DMXL2_HUMAN
Evidence for PS localization
Functions
May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles (PubMed). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 2417 | Arg | His | Deafness,autosomaldominant,71(DFNA71) | - |
| 1712 | Ala | Val | Developmentalandepilepticencephalopathy81(DEE81) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DMXL2_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 40.6250 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 40.6250 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 40.6250 | 4 | no |
| GO:0005524 | ATP binding | 25.0000 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 25.0000 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 25.0000 | 5 | no |
| GO:0015399 | primary active transmembrane transporter activity | 21.8750 | 4 | no |
| GO:0046872 | metal ion binding | 21.8750 | 4 | no |
| GO:0031267 | small GTPase binding | 15.6250 | 5 | yes |
| GO:0051020 | GTPase binding | 15.6250 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DMXL2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 43.7500 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 40.6250 | 4 | no |
| GO:0009894 | regulation of catabolic process | 37.5000 | 4 | no |
| GO:0010646 | regulation of cell communication | 37.5000 | 4 | no |
| GO:0051049 | regulation of transport | 34.3750 | 4 | no |
| GO:0031329 | regulation of cellular catabolic process | 31.2500 | 5 | no |
| GO:0008104 | protein localization | 31.2500 | 4 | no |
| GO:0010506 | regulation of autophagy | 28.1250 | 6 | no |
| GO:0016241 | regulation of macroautophagy | 28.1250 | 7 | no |
| GO:0009893 | positive regulation of metabolic process | 28.1250 | 4 | no |
| GO:0006996 | organelle organization | 28.1250 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 25.0000 | 5 | no |
| GO:0022607 | cellular component assembly | 25.0000 | 4 | no |
| GO:0023056 | positive regulation of signaling | 25.0000 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 25.0000 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 25.0000 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 25.0000 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 25.0000 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 25.0000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 25.0000 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 25.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 25.0000 | 4 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 25.0000 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 25.0000 | 6 | no |
| GO:0033043 | regulation of organelle organization | 25.0000 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 25.0000 | 4 | no |
| GO:0006873 | cellular ion homeostasis | 21.8750 | 4 | yes |
| GO:0030003 | cellular cation homeostasis | 21.8750 | 5 | yes |
| GO:0048878 | chemical homeostasis | 21.8750 | 4 | yes |
| GO:0050801 | ion homeostasis | 21.8750 | 5 | yes |
| GO:0055080 | cation homeostasis | 21.8750 | 6 | yes |
| GO:0098771 | inorganic ion homeostasis | 21.8750 | 6 | yes |
| GO:0009966 | regulation of signal transduction | 21.8750 | 4 | no |
| GO:0030030 | cell projection organization | 21.8750 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 21.8750 | 6 | no |
| GO:0051046 | regulation of secretion | 21.8750 | 5 | no |
| GO:1903530 | regulation of secretion by cell | 21.8750 | 4 | no |
| GO:0006885 | regulation of pH | 9.3750 | 8 | yes |
| GO:0030004 | cellular monovalent inorganic cation homeostasis | 9.3750 | 6 | yes |
| GO:0030641 | regulation of cellular pH | 9.3750 | 7 | yes |
| GO:0051452 | intracellular pH reduction | 9.3750 | 9 | yes |
| GO:0051453 | regulation of intracellular pH | 9.3750 | 8 | yes |
| GO:0055067 | monovalent inorganic cation homeostasis | 9.3750 | 7 | yes |
| GO:0007035 | vacuolar acidification | 6.2500 | 10 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| WDR7_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RB3GP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MTR1B_HUMAN | [view interactions] | High throughput | no | yes |
| NTAQ1_HUMAN | [view interactions] | High throughput | no | yes |
| ANTR1_HUMAN | [view interactions] | High throughput | no | no |
| NPY2R_HUMAN | [view interactions] | High throughput | no | no |
| YBEY_HUMAN | [view interactions] | High throughput | no | yes |
| C1QT2_HUMAN | [view interactions] | High throughput | no | yes |
| XRP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TSYL6_HUMAN | [view interactions] | High throughput | no | no |
| ROGDI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MATR3_HUMAN | [view interactions] | High throughput | no | yes |
| NCKP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYFP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PFKAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PFKAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IDH3G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB3D_HUMAN | [view interactions] | High throughput | no | yes |
| AKTIP_HUMAN | [view interactions] | High throughput | no | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| DEFI8_HUMAN | [view interactions] | High throughput | no | yes |
| ZUP1_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| NUDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| USB1_HUMAN | [view interactions] | High throughput | no | yes |
| VATG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRC25_HUMAN | [view interactions] | High throughput | no | yes |
| TPT1L_HUMAN | [view interactions] | High throughput | no | no |
| FPR1_HUMAN | [view interactions] | High throughput | no | no |
| VATG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLR_HUMAN | [view interactions] | High throughput | no | no |
| CBPC6_HUMAN | [view interactions] | High throughput | no | yes |
| VATB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AQP3_HUMAN | [view interactions] | High throughput | no | no |
| S22A4_HUMAN | [view interactions] | High throughput | no | yes |
| NK3R_HUMAN | [view interactions] | High throughput | no | no |
| CXCR4_HUMAN | [view interactions] | High throughput | no | no |
| OX2R_HUMAN | [view interactions] | High throughput | no | no |
| HCST_HUMAN | [view interactions] | High throughput | no | no |
| SPCS1_HUMAN | [view interactions] | High throughput | no | yes |
| ZHX1R_HUMAN | [view interactions] | High throughput | no | yes |
| EFNA4_HUMAN | [view interactions] | High throughput | no | no |
| H1BP3_HUMAN | [view interactions] | High throughput | no | yes |
| SLUR1_HUMAN | [view interactions] | High throughput | no | no |
| GPR45_HUMAN | [view interactions] | High throughput | no | no |
| VATE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATF_HUMAN | [view interactions] | High throughput | no | yes |
| VATH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC7_HUMAN | [view interactions] | High throughput | no | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBGPR_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MADD_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SKP1_HUMAN | [view interactions] | Computational | no | yes |