Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SPA2L_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

[View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SPA2L_HUMAN
GO:0019900 kinase binding 53.8462 4 no
GO:0019901 protein kinase binding 30.7692 5 no
GO:0043169 cation binding 30.7692 4 no
GO:0046872 metal ion binding 30.7692 5 no
GO:0003723 RNA binding 23.0769 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in SPA2L_HUMAN
GO:0051128 regulation of cellular component organization 69.2308 4 no
GO:0031323 regulation of cellular metabolic process 61.5385 4 no
GO:0048522 positive regulation of cellular process 61.5385 4 no
GO:0048523 negative regulation of cellular process 61.5385 4 no
GO:0060255 regulation of macromolecule metabolic process 61.5385 4 no
GO:0080090 regulation of primary metabolic process 61.5385 4 no
GO:0006996 organelle organization 53.8462 4 no
GO:0010646 regulation of cell communication 53.8462 4 no
GO:0044087 regulation of cellular component biogenesis 53.8462 4 no
GO:0051246 regulation of protein metabolic process 53.8462 5 no
GO:0009893 positive regulation of metabolic process 46.1538 4 no
GO:0009966 regulation of signal transduction 46.1538 4 no
GO:0010647 positive regulation of cell communication 46.1538 5 no
GO:0023056 positive regulation of signaling 46.1538 4 no
GO:0031325 positive regulation of cellular metabolic process 46.1538 5 no
GO:0048584 positive regulation of response to stimulus 46.1538 4 no
GO:1902531 regulation of intracellular signal transduction 46.1538 5 no
GO:0001932 regulation of protein phosphorylation 38.4615 7 no
GO:0009892 negative regulation of metabolic process 38.4615 4 no
GO:0009967 positive regulation of signal transduction 38.4615 5 no
GO:0009968 negative regulation of signal transduction 38.4615 5 no
GO:0010605 negative regulation of macromolecule metabolic process 38.4615 5 no
GO:0010648 negative regulation of cell communication 38.4615 5 no
GO:0019220 regulation of phosphate metabolic process 38.4615 6 no
GO:0023057 negative regulation of signaling 38.4615 4 no
GO:0031324 negative regulation of cellular metabolic process 38.4615 5 no
GO:0031399 regulation of protein modification process 38.4615 6 no
GO:0033043 regulation of organelle organization 38.4615 5 no
GO:0042325 regulation of phosphorylation 38.4615 7 no
GO:0042981 regulation of apoptotic process 38.4615 5 no
GO:0043067 regulation of programmed cell death 38.4615 4 no
GO:0043254 regulation of protein-containing complex assembly 38.4615 5 no
GO:0048585 negative regulation of response to stimulus 38.4615 4 no
GO:0051130 positive regulation of cellular component organization 38.4615 5 no
GO:0051174 regulation of phosphorus metabolic process 38.4615 5 no
GO:0051240 positive regulation of multicellular organismal process 38.4615 4 no
GO:0007010 cytoskeleton organization 38.4615 5 no
GO:0009894 regulation of catabolic process 38.4615 4 no
GO:0051049 regulation of transport 38.4615 4 no
GO:0031344 regulation of cell projection organization 38.4615 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 38.4615 6 no
GO:0022607 cellular component assembly 30.7692 4 no
GO:0030030 cell projection organization 30.7692 4 no
GO:0120036 plasma membrane bounded cell projection organization 30.7692 5 no
GO:0001933 negative regulation of protein phosphorylation 30.7692 8 no
GO:0002684 positive regulation of immune system process 30.7692 4 no
GO:0006355 regulation of DNA-templated transcription 30.7692 7 no
GO:0009889 regulation of biosynthetic process 30.7692 4 no
GO:0010468 regulation of gene expression 30.7692 6 no
GO:0010556 regulation of macromolecule biosynthetic process 30.7692 5 no
GO:0010563 negative regulation of phosphorus metabolic process 30.7692 6 no
GO:0010604 positive regulation of macromolecule metabolic process 30.7692 5 no
GO:0010638 positive regulation of organelle organization 30.7692 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 30.7692 5 no
GO:0031326 regulation of cellular biosynthetic process 30.7692 5 no
GO:0031400 negative regulation of protein modification process 30.7692 7 no
GO:0042127 regulation of cell population proliferation 30.7692 4 no
GO:0042326 negative regulation of phosphorylation 30.7692 8 no
GO:0043065 positive regulation of apoptotic process 30.7692 6 no
GO:0043068 positive regulation of programmed cell death 30.7692 5 no
GO:0044089 positive regulation of cellular component biogenesis 30.7692 5 no
GO:0045936 negative regulation of phosphate metabolic process 30.7692 7 no
GO:0051247 positive regulation of protein metabolic process 30.7692 6 no
GO:0051248 negative regulation of protein metabolic process 30.7692 6 no
GO:0051252 regulation of RNA metabolic process 30.7692 5 no
GO:0080134 regulation of response to stress 30.7692 4 no
GO:1902532 negative regulation of intracellular signal transduction 30.7692 6 no
GO:1902903 regulation of supramolecular fiber organization 30.7692 5 no
GO:2001141 regulation of RNA biosynthetic process 30.7692 6 no
GO:2001233 regulation of apoptotic signaling pathway 30.7692 5 no
GO:0050776 regulation of immune response 30.7692 4 no
GO:0098657 import into cell 30.7692 4 no
GO:0008104 protein localization 30.7692 4 no
GO:0015031 protein transport 30.7692 4 no
GO:0031329 regulation of cellular catabolic process 30.7692 5 no
GO:0032880 regulation of protein localization 30.7692 5 no
GO:0042176 regulation of protein catabolic process 30.7692 5 no
GO:0043549 regulation of kinase activity 30.7692 5 no
GO:0045859 regulation of protein kinase activity 30.7692 6 no
GO:0051338 regulation of transferase activity 30.7692 4 no
GO:0060341 regulation of cellular localization 30.7692 4 no
GO:0071702 organic substance transport 30.7692 4 no
GO:0071705 nitrogen compound transport 30.7692 4 no
GO:0031175 neuron projection development 23.0769 6 no
GO:0008285 negative regulation of cell population proliferation 23.0769 5 no
GO:0009891 positive regulation of biosynthetic process 23.0769 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 23.0769 6 no
GO:0031328 positive regulation of cellular biosynthetic process 23.0769 6 no
GO:0031334 positive regulation of protein-containing complex assembly 23.0769 6 no
GO:0043933 protein-containing complex organization 23.0769 4 no
GO:0045893 positive regulation of DNA-templated transcription 23.0769 8 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 23.0769 5 no
GO:0050865 regulation of cell activation 23.0769 4 no
GO:0051254 positive regulation of RNA metabolic process 23.0769 6 no
GO:0051493 regulation of cytoskeleton organization 23.0769 6 no
GO:0065003 protein-containing complex assembly 23.0769 5 no
GO:1902533 positive regulation of intracellular signal transduction 23.0769 6 no
GO:1902680 positive regulation of RNA biosynthetic process 23.0769 7 no
GO:1902905 positive regulation of supramolecular fiber organization 23.0769 6 no
GO:2001235 positive regulation of apoptotic signaling pathway 23.0769 6 no
GO:2001242 regulation of intrinsic apoptotic signaling pathway 23.0769 6 no
GO:0006974 DNA damage response 23.0769 4 no
GO:0043408 regulation of MAPK cascade 23.0769 6 no
GO:0050778 positive regulation of immune response 23.0769 5 no
GO:0141124 intracellular signaling cassette 23.0769 4 no
GO:0006469 negative regulation of protein kinase activity 23.0769 7 no
GO:0009890 negative regulation of biosynthetic process 23.0769 5 no
GO:0009896 positive regulation of catabolic process 23.0769 5 no
GO:0010506 regulation of autophagy 23.0769 6 no
GO:0010558 negative regulation of macromolecule biosynthetic process 23.0769 6 no
GO:0010629 negative regulation of gene expression 23.0769 7 no
GO:0030162 regulation of proteolysis 23.0769 6 no
GO:0031327 negative regulation of cellular biosynthetic process 23.0769 6 no
GO:0031331 positive regulation of cellular catabolic process 23.0769 6 no
GO:0031347 regulation of defense response 23.0769 5 no
GO:0032101 regulation of response to external stimulus 23.0769 4 no
GO:0033673 negative regulation of kinase activity 23.0769 6 no
GO:0043066 negative regulation of apoptotic process 23.0769 6 no
GO:0043069 negative regulation of programmed cell death 23.0769 5 no
GO:0043085 positive regulation of catalytic activity 23.0769 4 no
GO:0043086 negative regulation of catalytic activity 23.0769 4 no
GO:0050727 regulation of inflammatory response 23.0769 5 no
GO:0051129 negative regulation of cellular component organization 23.0769 5 no
GO:0051223 regulation of protein transport 23.0769 5 no
GO:0051347 positive regulation of transferase activity 23.0769 5 no
GO:0051348 negative regulation of transferase activity 23.0769 5 no
GO:0061136 regulation of proteasomal protein catabolic process 23.0769 6 no
GO:0070201 regulation of establishment of protein localization 23.0769 6 no
GO:1903050 regulation of proteolysis involved in protein catabolic process 23.0769 7 no
GO:2001236 regulation of extrinsic apoptotic signaling pathway 23.0769 6 no
GO:0010975 regulation of neuron projection development 23.0769 7 no
GO:0051094 positive regulation of developmental process 23.0769 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CYLD_HUMAN [view entry] [view interactions] Low throughput yes yes
RNF31_HUMAN [view interactions] Low throughput no yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
NCK2_HUMAN [view entry] [view interactions] High throughput yes yes
APOE_HUMAN [view entry] [view interactions] High throughput yes yes
DOPO_HUMAN [view interactions] High throughput no no
GFAP_HUMAN [view entry] [view interactions] High throughput yes no
NDUV2_HUMAN [view entry] [view interactions] High throughput yes yes
NOS3_HUMAN [view interactions] High throughput no no
PECA1_HUMAN [view interactions] High throughput no no
NDRG1_HUMAN [view entry] [view interactions] High throughput yes yes
PARK7_HUMAN [view entry] [view interactions] High throughput yes yes
ATX10_HUMAN [view entry] [view interactions] High throughput yes yes
TYDP1_HUMAN [view interactions] High throughput no no
JPH3_HUMAN [view interactions] High throughput no no
HD_HUMAN [view entry] [view interactions] High throughput yes yes
ATX3_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
GPR37_HUMAN [view interactions] High throughput no no
CE128_HUMAN [view interactions] High throughput no yes
CP135_HUMAN [view interactions] High throughput no no
TNIP2_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
DCA10_HUMAN [view interactions] High throughput no no
PAGE5_HUMAN [view interactions] High throughput no no
THB_HUMAN [view interactions] High throughput no no