IDH3G_HUMAN
Evidence for PS localization
Functions
Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in IDH3G_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 44.8980 | 4 | yes |
| GO:0046872 | metal ion binding | 42.8571 | 5 | yes |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 32.6531 | 4 | no |
| GO:0015399 | primary active transmembrane transporter activity | 32.6531 | 4 | no |
| GO:0022853 | active monoatomic ion transmembrane transporter activity | 32.6531 | 4 | no |
| GO:0022890 | inorganic cation transmembrane transporter activity | 32.6531 | 4 | no |
| GO:0000166 | nucleotide binding | 30.6122 | 4 | yes |
| GO:0015078 | proton transmembrane transporter activity | 30.6122 | 5 | no |
| GO:0015453 | oxidoreduction-driven active transmembrane transporter activity | 30.6122 | 5 | no |
| GO:0017076 | purine nucleotide binding | 26.5306 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 24.4898 | 6 | yes |
| GO:0043168 | anion binding | 24.4898 | 4 | yes |
| GO:0016655 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | 24.4898 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 16.3265 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 16.3265 | 4 | yes |
| GO:0005524 | ATP binding | 14.2857 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 14.2857 | 5 | yes |
| GO:0051287 | NAD binding | 14.2857 | 7 | yes |
| GO:0000287 | magnesium ion binding | 12.2449 | 6 | yes |
| GO:0004448 | isocitrate dehydrogenase [NAD(P)+] activity | 10.2041 | 5 | yes |
| GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | 10.2041 | 4 | yes |
| GO:0004449 | isocitrate dehydrogenase (NAD+) activity | 8.1633 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in IDH3G_HUMAN |
|---|---|---|---|---|
| GO:0006796 | phosphate-containing compound metabolic process | 46.9388 | 4 | no |
| GO:0006163 | purine nucleotide metabolic process | 40.8163 | 5 | no |
| GO:0006753 | nucleoside phosphate metabolic process | 40.8163 | 4 | no |
| GO:0009117 | nucleotide metabolic process | 40.8163 | 5 | no |
| GO:0072521 | purine-containing compound metabolic process | 40.8163 | 4 | no |
| GO:0009150 | purine ribonucleotide metabolic process | 38.7755 | 6 | no |
| GO:0009259 | ribonucleotide metabolic process | 38.7755 | 5 | no |
| GO:0019693 | ribose phosphate metabolic process | 38.7755 | 4 | no |
| GO:0015980 | energy derivation by oxidation of organic compounds | 36.7347 | 4 | no |
| GO:1901362 | organic cyclic compound biosynthetic process | 36.7347 | 4 | no |
| GO:1901566 | organonitrogen compound biosynthetic process | 36.7347 | 4 | no |
| GO:0009060 | aerobic respiration | 34.6939 | 6 | no |
| GO:0019646 | aerobic electron transport chain | 34.6939 | 6 | no |
| GO:0022900 | electron transport chain | 34.6939 | 4 | no |
| GO:0022904 | respiratory electron transport chain | 34.6939 | 5 | no |
| GO:0045333 | cellular respiration | 34.6939 | 5 | no |
| GO:0034654 | nucleobase-containing compound biosynthetic process | 34.6939 | 4 | no |
| GO:0022607 | cellular component assembly | 32.6531 | 4 | no |
| GO:0019752 | carboxylic acid metabolic process | 30.6122 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 30.6122 | 4 | yes |
| GO:0006164 | purine nucleotide biosynthetic process | 30.6122 | 6 | no |
| GO:0009152 | purine ribonucleotide biosynthetic process | 30.6122 | 7 | no |
| GO:0009165 | nucleotide biosynthetic process | 30.6122 | 6 | no |
| GO:0009260 | ribonucleotide biosynthetic process | 30.6122 | 6 | no |
| GO:0046390 | ribose phosphate biosynthetic process | 30.6122 | 5 | no |
| GO:0072522 | purine-containing compound biosynthetic process | 30.6122 | 5 | no |
| GO:0090407 | organophosphate biosynthetic process | 30.6122 | 4 | no |
| GO:1901137 | carbohydrate derivative biosynthetic process | 30.6122 | 4 | no |
| GO:1901293 | nucleoside phosphate biosynthetic process | 30.6122 | 5 | no |
| GO:0043933 | protein-containing complex organization | 28.5714 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 28.5714 | 4 | no |
| GO:0009205 | purine ribonucleoside triphosphate metabolic process | 26.5306 | 7 | no |
| GO:0046034 | ATP metabolic process | 26.5306 | 7 | no |
| GO:0065003 | protein-containing complex assembly | 26.5306 | 5 | no |
| GO:0048522 | positive regulation of cellular process | 26.5306 | 4 | no |
| GO:0006120 | mitochondrial electron transport, NADH to ubiquinone | 26.5306 | 7 | no |
| GO:0009141 | nucleoside triphosphate metabolic process | 26.5306 | 5 | no |
| GO:0009144 | purine nucleoside triphosphate metabolic process | 26.5306 | 6 | no |
| GO:0009199 | ribonucleoside triphosphate metabolic process | 26.5306 | 6 | no |
| GO:0009206 | purine ribonucleoside triphosphate biosynthetic process | 22.4490 | 8 | no |
| GO:0015986 | proton motive force-driven ATP synthesis | 22.4490 | 9 | no |
| GO:0042776 | proton motive force-driven mitochondrial ATP synthesis | 22.4490 | 10 | no |
| GO:0010646 | regulation of cell communication | 22.4490 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 22.4490 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 22.4490 | 4 | no |
| GO:0006754 | ATP biosynthetic process | 22.4490 | 8 | no |
| GO:0009142 | nucleoside triphosphate biosynthetic process | 22.4490 | 6 | no |
| GO:0009145 | purine nucleoside triphosphate biosynthetic process | 22.4490 | 7 | no |
| GO:0009201 | ribonucleoside triphosphate biosynthetic process | 22.4490 | 7 | no |
| GO:0072350 | tricarboxylic acid metabolic process | 14.2857 | 6 | yes |
| GO:0006102 | isocitrate metabolic process | 12.2449 | 5 | yes |
| GO:1902652 | secondary alcohol metabolic process | 12.2449 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| IDH3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IDH3B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IDH3G_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DMXL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCNQ1_HUMAN | [view interactions] | High throughput | no | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| OSMR_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| CIAO1_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| P5F1B_HUMAN | [view interactions] | High throughput | no | no |
| PO5F1_HUMAN | [view interactions] | High throughput | no | yes |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BCOR_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| MASU1_HUMAN | [view interactions] | High throughput | no | yes |
| PTH2R_HUMAN | [view interactions] | High throughput | no | no |
| RL35A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
| BPNT1_HUMAN | [view interactions] | High throughput | no | yes |
| SERB1_HUMAN | [view interactions] | High throughput | no | yes |
| SYYM_HUMAN | [view interactions] | High throughput | no | no |
| FAHD1_HUMAN | [view interactions] | High throughput | no | yes |
| RT07_HUMAN | [view interactions] | High throughput | no | yes |
| ICE2_HUMAN | [view interactions] | High throughput | no | no |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| ZFYV1_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| KPCD1_HUMAN | [view interactions] | High throughput | no | yes |
| KPCD2_HUMAN | [view interactions] | High throughput | no | yes |
| KPCD3_HUMAN | [view interactions] | High throughput | no | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| CL16A_HUMAN | [view interactions] | High throughput | no | yes |
| ERCC6_HUMAN | [view interactions] | High throughput | no | no |
| HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDV3_HUMAN | [view interactions] | High throughput | no | no |
| SBDS_HUMAN | [view interactions] | High throughput | no | yes |
| SUGP1_HUMAN | [view interactions] | High throughput | no | yes |
| MYPT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIM44_HUMAN | [view interactions] | High throughput | no | yes |
| RAB8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SCP2_HUMAN | [view interactions] | High throughput | no | no |
| PQBP1_HUMAN | [view interactions] | High throughput | no | yes |
| SPRE_HUMAN | [view interactions] | High throughput | no | yes |
| ADAS_HUMAN | [view interactions] | High throughput | no | yes |
| EDF1_HUMAN | [view interactions] | High throughput | no | yes |
| ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IDHC_HUMAN | [view interactions] | High throughput | no | no |
| AHSA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IDHP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PFKAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPG_HUMAN | [view interactions] | High throughput | no | yes |
| AT5L2_HUMAN | [view interactions] | High throughput | no | no |
| ATP5L_HUMAN | [view interactions] | High throughput | no | yes |
| CISD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA6_HUMAN | [view interactions] | High throughput | no | no |
| NDUA7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUB7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDUS2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDHB_HUMAN | [view interactions] | High throughput | no | yes |
| SUCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPA_HUMAN | [view interactions] | High throughput | no | yes |
| ATPB_HUMAN | [view interactions] | High throughput | no | yes |
| AATM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACPM_HUMAN | [view interactions] | High throughput | no | yes |
| ODPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDHA_HUMAN | [view interactions] | High throughput | no | yes |
| SDHF3_HUMAN | [view interactions] | High throughput | no | yes |
| QCR6L_HUMAN | [view interactions] | High throughput | no | yes |
| QCR6_HUMAN | [view interactions] | High throughput | no | yes |
| BCKD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |