XRP2_HUMAN
Evidence for PS localization
Functions
Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI002312 | MOD_NMyristoyl | MOD | 1 | 7 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in XRP2_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 48.0000 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 48.0000 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 48.0000 | 4 | yes |
| GO:0005525 | GTP binding | 28.0000 | 5 | yes |
| GO:0019001 | guanyl nucleotide binding | 28.0000 | 5 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 28.0000 | 5 | yes |
| GO:0031267 | small GTPase binding | 24.0000 | 5 | no |
| GO:0051020 | GTPase binding | 24.0000 | 4 | no |
| GO:0003924 | GTPase activity | 24.0000 | 7 | no |
| GO:0016462 | pyrophosphatase activity | 24.0000 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 24.0000 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 24.0000 | 6 | no |
| GO:0019003 | GDP binding | 24.0000 | 4 | no |
| GO:0030695 | GTPase regulator activity | 12.0000 | 4 | yes |
| GO:0046872 | metal ion binding | 12.0000 | 4 | yes |
| GO:0005096 | GTPase activator activity | 8.0000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in XRP2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 52.0000 | 4 | no |
| GO:0008104 | protein localization | 52.0000 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 44.0000 | 4 | no |
| GO:0015031 | protein transport | 44.0000 | 4 | yes |
| GO:0071702 | organic substance transport | 44.0000 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 44.0000 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 40.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 40.0000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 40.0000 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 40.0000 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 40.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 40.0000 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 36.0000 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 36.0000 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 36.0000 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 36.0000 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 36.0000 | 5 | no |
| GO:0010646 | regulation of cell communication | 32.0000 | 4 | no |
| GO:0031399 | regulation of protein modification process | 32.0000 | 6 | no |
| GO:0033365 | protein localization to organelle | 32.0000 | 5 | no |
| GO:0010468 | regulation of gene expression | 32.0000 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 32.0000 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 32.0000 | 6 | no |
| GO:0006996 | organelle organization | 32.0000 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 32.0000 | 4 | yes |
| GO:0006886 | intracellular protein transport | 32.0000 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 32.0000 | 7 | no |
| GO:0009966 | regulation of signal transduction | 32.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 28.0000 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.0000 | 4 | no |
| GO:0033043 | regulation of organelle organization | 24.0000 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 24.0000 | 4 | no |
| GO:0051049 | regulation of transport | 24.0000 | 4 | no |
| GO:0072594 | establishment of protein localization to organelle | 24.0000 | 4 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 24.0000 | 8 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 24.0000 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 24.0000 | 6 | no |
| GO:0016310 | phosphorylation | 24.0000 | 5 | no |
| GO:0030334 | regulation of cell migration | 24.0000 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 24.0000 | 7 | no |
| GO:0042327 | positive regulation of phosphorylation | 24.0000 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 24.0000 | 7 | no |
| GO:2000145 | regulation of cell motility | 24.0000 | 4 | no |
| GO:0006913 | nucleocytoplasmic transport | 24.0000 | 5 | no |
| GO:0051169 | nuclear transport | 24.0000 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 24.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 16.0000 | 4 | yes |
| GO:0030030 | cell projection organization | 16.0000 | 4 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 16.0000 | 5 | yes |
| GO:0030031 | cell projection assembly | 12.0000 | 5 | yes |
| GO:0070925 | organelle assembly | 12.0000 | 5 | yes |
| GO:0120031 | plasma membrane bounded cell projection assembly | 12.0000 | 6 | yes |
| GO:0044782 | cilium organization | 8.0000 | 5 | yes |
| GO:0048193 | Golgi vesicle transport | 8.0000 | 5 | yes |
| GO:0060271 | cilium assembly | 8.0000 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ARL3_HUMAN | [view interactions] | Low throughput | no | yes |
| ARL2_HUMAN | [view interactions] | Low throughput | no | yes |
| MRPP3_HUMAN | [view interactions] | High throughput | no | yes |
| QSOX1_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| NMRL1_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| APR_HUMAN | [view interactions] | High throughput | no | yes |
| TNPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZDH23_HUMAN | [view interactions] | High throughput | no | no |
| BPHL_HUMAN | [view interactions] | High throughput | no | no |
| MCM7_HUMAN | [view interactions] | High throughput | no | no |
| PCD10_HUMAN | [view interactions] | High throughput | no | yes |
| FUCT1_HUMAN | [view interactions] | High throughput | no | yes |
| LIPT_HUMAN | [view interactions] | High throughput | no | no |
| NMT2_HUMAN | [view interactions] | High throughput | no | yes |
| AHSP_HUMAN | [view interactions] | High throughput | no | no |
| YES_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OGDHL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX8_HUMAN | [view interactions] | High throughput | no | yes |
| OTUD3_HUMAN | [view interactions] | High throughput | no | yes |
| T2AG_HUMAN | [view interactions] | High throughput | no | no |
| GBRE_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TMM53_HUMAN | [view interactions] | High throughput | no | yes |
| WDR36_HUMAN | [view interactions] | High throughput | no | yes |
| PEBB_HUMAN | [view interactions] | High throughput | no | no |
| SNPC1_HUMAN | [view interactions] | High throughput | no | no |
| TEX29_HUMAN | [view interactions] | High throughput | no | no |
| TUSC3_HUMAN | [view interactions] | High throughput | no | yes |
| T2EB_HUMAN | [view interactions] | High throughput | no | yes |
| FRIH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AN13A_HUMAN | [view interactions] | High throughput | no | yes |
| RAMAC_HUMAN | [view interactions] | High throughput | no | yes |
| MCRI2_HUMAN | [view interactions] | High throughput | no | no |
| GSKIP_HUMAN | [view interactions] | High throughput | no | yes |
| FACC1_HUMAN | [view interactions] | High throughput | no | no |
| HXK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OSTF1_HUMAN | [view interactions] | High throughput | no | yes |
| UBP24_HUMAN | [view interactions] | High throughput | no | yes |
| XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO4_HUMAN | [view interactions] | High throughput | no | no |
| COG8_HUMAN | [view interactions] | High throughput | no | no |
| GLMN_HUMAN | [view interactions] | High throughput | no | no |
| DMXL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTL2_HUMAN | [view interactions] | High throughput | no | no |
| CTU1_HUMAN | [view interactions] | High throughput | no | no |
| ECM29_HUMAN | [view interactions] | High throughput | no | no |
| TKFC_HUMAN | [view interactions] | High throughput | no | no |
| PDS5A_HUMAN | [view interactions] | High throughput | no | yes |
| TRIPC_HUMAN | [view interactions] | High throughput | no | yes |
| KC1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTOR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRAF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
| APLP2_HUMAN | [view interactions] | High throughput | no | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| HASP_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| P20D2_HUMAN | [view interactions] | High throughput | no | yes |
| WDR83_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| S2541_HUMAN | [view interactions] | High throughput | no | no |
| IPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNPO2_HUMAN | [view interactions] | High throughput | no | yes |
| NMT1_HUMAN | [view interactions] | High throughput | no | yes |
| XPO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TSC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSTF2_HUMAN | [view interactions] | High throughput | no | yes |
| TBL3_HUMAN | [view interactions] | High throughput | no | yes |
| CND2_HUMAN | [view interactions] | High throughput | no | no |
| SYMPK_HUMAN | [view interactions] | High throughput | no | yes |
| TARB1_HUMAN | [view interactions] | High throughput | no | no |
| STAT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNPO3_HUMAN | [view interactions] | High throughput | no | yes |
| INT3_HUMAN | [view interactions] | High throughput | no | yes |
| TRXR1_HUMAN | [view interactions] | High throughput | no | yes |
| KNTC1_HUMAN | [view interactions] | High throughput | no | no |
| KC1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COG7_HUMAN | [view interactions] | High throughput | no | yes |
| MARC2_HUMAN | [view interactions] | High throughput | no | no |
| U119B_HUMAN | [view interactions] | Computational | no | yes |