RBGPR_HUMAN
Evidence for PS localization
Functions
Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RBGPR_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 30.0000 | 4 | no |
| GO:0046872 | metal ion binding | 30.0000 | 5 | no |
| GO:0000166 | nucleotide binding | 30.0000 | 4 | no |
| GO:0017076 | purine nucleotide binding | 30.0000 | 5 | no |
| GO:0043168 | anion binding | 28.0000 | 4 | no |
| GO:0003723 | RNA binding | 26.0000 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 26.0000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 26.0000 | 4 | no |
| GO:0005096 | GTPase activator activity | 6.0000 | 4 | yes |
| GO:0030695 | GTPase regulator activity | 6.0000 | 4 | yes |
| GO:0031267 | small GTPase binding | 6.0000 | 5 | yes |
| GO:0051020 | GTPase binding | 6.0000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RBGPR_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 58.0000 | 4 | yes |
| GO:0006996 | organelle organization | 46.0000 | 4 | no |
| GO:0008104 | protein localization | 44.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 44.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 42.0000 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 42.0000 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 42.0000 | 4 | yes |
| GO:0071702 | organic substance transport | 40.0000 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 38.0000 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 36.0000 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 36.0000 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 36.0000 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 34.0000 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 34.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 34.0000 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 32.0000 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 32.0000 | 5 | yes |
| GO:0033043 | regulation of organelle organization | 32.0000 | 5 | yes |
| GO:0022607 | cellular component assembly | 32.0000 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 32.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 32.0000 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 30.0000 | 5 | yes |
| GO:0051130 | positive regulation of cellular component organization | 30.0000 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 30.0000 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 28.0000 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.0000 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 28.0000 | 5 | no |
| GO:0010638 | positive regulation of organelle organization | 26.0000 | 6 | yes |
| GO:0015031 | protein transport | 26.0000 | 4 | yes |
| GO:0031399 | regulation of protein modification process | 26.0000 | 6 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 26.0000 | 6 | yes |
| GO:0060341 | regulation of cellular localization | 26.0000 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.0000 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.0000 | 5 | no |
| GO:0051049 | regulation of transport | 26.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 26.0000 | 6 | no |
| GO:0009894 | regulation of catabolic process | 24.0000 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 24.0000 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 24.0000 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 24.0000 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 24.0000 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 22.0000 | 5 | yes |
| GO:0031401 | positive regulation of protein modification process | 22.0000 | 7 | yes |
| GO:0032880 | regulation of protein localization | 22.0000 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.0000 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.0000 | 5 | no |
| GO:0006886 | intracellular protein transport | 20.0000 | 4 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 20.0000 | 6 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 20.0000 | 4 | yes |
| GO:0009896 | positive regulation of catabolic process | 16.0000 | 5 | yes |
| GO:0031329 | regulation of cellular catabolic process | 16.0000 | 5 | yes |
| GO:0033365 | protein localization to organelle | 16.0000 | 5 | yes |
| GO:0010506 | regulation of autophagy | 14.0000 | 6 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 14.0000 | 5 | yes |
| GO:0051336 | regulation of hydrolase activity | 14.0000 | 4 | yes |
| GO:0031331 | positive regulation of cellular catabolic process | 10.0000 | 6 | yes |
| GO:0072657 | protein localization to membrane | 8.0000 | 4 | yes |
| GO:1902115 | regulation of organelle assembly | 8.0000 | 5 | yes |
| GO:0010508 | positive regulation of autophagy | 6.0000 | 7 | yes |
| GO:0016241 | regulation of macroautophagy | 6.0000 | 7 | yes |
| GO:0043087 | regulation of GTPase activity | 6.0000 | 5 | yes |
| GO:0044088 | regulation of vacuole organization | 6.0000 | 6 | yes |
| GO:0070972 | protein localization to endoplasmic reticulum | 6.0000 | 6 | yes |
| GO:0072594 | establishment of protein localization to organelle | 6.0000 | 4 | yes |
| GO:0090150 | establishment of protein localization to membrane | 6.0000 | 4 | yes |
| GO:1902117 | positive regulation of organelle assembly | 6.0000 | 6 | yes |
| GO:2000785 | regulation of autophagosome assembly | 6.0000 | 6 | yes |
| GO:0016239 | positive regulation of macroautophagy | 4.0000 | 8 | yes |
| GO:0044090 | positive regulation of vacuole organization | 4.0000 | 7 | yes |
| GO:0050746 | regulation of lipoprotein metabolic process | 4.0000 | 5 | yes |
| GO:0050747 | positive regulation of lipoprotein metabolic process | 4.0000 | 6 | yes |
| GO:0072599 | establishment of protein localization to endoplasmic reticulum | 4.0000 | 5 | yes |
| GO:0097051 | establishment of protein localization to endoplasmic reticulum membrane | 4.0000 | 5 | yes |
| GO:1903059 | regulation of protein lipidation | 4.0000 | 6 | yes |
| GO:1903061 | positive regulation of protein lipidation | 4.0000 | 7 | yes |
| GO:1903371 | regulation of endoplasmic reticulum tubular network organization | 4.0000 | 6 | yes |
| GO:1903373 | positive regulation of endoplasmic reticulum tubular network organization | 4.0000 | 7 | yes |
| GO:2000786 | positive regulation of autophagosome assembly | 4.0000 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GSTK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPHA8_HUMAN | [view interactions] | High throughput | no | no |
| FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| RET_HUMAN | [view interactions] | High throughput | no | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOS6_HUMAN | [view interactions] | High throughput | no | no |
| SHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMAN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAXI1_HUMAN | [view interactions] | High throughput | no | no |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB3GP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| SIR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| TES_HUMAN | [view interactions] | High throughput | no | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| DNJ5G_HUMAN | [view interactions] | High throughput | no | no |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| TULP3_HUMAN | [view interactions] | High throughput | no | yes |
| PER1_HUMAN | [view interactions] | High throughput | no | no |
| REEP3_HUMAN | [view interactions] | High throughput | no | no |
| COPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPE_HUMAN | [view interactions] | High throughput | no | yes |
| YIPF5_HUMAN | [view interactions] | High throughput | no | yes |
| TLS1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RICTR_HUMAN | [view interactions] | High throughput | no | yes |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACACA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRBP2_HUMAN | [view interactions] | High throughput | no | yes |
| SPRNG_HUMAN | [view interactions] | High throughput | no | yes |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| RBM26_HUMAN | [view interactions] | High throughput | no | yes |
| NUP43_HUMAN | [view interactions] | High throughput | no | yes |
| UTP20_HUMAN | [view interactions] | High throughput | no | no |
| GABPA_HUMAN | [view interactions] | High throughput | no | no |
| GLCNE_HUMAN | [view interactions] | High throughput | no | yes |
| NUDC3_HUMAN | [view interactions] | High throughput | no | yes |
| RBM12_HUMAN | [view interactions] | High throughput | no | yes |
| SMRCD_HUMAN | [view interactions] | High throughput | no | yes |
| SEN34_HUMAN | [view interactions] | High throughput | no | yes |
| PR40A_HUMAN | [view interactions] | High throughput | no | no |
| RU17_HUMAN | [view interactions] | High throughput | no | yes |
| TCPZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBM25_HUMAN | [view interactions] | High throughput | no | yes |
| SMCA4_HUMAN | [view interactions] | High throughput | no | yes |
| MSH6_HUMAN | [view interactions] | High throughput | no | yes |
| PRP4B_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CIP4_HUMAN | [view interactions] | High throughput | no | no |
| ARID2_HUMAN | [view interactions] | High throughput | no | no |
| P4R3A_HUMAN | [view interactions] | High throughput | no | yes |
| P66A_HUMAN | [view interactions] | High throughput | no | yes |
| SMRC2_HUMAN | [view interactions] | High throughput | no | yes |
| SMRC1_HUMAN | [view interactions] | High throughput | no | yes |
| IMUP_HUMAN | [view interactions] | High throughput | no | yes |
| NUCKS_HUMAN | [view interactions] | High throughput | no | yes |
| RENT2_HUMAN | [view interactions] | High throughput | no | no |
| PP4R2_HUMAN | [view interactions] | High throughput | no | yes |
| F120A_HUMAN | [view interactions] | High throughput | no | yes |
| RHBL4_HUMAN | [view interactions] | High throughput | no | no |
| OTULL_HUMAN | [view interactions] | High throughput | no | no |
| SYVN1_HUMAN | [view interactions] | High throughput | no | yes |
| ST7_HUMAN | [view interactions] | High throughput | no | yes |
| FIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FKBP8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
| PTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S2546_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK14_HUMAN | [view interactions] | High throughput | no | yes |
| MK11_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC1_HUMAN | [view interactions] | High throughput | no | yes |
| DJC25_HUMAN | [view interactions] | High throughput | no | yes |
| SEC63_HUMAN | [view interactions] | High throughput | no | yes |
| AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| CKAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DERL1_HUMAN | [view interactions] | High throughput | no | yes |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| ELOV5_HUMAN | [view interactions] | High throughput | no | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI2_HUMAN | [view interactions] | High throughput | no | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| DHB11_HUMAN | [view interactions] | High throughput | no | yes |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| LNP_HUMAN | [view interactions] | High throughput | no | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMT1A_HUMAN | [view interactions] | High throughput | no | no |
| NU155_HUMAN | [view interactions] | High throughput | no | yes |
| PXMP2_HUMAN | [view interactions] | High throughput | no | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| REEP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| SEC62_HUMAN | [view interactions] | High throughput | no | yes |
| SSRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STIM1_HUMAN | [view interactions] | High throughput | no | yes |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| PPP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHEB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPAST_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC1_HUMAN | [view interactions] | High throughput | no | no |
| RCOR1_HUMAN | [view interactions] | High throughput | no | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESYT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESYT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TEX2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| RFA4_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| GBRAP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| MSPD2_HUMAN | [view interactions] | High throughput | no | yes |
| SIM43_HUMAN | [view interactions] | High throughput | no | no |
| RRBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTR1B_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| TP4A3_HUMAN | [view interactions] | High throughput | no | no |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |