RBGPR_HUMAN
Evidence for PS localization
Functions
Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RBGPR_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 23.2143 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 23.2143 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 23.2143 | 4 | no |
| GO:0003723 | RNA binding | 21.4286 | 4 | no |
| GO:0030695 | GTPase regulator activity | 10.7143 | 4 | yes |
| GO:0031267 | small GTPase binding | 10.7143 | 5 | yes |
| GO:0051020 | GTPase binding | 10.7143 | 4 | yes |
| GO:0005096 | GTPase activator activity | 7.1429 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RBGPR_HUMAN |
|---|---|---|---|---|
| GO:0006996 | organelle organization | 42.8571 | 4 | no |
| GO:0008104 | protein localization | 41.0714 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 41.0714 | 4 | yes |
| GO:0071702 | organic substance transport | 37.5000 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 37.5000 | 4 | yes |
| GO:0015031 | protein transport | 35.7143 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 33.9286 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 30.3571 | 4 | yes |
| GO:0022607 | cellular component assembly | 30.3571 | 4 | no |
| GO:0010646 | regulation of cell communication | 30.3571 | 4 | no |
| GO:0006886 | intracellular protein transport | 26.7857 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 26.7857 | 5 | no |
| GO:0023056 | positive regulation of signaling | 26.7857 | 4 | no |
| GO:0051049 | regulation of transport | 25.0000 | 4 | no |
| GO:0060341 | regulation of cellular localization | 21.4286 | 4 | no |
| GO:0009966 | regulation of signal transduction | 21.4286 | 4 | no |
| GO:0033043 | regulation of organelle organization | 19.6429 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 19.6429 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 16.0714 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 16.0714 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 14.2857 | 5 | yes |
| GO:0031323 | regulation of cellular metabolic process | 14.2857 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 14.2857 | 5 | yes |
| GO:0033365 | protein localization to organelle | 12.5000 | 5 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 12.5000 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 12.5000 | 5 | yes |
| GO:0080090 | regulation of primary metabolic process | 12.5000 | 4 | yes |
| GO:0010638 | positive regulation of organelle organization | 10.7143 | 6 | yes |
| GO:0031399 | regulation of protein modification process | 10.7143 | 6 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 10.7143 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 8.9286 | 4 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 8.9286 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 8.9286 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 8.9286 | 5 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 8.9286 | 6 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 8.9286 | 5 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 8.9286 | 6 | yes |
| GO:0072657 | protein localization to membrane | 8.9286 | 4 | yes |
| GO:1902115 | regulation of organelle assembly | 8.9286 | 5 | yes |
| GO:0009894 | regulation of catabolic process | 7.1429 | 4 | yes |
| GO:0009896 | positive regulation of catabolic process | 7.1429 | 5 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 7.1429 | 5 | yes |
| GO:0031329 | regulation of cellular catabolic process | 7.1429 | 5 | yes |
| GO:0031331 | positive regulation of cellular catabolic process | 7.1429 | 6 | yes |
| GO:0051336 | regulation of hydrolase activity | 7.1429 | 4 | yes |
| GO:0090150 | establishment of protein localization to membrane | 7.1429 | 4 | yes |
| GO:0010506 | regulation of autophagy | 5.3571 | 6 | yes |
| GO:0031401 | positive regulation of protein modification process | 5.3571 | 7 | yes |
| GO:0044088 | regulation of vacuole organization | 5.3571 | 6 | yes |
| GO:0070972 | protein localization to endoplasmic reticulum | 5.3571 | 6 | yes |
| GO:0072594 | establishment of protein localization to organelle | 5.3571 | 4 | yes |
| GO:1902117 | positive regulation of organelle assembly | 5.3571 | 6 | yes |
| GO:2000785 | regulation of autophagosome assembly | 5.3571 | 6 | yes |
| GO:0010508 | positive regulation of autophagy | 3.5714 | 7 | yes |
| GO:0016239 | positive regulation of macroautophagy | 3.5714 | 8 | yes |
| GO:0016241 | regulation of macroautophagy | 3.5714 | 7 | yes |
| GO:0043087 | regulation of GTPase activity | 3.5714 | 5 | yes |
| GO:0044090 | positive regulation of vacuole organization | 3.5714 | 7 | yes |
| GO:0050746 | regulation of lipoprotein metabolic process | 3.5714 | 5 | yes |
| GO:0050747 | positive regulation of lipoprotein metabolic process | 3.5714 | 6 | yes |
| GO:0072599 | establishment of protein localization to endoplasmic reticulum | 3.5714 | 5 | yes |
| GO:0097051 | establishment of protein localization to endoplasmic reticulum membrane | 3.5714 | 5 | yes |
| GO:1903059 | regulation of protein lipidation | 3.5714 | 6 | yes |
| GO:1903061 | positive regulation of protein lipidation | 3.5714 | 7 | yes |
| GO:1903371 | regulation of endoplasmic reticulum tubular network organization | 3.5714 | 6 | yes |
| GO:1903373 | positive regulation of endoplasmic reticulum tubular network organization | 3.5714 | 7 | yes |
| GO:2000112 | regulation of cellular macromolecule biosynthetic process | 3.5714 | 6 | yes |
| GO:2000786 | positive regulation of autophagosome assembly | 3.5714 | 7 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in RBGPR_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 3.5714 | 3 | no |
| DOID:0050155 | sensory system disease | 3.5714 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSTK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPHA8_HUMAN | [view interactions] | High throughput | no | no |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| RET_HUMAN | [view interactions] | High throughput | no | yes |
| EXOS6_HUMAN | [view interactions] | High throughput | no | no |
| SHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMAN1_HUMAN | [view interactions] | High throughput | no | yes |
| PAXI1_HUMAN | [view interactions] | High throughput | no | no |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB3GP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| SIR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| TES_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| DNJ5G_HUMAN | [view interactions] | High throughput | no | no |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| TULP3_HUMAN | [view interactions] | High throughput | no | yes |
| PER1_HUMAN | [view interactions] | High throughput | no | no |
| REEP3_HUMAN | [view interactions] | High throughput | no | no |
| COPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPE_HUMAN | [view interactions] | High throughput | no | yes |
| YIPF5_HUMAN | [view interactions] | High throughput | no | yes |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACACA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRBP2_HUMAN | [view interactions] | High throughput | no | yes |
| SPRNG_HUMAN | [view interactions] | High throughput | no | yes |
| RBM26_HUMAN | [view interactions] | High throughput | no | yes |
| NUP43_HUMAN | [view interactions] | High throughput | no | yes |
| UTP20_HUMAN | [view interactions] | High throughput | no | no |
| GABPA_HUMAN | [view interactions] | High throughput | no | no |
| GLCNE_HUMAN | [view interactions] | High throughput | no | yes |
| NUDC3_HUMAN | [view interactions] | High throughput | no | yes |
| RBM12_HUMAN | [view interactions] | High throughput | no | yes |
| SMRCD_HUMAN | [view interactions] | High throughput | no | yes |
| SEN34_HUMAN | [view interactions] | High throughput | no | yes |
| RHBL4_HUMAN | [view interactions] | High throughput | no | no |
| OTULL_HUMAN | [view interactions] | High throughput | no | no |
| SYVN1_HUMAN | [view interactions] | High throughput | no | yes |
| ST7_HUMAN | [view interactions] | High throughput | no | yes |
| FIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FKBP8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
| PTN1_HUMAN | [view interactions] | High throughput | no | yes |
| S2546_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK14_HUMAN | [view interactions] | High throughput | no | yes |
| MK11_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC1_HUMAN | [view interactions] | High throughput | no | yes |
| DJC25_HUMAN | [view interactions] | High throughput | no | yes |
| SEC63_HUMAN | [view interactions] | High throughput | no | yes |
| AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| CKAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DERL1_HUMAN | [view interactions] | High throughput | no | yes |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| ELOV5_HUMAN | [view interactions] | High throughput | no | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI2_HUMAN | [view interactions] | High throughput | no | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| DHB11_HUMAN | [view interactions] | High throughput | no | yes |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| LNP_HUMAN | [view interactions] | High throughput | no | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET7A_HUMAN | [view interactions] | High throughput | no | no |
| NU155_HUMAN | [view interactions] | High throughput | no | yes |
| PXMP2_HUMAN | [view interactions] | High throughput | no | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| REEP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| SEC62_HUMAN | [view interactions] | High throughput | no | yes |
| SSRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STIM1_HUMAN | [view interactions] | High throughput | no | yes |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| GBRAP_HUMAN | [view interactions] | High throughput | no | no |
| MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| MSPD2_HUMAN | [view interactions] | High throughput | no | yes |
| RRBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTR1B_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| TP4A3_HUMAN | [view interactions] | High throughput | no | no |
| RAE1_HUMAN | [view interactions] | Computational | no | yes |
| RAB6B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAE2_HUMAN | [view interactions] | Computational | no | yes |
| DMXL2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DC1L2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DCTN2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DC1L1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DCTN5_HUMAN | [view interactions] | Computational | no | yes |
| DC1I1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CAZA1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GDIB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAB18_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DCTN4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SNP25_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DC1I2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CAZA3_HUMAN | [view interactions] | Computational | no | no |
| ARP10_HUMAN | [view interactions] | Computational | no | no |
| DYL1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| MADD_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| VAMP2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| RIMS1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ACTZ_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| WDR7_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| DCTN3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CAZA2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DYL2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| RAB6A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DYHC1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| BICD2_HUMAN | [view interactions] | Computational | no | yes |
| GALT2_HUMAN | [view interactions] | Computational | no | yes |
| GALT1_HUMAN | [view interactions] | Computational | no | yes |
| STX1A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| UN13B_HUMAN | [view interactions] | Computational | no | no |
| DCTN6_HUMAN | [view interactions] | Computational | no | no |
| GDIA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |