Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ODP2_HUMAN

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. [View more on UniProt]

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Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in ODP2_HUMAN
GO:0046872 metal ion binding 35.4167 4 no
GO:0003723 RNA binding 26.0417 4 no
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 7.2917 4 yes
GO:0016407 acetyltransferase activity 5.2083 5 yes
GO:0016417 S-acyltransferase activity 4.1667 5 yes
GO:0016418 S-acetyltransferase activity 3.1250 6 yes
GO:0030523 dihydrolipoamide S-acyltransferase activity 2.0833 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ODP2_HUMAN
GO:0022607 cellular component assembly 32.2917 4 no
GO:0019752 carboxylic acid metabolic process 31.2500 5 yes
GO:0043436 oxoacid metabolic process 31.2500 4 yes
GO:0060255 regulation of macromolecule metabolic process 27.0833 4 no
GO:0048522 positive regulation of cellular process 27.0833 4 no
GO:0043933 protein-containing complex organization 26.0417 4 no
GO:0048523 negative regulation of cellular process 25.0000 4 no
GO:0006796 phosphate-containing compound metabolic process 23.9583 4 yes
GO:0080090 regulation of primary metabolic process 23.9583 4 no
GO:0006996 organelle organization 22.9167 4 no
GO:0015980 energy derivation by oxidation of organic compounds 22.9167 4 no
GO:0051171 regulation of nitrogen compound metabolic process 22.9167 4 no
GO:0032787 monocarboxylic acid metabolic process 21.8750 6 yes
GO:0009060 aerobic respiration 21.8750 6 no
GO:0022900 electron transport chain 21.8750 4 no
GO:0022904 respiratory electron transport chain 21.8750 5 no
GO:0045333 cellular respiration 21.8750 5 no
GO:0010468 regulation of gene expression 21.8750 5 no
GO:0031323 regulation of cellular metabolic process 21.8750 4 no
GO:0065003 protein-containing complex assembly 20.8333 5 no
GO:0051128 regulation of cellular component organization 20.8333 4 no
GO:0006753 nucleoside phosphate metabolic process 18.7500 4 yes
GO:0009117 nucleotide metabolic process 18.7500 5 yes
GO:0006163 purine nucleotide metabolic process 17.7083 5 yes
GO:0009150 purine ribonucleotide metabolic process 17.7083 6 yes
GO:0009259 ribonucleotide metabolic process 17.7083 5 yes
GO:0019693 ribose phosphate metabolic process 17.7083 4 yes
GO:0072521 purine-containing compound metabolic process 17.7083 4 yes
GO:0043603 cellular amide metabolic process 14.5833 4 yes
GO:0006637 acyl-CoA metabolic process 13.5417 4 yes
GO:0033865 nucleoside bisphosphate metabolic process 13.5417 5 yes
GO:0033875 ribonucleoside bisphosphate metabolic process 13.5417 6 yes
GO:0034032 purine nucleoside bisphosphate metabolic process 13.5417 5 yes
GO:1901362 organic cyclic compound biosynthetic process 11.4583 4 yes
GO:0006084 acetyl-CoA metabolic process 10.4167 5 yes
GO:0018130 heterocycle biosynthetic process 10.4167 4 yes
GO:0019438 aromatic compound biosynthetic process 10.4167 4 yes
GO:0044271 cellular nitrogen compound biosynthetic process 10.4167 4 yes
GO:1901566 organonitrogen compound biosynthetic process 10.4167 4 yes
GO:0006090 pyruvate metabolic process 9.3750 7 yes
GO:0006164 purine nucleotide biosynthetic process 9.3750 6 yes
GO:0009152 purine ribonucleotide biosynthetic process 9.3750 7 yes
GO:0009165 nucleotide biosynthetic process 9.3750 6 yes
GO:0009260 ribonucleotide biosynthetic process 9.3750 6 yes
GO:0033866 nucleoside bisphosphate biosynthetic process 9.3750 6 yes
GO:0034030 ribonucleoside bisphosphate biosynthetic process 9.3750 7 yes
GO:0034033 purine nucleoside bisphosphate biosynthetic process 9.3750 6 yes
GO:0034654 nucleobase-containing compound biosynthetic process 9.3750 4 yes
GO:0035384 thioester biosynthetic process 9.3750 4 yes
GO:0043604 amide biosynthetic process 9.3750 5 yes
GO:0044272 sulfur compound biosynthetic process 9.3750 4 yes
GO:0046390 ribose phosphate biosynthetic process 9.3750 5 yes
GO:0071616 acyl-CoA biosynthetic process 9.3750 5 yes
GO:0072522 purine-containing compound biosynthetic process 9.3750 5 yes
GO:0090407 organophosphate biosynthetic process 9.3750 4 yes
GO:1901137 carbohydrate derivative biosynthetic process 9.3750 4 yes
GO:1901293 nucleoside phosphate biosynthetic process 9.3750 5 yes
GO:0006085 acetyl-CoA biosynthetic process 8.3333 6 yes
GO:0006006 glucose metabolic process 6.2500 5 yes
GO:0006086 acetyl-CoA biosynthetic process from pyruvate 6.2500 7 yes
GO:0019318 hexose metabolic process 6.2500 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SIR3_HUMAN [view interactions] Low throughput no yes
ODP2_HUMAN [view entry] [view interactions] Low throughput yes yes
PDK1_HUMAN [view interactions] Low throughput no yes
C1QBP_HUMAN [view entry] [view interactions] Low throughput yes yes
PDK2_HUMAN [view interactions] Low throughput no yes
ODPX_HUMAN [view entry] [view interactions] Low throughput yes yes
SIR4_HUMAN [view interactions] Low throughput no yes
PDK3_HUMAN [view entry] [view interactions] Low throughput yes yes
ODPB_HUMAN [view entry] [view interactions] Low throughput yes yes
JUN_HUMAN [view interactions] High throughput no yes
CAV3_HUMAN [view interactions] High throughput no no
DESP_HUMAN [view entry] [view interactions] High throughput yes no
RYR2_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
CNDD3_HUMAN [view interactions] High throughput no no
ACPM_HUMAN [view interactions] High throughput no yes
KPCD3_HUMAN [view interactions] High throughput no yes
CUL1_HUMAN [view interactions] High throughput no yes
CSN5_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
AKIP_HUMAN [view interactions] High throughput no yes
CH60_HUMAN [view entry] [view interactions] High throughput yes yes
MGST3_HUMAN [view entry] [view interactions] High throughput yes yes
RAB9A_HUMAN [view interactions] High throughput no yes
SFXN1_HUMAN [view entry] [view interactions] High throughput yes yes
TR61B_HUMAN [view interactions] High throughput no yes
FHI1B_HUMAN [view interactions] High throughput no yes
FHI2A_HUMAN [view interactions] High throughput no yes
FHI2B_HUMAN [view interactions] High throughput no yes
PSA3_HUMAN [view interactions] High throughput no no
SIR7_HUMAN [view interactions] High throughput no yes
TS101_HUMAN [view entry] [view interactions] High throughput yes yes
PAF15_HUMAN [view interactions] High throughput no no
ADRB2_HUMAN [view entry] [view interactions] High throughput yes no
MDM2_HUMAN [view interactions] High throughput no yes
PPT1_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
MERL_HUMAN [view interactions] High throughput no yes
HCD2_HUMAN [view entry] [view interactions] High throughput yes yes
CISD3_HUMAN [view interactions] High throughput no yes
CDKN3_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
PARK7_HUMAN [view entry] [view interactions] High throughput yes yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
TF7L2_HUMAN [view interactions] High throughput no yes
U5S1_HUMAN [view interactions] High throughput no yes
HECD1_HUMAN [view interactions] High throughput no yes
UBR7_HUMAN [view interactions] High throughput no yes
UBE3A_HUMAN [view interactions] High throughput no yes
WWOX_HUMAN [view interactions] High throughput no yes
RECQ4_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
MYC_HUMAN [view interactions] High throughput no yes
K1C17_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
YAP1_HUMAN [view interactions] High throughput no yes
TIA1_HUMAN [view interactions] High throughput no no
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
BIRC3_HUMAN [view interactions] High throughput no no
FBXW8_HUMAN [view interactions] High throughput no yes
OBSL1_HUMAN [view interactions] High throughput no yes
CUL9_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
BACD3_HUMAN [view interactions] High throughput no yes
PINK1_HUMAN [view interactions] High throughput no yes
HPPD_HUMAN [view interactions] High throughput no no
EMC4_HUMAN [view interactions] High throughput no yes
RHG39_HUMAN [view entry] [view interactions] High throughput yes no
SYDE2_HUMAN [view interactions] High throughput no no
ANLN_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
KIF23_HUMAN [view interactions] High throughput no yes
BRD2_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
RBM39_HUMAN [view interactions] High throughput no yes
IF16_HUMAN [view interactions] High throughput no no
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes
UBP15_HUMAN [view entry] [view interactions] High throughput yes yes
PAGE4_HUMAN [view interactions] High throughput no no
MIF_HUMAN [view entry] [view interactions] High throughput yes yes
TMPS2_HUMAN [view interactions] High throughput no no
TOP3B_HUMAN [view interactions] High throughput no no
CATL1_HUMAN [view interactions] High throughput no yes
IFM1_HUMAN [view interactions] High throughput no no
DPP4_HUMAN [view interactions] High throughput no no
IFM3_HUMAN [view interactions] High throughput no yes
TM11B_HUMAN [view interactions] High throughput no no
CLC4D_HUMAN [view interactions] High throughput no no
CLC4E_HUMAN [view interactions] High throughput no no
DVL2_HUMAN [view interactions] High throughput no yes
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
CLU_HUMAN [view interactions] High throughput no yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
CLIP1_HUMAN [view entry] [view interactions] High throughput yes yes
FKBP5_HUMAN [view interactions] High throughput no yes
HEAT3_HUMAN [view interactions] High throughput no yes
CSK_HUMAN [view interactions] High throughput no yes
LDLR_HUMAN [view interactions] High throughput no yes
SPRNG_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
ODPA_HUMAN [view entry] [view interactions] High throughput yes yes
ODO1_HUMAN [view entry] [view interactions] High throughput yes yes
ODPAT_HUMAN [view interactions] High throughput no no
RM01_HUMAN [view interactions] High throughput no yes
NDUS4_HUMAN [view interactions] High throughput no yes
EMC5_HUMAN [view interactions] High throughput no yes
HNRPQ_HUMAN [view entry] [view interactions] High throughput yes yes
HS71L_HUMAN [view entry] [view interactions] High throughput yes no
ACAD9_HUMAN [view interactions] High throughput no yes
COX5B_HUMAN [view entry] [view interactions] High throughput yes yes
CISY_HUMAN [view entry] [view interactions] High throughput yes yes
CY1_HUMAN [view entry] [view interactions] High throughput yes yes
AT1B1_HUMAN [view entry] [view interactions] High throughput yes no
SDHB_HUMAN [view interactions] High throughput no yes
LMAN1_HUMAN [view interactions] High throughput no yes
NDUS2_HUMAN [view entry] [view interactions] High throughput yes yes
MIC19_HUMAN [view entry] [view interactions] High throughput yes yes
A16A1_HUMAN [view entry] [view interactions] High throughput yes no
COR1B_HUMAN [view entry] [view interactions] High throughput yes no
COR1C_HUMAN [view entry] [view interactions] High throughput yes yes
DHX9_HUMAN [view interactions] High throughput no yes
DHB4_HUMAN [view entry] [view interactions] High throughput yes yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
ILF3_HUMAN [view interactions] High throughput no yes
SYK_HUMAN [view interactions] High throughput no yes
SYLC_HUMAN [view interactions] High throughput no yes
LPPRC_HUMAN [view entry] [view interactions] High throughput yes yes
SYPM_HUMAN [view interactions] High throughput no yes
SYRC_HUMAN [view interactions] High throughput no yes
SND1_HUMAN [view entry] [view interactions] High throughput yes yes
EFTS_HUMAN [view interactions] High throughput no no
XRCC6_HUMAN [view interactions] High throughput no yes
SYEP_HUMAN [view interactions] High throughput no yes
COX41_HUMAN [view entry] [view interactions] High throughput yes yes
MDHM_HUMAN [view entry] [view interactions] High throughput yes yes
ETFD_HUMAN [view entry] [view interactions] High throughput yes yes
NDUB7_HUMAN [view entry] [view interactions] High throughput yes yes
NDUV1_HUMAN [view entry] [view interactions] High throughput yes yes
ACON_HUMAN [view entry] [view interactions] High throughput yes yes
ATPD_HUMAN [view interactions] High throughput no yes
AT5L2_HUMAN [view interactions] High throughput no no
ATP5L_HUMAN [view interactions] High throughput no yes
ATPA_HUMAN [view interactions] High throughput no yes
ATP5I_HUMAN [view interactions] High throughput no yes
CYC_HUMAN [view entry] [view interactions] High throughput yes yes
GPDM_HUMAN [view entry] [view interactions] High throughput yes yes
IDH3G_HUMAN [view entry] [view interactions] High throughput yes yes
IDH3A_HUMAN [view entry] [view interactions] High throughput yes yes
NDUAA_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA5_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA8_HUMAN [view entry] [view interactions] High throughput yes yes
NDUBA_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS3_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS7_HUMAN [view entry] [view interactions] High throughput yes no
NDUV2_HUMAN [view entry] [view interactions] High throughput yes yes
SDHA_HUMAN [view interactions] High throughput no yes
SUCB1_HUMAN [view entry] [view interactions] High throughput yes yes
QCR1_HUMAN [view entry] [view interactions] High throughput yes yes
QCR2_HUMAN [view entry] [view interactions] High throughput yes yes
UCRI_HUMAN [view entry] [view interactions] High throughput yes yes
MIC26_HUMAN [view entry] [view interactions] High throughput yes yes
COX5A_HUMAN [view entry] [view interactions] High throughput yes yes
NDUAC_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS1_HUMAN [view entry] [view interactions] High throughput yes no
SDHF3_HUMAN [view interactions] High throughput no yes
SUCA_HUMAN [view entry] [view interactions] High throughput yes yes
MRM1_HUMAN [view interactions] High throughput no no
KS6A6_HUMAN [view interactions] High throughput no yes
AUHM_HUMAN [view entry] [view interactions] High throughput yes yes
MTRFR_HUMAN [view interactions] High throughput no yes
CQ080_HUMAN [view interactions] High throughput no yes
GAL3A_HUMAN [view interactions] High throughput no yes
GAL3B_HUMAN [view interactions] High throughput no yes
MRES1_HUMAN [view interactions] High throughput no yes
MCUR1_HUMAN [view interactions] High throughput no no
CHCH1_HUMAN [view interactions] High throughput no yes
COX15_HUMAN [view interactions] High throughput no yes
QOR_HUMAN [view entry] [view interactions] High throughput yes yes
FAKD5_HUMAN [view interactions] High throughput no yes
EFGM_HUMAN [view interactions] High throughput no yes
HINT2_HUMAN [view interactions] High throughput no yes
ICT1_HUMAN [view interactions] High throughput no yes
MCUB_HUMAN [view interactions] High throughput no no
MET15_HUMAN [view interactions] High throughput no no
MET17_HUMAN [view interactions] High throughput no yes
RM11_HUMAN [view interactions] High throughput no yes
RT12_HUMAN [view interactions] High throughput no yes
RT26_HUMAN [view interactions] High throughput no yes
RRFM_HUMAN [view interactions] High throughput no yes
MTG1_HUMAN [view interactions] High throughput no yes
MTG2_HUMAN [view interactions] High throughput no yes
IF2M_HUMAN [view interactions] High throughput no yes
IF3M_HUMAN [view interactions] High throughput no yes
RF1M_HUMAN [view interactions] High throughput no yes
RF1ML_HUMAN [view interactions] High throughput no yes
NGRN_HUMAN [view interactions] High throughput no yes
OTC_HUMAN [view interactions] High throughput no no
MPPA_HUMAN [view interactions] High throughput no yes
MPPB_HUMAN [view interactions] High throughput no yes
RUSD3_HUMAN [view interactions] High throughput no yes
RUSD4_HUMAN [view interactions] High throughput no yes
SLIRP_HUMAN [view interactions] High throughput no yes
SSBP_HUMAN [view entry] [view interactions] High throughput yes yes
SURF1_HUMAN [view interactions] High throughput no yes
TACO1_HUMAN [view interactions] High throughput no yes
FAKD4_HUMAN [view interactions] High throughput no yes
TIM29_HUMAN [view interactions] High throughput no no
TRUB2_HUMAN [view interactions] High throughput no yes
EFTU_HUMAN [view entry] [view interactions] High throughput yes yes
VWA8_HUMAN [view interactions] High throughput no yes
EXD2_HUMAN [view interactions] High throughput no yes
LEG9_HUMAN [view interactions] High throughput no yes
DJC15_HUMAN [view interactions] High throughput no no
DNJC4_HUMAN [view interactions] High throughput no yes
HSC20_HUMAN [view interactions] High throughput no yes
GRP75_HUMAN [view entry] [view interactions] High throughput yes yes
DJC28_HUMAN [view interactions] High throughput no yes
DJC21_HUMAN [view interactions] High throughput no yes
SYAM_HUMAN [view interactions] High throughput no yes
COX8A_HUMAN [view interactions] High throughput no yes
BROMI_HUMAN [view interactions] High throughput no no
ACE2_HUMAN [view interactions] High throughput no no
HMGB1_HUMAN [view interactions] High throughput no yes
GLUT4_HUMAN [view interactions] High throughput no no
MLP3A_HUMAN [view entry] [view interactions] High throughput yes yes
MLP3B_HUMAN [view interactions] High throughput no yes
GBRL1_HUMAN [view interactions] High throughput no yes
HDAC6_HUMAN [view interactions] High throughput no yes
STA5B_HUMAN [view interactions] High throughput no yes
STA5A_HUMAN [view interactions] High throughput no no
FOXD4_HUMAN [view interactions] High throughput no no
DLDH_HUMAN [view entry] [view interactions] High throughput yes yes
KI67_HUMAN [view interactions] High throughput no no
ABHDB_HUMAN [view interactions] High throughput no yes
DOCK6_HUMAN [view interactions] High throughput no yes
ARHGG_HUMAN [view interactions] High throughput no yes
RHG23_HUMAN [view entry] [view interactions] High throughput yes yes
PKHG7_HUMAN [view interactions] High throughput no no
ODO2_HUMAN [view entry] [view interactions] High throughput yes yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
TGON2_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
TAL1_HUMAN [view interactions] High throughput no no
ANXA1_HUMAN [view entry] [view interactions] High throughput yes no
PDK4_HUMAN [view interactions] Computational no yes
ECHB_HUMAN [view entry] [view interactions] Computational yes yes
RXRA_HUMAN [view interactions] Computational no yes
ODBB_HUMAN [view interactions] Computational no yes
GCSH_HUMAN [view interactions] Computational no yes
PPARD_HUMAN [view interactions] Computational no yes
HMCS1_HUMAN [view interactions] Computational no yes
DHTK1_HUMAN [view interactions] Computational no no
PCKGC_HUMAN [view interactions] Computational no no
HMGCL_HUMAN [view interactions] Computational no yes
PDP1_HUMAN [view interactions] Computational no yes
MUTA_HUMAN [view interactions] Computational no yes
ACS2L_HUMAN [view interactions] Computational no yes
PCKGM_HUMAN [view interactions] Computational no no
ACACB_HUMAN [view interactions] Computational no no
PDPR_HUMAN [view interactions] Computational no yes
MMSA_HUMAN [view entry] [view interactions] Computational yes no
LIPT_HUMAN [view interactions] Computational no no
THIC_HUMAN [view interactions] Computational no yes
SUCB2_HUMAN [view interactions] Computational no no
LIPT2_HUMAN [view interactions] Computational no yes
ACSA_HUMAN [view interactions] Computational no no
PDP2_HUMAN [view interactions] Computational no yes
ODBA_HUMAN [view interactions] Computational no yes
OGDHL_HUMAN [view entry] [view interactions] Computational yes yes
ACACA_HUMAN [view entry] [view interactions] Computational yes yes
HMGC2_HUMAN [view interactions] Computational no no
FAS_HUMAN [view entry] [view interactions] Computational yes no
THIK_HUMAN [view entry] [view interactions] Computational yes yes
HMCS2_HUMAN [view interactions] Computational no no
THIM_HUMAN [view interactions] Computational no yes
ACLY_HUMAN [view entry] [view interactions] Computational yes yes
THIL_HUMAN [view entry] [view interactions] Computational yes yes
PYC_HUMAN [view entry] [view interactions] Computational yes yes
DCMC_HUMAN [view interactions] Computational no no
ACO12_HUMAN [view interactions] Computational no no