XRP2_HUMAN
Evidence for PS localization
Functions
Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI002312 | MOD_NMyristoyl | MOD | 1 | 7 | - |
| ELMI002312 | MOD_NMyristoyl | MOD | 1 | 7 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in XRP2_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 48.1481 | 4 | yes |
| GO:0000166 | nucleotide binding | 44.4444 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 44.4444 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 44.4444 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 44.4444 | 4 | yes |
| GO:0005525 | GTP binding | 25.9259 | 5 | yes |
| GO:0019001 | guanyl nucleotide binding | 25.9259 | 6 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 25.9259 | 5 | yes |
| GO:0003924 | GTPase activity | 22.2222 | 7 | no |
| GO:0016462 | pyrophosphatase activity | 22.2222 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 22.2222 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 22.2222 | 6 | no |
| GO:0019003 | GDP binding | 22.2222 | 5 | no |
| GO:0031267 | small GTPase binding | 22.2222 | 5 | no |
| GO:0051020 | GTPase binding | 22.2222 | 4 | no |
| GO:0043169 | cation binding | 14.8148 | 4 | yes |
| GO:0046872 | metal ion binding | 14.8148 | 5 | yes |
| GO:0030695 | GTPase regulator activity | 11.1111 | 4 | yes |
| GO:0005096 | GTPase activator activity | 7.4074 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in XRP2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 59.2593 | 4 | no |
| GO:0008104 | protein localization | 55.5556 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 44.4444 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 44.4444 | 4 | no |
| GO:0071702 | organic substance transport | 40.7407 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 40.7407 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 40.7407 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 40.7407 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 40.7407 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 40.7407 | 4 | no |
| GO:0015031 | protein transport | 40.7407 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 37.0370 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 33.3333 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 33.3333 | 5 | no |
| GO:0033365 | protein localization to organelle | 33.3333 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 33.3333 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 33.3333 | 6 | no |
| GO:0006996 | organelle organization | 33.3333 | 4 | yes |
| GO:0006886 | intracellular protein transport | 29.6296 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 29.6296 | 4 | no |
| GO:0009966 | regulation of signal transduction | 29.6296 | 4 | no |
| GO:0010468 | regulation of gene expression | 29.6296 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 29.6296 | 5 | no |
| GO:0010646 | regulation of cell communication | 29.6296 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 29.6296 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 29.6296 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 29.6296 | 7 | no |
| GO:0031399 | regulation of protein modification process | 29.6296 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 29.6296 | 7 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 25.9259 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 25.9259 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 25.9259 | 4 | no |
| GO:0072594 | establishment of protein localization to organelle | 25.9259 | 4 | no |
| GO:0141124 | intracellular signaling cassette | 25.9259 | 4 | no |
| GO:0006915 | apoptotic process | 25.9259 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 25.9259 | 4 | no |
| GO:0006913 | nucleocytoplasmic transport | 22.2222 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 22.2222 | 5 | no |
| GO:0009894 | regulation of catabolic process | 22.2222 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 22.2222 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 22.2222 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 22.2222 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 22.2222 | 5 | no |
| GO:0016310 | phosphorylation | 22.2222 | 5 | no |
| GO:0023056 | positive regulation of signaling | 22.2222 | 4 | no |
| GO:0030334 | regulation of cell migration | 22.2222 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 22.2222 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 22.2222 | 6 | no |
| GO:0042127 | regulation of cell population proliferation | 22.2222 | 4 | no |
| GO:0051169 | nuclear transport | 22.2222 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 22.2222 | 4 | no |
| GO:2000145 | regulation of cell motility | 22.2222 | 4 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 22.2222 | 8 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 22.2222 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 22.2222 | 7 | no |
| GO:0042327 | positive regulation of phosphorylation | 22.2222 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 22.2222 | 7 | no |
| GO:0022607 | cellular component assembly | 18.5185 | 4 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 14.8148 | 5 | yes |
| GO:0030030 | cell projection organization | 14.8148 | 4 | yes |
| GO:0070925 | organelle assembly | 11.1111 | 5 | yes |
| GO:0120031 | plasma membrane bounded cell projection assembly | 11.1111 | 6 | yes |
| GO:0030031 | cell projection assembly | 11.1111 | 5 | yes |
| GO:0044782 | cilium organization | 7.4074 | 5 | yes |
| GO:0060271 | cilium assembly | 7.4074 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ARL3_HUMAN | [view interactions] | Low throughput | no | yes |
| ARL2_HUMAN | [view interactions] | Low throughput | no | yes |
| BAG6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HUWE1_HUMAN | [view interactions] | Low throughput | no | yes |
| OSTF1_HUMAN | [view interactions] | High throughput | no | yes |
| PRAF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTOR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KC1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRIPC_HUMAN | [view interactions] | High throughput | no | yes |
| PDS5A_HUMAN | [view interactions] | High throughput | no | yes |
| TKFC_HUMAN | [view interactions] | High throughput | no | no |
| ECM29_HUMAN | [view interactions] | High throughput | no | no |
| CTU1_HUMAN | [view interactions] | High throughput | no | no |
| CTL2_HUMAN | [view interactions] | High throughput | no | no |
| DMXL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLMN_HUMAN | [view interactions] | High throughput | no | no |
| COG8_HUMAN | [view interactions] | High throughput | no | no |
| XPO4_HUMAN | [view interactions] | High throughput | no | no |
| XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP24_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
| NF2L2_HUMAN | [view interactions] | High throughput | no | yes |
| APLP2_HUMAN | [view interactions] | High throughput | no | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| HASP_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| P20D2_HUMAN | [view interactions] | High throughput | no | yes |
| WDR83_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCNK3_HUMAN | [view interactions] | High throughput | no | no |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| S2541_HUMAN | [view interactions] | High throughput | no | no |
| IPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNPO2_HUMAN | [view interactions] | High throughput | no | yes |
| NMT1_HUMAN | [view interactions] | High throughput | no | yes |
| XPO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TSC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSTF2_HUMAN | [view interactions] | High throughput | no | yes |
| TBL3_HUMAN | [view interactions] | High throughput | no | yes |
| CND2_HUMAN | [view interactions] | High throughput | no | no |
| SYMPK_HUMAN | [view interactions] | High throughput | no | yes |
| TARB1_HUMAN | [view interactions] | High throughput | no | no |
| STAT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNPO3_HUMAN | [view interactions] | High throughput | no | yes |
| INT3_HUMAN | [view interactions] | High throughput | no | yes |
| TRXR1_HUMAN | [view interactions] | High throughput | no | yes |
| KNTC1_HUMAN | [view interactions] | High throughput | no | no |
| KC1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COG7_HUMAN | [view interactions] | High throughput | no | yes |
| MARC2_HUMAN | [view interactions] | High throughput | no | no |
| MRPP3_HUMAN | [view interactions] | High throughput | no | yes |
| QSOX1_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| NMRL1_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| APR_HUMAN | [view interactions] | High throughput | no | yes |
| TNPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZDH23_HUMAN | [view interactions] | High throughput | no | no |
| BPHL_HUMAN | [view interactions] | High throughput | no | no |
| MCM7_HUMAN | [view interactions] | High throughput | no | no |
| PCD10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FUCT1_HUMAN | [view interactions] | High throughput | no | yes |
| LIPT_HUMAN | [view interactions] | High throughput | no | no |
| NMT2_HUMAN | [view interactions] | High throughput | no | yes |
| AHSP_HUMAN | [view interactions] | High throughput | no | no |
| YES_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OGDHL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX8_HUMAN | [view interactions] | High throughput | no | yes |
| OTUD3_HUMAN | [view interactions] | High throughput | no | yes |
| T2AG_HUMAN | [view interactions] | High throughput | no | no |
| GBRE_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TMM53_HUMAN | [view interactions] | High throughput | no | yes |
| WDR36_HUMAN | [view interactions] | High throughput | no | no |
| PEBB_HUMAN | [view interactions] | High throughput | no | no |
| SNPC1_HUMAN | [view interactions] | High throughput | no | no |
| TEX29_HUMAN | [view interactions] | High throughput | no | no |
| TUSC3_HUMAN | [view interactions] | High throughput | no | yes |
| T2EB_HUMAN | [view interactions] | High throughput | no | yes |
| FRIH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AN13A_HUMAN | [view interactions] | High throughput | no | yes |
| RAMAC_HUMAN | [view interactions] | High throughput | no | yes |
| MCRI2_HUMAN | [view interactions] | High throughput | no | no |
| GSKIP_HUMAN | [view interactions] | High throughput | no | yes |
| FACC1_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| MIDN_HUMAN | [view interactions] | High throughput | no | no |
| HXK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NFAC3_HUMAN | [view interactions] | High throughput | no | no |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MUC18_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |