Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NDRG2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NDRG2_HUMAN
GO:0017076 purine nucleotide binding 43.4783 4 no
GO:0030554 adenyl nucleotide binding 43.4783 5 no
GO:0032555 purine ribonucleotide binding 39.1304 4 no
GO:0032559 adenyl ribonucleotide binding 39.1304 5 no
GO:0005524 ATP binding 34.7826 5 no
GO:0035639 purine ribonucleoside triphosphate binding 34.7826 4 no
GO:0003723 RNA binding 30.4348 4 no
GO:0019900 kinase binding 26.0870 4 no
GO:0031625 ubiquitin protein ligase binding 26.0870 5 no
GO:0044389 ubiquitin-like protein ligase binding 26.0870 4 no
GO:0046872 metal ion binding 26.0870 4 no
GO:0019901 protein kinase binding 21.7391 5 no
GO:0003779 actin binding 21.7391 4 no
GO:0045296 cadherin binding 21.7391 4 no
GO:0016462 pyrophosphatase activity 21.7391 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 21.7391 4 no
GO:0016887 ATP hydrolysis activity 21.7391 7 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 21.7391 6 no

Biological process

Term Name % Distance from top the of the tree Annotated in NDRG2_HUMAN
GO:0048523 negative regulation of cellular process 60.8696 4 yes
GO:0060255 regulation of macromolecule metabolic process 56.5217 4 yes
GO:0031323 regulation of cellular metabolic process 52.1739 4 no
GO:0080090 regulation of primary metabolic process 52.1739 4 no
GO:0010468 regulation of gene expression 47.8261 5 yes
GO:0010646 regulation of cell communication 47.8261 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 47.8261 4 no
GO:0048522 positive regulation of cellular process 47.8261 4 no
GO:0051128 regulation of cellular component organization 43.4783 4 no
GO:0071310 cellular response to organic substance 43.4783 4 no
GO:0051049 regulation of transport 43.4783 4 no
GO:0009893 positive regulation of metabolic process 39.1304 4 no
GO:0010604 positive regulation of macromolecule metabolic process 39.1304 5 no
GO:0031325 positive regulation of cellular metabolic process 39.1304 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 39.1304 5 no
GO:0009892 negative regulation of metabolic process 34.7826 4 yes
GO:0010648 negative regulation of cell communication 34.7826 5 yes
GO:0023057 negative regulation of signaling 34.7826 4 yes
GO:0051246 regulation of protein metabolic process 34.7826 5 no
GO:0009889 regulation of biosynthetic process 34.7826 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 34.7826 5 no
GO:0031326 regulation of cellular biosynthetic process 34.7826 5 no
GO:0051252 regulation of RNA metabolic process 34.7826 5 no
GO:0009966 regulation of signal transduction 30.4348 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 30.4348 5 yes
GO:1902531 regulation of intracellular signal transduction 30.4348 5 yes
GO:0051129 negative regulation of cellular component organization 30.4348 5 no
GO:0009057 macromolecule catabolic process 30.4348 4 no
GO:0006355 regulation of DNA-templated transcription 30.4348 6 no
GO:0006796 phosphate-containing compound metabolic process 30.4348 4 no
GO:0010556 regulation of macromolecule biosynthetic process 30.4348 5 no
GO:1903506 regulation of nucleic acid-templated transcription 30.4348 7 no
GO:2001141 regulation of RNA biosynthetic process 30.4348 6 no
GO:0014070 response to organic cyclic compound 30.4348 4 no
GO:0071407 cellular response to organic cyclic compound 30.4348 5 no
GO:0008285 negative regulation of cell population proliferation 26.0870 5 yes
GO:0009968 negative regulation of signal transduction 26.0870 5 yes
GO:0042127 regulation of cell population proliferation 26.0870 4 yes
GO:0048585 negative regulation of response to stimulus 26.0870 4 yes
GO:0006996 organelle organization 26.0870 4 no
GO:0009894 regulation of catabolic process 26.0870 4 no
GO:0010941 regulation of cell death 26.0870 4 no
GO:0031324 negative regulation of cellular metabolic process 26.0870 5 no
GO:0031399 regulation of protein modification process 26.0870 6 no
GO:0044087 regulation of cellular component biogenesis 26.0870 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 26.0870 5 no
GO:0022607 cellular component assembly 26.0870 4 no
GO:0032880 regulation of protein localization 26.0870 5 no
GO:0036211 protein modification process 26.0870 4 no
GO:0043412 macromolecule modification 26.0870 4 no
GO:0051240 positive regulation of multicellular organismal process 26.0870 4 no
GO:0051247 positive regulation of protein metabolic process 26.0870 6 no
GO:0060341 regulation of cellular localization 26.0870 4 no
GO:0090304 nucleic acid metabolic process 26.0870 4 no
GO:0016192 vesicle-mediated transport 26.0870 4 no
GO:0008104 protein localization 26.0870 4 no
GO:0051726 regulation of cell cycle 26.0870 4 no
GO:0010629 negative regulation of gene expression 21.7391 6 yes
GO:0030162 regulation of proteolysis 21.7391 6 no
GO:0031329 regulation of cellular catabolic process 21.7391 5 no
GO:0031400 negative regulation of protein modification process 21.7391 7 no
GO:0042176 regulation of protein catabolic process 21.7391 5 no
GO:0042981 regulation of apoptotic process 21.7391 6 no
GO:0043066 negative regulation of apoptotic process 21.7391 7 no
GO:0043067 regulation of programmed cell death 21.7391 5 no
GO:0043069 negative regulation of programmed cell death 21.7391 6 no
GO:0051248 negative regulation of protein metabolic process 21.7391 6 no
GO:0060548 negative regulation of cell death 21.7391 5 no
GO:0080134 regulation of response to stress 21.7391 4 no
GO:0080135 regulation of cellular response to stress 21.7391 4 no
GO:2001233 regulation of apoptotic signaling pathway 21.7391 5 no
GO:2001234 negative regulation of apoptotic signaling pathway 21.7391 6 no
GO:0016070 RNA metabolic process 21.7391 5 no
GO:0033043 regulation of organelle organization 21.7391 5 no
GO:0043933 protein-containing complex organization 21.7391 4 no
GO:0045595 regulation of cell differentiation 21.7391 4 no
GO:0045597 positive regulation of cell differentiation 21.7391 5 no
GO:0051094 positive regulation of developmental process 21.7391 4 no
GO:0051130 positive regulation of cellular component organization 21.7391 5 no
GO:0070201 regulation of establishment of protein localization 21.7391 6 no
GO:1902903 regulation of supramolecular fiber organization 21.7391 5 no
GO:2000026 regulation of multicellular organismal development 21.7391 4 no
GO:0044265 cellular macromolecule catabolic process 21.7391 4 no
GO:0061024 membrane organization 21.7391 4 no
GO:0006163 purine nucleotide metabolic process 21.7391 5 no
GO:0006753 nucleoside phosphate metabolic process 21.7391 4 no
GO:0009117 nucleotide metabolic process 21.7391 5 no
GO:0009141 nucleoside triphosphate metabolic process 21.7391 5 no
GO:0009144 purine nucleoside triphosphate metabolic process 21.7391 6 no
GO:0009150 purine ribonucleotide metabolic process 21.7391 6 no
GO:0009199 ribonucleoside triphosphate metabolic process 21.7391 6 no
GO:0009205 purine ribonucleoside triphosphate metabolic process 21.7391 7 no
GO:0009259 ribonucleotide metabolic process 21.7391 5 no
GO:0010647 positive regulation of cell communication 21.7391 5 no
GO:0019693 ribose phosphate metabolic process 21.7391 4 no
GO:0023056 positive regulation of signaling 21.7391 4 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 21.7391 6 no
GO:0046034 ATP metabolic process 21.7391 7 no
GO:0051050 positive regulation of transport 21.7391 4 no
GO:0051254 positive regulation of RNA metabolic process 21.7391 6 no
GO:0072521 purine-containing compound metabolic process 21.7391 4 no
GO:0006986 response to unfolded protein 21.7391 4 no
GO:0034620 cellular response to unfolded protein 21.7391 5 no
GO:0035967 cellular response to topologically incorrect protein 21.7391 4 no
GO:0051084 de novo post-translational protein folding 21.7391 4 no
GO:0051085 chaperone cofactor-dependent protein refolding 21.7391 4 no
GO:0010628 positive regulation of gene expression 21.7391 6 no
GO:0033993 response to lipid 21.7391 4 no
GO:0043269 regulation of ion transport 21.7391 5 no
GO:0001817 regulation of cytokine production 17.3913 4 yes
GO:1902532 negative regulation of intracellular signal transduction 17.3913 6 yes
GO:0051241 negative regulation of multicellular organismal process 13.0435 4 yes
GO:0016055 Wnt signaling pathway 8.6957 5 yes
GO:0043408 regulation of MAPK cascade 8.6957 6 yes
GO:0048660 regulation of smooth muscle cell proliferation 8.6957 5 yes
GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling 8.6957 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ESR1_HUMAN [view interactions] Low throughput no no
PRAF1_HUMAN [view interactions] Low throughput no yes
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
AT1B1_HUMAN [view entry] [view interactions] Low throughput yes no
FBX11_HUMAN [view interactions] Low throughput no no
SNAI1_HUMAN [view interactions] Low throughput no yes
TRI32_HUMAN [view entry] [view interactions] Low throughput yes yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
CAV3_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
AGTR1_HUMAN [view interactions] High throughput no no
CCR4_HUMAN [view interactions] High throughput no yes
CLN8_HUMAN [view interactions] High throughput no no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
BAG5_HUMAN [view entry] [view interactions] High throughput yes no
NDRG1_HUMAN [view entry] [view interactions] High throughput yes yes
DD19B_HUMAN [view interactions] High throughput no yes
LNX1_HUMAN [view interactions] High throughput no yes
CDK15_HUMAN [view interactions] High throughput no no
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
DX39A_HUMAN [view interactions] High throughput no yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
OR2A4_HUMAN [view interactions] High throughput no no
PICK1_HUMAN [view entry] [view interactions] High throughput yes yes
2ABB_HUMAN [view interactions] High throughput no yes
KLH11_HUMAN [view interactions] High throughput no yes
DSCR6_HUMAN [view interactions] High throughput no no
STX17_HUMAN [view interactions] High throughput no yes
RN115_HUMAN [view interactions] High throughput no yes
TUSC2_HUMAN [view interactions] High throughput no no
PLCA_HUMAN [view interactions] High throughput no yes
SSBP2_HUMAN [view interactions] High throughput no yes
FNDC5_HUMAN [view interactions] High throughput no no
HSP76_HUMAN [view entry] [view interactions] High throughput yes yes
HSP72_HUMAN [view entry] [view interactions] High throughput yes no
PHF11_HUMAN [view interactions] High throughput no no
PIGT_HUMAN [view interactions] High throughput no no
SSUH2_HUMAN [view interactions] High throughput no no
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
GGT7_HUMAN [view interactions] High throughput no yes
PINK1_HUMAN [view interactions] High throughput no yes
NRSN1_HUMAN [view interactions] High throughput no yes
CCR1_HUMAN [view interactions] High throughput no no
MBNL1_HUMAN [view interactions] High throughput no yes
SARAF_HUMAN [view interactions] High throughput no no
CR021_HUMAN [view interactions] High throughput no no
ADT3_HUMAN [view entry] [view interactions] High throughput yes yes
AT1A1_HUMAN [view entry] [view interactions] High throughput yes no
NDRG4_HUMAN [view interactions] High throughput no no
CAP2_HUMAN [view entry] [view interactions] High throughput yes yes
PDK2_HUMAN [view interactions] High throughput no yes
PFKAM_HUMAN [view entry] [view interactions] High throughput yes yes
TPM2_HUMAN [view entry] [view interactions] High throughput yes yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
MCRS1_HUMAN [view interactions] Computational no yes
ST38L_HUMAN [view entry] [view interactions] Computational yes yes