Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ODP2_HUMAN

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. [View more on UniProt]

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Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in ODP2_HUMAN
GO:0043169 cation binding 37.2549 4 no
GO:0046872 metal ion binding 36.2745 5 no
GO:0003723 RNA binding 24.5098 4 no
GO:0000166 nucleotide binding 20.5882 4 no
GO:0008324 monoatomic cation transmembrane transporter activity 20.5882 4 no
GO:0022890 inorganic cation transmembrane transporter activity 20.5882 4 no
GO:0016417 S-acyltransferase activity 2.9412 5 yes
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 2.9412 4 yes
GO:0016407 acetyltransferase activity 1.9608 5 yes
GO:0016418 S-acetyltransferase activity 1.9608 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ODP2_HUMAN
GO:0006796 phosphate-containing compound metabolic process 34.3137 4 yes
GO:0048523 negative regulation of cellular process 33.3333 4 no
GO:0022607 cellular component assembly 33.3333 4 no
GO:0048522 positive regulation of cellular process 32.3529 4 no
GO:0031323 regulation of cellular metabolic process 30.3922 4 no
GO:0043933 protein-containing complex organization 30.3922 4 no
GO:0060255 regulation of macromolecule metabolic process 30.3922 4 no
GO:0006996 organelle organization 29.4118 4 no
GO:0080090 regulation of primary metabolic process 29.4118 4 no
GO:0006753 nucleoside phosphate metabolic process 28.4314 4 yes
GO:0009117 nucleotide metabolic process 28.4314 5 yes
GO:0051128 regulation of cellular component organization 28.4314 4 no
GO:0006163 purine nucleotide metabolic process 27.4510 5 yes
GO:0072521 purine-containing compound metabolic process 27.4510 4 yes
GO:0009150 purine ribonucleotide metabolic process 25.4902 6 yes
GO:0009259 ribonucleotide metabolic process 25.4902 5 yes
GO:0019693 ribose phosphate metabolic process 25.4902 4 yes
GO:0009889 regulation of biosynthetic process 25.4902 4 no
GO:0010646 regulation of cell communication 25.4902 4 no
GO:0031326 regulation of cellular biosynthetic process 25.4902 5 no
GO:0010468 regulation of gene expression 24.5098 6 no
GO:0010556 regulation of macromolecule biosynthetic process 24.5098 5 no
GO:0019752 carboxylic acid metabolic process 22.5490 5 yes
GO:0043436 oxoacid metabolic process 22.5490 4 yes
GO:0008104 protein localization 22.5490 4 no
GO:0009966 regulation of signal transduction 22.5490 4 no
GO:0065003 protein-containing complex assembly 22.5490 5 no
GO:0015980 energy derivation by oxidation of organic compounds 22.5490 4 no
GO:0022900 electron transport chain 22.5490 4 no
GO:0022904 respiratory electron transport chain 22.5490 5 no
GO:1901362 organic cyclic compound biosynthetic process 21.5686 4 yes
GO:0009892 negative regulation of metabolic process 21.5686 4 no
GO:0009060 aerobic respiration 21.5686 6 no
GO:0045333 cellular respiration 21.5686 5 no
GO:0009893 positive regulation of metabolic process 20.5882 4 no
GO:0010605 negative regulation of macromolecule metabolic process 20.5882 5 no
GO:0034654 nucleobase-containing compound biosynthetic process 19.6078 4 yes
GO:1901566 organonitrogen compound biosynthetic process 18.6275 4 yes
GO:0006164 purine nucleotide biosynthetic process 17.6471 6 yes
GO:0009152 purine ribonucleotide biosynthetic process 17.6471 7 yes
GO:0009165 nucleotide biosynthetic process 17.6471 6 yes
GO:0009260 ribonucleotide biosynthetic process 17.6471 6 yes
GO:0046390 ribose phosphate biosynthetic process 17.6471 5 yes
GO:0072522 purine-containing compound biosynthetic process 17.6471 5 yes
GO:0090407 organophosphate biosynthetic process 17.6471 4 yes
GO:1901137 carbohydrate derivative biosynthetic process 17.6471 4 yes
GO:1901293 nucleoside phosphate biosynthetic process 17.6471 5 yes
GO:0032787 monocarboxylic acid metabolic process 14.7059 6 yes
GO:0033865 nucleoside bisphosphate metabolic process 10.7843 5 yes
GO:0033875 ribonucleoside bisphosphate metabolic process 10.7843 6 yes
GO:0034032 purine nucleoside bisphosphate metabolic process 10.7843 5 yes
GO:0006084 acetyl-CoA metabolic process 6.8627 4 yes
GO:0006090 pyruvate metabolic process 6.8627 7 yes
GO:0006006 glucose metabolic process 5.8824 5 yes
GO:0006085 acetyl-CoA biosynthetic process 5.8824 5 yes
GO:0006086 acetyl-CoA biosynthetic process from pyruvate 5.8824 6 yes
GO:0019318 hexose metabolic process 5.8824 4 yes
GO:0033866 nucleoside bisphosphate biosynthetic process 5.8824 6 yes
GO:0034030 ribonucleoside bisphosphate biosynthetic process 5.8824 7 yes
GO:0034033 purine nucleoside bisphosphate biosynthetic process 5.8824 6 yes
GO:0035384 thioester biosynthetic process 5.8824 4 yes
GO:0044272 sulfur compound biosynthetic process 5.8824 4 yes
GO:0071616 acyl-CoA biosynthetic process 5.8824 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PDK2_HUMAN [view interactions] Low throughput no yes
ODPX_HUMAN [view entry] [view interactions] Low throughput yes yes
SIR4_HUMAN [view interactions] Low throughput no yes
PDK3_HUMAN [view entry] [view interactions] Low throughput yes yes
ODPB_HUMAN [view entry] [view interactions] Low throughput yes yes
SIR3_HUMAN [view interactions] Low throughput no yes
ODP2_HUMAN [view entry] [view interactions] Low throughput yes yes
PDK1_HUMAN [view interactions] Low throughput no yes
C1QBP_HUMAN [view entry] [view interactions] Low throughput yes yes
ANM1_HUMAN [view interactions] High throughput no yes
MYCN_HUMAN [view interactions] High throughput no no
TLS1_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
ARMC5_HUMAN [view interactions] High throughput no yes
LATS1_HUMAN [view entry] [view interactions] High throughput yes yes
BAP1_HUMAN [view interactions] High throughput no yes
HAPR1_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
UBP48_HUMAN [view interactions] High throughput no yes
RHG24_HUMAN [view interactions] High throughput no yes
CBL_HUMAN [view interactions] High throughput no yes
MET14_HUMAN [view interactions] High throughput no yes
EZH2_HUMAN [view interactions] High throughput no no
UBP36_HUMAN [view interactions] High throughput no yes
PML_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
CSK_HUMAN [view interactions] High throughput no yes
LDLR_HUMAN [view interactions] High throughput no yes
SPRNG_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
ODPA_HUMAN [view entry] [view interactions] High throughput yes yes
ODO1_HUMAN [view entry] [view interactions] High throughput yes yes
ODPAT_HUMAN [view interactions] High throughput no no
RM01_HUMAN [view interactions] High throughput no yes
NDUS4_HUMAN [view interactions] High throughput no yes
EMC5_HUMAN [view interactions] High throughput no yes
HNRPQ_HUMAN [view entry] [view interactions] High throughput yes yes
HS71L_HUMAN [view entry] [view interactions] High throughput yes no
ACAD9_HUMAN [view interactions] High throughput no yes
COX5B_HUMAN [view entry] [view interactions] High throughput yes yes
CISY_HUMAN [view entry] [view interactions] High throughput yes yes
CY1_HUMAN [view entry] [view interactions] High throughput yes yes
AT1B1_HUMAN [view entry] [view interactions] High throughput yes no
SDHB_HUMAN [view interactions] High throughput no yes
LMAN1_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS2_HUMAN [view entry] [view interactions] High throughput yes yes
MIC19_HUMAN [view entry] [view interactions] High throughput yes yes
A16A1_HUMAN [view entry] [view interactions] High throughput yes no
COR1B_HUMAN [view entry] [view interactions] High throughput yes no
COR1C_HUMAN [view entry] [view interactions] High throughput yes yes
DHX9_HUMAN [view interactions] High throughput no yes
DHB4_HUMAN [view entry] [view interactions] High throughput yes yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
ILF3_HUMAN [view interactions] High throughput no yes
SYK_HUMAN [view interactions] High throughput no yes
SYLC_HUMAN [view interactions] High throughput no yes
LPPRC_HUMAN [view entry] [view interactions] High throughput yes yes
SYPM_HUMAN [view interactions] High throughput no yes
SYRC_HUMAN [view interactions] High throughput no yes
SND1_HUMAN [view entry] [view interactions] High throughput yes yes
EFTS_HUMAN [view interactions] High throughput no no
XRCC6_HUMAN [view interactions] High throughput no yes
SYEP_HUMAN [view interactions] High throughput no yes
COX41_HUMAN [view entry] [view interactions] High throughput yes yes
MDHM_HUMAN [view entry] [view interactions] High throughput yes yes
ETFD_HUMAN [view entry] [view interactions] High throughput yes yes
NDUB7_HUMAN [view entry] [view interactions] High throughput yes yes
NDUV1_HUMAN [view entry] [view interactions] High throughput yes yes
ACON_HUMAN [view entry] [view interactions] High throughput yes yes
ATPD_HUMAN [view interactions] High throughput no yes
AT5L2_HUMAN [view interactions] High throughput no no
ATP5L_HUMAN [view interactions] High throughput no yes
ATPA_HUMAN [view interactions] High throughput no yes
ATP5I_HUMAN [view interactions] High throughput no yes
CYC_HUMAN [view entry] [view interactions] High throughput yes yes
GPDM_HUMAN [view entry] [view interactions] High throughput yes yes
IDH3G_HUMAN [view entry] [view interactions] High throughput yes yes
IDH3A_HUMAN [view entry] [view interactions] High throughput yes yes
NDUAA_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA5_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA8_HUMAN [view entry] [view interactions] High throughput yes yes
NDUBA_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS3_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS7_HUMAN [view entry] [view interactions] High throughput yes no
NDUV2_HUMAN [view entry] [view interactions] High throughput yes yes
SDHA_HUMAN [view interactions] High throughput no yes
SUCB1_HUMAN [view entry] [view interactions] High throughput yes yes
QCR1_HUMAN [view entry] [view interactions] High throughput yes yes
QCR2_HUMAN [view entry] [view interactions] High throughput yes yes
UCRI_HUMAN [view entry] [view interactions] High throughput yes yes
MIC26_HUMAN [view entry] [view interactions] High throughput yes yes
COX5A_HUMAN [view entry] [view interactions] High throughput yes yes
NDUAC_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS1_HUMAN [view entry] [view interactions] High throughput yes no
SDHF3_HUMAN [view interactions] High throughput no yes
SUCA_HUMAN [view entry] [view interactions] High throughput yes yes
NAA10_HUMAN [view interactions] High throughput no yes
CAZA1_HUMAN [view entry] [view interactions] High throughput yes yes
IF5A1_HUMAN [view interactions] High throughput no yes
EXOC2_HUMAN [view entry] [view interactions] High throughput yes no
MRM1_HUMAN [view interactions] High throughput no no
KS6A6_HUMAN [view interactions] High throughput no yes
AUHM_HUMAN [view entry] [view interactions] High throughput yes yes
MTRFR_HUMAN [view interactions] High throughput no yes
CQ080_HUMAN [view interactions] High throughput no yes
GAL3A_HUMAN [view interactions] High throughput no yes
GAL3B_HUMAN [view interactions] High throughput no no
MRES1_HUMAN [view interactions] High throughput no yes
MCUR1_HUMAN [view interactions] High throughput no no
CHCH1_HUMAN [view interactions] High throughput no yes
COX15_HUMAN [view interactions] High throughput no yes
QOR_HUMAN [view entry] [view interactions] High throughput yes yes
FAKD5_HUMAN [view interactions] High throughput no yes
EFGM_HUMAN [view interactions] High throughput no yes
HINT2_HUMAN [view interactions] High throughput no yes
ICT1_HUMAN [view interactions] High throughput no yes
MCUB_HUMAN [view interactions] High throughput no no
MET15_HUMAN [view interactions] High throughput no no
MET17_HUMAN [view interactions] High throughput no yes
RM11_HUMAN [view interactions] High throughput no yes
RT12_HUMAN [view interactions] High throughput no yes
RT26_HUMAN [view interactions] High throughput no yes
RRFM_HUMAN [view interactions] High throughput no yes
MTG1_HUMAN [view interactions] High throughput no yes
MTG2_HUMAN [view interactions] High throughput no yes
HMGB1_HUMAN [view interactions] High throughput no yes
IF2M_HUMAN [view interactions] High throughput no yes
GLUT4_HUMAN [view interactions] High throughput no no
IF3M_HUMAN [view interactions] High throughput no yes
MLP3A_HUMAN [view entry] [view interactions] High throughput yes yes
RF1M_HUMAN [view interactions] High throughput no yes
MLP3B_HUMAN [view interactions] High throughput no yes
RF1ML_HUMAN [view interactions] High throughput no yes
GBRL1_HUMAN [view interactions] High throughput no yes
NGRN_HUMAN [view interactions] High throughput no yes
OTC_HUMAN [view interactions] High throughput no no
HDAC6_HUMAN [view interactions] High throughput no yes
MPPA_HUMAN [view interactions] High throughput no yes
STA5B_HUMAN [view interactions] High throughput no yes
MPPB_HUMAN [view interactions] High throughput no yes
STA5A_HUMAN [view interactions] High throughput no no
RUSD3_HUMAN [view interactions] High throughput no yes
FOXD4_HUMAN [view interactions] High throughput no no
RUSD4_HUMAN [view interactions] High throughput no yes
SLIRP_HUMAN [view interactions] High throughput no yes
DLDH_HUMAN [view entry] [view interactions] High throughput yes yes
SSBP_HUMAN [view entry] [view interactions] High throughput yes yes
KI67_HUMAN [view interactions] High throughput no no
SURF1_HUMAN [view interactions] High throughput no yes
ABHDB_HUMAN [view interactions] High throughput no yes
TACO1_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
FAKD4_HUMAN [view interactions] High throughput no yes
DOCK6_HUMAN [view interactions] High throughput no yes
TIM29_HUMAN [view interactions] High throughput no no
ARHGG_HUMAN [view interactions] High throughput no yes
TRUB2_HUMAN [view interactions] High throughput no yes
RHG23_HUMAN [view entry] [view interactions] High throughput yes yes
EFTU_HUMAN [view entry] [view interactions] High throughput yes yes
PKHG7_HUMAN [view interactions] High throughput no no
VWA8_HUMAN [view interactions] High throughput no yes
ODO2_HUMAN [view entry] [view interactions] High throughput yes yes
EXD2_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
LEG9_HUMAN [view interactions] High throughput no yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
DJC15_HUMAN [view interactions] High throughput no no
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
DNJC4_HUMAN [view interactions] High throughput no yes
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
HSC20_HUMAN [view interactions] High throughput no yes
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
GRP75_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
DJC28_HUMAN [view interactions] High throughput no yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
DJC21_HUMAN [view interactions] High throughput no yes
TAL1_HUMAN [view interactions] High throughput no no
SYAM_HUMAN [view interactions] High throughput no yes
COX8A_HUMAN [view interactions] High throughput no yes
ANXA1_HUMAN [view entry] [view interactions] High throughput yes no
BROMI_HUMAN [view interactions] High throughput no no
JUN_HUMAN [view interactions] High throughput no yes
ACE2_HUMAN [view interactions] High throughput no no
CAV3_HUMAN [view interactions] High throughput no no
CLPP_HUMAN [view interactions] High throughput no yes
DESP_HUMAN [view entry] [view interactions] High throughput yes no
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
RYR2_HUMAN [view entry] [view interactions] High throughput yes yes
BCKD_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
ETFB_HUMAN [view entry] [view interactions] High throughput yes yes
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
RFA1_HUMAN [view interactions] High throughput no yes
CNDD3_HUMAN [view interactions] High throughput no no
RFA2_HUMAN [view interactions] High throughput no yes
SCN2A_HUMAN [view entry] [view interactions] High throughput yes yes
RFA3_HUMAN [view interactions] High throughput no yes
MD13L_HUMAN [view interactions] High throughput no no
TLK2_HUMAN [view interactions] High throughput no no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
CNTRB_HUMAN [view interactions] High throughput no yes
CP135_HUMAN [view interactions] High throughput no no
POC5_HUMAN [view interactions] High throughput no yes
ACPM_HUMAN [view interactions] High throughput no yes
KPCD3_HUMAN [view interactions] High throughput no yes
CUL1_HUMAN [view interactions] High throughput no yes
CSN5_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
HUNK_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
SOX4_HUMAN [view interactions] High throughput no yes
AKIP_HUMAN [view interactions] High throughput no yes
CH60_HUMAN [view entry] [view interactions] High throughput yes yes
MGST3_HUMAN [view entry] [view interactions] High throughput yes yes
RAB9A_HUMAN [view interactions] High throughput no yes
SFXN1_HUMAN [view entry] [view interactions] High throughput yes yes
TR61B_HUMAN [view interactions] High throughput no yes
FHI1B_HUMAN [view interactions] High throughput no yes
FHI2A_HUMAN [view interactions] High throughput no yes
FHI2B_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
PSA3_HUMAN [view interactions] High throughput no no
SIR7_HUMAN [view interactions] High throughput no yes
TS101_HUMAN [view entry] [view interactions] High throughput yes yes
PAF15_HUMAN [view interactions] High throughput no no
ADRB2_HUMAN [view entry] [view interactions] High throughput yes no
MDM2_HUMAN [view entry] [view interactions] High throughput yes yes
PPT1_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
MERL_HUMAN [view interactions] High throughput no yes
HCD2_HUMAN [view entry] [view interactions] High throughput yes yes
CISD3_HUMAN [view interactions] High throughput no yes
CDKN3_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
PARK7_HUMAN [view entry] [view interactions] High throughput yes yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
TF7L2_HUMAN [view interactions] High throughput no yes
U5S1_HUMAN [view interactions] High throughput no yes
HECD1_HUMAN [view interactions] High throughput no yes
UBR7_HUMAN [view interactions] High throughput no yes
UBE3A_HUMAN [view entry] [view interactions] High throughput yes yes
WWOX_HUMAN [view interactions] High throughput no yes
RECQ4_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
MYC_HUMAN [view interactions] High throughput no yes
K1C17_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
YAP1_HUMAN [view interactions] High throughput no yes
TIA1_HUMAN [view interactions] High throughput no no
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
BIRC3_HUMAN [view interactions] High throughput no no
FBXW8_HUMAN [view interactions] High throughput no yes
OBSL1_HUMAN [view interactions] High throughput no yes
CUL9_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
BACD3_HUMAN [view interactions] High throughput no yes
PINK1_HUMAN [view interactions] High throughput no yes
HPPD_HUMAN [view interactions] High throughput no no
EMC4_HUMAN [view interactions] High throughput no yes
RHG39_HUMAN [view entry] [view interactions] High throughput yes no
SYDE2_HUMAN [view interactions] High throughput no no
ANLN_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
KIF23_HUMAN [view interactions] High throughput no yes
BRD2_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
RBM39_HUMAN [view interactions] High throughput no yes
IF16_HUMAN [view interactions] High throughput no no
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes
UBP15_HUMAN [view entry] [view interactions] High throughput yes yes
PAGE4_HUMAN [view interactions] High throughput no no
MIF_HUMAN [view entry] [view interactions] High throughput yes yes
TMPS2_HUMAN [view interactions] High throughput no no
TOP3B_HUMAN [view interactions] High throughput no no
CATL1_HUMAN [view interactions] High throughput no yes
IFM1_HUMAN [view interactions] High throughput no no
DPP4_HUMAN [view interactions] High throughput no no
IFM3_HUMAN [view interactions] High throughput no yes
TM11B_HUMAN [view interactions] High throughput no no
CLC4D_HUMAN [view interactions] High throughput no no
CLC4E_HUMAN [view interactions] High throughput no no
DVL2_HUMAN [view interactions] High throughput no yes
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
CLU_HUMAN [view interactions] High throughput no yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
CLIP1_HUMAN [view entry] [view interactions] High throughput yes yes
FKBP5_HUMAN [view interactions] High throughput no yes
HEAT3_HUMAN [view interactions] High throughput no yes