DHB4_HUMAN
Evidence for PS localization
Functions
Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from straight-chain, 2-methyl-branched-chain fatty acids bile acid intermediates. With EHHADH, catalyzes the hydration of trans-2-enoyl-CoA and the dehydrogenation of 3-hydroxyacyl-CoA, but with opposite chiral specificity (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DHB4_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 26.5625 | 4 | no |
| GO:0043168 | anion binding | 26.5625 | 4 | no |
| GO:0017076 | purine nucleotide binding | 23.4375 | 5 | no |
| GO:0042803 | protein homodimerization activity | 14.0625 | 4 | yes |
| GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | 9.3750 | 4 | yes |
| GO:0003857 | 3-hydroxyacyl-CoA dehydrogenase activity | 4.6875 | 5 | yes |
| GO:0016836 | hydro-lyase activity | 4.6875 | 4 | yes |
| GO:0004300 | enoyl-CoA hydratase activity | 3.1250 | 5 | yes |
| GO:0004303 | estradiol 17-beta-dehydrogenase [NAD(P)] activity | 3.1250 | 5 | yes |
| GO:0018812 | 3-hydroxyacyl-CoA dehydratase activity | 3.1250 | 6 | yes |
| GO:0033764 | steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | 3.1250 | 4 | yes |
| GO:0033989 | 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity | 3.1250 | 5 | yes |
| GO:0044594 | 17-beta-hydroxysteroid dehydrogenase (NAD+) activity | 3.1250 | 5 | yes |
| GO:0106386 | (3R)-hydroxyacyl-CoA dehydrogenase (NAD+) activity | 3.1250 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DHB4_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 46.8750 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 39.0625 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 39.0625 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 39.0625 | 4 | no |
| GO:0010646 | regulation of cell communication | 35.9375 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 35.9375 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 34.3750 | 4 | no |
| GO:0006996 | organelle organization | 32.8125 | 4 | no |
| GO:0008104 | protein localization | 32.8125 | 4 | no |
| GO:0009966 | regulation of signal transduction | 31.2500 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 31.2500 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 31.2500 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 29.6875 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 29.6875 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 28.1250 | 5 | no |
| GO:0010468 | regulation of gene expression | 28.1250 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 28.1250 | 5 | no |
| GO:0071702 | organic substance transport | 26.5625 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 26.5625 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 26.5625 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.5625 | 5 | no |
| GO:0019752 | carboxylic acid metabolic process | 25.0000 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 25.0000 | 4 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 23.4375 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 23.4375 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 23.4375 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 23.4375 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 23.4375 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 23.4375 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 23.4375 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 23.4375 | 6 | no |
| GO:0032787 | monocarboxylic acid metabolic process | 21.8750 | 6 | yes |
| GO:0051049 | regulation of transport | 21.8750 | 4 | no |
| GO:0033043 | regulation of organelle organization | 21.8750 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 21.8750 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 21.8750 | 6 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 21.8750 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 21.8750 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 20.3125 | 5 | no |
| GO:0023056 | positive regulation of signaling | 20.3125 | 4 | no |
| GO:0043933 | protein-containing complex organization | 20.3125 | 4 | no |
| GO:0071310 | cellular response to organic substance | 20.3125 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 20.3125 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 20.3125 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 20.3125 | 5 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 20.3125 | 6 | no |
| GO:0031399 | regulation of protein modification process | 20.3125 | 6 | no |
| GO:0006163 | purine nucleotide metabolic process | 14.0625 | 5 | yes |
| GO:0006631 | fatty acid metabolic process | 14.0625 | 4 | yes |
| GO:0006753 | nucleoside phosphate metabolic process | 14.0625 | 4 | yes |
| GO:0009117 | nucleotide metabolic process | 14.0625 | 5 | yes |
| GO:0009150 | purine ribonucleotide metabolic process | 14.0625 | 6 | yes |
| GO:0009259 | ribonucleotide metabolic process | 14.0625 | 5 | yes |
| GO:0016054 | organic acid catabolic process | 14.0625 | 4 | yes |
| GO:0019693 | ribose phosphate metabolic process | 14.0625 | 4 | yes |
| GO:0046395 | carboxylic acid catabolic process | 14.0625 | 5 | yes |
| GO:0072521 | purine-containing compound metabolic process | 14.0625 | 4 | yes |
| GO:0006635 | fatty acid beta-oxidation | 10.9375 | 6 | yes |
| GO:0008202 | steroid metabolic process | 10.9375 | 4 | yes |
| GO:0009062 | fatty acid catabolic process | 10.9375 | 5 | yes |
| GO:0016042 | lipid catabolic process | 10.9375 | 4 | yes |
| GO:0019395 | fatty acid oxidation | 10.9375 | 5 | yes |
| GO:0030258 | lipid modification | 10.9375 | 4 | yes |
| GO:0033865 | nucleoside bisphosphate metabolic process | 10.9375 | 5 | yes |
| GO:0033875 | ribonucleoside bisphosphate metabolic process | 10.9375 | 6 | yes |
| GO:0034032 | purine nucleoside bisphosphate metabolic process | 10.9375 | 5 | yes |
| GO:0034440 | lipid oxidation | 10.9375 | 5 | yes |
| GO:0044242 | cellular lipid catabolic process | 10.9375 | 4 | yes |
| GO:0072329 | monocarboxylic acid catabolic process | 10.9375 | 6 | yes |
| GO:0001649 | osteoblast differentiation | 7.8125 | 4 | yes |
| GO:0000038 | very long-chain fatty acid metabolic process | 4.6875 | 5 | yes |
| GO:0002064 | epithelial cell development | 4.6875 | 4 | yes |
| GO:0035337 | fatty-acyl-CoA metabolic process | 3.1250 | 4 | yes |
| GO:0036111 | very long-chain fatty-acyl-CoA metabolic process | 3.1250 | 5 | yes |
| GO:0036112 | medium-chain fatty-acyl-CoA metabolic process | 3.1250 | 5 | yes |
| GO:1901568 | fatty acid derivative metabolic process | 3.1250 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PLEK_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DHB4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SGK3_HUMAN | [view interactions] | Low throughput | no | yes |
| SPOP_HUMAN | [view interactions] | Low throughput | no | no |
| SKP2_HUMAN | [view interactions] | Low throughput | no | yes |
| ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAGL_HUMAN | [view interactions] | High throughput | no | no |
| PPM1A_HUMAN | [view interactions] | High throughput | no | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDHA_HUMAN | [view interactions] | High throughput | no | yes |
| DHX16_HUMAN | [view interactions] | High throughput | no | yes |
| SCP2_HUMAN | [view interactions] | High throughput | no | no |
| CO6A1_HUMAN | [view interactions] | High throughput | no | no |
| PEX14_HUMAN | [view interactions] | High throughput | no | yes |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CATA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LTK_HUMAN | [view interactions] | High throughput | no | no |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDRG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTBP3_HUMAN | [view interactions] | High throughput | no | no |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC5_HUMAN | [view interactions] | High throughput | no | yes |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| CDK7_HUMAN | [view interactions] | High throughput | no | yes |
| MK08_HUMAN | [view interactions] | High throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RELB_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| TIAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPGR1_HUMAN | [view interactions] | High throughput | no | no |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| VGFR1_HUMAN | [view interactions] | High throughput | no | no |
| FLT3_HUMAN | [view interactions] | High throughput | no | no |
| LMTK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MERTK_HUMAN | [view interactions] | High throughput | no | yes |
| ROR1_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEX5_HUMAN | [view interactions] | High throughput | no | yes |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HECW2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| MERL_HUMAN | [view interactions] | High throughput | no | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| DUS4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IKZF1_HUMAN | [view interactions] | High throughput | no | no |
| CBAR1_HUMAN | [view interactions] | High throughput | no | no |
| TTC23_HUMAN | [view interactions] | High throughput | no | yes |
| TEDC2_HUMAN | [view interactions] | High throughput | no | no |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| CEBPB_HUMAN | [view interactions] | High throughput | no | no |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| COMP_HUMAN | [view interactions] | High throughput | no | no |
| MRP6_HUMAN | [view interactions] | High throughput | no | no |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| NFX1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| NMRL1_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| PD1L1_HUMAN | [view interactions] | High throughput | no | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| TRI59_HUMAN | [view interactions] | High throughput | no | no |
| PAHX_HUMAN | [view interactions] | High throughput | no | yes |
| LRSM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RC3H2_HUMAN | [view interactions] | High throughput | no | yes |
| FGD5_HUMAN | [view interactions] | High throughput | no | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BFAR_HUMAN | [view interactions] | High throughput | no | no |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| MSX2_HUMAN | [view interactions] | High throughput | no | no |
| ATG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| MEN1_HUMAN | [view interactions] | High throughput | no | yes |
| LOXL2_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| R113A_HUMAN | [view interactions] | High throughput | no | yes |
| GATA4_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SLX4_HUMAN | [view interactions] | High throughput | no | yes |
| PIAS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIDN_HUMAN | [view interactions] | High throughput | no | no |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| THIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRHPR_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SSBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RACK1_HUMAN | [view interactions] | High throughput | no | yes |
| VAMP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DECR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IDHC_HUMAN | [view interactions] | High throughput | no | no |
| SYCM_HUMAN | [view interactions] | High throughput | no | yes |
| ODP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYEP_HUMAN | [view interactions] | High throughput | no | yes |
| A16A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NB5R1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHX9_HUMAN | [view interactions] | High throughput | no | yes |
| EMC2_HUMAN | [view interactions] | High throughput | no | yes |
| HACD3_HUMAN | [view interactions] | High throughput | no | yes |
| ILF3_HUMAN | [view interactions] | High throughput | no | yes |
| SYK_HUMAN | [view interactions] | High throughput | no | yes |
| SYLC_HUMAN | [view interactions] | High throughput | no | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYPM_HUMAN | [view interactions] | High throughput | no | yes |
| PGAM5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYRC_HUMAN | [view interactions] | High throughput | no | yes |
| SCPDL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S2513_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPAT7_HUMAN | [view interactions] | High throughput | no | no |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX3_HUMAN | [view interactions] | High throughput | no | yes |
| XRCC6_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV2_HUMAN | [view interactions] | High throughput | no | yes |
| PECR_HUMAN | [view interactions] | High throughput | no | yes |
| RETST_HUMAN | [view interactions] | High throughput | no | yes |
| UFC1_HUMAN | [view interactions] | High throughput | no | yes |
| ACOX1_HUMAN | [view interactions] | High throughput | no | yes |
| DR4L2_HUMAN | [view interactions] | High throughput | no | no |
| DHRS4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HCDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CACP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSDL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PYGL_HUMAN | [view interactions] | High throughput | no | yes |
| MOB2_HUMAN | [view interactions] | High throughput | no | no |
| ARFG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AFG1L_HUMAN | [view interactions] | High throughput | no | yes |
| DUS22_HUMAN | [view interactions] | High throughput | no | yes |
| CUL4B_HUMAN | [view interactions] | High throughput | no | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| MIRO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VWA8_HUMAN | [view interactions] | High throughput | no | yes |
| ADAS_HUMAN | [view interactions] | High throughput | no | yes |
| ANC2_HUMAN | [view interactions] | High throughput | no | no |
| DYR2_HUMAN | [view interactions] | High throughput | no | yes |
| PEX3_HUMAN | [view interactions] | High throughput | no | yes |
| PXMP2_HUMAN | [view interactions] | High throughput | no | no |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| BAK_HUMAN | [view interactions] | High throughput | no | no |
| CASP9_HUMAN | [view interactions] | High throughput | no | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
| GBRAP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBA5_HUMAN | [view interactions] | High throughput | no | yes |
| TYSD1_HUMAN | [view interactions] | High throughput | no | yes |
| RC3H1_HUMAN | [view interactions] | High throughput | no | yes |
| NEDD1_HUMAN | [view interactions] | High throughput | no | yes |
| RGAP1_HUMAN | [view interactions] | High throughput | no | no |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| MTX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FOS_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SORT_HUMAN | [view interactions] | High throughput | no | yes |
| PAK4_HUMAN | [view interactions] | High throughput | no | yes |