 regulation of protein transport 28.5714 5 no
GO:0051247 positive regulation of protein metabolic process 28.5714 6 no
GO:0051248 negative regulation of protein metabolic process 28.5714 6 no
GO:0060341 regulation of cellular localization 28.5714 4 no
GO:0070201 regulation of establishment of protein localization 28.5714 6 no
GO:0008104 protein localization 28.5714 4 no
GO:0015031 protein transport 28.5714 4 no
GO:0042176 regulation of protein catabolic process 28.5714 5 no
GO:0071702 organic substance transport 28.5714 4 no
GO:0071705 nitrogen compound transport 28.5714 4 no
GO:0030030 cell projection organization 28.5714 4 no
GO:0120036 plasma membrane bounded cell projection organization 28.5714 5 no
GO:0042127 regulation of cell population proliferation 28.5714 4 no
GO:1902903 regulation of supramolecular fiber organization 28.5714 5 no
GO:0006355 regulation of DNA-templated transcription 28.5714 6 no
GO:0009889 regulation of biosynthetic process 28.5714 4 no
GO:0010468 regulation of gene expression 28.5714 5 no
GO:0010556 regulation of macromolecule biosynthetic process 28.5714 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 28.5714 5 no
GO:0031326 regulation of cellular biosynthetic process 28.5714 5 no
GO:0051252 regulation of RNA metabolic process 28.5714 5 no
GO:1902533 positive regulation of intracellular signal transduction 28.5714 6 no
GO:1903506 regulation of nucleic acid-templated transcription 28.5714 7 no
GO:2001141 regulation of RNA biosynthetic process 28.5714 6 no
GO:0031347 regulation of defense response 28.5714 5 no
GO:0032101 regulation of response to external stimulus 28.5714 4 no
GO:0050727 regulation of inflammatory response 28.5714 5 no
GO:0007010 cytoskeleton organization 28.5714 5 no
GO:0009896 positive regulation of catabolic process 21.4286 5 no
GO:0010506 regulation of autophagy 21.4286 6 no
GO:0031331 positive regulation of cellular catabolic process 21.4286 6 no
GO:0043066 negative regulation of apoptotic process 21.4286 7 no
GO:0043069 negative regulation of programmed cell death 21.4286 6 no
GO:0051050 positive regulation of transport 21.4286 4 no
GO:0060548 negative regulation of cell death 21.4286 5 no
GO:2001236 regulation of extrinsic apoptotic signaling pathway 21.4286 6 no
GO:0006469 negative regulation of protein kinase activity 21.4286 7 no
GO:0010975 regulation of neuron projection development 21.4286 7 no
GO:0033673 negative regulation of kinase activity 21.4286 6 no
GO:0043085 positive regulation of catalytic activity 21.4286 4 no
GO:0043086 negative regulation of catalytic activity 21.4286 4 no
GO:0051051 negative regulation of transport 21.4286 4 no
GO:0051224 negative regulation of protein transport 21.4286 5 no
GO:0051348 negative regulation of transferase activity 21.4286 5 no
GO:1903828 negative regulation of protein localization 21.4286 5 no
GO:1904950 negative regulation of establishment of protein localization 21.4286 6 no
GO:0030162 regulation of proteolysis 21.4286 6 no
GO:0061136 regulation of proteasomal protein catabolic process 21.4286 6 no
GO:1903050 regulation of proteolysis involved in protein catabolic process 21.4286 7 no
GO:0022607 cellular component assembly 21.4286 4 no
GO:0031175 neuron projection development 21.4286 6 no
GO:0006974 cellular response to DNA damage stimulus 21.4286 4 no
GO:0008285 negative regulation of cell population proliferation 21.4286 5 no
GO:0031334 positive regulation of protein-containing complex assembly 21.4286 6 no
GO:0043408 regulation of MAPK cascade 21.4286 6 no
GO:0051493 regulation of cytoskeleton organization 21.4286 6 no
GO:1902905 positive regulation of supramolecular fiber organization 21.4286 6 no
GO:0051129 negative regulation of cellular component organization 21.4286 5 no
GO:0051240 positive regulation of multicellular organismal process 21.4286 4 no
GO:0009890 negative regulation of biosynthetic process 21.4286 5 no
GO:0009891 positive regulation of biosynthetic process 21.4286 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 21.4286 6 no
GO:0031328 positive regulation of cellular biosynthetic process 21.4286 6 no
GO:0045893 positive regulation of DNA-templated transcription 21.4286 7 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 21.4286 6 no
GO:0051254 positive regulation of RNA metabolic process 21.4286 6 no
GO:0080135 regulation of cellular response to stress 21.4286 4 no
GO:1902680 positive regulation of RNA biosynthetic process 21.4286 7 no
GO:1903508 positive regulation of nucleic acid-templated transcription 21.4286 8 no
GO:2001235 positive regulation of apoptotic signaling pathway 21.4286 6 no
GO:2001242 regulation of intrinsic apoptotic signaling pathway 21.4286 6 no
GO:0010629 negative regulation of gene expression 21.4286 6 no
GO:0036211 protein modification process 21.4286 4 no
GO:0043412 macromolecule modification 21.4286 4 no
GO:0050776 regulation of immune response 21.4286 4 no
GO:1902532 negative regulation of intracellular signal transduction 21.4286 6 no
GO:0009057 macromolecule catabolic process 21.4286 4 no

Disease

Term Name % Distance from top the of the tree Annotated in SPA2L_HUMAN
DOID:331 central nervous system disease 21.4286 3 no
DOID:1289 neurodegenerative disease 14.2857 4 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
NCK2_HUMAN [view entry] [view interactions] High throughput yes yes
APOE_HUMAN [view entry] [view interactions] High throughput yes yes
DOPO_HUMAN [view interactions] High throughput no no
GFAP_HUMAN [view entry] [view interactions] High throughput yes no
NDUV2_HUMAN [view entry] [view interactions] High throughput yes yes
NOS3_HUMAN [view interactions] High throughput no no
PECA1_HUMAN [view interactions] High throughput no no
NDRG1_HUMAN [view entry] [view interactions] High throughput yes yes
PARK7_HUMAN [view entry] [view interactions] High throughput yes yes
ATX10_HUMAN [view entry] [view interactions] High throughput yes yes
TYDP1_HUMAN [view interactions] High throughput no no
JPH3_HUMAN [view interactions] High throughput no no
HD_HUMAN [view entry] [view interactions] High throughput yes yes
ATX3_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
GPR37_HUMAN [view interactions] High throughput no no
CE128_HUMAN [view interactions] High throughput no yes
CP135_HUMAN [view interactions] High throughput no no
TNIP2_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
DCA10_HUMAN [view interactions] High throughput no no
PAGE5_HUMAN [view interactions] High throughput no no
THB_HUMAN [view interactions] High throughput no no
SPAT2_HUMAN [view interactions] Computational no yes
RNF31_HUMAN [view interactions] Computational no yes
SHRPN_HUMAN [view entry] [view interactions] Computational yes yes
HOIL1_HUMAN [view interactions] Computational no no