ODPX_HUMAN
Evidence for PS localization
Functions
Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ODPX_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 25.6410 | 4 | no |
| GO:0017076 | purine nucleotide binding | 23.0769 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 23.0769 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 23.0769 | 4 | no |
| GO:0019900 | kinase binding | 23.0769 | 4 | no |
| GO:0019901 | protein kinase binding | 23.0769 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ODPX_HUMAN |
|---|---|---|---|---|
| GO:0006796 | phosphate-containing compound metabolic process | 41.0256 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 41.0256 | 4 | no |
| GO:0019752 | carboxylic acid metabolic process | 33.3333 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 33.3333 | 4 | yes |
| GO:0043412 | macromolecule modification | 33.3333 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 33.3333 | 4 | no |
| GO:0036211 | protein modification process | 30.7692 | 4 | no |
| GO:0006163 | purine nucleotide metabolic process | 28.2051 | 5 | yes |
| GO:0006753 | nucleoside phosphate metabolic process | 28.2051 | 4 | yes |
| GO:0009117 | nucleotide metabolic process | 28.2051 | 5 | yes |
| GO:0009150 | purine ribonucleotide metabolic process | 28.2051 | 6 | yes |
| GO:0009259 | ribonucleotide metabolic process | 28.2051 | 5 | yes |
| GO:0019693 | ribose phosphate metabolic process | 28.2051 | 4 | yes |
| GO:0072521 | purine-containing compound metabolic process | 28.2051 | 4 | yes |
| GO:0006996 | organelle organization | 28.2051 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 28.2051 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 28.2051 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 28.2051 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 25.6410 | 4 | no |
| GO:0010468 | regulation of gene expression | 25.6410 | 5 | no |
| GO:0006637 | acyl-CoA metabolic process | 23.0769 | 4 | yes |
| GO:0032787 | monocarboxylic acid metabolic process | 23.0769 | 6 | yes |
| GO:0033865 | nucleoside bisphosphate metabolic process | 23.0769 | 5 | yes |
| GO:0033875 | ribonucleoside bisphosphate metabolic process | 23.0769 | 6 | yes |
| GO:0034032 | purine nucleoside bisphosphate metabolic process | 23.0769 | 5 | yes |
| GO:0043603 | cellular amide metabolic process | 23.0769 | 4 | yes |
| GO:0022607 | cellular component assembly | 23.0769 | 4 | no |
| GO:0010646 | regulation of cell communication | 23.0769 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 23.0769 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 23.0769 | 5 | no |
| GO:0007010 | cytoskeleton organization | 20.5128 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 20.5128 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 20.5128 | 4 | no |
| GO:0009966 | regulation of signal transduction | 20.5128 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 20.5128 | 5 | no |
| GO:0097435 | supramolecular fiber organization | 20.5128 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 20.5128 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 20.5128 | 5 | no |
| GO:1901362 | organic cyclic compound biosynthetic process | 17.9487 | 4 | yes |
| GO:0006084 | acetyl-CoA metabolic process | 15.3846 | 5 | yes |
| GO:0006090 | pyruvate metabolic process | 15.3846 | 7 | yes |
| GO:0018130 | heterocycle biosynthetic process | 15.3846 | 4 | yes |
| GO:0019438 | aromatic compound biosynthetic process | 15.3846 | 4 | yes |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 15.3846 | 4 | yes |
| GO:1901566 | organonitrogen compound biosynthetic process | 15.3846 | 4 | yes |
| GO:0006085 | acetyl-CoA biosynthetic process | 12.8205 | 6 | yes |
| GO:0006086 | acetyl-CoA biosynthetic process from pyruvate | 12.8205 | 7 | yes |
| GO:0006164 | purine nucleotide biosynthetic process | 12.8205 | 6 | yes |
| GO:0009152 | purine ribonucleotide biosynthetic process | 12.8205 | 7 | yes |
| GO:0009165 | nucleotide biosynthetic process | 12.8205 | 6 | yes |
| GO:0009260 | ribonucleotide biosynthetic process | 12.8205 | 6 | yes |
| GO:0033866 | nucleoside bisphosphate biosynthetic process | 12.8205 | 6 | yes |
| GO:0034030 | ribonucleoside bisphosphate biosynthetic process | 12.8205 | 7 | yes |
| GO:0034033 | purine nucleoside bisphosphate biosynthetic process | 12.8205 | 6 | yes |
| GO:0034654 | nucleobase-containing compound biosynthetic process | 12.8205 | 4 | yes |
| GO:0035384 | thioester biosynthetic process | 12.8205 | 4 | yes |
| GO:0043604 | amide biosynthetic process | 12.8205 | 5 | yes |
| GO:0044272 | sulfur compound biosynthetic process | 12.8205 | 4 | yes |
| GO:0046390 | ribose phosphate biosynthetic process | 12.8205 | 5 | yes |
| GO:0071616 | acyl-CoA biosynthetic process | 12.8205 | 5 | yes |
| GO:0072522 | purine-containing compound biosynthetic process | 12.8205 | 5 | yes |
| GO:0090407 | organophosphate biosynthetic process | 12.8205 | 4 | yes |
| GO:1901137 | carbohydrate derivative biosynthetic process | 12.8205 | 4 | yes |
| GO:1901293 | nucleoside phosphate biosynthetic process | 12.8205 | 5 | yes |
| GO:0061732 | mitochondrial acetyl-CoA biosynthetic process from pyruvate | 10.2564 | 8 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ODP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SIR4_HUMAN | [view interactions] | Low throughput | no | yes |
| DLDH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EP300_HUMAN | [view interactions] | Low throughput | no | yes |
| NDF1_HUMAN | [view interactions] | Low throughput | no | yes |
| ODPB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PDK2_HUMAN | [view interactions] | Low throughput | no | yes |
| ATRAP_HUMAN | [view interactions] | High throughput | no | yes |
| ACTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| STA5B_HUMAN | [view interactions] | High throughput | no | yes |
| STA5A_HUMAN | [view interactions] | High throughput | no | no |
| FOXD4_HUMAN | [view interactions] | High throughput | no | no |
| PDK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF2M_HUMAN | [view interactions] | High throughput | no | yes |
| AAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DESP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RYR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OSMR_HUMAN | [view interactions] | High throughput | no | yes |
| CNDD3_HUMAN | [view interactions] | High throughput | no | no |
| CIDEB_HUMAN | [view interactions] | High throughput | no | yes |
| EWS_HUMAN | [view interactions] | High throughput | no | yes |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| PDK1_HUMAN | [view interactions] | High throughput | no | yes |
| ST38L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LGR4_HUMAN | [view interactions] | High throughput | no | yes |
| CDN1A_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| LEG3_HUMAN | [view interactions] | High throughput | no | yes |
| MERL_HUMAN | [view interactions] | High throughput | no | yes |
| PPCEL_HUMAN | [view interactions] | High throughput | no | yes |
| HECD1_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| DPYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRD2_HUMAN | [view interactions] | High throughput | no | yes |
| UBP15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLU_HUMAN | [view interactions] | High throughput | no | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND1_HUMAN | [view interactions] | High throughput | no | no |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPCP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MRP1_HUMAN | [view interactions] | High throughput | no | no |
| MARC1_HUMAN | [view interactions] | High throughput | no | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A16A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHX9_HUMAN | [view interactions] | High throughput | no | yes |
| SYEP_HUMAN | [view interactions] | High throughput | no | yes |
| DHB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ILF3_HUMAN | [view interactions] | High throughput | no | yes |
| SYK_HUMAN | [view interactions] | High throughput | no | yes |
| SYLC_HUMAN | [view interactions] | High throughput | no | yes |
| LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYPM_HUMAN | [view interactions] | High throughput | no | yes |
| SYRC_HUMAN | [view interactions] | High throughput | no | yes |
| XRCC6_HUMAN | [view interactions] | High throughput | no | yes |
| SUCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACAD9_HUMAN | [view interactions] | High throughput | no | yes |
| CQ080_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | yes |
| MRES1_HUMAN | [view interactions] | High throughput | no | yes |
| EFGM_HUMAN | [view interactions] | High throughput | no | yes |
| HINT2_HUMAN | [view interactions] | High throughput | no | yes |
| MCUB_HUMAN | [view interactions] | High throughput | no | no |
| MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET17_HUMAN | [view interactions] | High throughput | no | yes |
| RM11_HUMAN | [view interactions] | High throughput | no | yes |
| RT26_HUMAN | [view interactions] | High throughput | no | yes |
| RRFM_HUMAN | [view interactions] | High throughput | no | yes |
| MTG2_HUMAN | [view interactions] | High throughput | no | yes |
| RF1M_HUMAN | [view interactions] | High throughput | no | yes |
| RF1ML_HUMAN | [view interactions] | High throughput | no | yes |
| MPPA_HUMAN | [view interactions] | High throughput | no | yes |
| MPPB_HUMAN | [view interactions] | High throughput | no | yes |
| TACO1_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
| TRUB2_HUMAN | [view interactions] | High throughput | no | yes |
| EFTS_HUMAN | [view interactions] | High throughput | no | no |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| TM11B_HUMAN | [view interactions] | High throughput | no | no |
| TMPS4_HUMAN | [view interactions] | High throughput | no | yes |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| RXRA_HUMAN | [view interactions] | Computational | no | yes |
| PDK4_HUMAN | [view interactions] | Computational | no | yes |
| PDP2_HUMAN | [view interactions] | Computational | no | yes |
| ODPAT_HUMAN | [view interactions] | Computational | no | no |
| ODBA_HUMAN | [view interactions] | Computational | no | yes |
| ODO2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PDPR_HUMAN | [view interactions] | Computational | no | yes |
| LIPT_HUMAN | [view interactions] | Computational | no | no |
| DHTK1_HUMAN | [view interactions] | Computational | no | no |
| PPARD_HUMAN | [view interactions] | Computational | no | yes |
| ODBB_HUMAN | [view interactions] | Computational | no | yes |
| GCSH_HUMAN | [view interactions] | Computational | no | yes |
| PDP1_HUMAN | [view interactions] | Computational | no | yes |