NDRG2_HUMAN
Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in NDRG2_HUMAN |
---|---|---|---|---|
GO:0000166 | nucleotide binding | 34.7826 | 4 | no |
GO:0017076 | purine nucleotide binding | 34.7826 | 5 | no |
GO:0030554 | adenyl nucleotide binding | 34.7826 | 6 | no |
GO:0032555 | purine ribonucleotide binding | 34.7826 | 4 | no |
GO:0032559 | adenyl ribonucleotide binding | 34.7826 | 5 | no |
GO:0043168 | anion binding | 34.7826 | 4 | no |
GO:0019900 | kinase binding | 30.4348 | 4 | no |
GO:0003723 | RNA binding | 30.4348 | 4 | no |
GO:0005524 | ATP binding | 30.4348 | 5 | no |
GO:0031625 | ubiquitin protein ligase binding | 30.4348 | 5 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 30.4348 | 4 | no |
GO:0044389 | ubiquitin-like protein ligase binding | 30.4348 | 4 | no |
GO:0043169 | cation binding | 26.0870 | 4 | no |
GO:0046872 | metal ion binding | 26.0870 | 5 | no |
GO:0019901 | protein kinase binding | 26.0870 | 5 | no |
GO:0016462 | pyrophosphatase activity | 26.0870 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 26.0870 | 4 | no |
GO:0016887 | ATP hydrolysis activity | 26.0870 | 7 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 26.0870 | 6 | no |
GO:0045296 | cadherin binding | 21.7391 | 4 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in NDRG2_HUMAN |
---|---|---|---|---|
GO:0031323 | regulation of cellular metabolic process | 60.8696 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 60.8696 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 60.8696 | 4 | yes |
GO:0031326 | regulation of cellular biosynthetic process | 56.5217 | 5 | yes |
GO:0009889 | regulation of biosynthetic process | 56.5217 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 52.1739 | 4 | no |
GO:0010468 | regulation of gene expression | 52.1739 | 6 | yes |
GO:0010556 | regulation of macromolecule biosynthetic process | 52.1739 | 5 | yes |
GO:0010646 | regulation of cell communication | 47.8261 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 47.8261 | 4 | no |
GO:0048522 | positive regulation of cellular process | 43.4783 | 4 | no |
GO:0051049 | regulation of transport | 39.1304 | 4 | no |
GO:0051129 | negative regulation of cellular component organization | 39.1304 | 5 | no |
GO:0010648 | negative regulation of cell communication | 34.7826 | 5 | yes |
GO:0023057 | negative regulation of signaling | 34.7826 | 4 | yes |
GO:0009057 | macromolecule catabolic process | 34.7826 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 34.7826 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 34.7826 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 34.7826 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 34.7826 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 34.7826 | 5 | no |
GO:0051252 | regulation of RNA metabolic process | 34.7826 | 5 | no |
GO:0009892 | negative regulation of metabolic process | 34.7826 | 4 | yes |
GO:0009966 | regulation of signal transduction | 34.7826 | 4 | yes |
GO:0010605 | negative regulation of macromolecule metabolic process | 30.4348 | 5 | yes |
GO:0031324 | negative regulation of cellular metabolic process | 30.4348 | 5 | yes |
GO:0031327 | negative regulation of cellular biosynthetic process | 30.4348 | 6 | yes |
GO:0048585 | negative regulation of response to stimulus | 30.4348 | 4 | yes |
GO:0006355 | regulation of DNA-templated transcription | 30.4348 | 7 | no |
GO:0014070 | response to organic cyclic compound | 30.4348 | 4 | no |
GO:0071310 | cellular response to organic substance | 30.4348 | 4 | no |
GO:0071407 | cellular response to organic cyclic compound | 30.4348 | 5 | no |
GO:2001141 | regulation of RNA biosynthetic process | 30.4348 | 6 | no |
GO:0044087 | regulation of cellular component biogenesis | 30.4348 | 4 | no |
GO:0006996 | organelle organization | 30.4348 | 4 | no |
GO:0009890 | negative regulation of biosynthetic process | 30.4348 | 5 | yes |
GO:0009968 | negative regulation of signal transduction | 30.4348 | 5 | yes |
GO:0010558 | negative regulation of macromolecule biosynthetic process | 26.0870 | 6 | yes |
GO:0042127 | regulation of cell population proliferation | 26.0870 | 4 | yes |
GO:1902531 | regulation of intracellular signal transduction | 26.0870 | 5 | yes |
GO:0036211 | protein modification process | 26.0870 | 4 | no |
GO:0043412 | macromolecule modification | 26.0870 | 4 | no |
GO:0008104 | protein localization | 26.0870 | 4 | no |
GO:0009891 | positive regulation of biosynthetic process | 26.0870 | 5 | no |
GO:0009894 | regulation of catabolic process | 26.0870 | 4 | no |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 26.0870 | 6 | no |
GO:0022607 | cellular component assembly | 26.0870 | 4 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 26.0870 | 6 | no |
GO:0032880 | regulation of protein localization | 26.0870 | 5 | no |
GO:0045595 | regulation of cell differentiation | 26.0870 | 4 | no |
GO:0060284 | regulation of cell development | 26.0870 | 5 | no |
GO:0060341 | regulation of cellular localization | 26.0870 | 4 | no |
GO:2000026 | regulation of multicellular organismal development | 26.0870 | 4 | no |
GO:0006796 | phosphate-containing compound metabolic process | 26.0870 | 4 | no |
GO:0016070 | RNA metabolic process | 26.0870 | 5 | no |
GO:0031399 | regulation of protein modification process | 26.0870 | 6 | no |
GO:0033043 | regulation of organelle organization | 26.0870 | 5 | no |
GO:0042981 | regulation of apoptotic process | 26.0870 | 5 | no |
GO:0043066 | negative regulation of apoptotic process | 26.0870 | 6 | no |
GO:0043067 | regulation of programmed cell death | 26.0870 | 4 | no |
GO:0043069 | negative regulation of programmed cell death | 26.0870 | 5 | no |
GO:0051240 | positive regulation of multicellular organismal process | 26.0870 | 4 | no |
GO:0051247 | positive regulation of protein metabolic process | 26.0870 | 6 | no |
GO:0090304 | nucleic acid metabolic process | 26.0870 | 4 | no |
GO:2001233 | regulation of apoptotic signaling pathway | 26.0870 | 5 | no |
GO:2001234 | negative regulation of apoptotic signaling pathway | 26.0870 | 6 | no |
GO:0043933 | protein-containing complex organization | 26.0870 | 4 | no |
GO:0061024 | membrane organization | 26.0870 | 4 | no |
GO:0008285 | negative regulation of cell population proliferation | 26.0870 | 5 | yes |
GO:0010629 | negative regulation of gene expression | 21.7391 | 7 | yes |
GO:1902532 | negative regulation of intracellular signal transduction | 21.7391 | 6 | yes |
GO:0001558 | regulation of cell growth | 21.7391 | 4 | no |
GO:0042176 | regulation of protein catabolic process | 21.7391 | 5 | no |
GO:0070201 | regulation of establishment of protein localization | 21.7391 | 6 | no |
GO:0006163 | purine nucleotide metabolic process | 21.7391 | 5 | no |
GO:0006753 | nucleoside phosphate metabolic process | 21.7391 | 4 | no |
GO:0009117 | nucleotide metabolic process | 21.7391 | 5 | no |
GO:0009141 | nucleoside triphosphate metabolic process | 21.7391 | 5 | no |
GO:0009144 | purine nucleoside triphosphate metabolic process | 21.7391 | 6 | no |
GO:0009150 | purine ribonucleotide metabolic process | 21.7391 | 6 | no |
GO:0009199 | ribonucleoside triphosphate metabolic process | 21.7391 | 6 | no |
GO:0009205 | purine ribonucleoside triphosphate metabolic process | 21.7391 | 7 | no |
GO:0009259 | ribonucleotide metabolic process | 21.7391 | 5 | no |
GO:0010647 | positive regulation of cell communication | 21.7391 | 5 | no |
GO:0019693 | ribose phosphate metabolic process | 21.7391 | 4 | no |
GO:0023056 | positive regulation of signaling | 21.7391 | 4 | no |
GO:0030162 | regulation of proteolysis | 21.7391 | 6 | no |
GO:0031400 | negative regulation of protein modification process | 21.7391 | 7 | no |
GO:0033993 | response to lipid | 21.7391 | 4 | no |
GO:0045597 | positive regulation of cell differentiation | 21.7391 | 5 | no |
GO:0046034 | ATP metabolic process | 21.7391 | 7 | no |
GO:0051084 | de novo post-translational protein folding | 21.7391 | 4 | no |
GO:0051085 | chaperone cofactor-dependent protein refolding | 21.7391 | 4 | no |
GO:0051094 | positive regulation of developmental process | 21.7391 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 21.7391 | 5 | no |
GO:0051248 | negative regulation of protein metabolic process | 21.7391 | 6 | no |
GO:0051726 | regulation of cell cycle | 21.7391 | 4 | no |
GO:0072521 | purine-containing compound metabolic process | 21.7391 | 4 | no |
GO:1902903 | regulation of supramolecular fiber organization | 21.7391 | 5 | no |
GO:0051241 | negative regulation of multicellular organismal process | 17.3913 | 4 | yes |
GO:0001817 | regulation of cytokine production | 17.3913 | 4 | yes |
GO:0016055 | Wnt signaling pathway | 8.6957 | 4 | yes |
GO:0043408 | regulation of MAPK cascade | 8.6957 | 6 | yes |
GO:0048660 | regulation of smooth muscle cell proliferation | 8.6957 | 5 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
ESR1_HUMAN | [view interactions] | Low throughput | no | no |
PRAF1_HUMAN | [view interactions] | Low throughput | no | yes |
CTNB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
AT1B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
FBX11_HUMAN | [view interactions] | Low throughput | no | no |
SNAI1_HUMAN | [view interactions] | Low throughput | no | yes |
TRI32_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAV3_HUMAN | [view interactions] | High throughput | no | no |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
AGTR1_HUMAN | [view interactions] | High throughput | no | no |
CCR4_HUMAN | [view interactions] | High throughput | no | yes |
CLN8_HUMAN | [view interactions] | High throughput | no | no |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BAG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NDRG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DD19B_HUMAN | [view interactions] | High throughput | no | yes |
LNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CDK15_HUMAN | [view interactions] | High throughput | no | no |
HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DX39A_HUMAN | [view interactions] | High throughput | no | yes |
HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OR2A4_HUMAN | [view interactions] | High throughput | no | no |
PICK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
2ABB_HUMAN | [view interactions] | High throughput | no | yes |
KLH11_HUMAN | [view interactions] | High throughput | no | yes |
DSCR6_HUMAN | [view interactions] | High throughput | no | no |
STX17_HUMAN | [view interactions] | High throughput | no | yes |
RN115_HUMAN | [view interactions] | High throughput | no | yes |
TUSC2_HUMAN | [view interactions] | High throughput | no | no |
PLCA_HUMAN | [view interactions] | High throughput | no | yes |
SSBP2_HUMAN | [view interactions] | High throughput | no | yes |
FNDC5_HUMAN | [view interactions] | High throughput | no | no |
HSP76_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HSP72_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PHF11_HUMAN | [view interactions] | High throughput | no | no |
PIGT_HUMAN | [view interactions] | High throughput | no | no |
SSUH2_HUMAN | [view interactions] | High throughput | no | no |
HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GGT7_HUMAN | [view interactions] | High throughput | no | yes |
PINK1_HUMAN | [view interactions] | High throughput | no | yes |
NRSN1_HUMAN | [view interactions] | High throughput | no | yes |
CCR1_HUMAN | [view interactions] | High throughput | no | no |
MBNL1_HUMAN | [view interactions] | High throughput | no | yes |
SARAF_HUMAN | [view interactions] | High throughput | no | no |
CR021_HUMAN | [view interactions] | High throughput | no | no |
ADT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AT1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
UBP48_HUMAN | [view interactions] | High throughput | no | yes |
SPPL3_HUMAN | [view interactions] | High throughput | no | no |
NDRG4_HUMAN | [view interactions] | High throughput | no | no |
CAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PDK2_HUMAN | [view interactions] | High throughput | no | yes |
PFKAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TPM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |