IDH3G_HUMAN
Evidence for PS localization
Functions
Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in IDH3G_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 37.0370 | 4 | yes |
| GO:0015399 | primary active transmembrane transporter activity | 31.4815 | 4 | no |
| GO:0015453 | oxidoreduction-driven active transmembrane transporter activity | 27.7778 | 5 | no |
| GO:0003954 | NADH dehydrogenase activity | 22.2222 | 4 | no |
| GO:0003955 | NAD(P)H dehydrogenase (quinone) activity | 22.2222 | 5 | no |
| GO:0008137 | NADH dehydrogenase (ubiquinone) activity | 22.2222 | 4 | no |
| GO:0016655 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | 22.2222 | 4 | no |
| GO:0050136 | NADH dehydrogenase (quinone) activity | 22.2222 | 5 | no |
| GO:0017076 | purine nucleotide binding | 12.9630 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 12.9630 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 12.9630 | 4 | yes |
| GO:0051287 | NAD binding | 12.9630 | 4 | yes |
| GO:0005524 | ATP binding | 11.1111 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 11.1111 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 11.1111 | 5 | yes |
| GO:0000287 | magnesium ion binding | 9.2593 | 5 | yes |
| GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | 9.2593 | 4 | yes |
| GO:0004448 | isocitrate dehydrogenase [NAD(P)+] activity | 7.4074 | 5 | yes |
| GO:0004449 | isocitrate dehydrogenase (NAD+) activity | 5.5556 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in IDH3G_HUMAN |
|---|---|---|---|---|
| GO:0019752 | carboxylic acid metabolic process | 35.1852 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 35.1852 | 4 | yes |
| GO:0015980 | energy derivation by oxidation of organic compounds | 35.1852 | 4 | no |
| GO:0009060 | aerobic respiration | 33.3333 | 6 | no |
| GO:0045333 | cellular respiration | 33.3333 | 5 | no |
| GO:0022607 | cellular component assembly | 29.6296 | 4 | no |
| GO:0019646 | aerobic electron transport chain | 29.6296 | 6 | no |
| GO:0022900 | electron transport chain | 29.6296 | 4 | no |
| GO:0022904 | respiratory electron transport chain | 29.6296 | 5 | no |
| GO:0048522 | positive regulation of cellular process | 24.0741 | 4 | no |
| GO:0043933 | protein-containing complex organization | 24.0741 | 4 | no |
| GO:0006120 | mitochondrial electron transport, NADH to ubiquinone | 24.0741 | 7 | no |
| GO:0031323 | regulation of cellular metabolic process | 22.2222 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 22.2222 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 22.2222 | 4 | no |
| GO:0006753 | nucleoside phosphate metabolic process | 20.3704 | 4 | no |
| GO:0009117 | nucleotide metabolic process | 20.3704 | 5 | no |
| GO:0072350 | tricarboxylic acid metabolic process | 12.9630 | 6 | yes |
| GO:0006102 | isocitrate metabolic process | 9.2593 | 5 | yes |
| GO:1902652 | secondary alcohol metabolic process | 9.2593 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in IDH3G_HUMAN |
|---|---|---|---|---|
| DOID:0050155 | sensory system disease | 5.5556 | 3 | no |
| DOID:10584 | retinitis pigmentosa | 3.7037 | 7 | no |
| DOID:5614 | eye disease | 3.7037 | 4 | no |
| DOID:8466 | retinal degeneration | 3.7037 | 6 | no |
| DOID:9799 | eye degenerative disease | 3.7037 | 5 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| IDH3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IDH3B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DMXL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCNQ1_HUMAN | [view interactions] | High throughput | no | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| OSMR_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| CIAO1_HUMAN | [view interactions] | High throughput | no | yes |
| P5F1B_HUMAN | [view interactions] | High throughput | no | no |
| PO5F1_HUMAN | [view interactions] | High throughput | no | yes |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BCOR_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| MASU1_HUMAN | [view interactions] | High throughput | no | yes |
| PTH2R_HUMAN | [view interactions] | High throughput | no | no |
| RL35A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
| BPNT1_HUMAN | [view interactions] | High throughput | no | yes |
| PAIRB_HUMAN | [view interactions] | High throughput | no | yes |
| SYYM_HUMAN | [view interactions] | High throughput | no | no |
| FAHD1_HUMAN | [view interactions] | High throughput | no | yes |
| RT07_HUMAN | [view interactions] | High throughput | no | yes |
| ICE2_HUMAN | [view interactions] | High throughput | no | no |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| ZFYV1_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| ERCC6_HUMAN | [view interactions] | High throughput | no | no |
| HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDV3_HUMAN | [view interactions] | High throughput | no | no |
| SBDS_HUMAN | [view interactions] | High throughput | no | yes |
| SUGP1_HUMAN | [view interactions] | High throughput | no | yes |
| MYPT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIM44_HUMAN | [view interactions] | High throughput | no | yes |
| RAB8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SCP2_HUMAN | [view interactions] | High throughput | no | no |
| PQBP1_HUMAN | [view interactions] | High throughput | no | yes |
| SPRE_HUMAN | [view interactions] | High throughput | no | yes |
| ADAS_HUMAN | [view interactions] | High throughput | no | yes |
| EDF1_HUMAN | [view interactions] | High throughput | no | yes |
| ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IDHC_HUMAN | [view interactions] | High throughput | no | no |
| AHSA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IDHP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PFKAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPG_HUMAN | [view interactions] | High throughput | no | yes |
| AT5L2_HUMAN | [view interactions] | High throughput | no | no |
| ATP5L_HUMAN | [view interactions] | High throughput | no | yes |
| CISD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA6_HUMAN | [view interactions] | High throughput | no | no |
| NDUA7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUB7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDUS2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDHB_HUMAN | [view interactions] | High throughput | no | yes |
| SUCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPA_HUMAN | [view interactions] | High throughput | no | yes |
| ATPB_HUMAN | [view interactions] | High throughput | no | yes |
| AATM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACPM_HUMAN | [view interactions] | High throughput | no | yes |
| ODPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDHA_HUMAN | [view interactions] | High throughput | no | yes |
| SDHF3_HUMAN | [view interactions] | High throughput | no | yes |
| QCR6L_HUMAN | [view interactions] | High throughput | no | yes |
| QCR6_HUMAN | [view interactions] | High throughput | no | yes |
| TOM6_HUMAN | [view interactions] | Computational | no | yes |
| TIM22_HUMAN | [view interactions] | Computational | no | no |
| TOM7_HUMAN | [view interactions] | Computational | no | no |
| ALAT2_HUMAN | [view interactions] | Computational | no | yes |
| OGDHL_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ADT1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NIT2_HUMAN | [view interactions] | Computational | no | yes |
| ARLY_HUMAN | [view interactions] | Computational | no | no |
| DHE3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DHE4_HUMAN | [view interactions] | Computational | no | yes |
| ODO1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| BCS1_HUMAN | [view interactions] | Computational | no | yes |
| TOM40_HUMAN | [view interactions] | Computational | no | yes |
| PUR8_HUMAN | [view interactions] | Computational | no | yes |
| AATC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TOM20_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| OXLA_HUMAN | [view interactions] | Computational | no | no |
| MDHM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ALAT1_HUMAN | [view interactions] | Computational | no | no |
| TOM5_HUMAN | [view interactions] | Computational | no | yes |
| AATC2_HUMAN | [view interactions] | Computational | no | no |
| GRP75_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RIMKB_HUMAN | [view interactions] | Computational | no | no |
| SSDH_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TOM70_HUMAN | [view interactions] | Computational | no | yes |
| AT5G1_HUMAN | [view interactions] | Computational | no | no |
| MPPB_HUMAN | [view interactions] | Computational | no | yes |
| ACOHC_HUMAN | [view interactions] | Computational | no | yes |
| TOM22_HUMAN | [view interactions] | Computational | no | yes |