ODPX_HUMAN
Evidence for PS localization
Functions
Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ODPX_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 30.9524 | 4 | no |
| GO:0043169 | cation binding | 23.8095 | 4 | no |
| GO:0046872 | metal ion binding | 23.8095 | 5 | no |
| GO:0003723 | RNA binding | 23.8095 | 4 | no |
| GO:0000166 | nucleotide binding | 23.8095 | 4 | no |
| GO:0017076 | purine nucleotide binding | 21.4286 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 21.4286 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 21.4286 | 4 | no |
| GO:0019900 | kinase binding | 21.4286 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ODPX_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 45.2381 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 40.4762 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 35.7143 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 33.3333 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 30.9524 | 4 | no |
| GO:0019752 | carboxylic acid metabolic process | 28.5714 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 28.5714 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 28.5714 | 4 | no |
| GO:0010646 | regulation of cell communication | 28.5714 | 4 | no |
| GO:0022607 | cellular component assembly | 28.5714 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 28.5714 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 28.5714 | 4 | no |
| GO:0006996 | organelle organization | 28.5714 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 28.5714 | 4 | no |
| GO:0009966 | regulation of signal transduction | 26.1905 | 4 | no |
| GO:0010468 | regulation of gene expression | 26.1905 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 26.1905 | 5 | no |
| GO:0043933 | protein-containing complex organization | 26.1905 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 26.1905 | 4 | no |
| GO:0043412 | macromolecule modification | 26.1905 | 4 | no |
| GO:0006163 | purine nucleotide metabolic process | 23.8095 | 5 | yes |
| GO:0006753 | nucleoside phosphate metabolic process | 23.8095 | 4 | yes |
| GO:0009117 | nucleotide metabolic process | 23.8095 | 5 | yes |
| GO:0072521 | purine-containing compound metabolic process | 23.8095 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 23.8095 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 23.8095 | 5 | no |
| GO:0036211 | protein modification process | 23.8095 | 4 | no |
| GO:0009150 | purine ribonucleotide metabolic process | 21.4286 | 6 | yes |
| GO:0009259 | ribonucleotide metabolic process | 21.4286 | 5 | yes |
| GO:0019693 | ribose phosphate metabolic process | 21.4286 | 4 | yes |
| GO:0032787 | monocarboxylic acid metabolic process | 21.4286 | 6 | yes |
| GO:0009893 | positive regulation of metabolic process | 21.4286 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 21.4286 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 21.4286 | 5 | no |
| GO:0023056 | positive regulation of signaling | 21.4286 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 21.4286 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 21.4286 | 5 | no |
| GO:0033865 | nucleoside bisphosphate metabolic process | 19.0476 | 5 | yes |
| GO:0033875 | ribonucleoside bisphosphate metabolic process | 19.0476 | 6 | yes |
| GO:0034032 | purine nucleoside bisphosphate metabolic process | 19.0476 | 5 | yes |
| GO:1901362 | organic cyclic compound biosynthetic process | 19.0476 | 4 | yes |
| GO:0006090 | pyruvate metabolic process | 14.2857 | 7 | yes |
| GO:0034654 | nucleobase-containing compound biosynthetic process | 14.2857 | 4 | yes |
| GO:1901566 | organonitrogen compound biosynthetic process | 14.2857 | 4 | yes |
| GO:0006084 | acetyl-CoA metabolic process | 11.9048 | 4 | yes |
| GO:0006085 | acetyl-CoA biosynthetic process | 11.9048 | 5 | yes |
| GO:0006086 | acetyl-CoA biosynthetic process from pyruvate | 11.9048 | 6 | yes |
| GO:0006164 | purine nucleotide biosynthetic process | 11.9048 | 6 | yes |
| GO:0009152 | purine ribonucleotide biosynthetic process | 11.9048 | 7 | yes |
| GO:0009165 | nucleotide biosynthetic process | 11.9048 | 6 | yes |
| GO:0009260 | ribonucleotide biosynthetic process | 11.9048 | 6 | yes |
| GO:0033866 | nucleoside bisphosphate biosynthetic process | 11.9048 | 6 | yes |
| GO:0034030 | ribonucleoside bisphosphate biosynthetic process | 11.9048 | 7 | yes |
| GO:0034033 | purine nucleoside bisphosphate biosynthetic process | 11.9048 | 6 | yes |
| GO:0035384 | thioester biosynthetic process | 11.9048 | 4 | yes |
| GO:0044272 | sulfur compound biosynthetic process | 11.9048 | 4 | yes |
| GO:0046390 | ribose phosphate biosynthetic process | 11.9048 | 5 | yes |
| GO:0071616 | acyl-CoA biosynthetic process | 11.9048 | 4 | yes |
| GO:0072522 | purine-containing compound biosynthetic process | 11.9048 | 5 | yes |
| GO:0090407 | organophosphate biosynthetic process | 11.9048 | 4 | yes |
| GO:1901137 | carbohydrate derivative biosynthetic process | 11.9048 | 4 | yes |
| GO:1901293 | nucleoside phosphate biosynthetic process | 11.9048 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ODP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SIR4_HUMAN | [view interactions] | Low throughput | no | yes |
| DLDH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EP300_HUMAN | [view interactions] | Low throughput | no | yes |
| NDF1_HUMAN | [view interactions] | Low throughput | no | yes |
| ODPB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PDK2_HUMAN | [view interactions] | Low throughput | no | yes |
| ATRAP_HUMAN | [view interactions] | High throughput | no | yes |
| ACTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| STA5B_HUMAN | [view interactions] | High throughput | no | yes |
| STA5A_HUMAN | [view interactions] | High throughput | no | no |
| FOXD4_HUMAN | [view interactions] | High throughput | no | no |
| PDK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF2M_HUMAN | [view interactions] | High throughput | no | yes |
| AAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DESP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RYR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OSMR_HUMAN | [view interactions] | High throughput | no | yes |
| CNDD3_HUMAN | [view interactions] | High throughput | no | no |
| MD13L_HUMAN | [view interactions] | High throughput | no | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CK5P2_HUMAN | [view interactions] | High throughput | no | yes |
| CP135_HUMAN | [view interactions] | High throughput | no | no |
| POC5_HUMAN | [view interactions] | High throughput | no | yes |
| CIDEB_HUMAN | [view interactions] | High throughput | no | yes |
| EWS_HUMAN | [view interactions] | High throughput | no | yes |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| PDK1_HUMAN | [view interactions] | High throughput | no | yes |
| ST38L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LGR4_HUMAN | [view interactions] | High throughput | no | yes |
| CDN1A_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| LEG3_HUMAN | [view interactions] | High throughput | no | yes |
| MERL_HUMAN | [view interactions] | High throughput | no | yes |
| PPCEL_HUMAN | [view interactions] | High throughput | no | yes |
| HECD1_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| DPYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRD2_HUMAN | [view interactions] | High throughput | no | yes |
| UBP15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLU_HUMAN | [view interactions] | High throughput | no | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND1_HUMAN | [view interactions] | High throughput | no | no |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANM1_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| MILK2_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S25A3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MRP1_HUMAN | [view interactions] | High throughput | no | no |
| MARC1_HUMAN | [view interactions] | High throughput | no | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A16A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHX9_HUMAN | [view interactions] | High throughput | no | yes |
| SYEP_HUMAN | [view interactions] | High throughput | no | yes |
| DHB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ILF3_HUMAN | [view interactions] | High throughput | no | yes |
| SYK_HUMAN | [view interactions] | High throughput | no | yes |
| SYLC_HUMAN | [view interactions] | High throughput | no | yes |
| LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYPM_HUMAN | [view interactions] | High throughput | no | yes |
| SYRC_HUMAN | [view interactions] | High throughput | no | yes |
| XRCC6_HUMAN | [view interactions] | High throughput | no | yes |
| SUCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PUR8_HUMAN | [view interactions] | High throughput | no | yes |
| DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACAD9_HUMAN | [view interactions] | High throughput | no | yes |
| CQ080_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | no |
| MRES1_HUMAN | [view interactions] | High throughput | no | yes |
| EFGM_HUMAN | [view interactions] | High throughput | no | yes |
| HINT2_HUMAN | [view interactions] | High throughput | no | yes |
| MCUB_HUMAN | [view interactions] | High throughput | no | no |
| MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET17_HUMAN | [view interactions] | High throughput | no | yes |
| RM11_HUMAN | [view interactions] | High throughput | no | yes |
| RT26_HUMAN | [view interactions] | High throughput | no | yes |
| RRFM_HUMAN | [view interactions] | High throughput | no | yes |
| MTG2_HUMAN | [view interactions] | High throughput | no | yes |
| RF1M_HUMAN | [view interactions] | High throughput | no | yes |
| RF1ML_HUMAN | [view interactions] | High throughput | no | yes |
| MPPA_HUMAN | [view interactions] | High throughput | no | yes |
| MPPB_HUMAN | [view interactions] | High throughput | no | yes |
| TACO1_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
| TRUB2_HUMAN | [view interactions] | High throughput | no | yes |
| EFTS_HUMAN | [view interactions] | High throughput | no | no |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| TM11B_HUMAN | [view interactions] | High throughput | no | no |
| TMPS4_HUMAN | [view interactions] | High throughput | no | yes |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| FBW1A_HUMAN | [view interactions] | High throughput | no | yes |
| ESYT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |