RB3GP_HUMAN
Evidence for PS localization
Functions
Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI003573 | TRG_ER_FFAT_1 | TRG | 583 | 591 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RB3GP_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 27.2727 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 27.2727 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 27.2727 | 4 | no |
| GO:0030695 | GTPase regulator activity | 9.0909 | 4 | yes |
| GO:0031267 | small GTPase binding | 9.0909 | 5 | yes |
| GO:0051020 | GTPase binding | 9.0909 | 4 | yes |
| GO:0005096 | GTPase activator activity | 7.2727 | 4 | yes |
| GO:0005085 | guanyl-nucleotide exchange factor activity | 3.6364 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RB3GP_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 41.8182 | 4 | yes |
| GO:0006996 | organelle organization | 40.0000 | 4 | yes |
| GO:0008104 | protein localization | 38.1818 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 34.5455 | 4 | yes |
| GO:0071702 | organic substance transport | 32.7273 | 4 | no |
| GO:0071705 | nitrogen compound transport | 32.7273 | 4 | no |
| GO:0015031 | protein transport | 30.9091 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 30.9091 | 4 | no |
| GO:0022607 | cellular component assembly | 25.4545 | 4 | no |
| GO:0010646 | regulation of cell communication | 25.4545 | 4 | yes |
| GO:0006886 | intracellular protein transport | 23.6364 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 23.6364 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 23.6364 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 23.6364 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 21.8182 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 21.8182 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 21.8182 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 21.8182 | 5 | yes |
| GO:0051049 | regulation of transport | 21.8182 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 21.8182 | 5 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 21.8182 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 21.8182 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 20.0000 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 18.1818 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 16.3636 | 5 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 16.3636 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 14.5455 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 14.5455 | 5 | yes |
| GO:0051050 | positive regulation of transport | 14.5455 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 14.5455 | 5 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 12.7273 | 5 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 12.7273 | 6 | yes |
| GO:0033365 | protein localization to organelle | 12.7273 | 5 | yes |
| GO:0043085 | positive regulation of catalytic activity | 12.7273 | 4 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 12.7273 | 6 | yes |
| GO:0009894 | regulation of catabolic process | 10.9091 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 10.9091 | 5 | yes |
| GO:0010638 | positive regulation of organelle organization | 10.9091 | 6 | yes |
| GO:0031399 | regulation of protein modification process | 10.9091 | 6 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 10.9091 | 4 | yes |
| GO:1902115 | regulation of organelle assembly | 10.9091 | 5 | yes |
| GO:0009896 | positive regulation of catabolic process | 9.0909 | 5 | yes |
| GO:0031329 | regulation of cellular catabolic process | 9.0909 | 5 | yes |
| GO:0031331 | positive regulation of cellular catabolic process | 9.0909 | 6 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 9.0909 | 5 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 9.0909 | 5 | yes |
| GO:0051336 | regulation of hydrolase activity | 9.0909 | 4 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 9.0909 | 4 | yes |
| GO:0017157 | regulation of exocytosis | 7.2727 | 5 | yes |
| GO:0031401 | positive regulation of protein modification process | 7.2727 | 7 | yes |
| GO:0043269 | regulation of ion transport | 7.2727 | 5 | yes |
| GO:0051046 | regulation of secretion | 7.2727 | 5 | yes |
| GO:0051047 | positive regulation of secretion | 7.2727 | 5 | yes |
| GO:0051345 | positive regulation of hydrolase activity | 7.2727 | 5 | yes |
| GO:0072657 | protein localization to membrane | 7.2727 | 4 | yes |
| GO:1902117 | positive regulation of organelle assembly | 7.2727 | 6 | yes |
| GO:1903305 | regulation of regulated secretory pathway | 7.2727 | 6 | yes |
| GO:1903530 | regulation of secretion by cell | 7.2727 | 4 | yes |
| GO:1903532 | positive regulation of secretion by cell | 7.2727 | 5 | yes |
| GO:2000785 | regulation of autophagosome assembly | 5.4545 | 6 | yes |
| GO:0001654 | eye development | 5.4545 | 5 | yes |
| GO:0007423 | sensory organ development | 5.4545 | 4 | yes |
| GO:0010506 | regulation of autophagy | 5.4545 | 6 | yes |
| GO:0044088 | regulation of vacuole organization | 5.4545 | 6 | yes |
| GO:0046928 | regulation of neurotransmitter secretion | 5.4545 | 4 | yes |
| GO:0048168 | regulation of neuronal synaptic plasticity | 5.4545 | 4 | yes |
| GO:0051588 | regulation of neurotransmitter transport | 5.4545 | 5 | yes |
| GO:0070972 | protein localization to endoplasmic reticulum | 5.4545 | 6 | yes |
| GO:0072594 | establishment of protein localization to organelle | 5.4545 | 4 | yes |
| GO:0090150 | establishment of protein localization to membrane | 5.4545 | 4 | yes |
| GO:2000112 | regulation of cellular macromolecule biosynthetic process | 5.4545 | 6 | yes |
| GO:2000300 | regulation of synaptic vesicle exocytosis | 5.4545 | 5 | yes |
| GO:2000786 | positive regulation of autophagosome assembly | 3.6364 | 7 | yes |
| GO:0007420 | brain development | 3.6364 | 4 | yes |
| GO:0010508 | positive regulation of autophagy | 3.6364 | 7 | yes |
| GO:0016239 | positive regulation of macroautophagy | 3.6364 | 8 | yes |
| GO:0016241 | regulation of macroautophagy | 3.6364 | 7 | yes |
| GO:0032890 | regulation of organic acid transport | 3.6364 | 5 | yes |
| GO:0034389 | lipid droplet organization | 3.6364 | 5 | yes |
| GO:0043010 | camera-type eye development | 3.6364 | 6 | yes |
| GO:0043087 | regulation of GTPase activity | 3.6364 | 5 | yes |
| GO:0043270 | positive regulation of ion transport | 3.6364 | 5 | yes |
| GO:0044090 | positive regulation of vacuole organization | 3.6364 | 7 | yes |
| GO:0048172 | regulation of short-term neuronal synaptic plasticity | 3.6364 | 5 | yes |
| GO:0050746 | regulation of lipoprotein metabolic process | 3.6364 | 5 | yes |
| GO:0050747 | positive regulation of lipoprotein metabolic process | 3.6364 | 6 | yes |
| GO:0050806 | positive regulation of synaptic transmission | 3.6364 | 5 | yes |
| GO:0051952 | regulation of amine transport | 3.6364 | 5 | yes |
| GO:0051966 | regulation of synaptic transmission, glutamatergic | 3.6364 | 6 | yes |
| GO:0072599 | establishment of protein localization to endoplasmic reticulum | 3.6364 | 5 | yes |
| GO:0097051 | establishment of protein localization to endoplasmic reticulum membrane | 3.6364 | 5 | yes |
| GO:1903059 | regulation of protein lipidation | 3.6364 | 6 | yes |
| GO:1903061 | positive regulation of protein lipidation | 3.6364 | 7 | yes |
| GO:1903371 | regulation of endoplasmic reticulum tubular network organization | 3.6364 | 6 | yes |
| GO:1903373 | positive regulation of endoplasmic reticulum tubular network organization | 3.6364 | 7 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in RB3GP_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 3.6364 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| WDR7_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DMXL2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| E2F4_HUMAN | [view interactions] | Low throughput | no | no |
| RPH3L_HUMAN | [view interactions] | Low throughput | no | no |
| STIM1_HUMAN | [view interactions] | High throughput | no | yes |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| TM11B_HUMAN | [view interactions] | High throughput | no | no |
| TMPS4_HUMAN | [view interactions] | High throughput | no | yes |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| SCNAA_HUMAN | [view interactions] | High throughput | no | no |
| MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DEFM_HUMAN | [view interactions] | High throughput | no | yes |
| PAB4L_HUMAN | [view interactions] | High throughput | no | no |
| YJU2_HUMAN | [view interactions] | High throughput | no | yes |
| BT2A1_HUMAN | [view interactions] | High throughput | no | yes |
| CF141_HUMAN | [view interactions] | High throughput | no | no |
| VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCAT1_HUMAN | [view interactions] | High throughput | no | no |
| RCCD1_HUMAN | [view interactions] | High throughput | no | yes |
| LOX5_HUMAN | [view interactions] | High throughput | no | no |
| BRAF_HUMAN | [view interactions] | High throughput | no | yes |
| MSPD2_HUMAN | [view interactions] | High throughput | no | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATG2A_HUMAN | [view interactions] | High throughput | no | yes |
| TP4A3_HUMAN | [view interactions] | High throughput | no | no |
| MAGA6_HUMAN | [view interactions] | High throughput | no | no |
| GSTK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RXRB_HUMAN | [view interactions] | High throughput | no | yes |
| NPHP1_HUMAN | [view interactions] | High throughput | no | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| RET_HUMAN | [view interactions] | High throughput | no | yes |
| FEZ1_HUMAN | [view interactions] | High throughput | no | no |
| FEZ2_HUMAN | [view interactions] | High throughput | no | yes |
| RB22A_HUMAN | [view interactions] | High throughput | no | yes |
| RB39A_HUMAN | [view interactions] | High throughput | no | no |
| RB39B_HUMAN | [view interactions] | High throughput | no | no |
| LMAN1_HUMAN | [view interactions] | High throughput | no | yes |
| PAXI1_HUMAN | [view interactions] | High throughput | no | no |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBGPR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| SIR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCA15_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| RBG1L_HUMAN | [view interactions] | High throughput | no | yes |
| SRRT_HUMAN | [view interactions] | High throughput | no | yes |
| ZC3HE_HUMAN | [view interactions] | High throughput | no | yes |
| DOCK5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRS6B_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| TES_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| FLCN_HUMAN | [view interactions] | High throughput | no | yes |
| IF44L_HUMAN | [view interactions] | High throughput | no | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| TULP3_HUMAN | [view interactions] | High throughput | no | yes |
| COG7_HUMAN | [view interactions] | High throughput | no | yes |
| SRP14_HUMAN | [view interactions] | High throughput | no | no |
| REEP3_HUMAN | [view interactions] | High throughput | no | no |
| PK1L2_HUMAN | [view interactions] | High throughput | no | no |
| OC90_HUMAN | [view interactions] | High throughput | no | no |
| PER1_HUMAN | [view interactions] | High throughput | no | no |
| TGM2_HUMAN | [view interactions] | High throughput | no | no |
| PCY1A_HUMAN | [view interactions] | High throughput | no | yes |
| GLT12_HUMAN | [view interactions] | High throughput | no | yes |
| PRTN3_HUMAN | [view interactions] | High throughput | no | no |
| GMFB_HUMAN | [view interactions] | High throughput | no | yes |
| DUS16_HUMAN | [view interactions] | High throughput | no | yes |
| NK3R_HUMAN | [view interactions] | High throughput | no | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| COPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPE_HUMAN | [view interactions] | High throughput | no | yes |
| YIPF5_HUMAN | [view interactions] | High throughput | no | yes |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GABPA_HUMAN | [view interactions] | High throughput | no | no |
| GLCNE_HUMAN | [view interactions] | High throughput | no | yes |
| NCOA7_HUMAN | [view interactions] | High throughput | no | yes |
| SEN34_HUMAN | [view interactions] | High throughput | no | yes |
| OTULL_HUMAN | [view interactions] | High throughput | no | no |
| ST7_HUMAN | [view interactions] | High throughput | no | yes |
| FIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FKBP8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
| PTN1_HUMAN | [view interactions] | High throughput | no | yes |
| S2546_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC1_HUMAN | [view interactions] | High throughput | no | yes |
| DJC25_HUMAN | [view interactions] | High throughput | no | yes |
| SEC63_HUMAN | [view interactions] | High throughput | no | yes |
| AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP31_HUMAN | [view interactions] | High throughput | no | yes |
| CKAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DERL1_HUMAN | [view interactions] | High throughput | no | yes |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| ELOV5_HUMAN | [view interactions] | High throughput | no | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI2_HUMAN | [view interactions] | High throughput | no | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| GOGA1_HUMAN | [view interactions] | High throughput | no | yes |
| DHB11_HUMAN | [view interactions] | High throughput | no | yes |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| LNP_HUMAN | [view interactions] | High throughput | no | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET7A_HUMAN | [view interactions] | High throughput | no | no |
| PXMP2_HUMAN | [view interactions] | High throughput | no | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| REEP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| SEC62_HUMAN | [view interactions] | High throughput | no | yes |
| SSRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAZA1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DC1I1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAB18_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DC1L1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DCTN2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DC1L2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAE1_HUMAN | [view interactions] | Computational | no | yes |
| RAB6B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DYL1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CAZA3_HUMAN | [view interactions] | Computational | no | no |
| DC1I2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DCTN4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CAZA2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAB6A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DCTN3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DCTN6_HUMAN | [view interactions] | Computational | no | no |
| DCTN5_HUMAN | [view interactions] | Computational | no | yes |
| GDIB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAE2_HUMAN | [view interactions] | Computational | no | yes |
| ARP10_HUMAN | [view interactions] | Computational | no | no |
| DYHC1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| BICD2_HUMAN | [view interactions] | Computational | no | yes |
| RAB3A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DYL2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ACTZ_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GDIA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GALT1_HUMAN | [view interactions] | Computational | no | yes |
| GALT2_HUMAN | [view interactions] | Computational | no | yes |