RB3GP_HUMAN
Evidence for PS localization
Functions
Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI003573 | TRG_ER_FFAT_1 | TRG | 583 | 591 | - |
| ELMI003573 | TRG_ER_FFAT_1 | TRG | 583 | 591 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RB3GP_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 23.9130 | 4 | no |
| GO:0046872 | metal ion binding | 23.9130 | 5 | no |
| GO:0000166 | nucleotide binding | 23.9130 | 4 | no |
| GO:0017076 | purine nucleotide binding | 23.9130 | 5 | no |
| GO:0043168 | anion binding | 23.9130 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 21.7391 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 21.7391 | 4 | no |
| GO:0031267 | small GTPase binding | 8.6957 | 5 | yes |
| GO:0051020 | GTPase binding | 8.6957 | 4 | yes |
| GO:0005096 | GTPase activator activity | 6.5217 | 4 | yes |
| GO:0030695 | GTPase regulator activity | 6.5217 | 4 | yes |
| GO:0005085 | guanyl-nucleotide exchange factor activity | 4.3478 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RB3GP_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | yes |
| GO:0006996 | organelle organization | 43.4783 | 4 | yes |
| GO:0008104 | protein localization | 41.3043 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 39.1304 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 36.9565 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 36.9565 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 36.9565 | 4 | yes |
| GO:0010646 | regulation of cell communication | 34.7826 | 4 | yes |
| GO:0071702 | organic substance transport | 34.7826 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 32.6087 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 32.6087 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 32.6087 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 30.4348 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 30.4348 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 30.4348 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 30.4348 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 28.2609 | 5 | yes |
| GO:0051130 | positive regulation of cellular component organization | 28.2609 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 28.2609 | 5 | yes |
| GO:0022607 | cellular component assembly | 28.2609 | 4 | no |
| GO:0071705 | nitrogen compound transport | 28.2609 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 28.2609 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 28.2609 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 28.2609 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.2609 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 26.0870 | 5 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 26.0870 | 6 | yes |
| GO:0009967 | positive regulation of signal transduction | 26.0870 | 5 | no |
| GO:0031399 | regulation of protein modification process | 23.9130 | 6 | yes |
| GO:0051049 | regulation of transport | 23.9130 | 4 | yes |
| GO:0015031 | protein transport | 23.9130 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 23.9130 | 5 | no |
| GO:0036211 | protein modification process | 23.9130 | 4 | no |
| GO:0043412 | macromolecule modification | 23.9130 | 4 | no |
| GO:0010468 | regulation of gene expression | 23.9130 | 6 | no |
| GO:0009894 | regulation of catabolic process | 21.7391 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 21.7391 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 21.7391 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 21.7391 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 21.7391 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 19.5652 | 5 | yes |
| GO:0031401 | positive regulation of protein modification process | 19.5652 | 7 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 19.5652 | 4 | yes |
| GO:0009896 | positive regulation of catabolic process | 17.3913 | 5 | yes |
| GO:0010638 | positive regulation of organelle organization | 17.3913 | 6 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 17.3913 | 6 | yes |
| GO:0043085 | positive regulation of catalytic activity | 17.3913 | 4 | yes |
| GO:0033365 | protein localization to organelle | 15.2174 | 5 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 15.2174 | 5 | yes |
| GO:0051050 | positive regulation of transport | 15.2174 | 4 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 15.2174 | 4 | yes |
| GO:0031329 | regulation of cellular catabolic process | 13.0435 | 5 | yes |
| GO:0051046 | regulation of secretion | 13.0435 | 5 | yes |
| GO:0051336 | regulation of hydrolase activity | 13.0435 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 13.0435 | 4 | yes |
| GO:1903530 | regulation of secretion by cell | 13.0435 | 4 | yes |
| GO:0010506 | regulation of autophagy | 10.8696 | 6 | yes |
| GO:0017157 | regulation of exocytosis | 10.8696 | 5 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 10.8696 | 5 | yes |
| GO:0051345 | positive regulation of hydrolase activity | 10.8696 | 5 | yes |
| GO:0031331 | positive regulation of cellular catabolic process | 8.6957 | 6 | yes |
| GO:0046928 | regulation of neurotransmitter secretion | 8.6957 | 5 | yes |
| GO:0051047 | positive regulation of secretion | 8.6957 | 5 | yes |
| GO:0051588 | regulation of neurotransmitter transport | 8.6957 | 5 | yes |
| GO:0072657 | protein localization to membrane | 8.6957 | 4 | yes |
| GO:0090150 | establishment of protein localization to membrane | 8.6957 | 4 | yes |
| GO:1902115 | regulation of organelle assembly | 8.6957 | 5 | yes |
| GO:1903305 | regulation of regulated secretory pathway | 8.6957 | 6 | yes |
| GO:1903532 | positive regulation of secretion by cell | 8.6957 | 5 | yes |
| GO:0001654 | eye development | 6.5217 | 5 | yes |
| GO:0007423 | sensory organ development | 6.5217 | 4 | yes |
| GO:0010508 | positive regulation of autophagy | 6.5217 | 7 | yes |
| GO:0044088 | regulation of vacuole organization | 6.5217 | 6 | yes |
| GO:0050806 | positive regulation of synaptic transmission | 6.5217 | 5 | yes |
| GO:0070972 | protein localization to endoplasmic reticulum | 6.5217 | 6 | yes |
| GO:0072594 | establishment of protein localization to organelle | 6.5217 | 4 | yes |
| GO:1902117 | positive regulation of organelle assembly | 6.5217 | 6 | yes |
| GO:2000300 | regulation of synaptic vesicle exocytosis | 6.5217 | 6 | yes |
| GO:2000785 | regulation of autophagosome assembly | 6.5217 | 6 | yes |
| GO:0007420 | brain development | 4.3478 | 4 | yes |
| GO:0016239 | positive regulation of macroautophagy | 4.3478 | 8 | yes |
| GO:0016241 | regulation of macroautophagy | 4.3478 | 7 | yes |
| GO:0032890 | regulation of organic acid transport | 4.3478 | 5 | yes |
| GO:0034389 | lipid droplet organization | 4.3478 | 5 | yes |
| GO:0043010 | camera-type eye development | 4.3478 | 6 | yes |
| GO:0043087 | regulation of GTPase activity | 4.3478 | 5 | yes |
| GO:0044090 | positive regulation of vacuole organization | 4.3478 | 7 | yes |
| GO:0048168 | regulation of neuronal synaptic plasticity | 4.3478 | 4 | yes |
| GO:0050746 | regulation of lipoprotein metabolic process | 4.3478 | 5 | yes |
| GO:0050747 | positive regulation of lipoprotein metabolic process | 4.3478 | 6 | yes |
| GO:0051590 | positive regulation of neurotransmitter transport | 4.3478 | 5 | yes |
| GO:0051952 | regulation of amine transport | 4.3478 | 5 | yes |
| GO:0051966 | regulation of synaptic transmission, glutamatergic | 4.3478 | 6 | yes |
| GO:0072599 | establishment of protein localization to endoplasmic reticulum | 4.3478 | 5 | yes |
| GO:0097051 | establishment of protein localization to endoplasmic reticulum membrane | 4.3478 | 5 | yes |
| GO:1903059 | regulation of protein lipidation | 4.3478 | 6 | yes |
| GO:1903061 | positive regulation of protein lipidation | 4.3478 | 7 | yes |
| GO:1903371 | regulation of endoplasmic reticulum tubular network organization | 4.3478 | 6 | yes |
| GO:1903373 | positive regulation of endoplasmic reticulum tubular network organization | 4.3478 | 7 | yes |
| GO:2000786 | positive regulation of autophagosome assembly | 4.3478 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| WDR7_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DMXL2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| E2F4_HUMAN | [view interactions] | Low throughput | no | no |
| RPH3L_HUMAN | [view interactions] | Low throughput | no | no |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC1_HUMAN | [view interactions] | High throughput | no | yes |
| DJC25_HUMAN | [view interactions] | High throughput | no | yes |
| SEC63_HUMAN | [view interactions] | High throughput | no | yes |
| AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP31_HUMAN | [view interactions] | High throughput | no | yes |
| CKAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DERL1_HUMAN | [view interactions] | High throughput | no | yes |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| ELOV5_HUMAN | [view interactions] | High throughput | no | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI2_HUMAN | [view interactions] | High throughput | no | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| GOGA1_HUMAN | [view interactions] | High throughput | no | yes |
| DHB11_HUMAN | [view interactions] | High throughput | no | yes |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| LNP_HUMAN | [view interactions] | High throughput | no | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMT1A_HUMAN | [view interactions] | High throughput | no | no |
| PXMP2_HUMAN | [view interactions] | High throughput | no | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| REEP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| SEC62_HUMAN | [view interactions] | High throughput | no | yes |
| SSRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STIM1_HUMAN | [view interactions] | High throughput | no | yes |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| TM11B_HUMAN | [view interactions] | High throughput | no | no |
| TMPS4_HUMAN | [view interactions] | High throughput | no | yes |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| DHCR7_HUMAN | [view interactions] | High throughput | no | yes |
| KCNQ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| KTI12_HUMAN | [view interactions] | High throughput | no | yes |
| COP1_HUMAN | [view interactions] | High throughput | no | no |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESYT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESYT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDZD8_HUMAN | [view interactions] | High throughput | no | yes |
| TEX2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| SCNAA_HUMAN | [view interactions] | High throughput | no | no |
| MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YJU2_HUMAN | [view interactions] | High throughput | no | yes |
| PAB4L_HUMAN | [view interactions] | High throughput | no | no |
| DEFM_HUMAN | [view interactions] | High throughput | no | yes |
| BT2A1_HUMAN | [view interactions] | High throughput | no | yes |
| CF141_HUMAN | [view interactions] | High throughput | no | no |
| VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCAT1_HUMAN | [view interactions] | High throughput | no | no |
| RCCD1_HUMAN | [view interactions] | High throughput | no | yes |
| LOX5_HUMAN | [view interactions] | High throughput | no | no |
| BRAF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MSPD2_HUMAN | [view interactions] | High throughput | no | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATG2A_HUMAN | [view interactions] | High throughput | no | yes |
| TP4A3_HUMAN | [view interactions] | High throughput | no | no |
| MAGA6_HUMAN | [view interactions] | High throughput | no | no |
| GSTK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADNP_HUMAN | [view interactions] | High throughput | no | yes |
| CHD8_HUMAN | [view interactions] | High throughput | no | no |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RXRB_HUMAN | [view interactions] | High throughput | no | yes |
| NPHP1_HUMAN | [view interactions] | High throughput | no | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| RET_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| FEZ1_HUMAN | [view interactions] | High throughput | no | no |
| FEZ2_HUMAN | [view interactions] | High throughput | no | yes |
| RB22A_HUMAN | [view interactions] | High throughput | no | yes |
| RB39A_HUMAN | [view interactions] | High throughput | no | no |
| RB39B_HUMAN | [view interactions] | High throughput | no | no |
| LMAN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAXI1_HUMAN | [view interactions] | High throughput | no | no |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBGPR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| SIR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCA15_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| RBG1L_HUMAN | [view interactions] | High throughput | no | yes |
| SRRT_HUMAN | [view interactions] | High throughput | no | yes |
| ZC3HE_HUMAN | [view interactions] | High throughput | no | yes |
| DOCK5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRS6B_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| TES_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| FLCN_HUMAN | [view interactions] | High throughput | no | yes |
| IF44L_HUMAN | [view interactions] | High throughput | no | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| TULP3_HUMAN | [view interactions] | High throughput | no | yes |
| COG7_HUMAN | [view interactions] | High throughput | no | yes |
| SRP14_HUMAN | [view interactions] | High throughput | no | no |
| REEP3_HUMAN | [view interactions] | High throughput | no | no |
| PK1L2_HUMAN | [view interactions] | High throughput | no | no |
| OC90_HUMAN | [view interactions] | High throughput | no | no |
| PER1_HUMAN | [view interactions] | High throughput | no | no |
| TGM2_HUMAN | [view interactions] | High throughput | no | no |
| PCY1A_HUMAN | [view interactions] | High throughput | no | yes |
| GLT12_HUMAN | [view interactions] | High throughput | no | yes |
| PRTN3_HUMAN | [view interactions] | High throughput | no | no |
| GMFB_HUMAN | [view interactions] | High throughput | no | yes |
| DUS16_HUMAN | [view interactions] | High throughput | no | yes |
| NK3R_HUMAN | [view interactions] | High throughput | no | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| COPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPE_HUMAN | [view interactions] | High throughput | no | yes |
| YIPF5_HUMAN | [view interactions] | High throughput | no | yes |
| IF2B3_HUMAN | [view interactions] | High throughput | no | no |
| TLS1_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| RICTR_HUMAN | [view interactions] | High throughput | no | yes |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GABPA_HUMAN | [view interactions] | High throughput | no | no |
| GLCNE_HUMAN | [view interactions] | High throughput | no | yes |
| NCOA7_HUMAN | [view interactions] | High throughput | no | yes |
| SEN34_HUMAN | [view interactions] | High throughput | no | yes |
| RU17_HUMAN | [view interactions] | High throughput | no | yes |
| MSH6_HUMAN | [view interactions] | High throughput | no | yes |
| TCP4_HUMAN | [view interactions] | High throughput | no | yes |
| PRP4B_HUMAN | [view interactions] | High throughput | no | yes |
| RBBP5_HUMAN | [view interactions] | High throughput | no | yes |
| PELO_HUMAN | [view interactions] | High throughput | no | yes |
| REN3B_HUMAN | [view interactions] | High throughput | no | yes |
| OTULL_HUMAN | [view interactions] | High throughput | no | no |
| ST7_HUMAN | [view interactions] | High throughput | no | yes |
| FIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FKBP8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
| PTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S2546_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |