Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

TSC2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed, PubMed). Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed). May also play a role in microtubule-mediated protein transport . Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
292 Leu Pro Tuberoussclerosis2(TSC2) -
407 Tyr Asp Tuberoussclerosis2(TSC2) -
449 Met Ile Tuberoussclerosis2(TSC2) -
611 Arg Gln Lymphangioleiomyomatosis(LAM) -
611 Arg Gln Tuberoussclerosis2(TSC2) -
611 Arg Trp Tuberoussclerosis2(TSC2) -
826 Leu Met Tuberoussclerosis2(TSC2) -
905 Arg Gln Tuberoussclerosis2(TSC2) -
905 Arg Trp Tuberoussclerosis2(TSC2) -
1084 Asp Glu Tuberoussclerosis2(TSC2) -
1200 Arg Trp Tuberoussclerosis2(TSC2) -
1227 Pro Leu Tuberoussclerosis2(TSC2) -
1240 Arg Trp Tuberoussclerosis2(TSC2) -
1295 Asp Val Tuberoussclerosis2(TSC2) -
1549 Tyr Cys Tuberoussclerosis2(TSC2) -
1643 Asn Ile Tuberoussclerosis2(TSC2) -
1650 Tyr Cys Tuberoussclerosis2(TSC2) -
1690 Asp Tyr Tuberoussclerosis2(TSC2) -
1712 Ala Glu Tuberoussclerosis2(TSC2) -
1750 Leu Phe Tuberoussclerosis2(TSC2) -
227 Cys Tyr Tuberoussclerosis2(TSC2) -
331 Asn Lys Tuberoussclerosis2(TSC2) -
486 Asn Ile Tuberoussclerosis2(TSC2) -
816 Pro Leu Tuberoussclerosis2(TSC2) -
1144 Val Met Tuberoussclerosis2(TSC2) -
1315 Pro Ser Tuberoussclerosis2(TSC2) -
1709 Pro Leu Tuberoussclerosis2(TSC2) -
1743 Arg Gln Tuberoussclerosis2(TSC2) -
1773 His Pro Tuberoussclerosis2(TSC2) -
1783 Glu Gln Tuberoussclerosis2(TSC2) -
258 Lys Asn Tuberoussclerosis2(TSC2) -
261 Arg Pro Tuberoussclerosis2(TSC2) -
294 Gly Glu Tuberoussclerosis2(TSC2) -
361 Leu Pro Tuberoussclerosis2(TSC2) -
525 Asn Ser Tuberoussclerosis2(TSC2) -
599 Lys Met Tuberoussclerosis2(TSC2) -
614 Ala Asp Tuberoussclerosis2(TSC2) -
696 Cys Tyr Tuberoussclerosis2(TSC2) -
717 Leu Arg Tuberoussclerosis2(TSC2) -
895 Met Val Tuberoussclerosis2(TSC2) -
1497 Pro Arg Tuberoussclerosis2(TSC2) -
1498 Ser Asn Tuberoussclerosis2(TSC2) -
1620 His Tyr Tuberoussclerosis2(TSC2) -
1643 Asn Lys Tuberoussclerosis2(TSC2) -
1651 Asn Ser Tuberoussclerosis2(TSC2) -
1675 Pro Leu Tuberoussclerosis2(TSC2) -
1681 Asn Lys Tuberoussclerosis2(TSC2) -
1704 Ser Thr Tuberoussclerosis2(TSC2) -
1743 Arg Pro Tuberoussclerosis2(TSC2) -
1744 Leu Pro Tuberoussclerosis2(TSC2) -
1653 Ser Phe Tuberoussclerosis2(TSC2) -
1027 Leu Pro Tuberoussclerosis2(TSC2) -
1547 Val Ile Focalcorticaldysplasia2(FCORD2) -

Linear motifs

ELM instance Name Type Start End Partner
ELMI002554 MOD_PKB_1 MOD 934 942 -
ELMI002555 MOD_PKB_1 MOD 976 984 -
ELMI002556 MOD_PKB_1 MOD 1127 1135 -
ELMI002557 MOD_PKB_1 MOD 1457 1465 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in TSC2_HUMAN
GO:0017076 purine nucleotide binding 37.7049 4 no
GO:0032555 purine ribonucleotide binding 37.7049 4 no
GO:0035639 purine ribonucleoside triphosphate binding 37.7049 4 no
GO:0019900 kinase binding 29.5082 4 no
GO:0019901 protein kinase binding 29.5082 5 no
GO:0046872 metal ion binding 22.9508 4 no
GO:0004712 protein serine/threonine/tyrosine kinase activity 21.3115 4 no
GO:0005524 ATP binding 21.3115 5 no
GO:0016301 kinase activity 21.3115 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 21.3115 4 no
GO:0030554 adenyl nucleotide binding 21.3115 5 no
GO:0032559 adenyl ribonucleotide binding 21.3115 5 no
GO:0019902 phosphatase binding 16.3934 4 yes
GO:0051020 GTPase binding 8.1967 4 yes
GO:0030695 GTPase regulator activity 6.5574 4 yes
GO:0031267 small GTPase binding 6.5574 5 yes
GO:0042803 protein homodimerization activity 6.5574 4 yes
GO:0005096 GTPase activator activity 4.9180 4 yes
GO:0051879 Hsp90 protein binding 4.9180 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in TSC2_HUMAN
GO:0048522 positive regulation of cellular process 73.7705 4 yes
GO:0031323 regulation of cellular metabolic process 67.2131 4 yes
GO:0080090 regulation of primary metabolic process 67.2131 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 65.5738 4 yes
GO:0060255 regulation of macromolecule metabolic process 65.5738 4 yes
GO:0048523 negative regulation of cellular process 63.9344 4 yes
GO:0010646 regulation of cell communication 60.6557 4 yes
GO:0051128 regulation of cellular component organization 57.3770 4 yes
GO:0051246 regulation of protein metabolic process 55.7377 5 yes
GO:0009966 regulation of signal transduction 52.4590 4 yes
GO:0009893 positive regulation of metabolic process 50.8197 4 yes
GO:0051049 regulation of transport 47.5410 4 yes
GO:0031325 positive regulation of cellular metabolic process 45.9016 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 44.2623 5 no
GO:0019220 regulation of phosphate metabolic process 42.6230 6 yes
GO:0051174 regulation of phosphorus metabolic process 42.6230 5 yes
GO:1902531 regulation of intracellular signal transduction 42.6230 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 42.6230 5 no
GO:0008104 protein localization 40.9836 4 yes
GO:0009892 negative regulation of metabolic process 40.9836 4 yes
GO:0031399 regulation of protein modification process 39.3443 6 yes
GO:0010605 negative regulation of macromolecule metabolic process 37.7049 5 yes
GO:0042325 regulation of phosphorylation 37.7049 7 yes
GO:0010468 regulation of gene expression 37.7049 5 no
GO:0036211 protein modification process 37.7049 4 no
GO:0043412 macromolecule modification 37.7049 4 no
GO:0051247 positive regulation of protein metabolic process 36.0656 6 no
GO:0001932 regulation of protein phosphorylation 34.4262 7 yes
GO:0031324 negative regulation of cellular metabolic process 34.4262 5 yes
GO:0033043 regulation of organelle organization 34.4262 5 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 34.4262 5 yes
GO:0071702 organic substance transport 34.4262 4 yes
GO:0009889 regulation of biosynthetic process 34.4262 4 no
GO:0031326 regulation of cellular biosynthetic process 34.4262 5 no
GO:0043085 positive regulation of catalytic activity 32.7869 4 yes
GO:0051338 regulation of transferase activity 32.7869 4 yes
GO:0071705 nitrogen compound transport 32.7869 4 yes
GO:0006796 phosphate-containing compound metabolic process 32.7869 4 no
GO:0010556 regulation of macromolecule biosynthetic process 32.7869 5 no
GO:0009894 regulation of catabolic process 31.1475 4 yes
GO:0015031 protein transport 31.1475 4 yes
GO:0051248 negative regulation of protein metabolic process 31.1475 6 yes
GO:0010941 regulation of cell death 31.1475 4 no
GO:0010648 negative regulation of cell communication 29.5082 5 yes
GO:0023057 negative regulation of signaling 29.5082 4 yes
GO:0051336 regulation of hydrolase activity 29.5082 4 yes
GO:0051726 regulation of cell cycle 29.5082 4 yes
GO:0006996 organelle organization 29.5082 4 no
GO:0006886 intracellular protein transport 27.8689 4 yes
GO:0016192 vesicle-mediated transport 27.8689 4 yes
GO:0016310 phosphorylation 27.8689 5 no
GO:0042981 regulation of apoptotic process 27.8689 6 no
GO:0043067 regulation of programmed cell death 27.8689 5 no
GO:0045595 regulation of cell differentiation 27.8689 4 no
GO:0071310 cellular response to organic substance 27.8689 4 no
GO:0031329 regulation of cellular catabolic process 26.2295 5 yes
GO:0043549 regulation of kinase activity 26.2295 5 yes
GO:0060627 regulation of vesicle-mediated transport 26.2295 4 yes
GO:0006468 protein phosphorylation 26.2295 5 no
GO:0010562 positive regulation of phosphorus metabolic process 26.2295 6 no
GO:0031401 positive regulation of protein modification process 26.2295 7 no
GO:0042327 positive regulation of phosphorylation 26.2295 8 no
GO:0045937 positive regulation of phosphate metabolic process 26.2295 7 no
GO:0051130 positive regulation of cellular component organization 26.2295 5 no
GO:0048584 positive regulation of response to stimulus 26.2295 4 no
GO:0001934 positive regulation of protein phosphorylation 24.5902 8 no
GO:0010243 response to organonitrogen compound 24.5902 4 no
GO:0051050 positive regulation of transport 24.5902 4 no
GO:0060341 regulation of cellular localization 24.5902 4 no
GO:0060548 negative regulation of cell death 24.5902 5 no
GO:0010647 positive regulation of cell communication 24.5902 5 no
GO:0023056 positive regulation of signaling 24.5902 4 no
GO:0042127 regulation of cell population proliferation 22.9508 4 yes
GO:0045859 regulation of protein kinase activity 22.9508 6 yes
GO:0048585 negative regulation of response to stimulus 22.9508 4 yes
GO:0051345 positive regulation of hydrolase activity 22.9508 5 yes
GO:0018193 peptidyl-amino acid modification 22.9508 5 no
GO:0031344 regulation of cell projection organization 22.9508 5 no
GO:0043066 negative regulation of apoptotic process 22.9508 7 no
GO:0043069 negative regulation of programmed cell death 22.9508 6 no
GO:0051094 positive regulation of developmental process 22.9508 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 22.9508 6 no
GO:0044087 regulation of cellular component biogenesis 22.9508 4 no
GO:0009967 positive regulation of signal transduction 22.9508 5 no
GO:0030030 cell projection organization 22.9508 4 no
GO:0009896 positive regulation of catabolic process 21.3115 5 yes
GO:0009968 negative regulation of signal transduction 21.3115 5 yes
GO:0010563 negative regulation of phosphorus metabolic process 21.3115 6 yes
GO:0031400 negative regulation of protein modification process 21.3115 7 yes
GO:0045936 negative regulation of phosphate metabolic process 21.3115 7 yes
GO:0051051 negative regulation of transport 21.3115 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.3115 5 no
GO:0032880 regulation of protein localization 21.3115 5 no
GO:0034762 regulation of transmembrane transport 21.3115 4 no
GO:0051347 positive regulation of transferase activity 21.3115 5 no
GO:1901701 cellular response to oxygen-containing compound 21.3115 4 no
GO:0120036 plasma membrane bounded cell projection organization 21.3115 5 no
GO:0006915 apoptotic process 19.6721 4 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 19.6721 4 yes
GO:0010506 regulation of autophagy 19.6721 6 yes
GO:0043086 negative regulation of catalytic activity 19.6721 4 yes
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 18.0328 5 yes
GO:0031331 positive regulation of cellular catabolic process 18.0328 6 yes
GO:0001933 negative regulation of protein phosphorylation 16.3934 8 yes
GO:0042326 negative regulation of phosphorylation 16.3934 8 yes
GO:0051129 negative regulation of cellular component organization 16.3934 5 yes
GO:0016241 regulation of macroautophagy 14.7541 7 yes
GO:0043087 regulation of GTPase activity 14.7541 5 yes
GO:1902532 negative regulation of intracellular signal transduction 14.7541 6 yes
GO:0006897 endocytosis 13.1148 5 yes
GO:0051348 negative regulation of transferase activity 13.1148 5 yes
GO:0006469 negative regulation of protein kinase activity 11.4754 7 yes
GO:0010508 positive regulation of autophagy 11.4754 7 yes
GO:0033365 protein localization to organelle 11.4754 5 yes
GO:0033673 negative regulation of kinase activity 11.4754 6 yes
GO:0043547 positive regulation of GTPase activity 11.4754 6 yes
GO:0009895 negative regulation of catabolic process 9.8361 5 yes
GO:0030100 regulation of endocytosis 9.8361 5 yes
GO:0051896 regulation of protein kinase B signaling 9.8361 6 yes
GO:0072594 establishment of protein localization to organelle 9.8361 4 yes
GO:0001843 neural tube closure 8.1967 5 yes
GO:0008285 negative regulation of cell population proliferation 8.1967 5 yes
GO:0010507 negative regulation of autophagy 8.1967 7 yes
GO:0010639 negative regulation of organelle organization 8.1967 6 yes
GO:0010821 regulation of mitochondrion organization 8.1967 6 yes
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling 8.1967 6 yes
GO:0016239 positive regulation of macroautophagy 8.1967 8 yes
GO:0016242 negative regulation of macroautophagy 8.1967 8 yes
GO:0030111 regulation of Wnt signaling pathway 8.1967 5 yes
GO:0031330 negative regulation of cellular catabolic process 8.1967 6 yes
GO:0032006 regulation of TOR signaling 8.1967 6 yes
GO:0043491 protein kinase B signaling 8.1967 4 yes
GO:0060606 tube closure 8.1967 4 yes
GO:0006913 nucleocytoplasmic transport 6.5574 5 yes
GO:0007507 heart development 6.5574 4 yes
GO:0034504 protein localization to nucleus 6.5574 6 yes
GO:0043276 anoikis 6.5574 5 yes
GO:0046626 regulation of insulin receptor signaling pathway 6.5574 5 yes
GO:0048009 insulin-like growth factor receptor signaling pathway 6.5574 6 yes
GO:0051169 nuclear transport 6.5574 4 yes
GO:1900076 regulation of cellular response to insulin stimulus 6.5574 4 yes
GO:0006606 protein import into nucleus 4.9180 5 yes
GO:0010823 negative regulation of mitochondrion organization 4.9180 7 yes
GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling 4.9180 7 yes
GO:0030178 negative regulation of Wnt signaling pathway 4.9180 6 yes
GO:0032007 negative regulation of TOR signaling 4.9180 7 yes
GO:0046627 negative regulation of insulin receptor signaling pathway 4.9180 6 yes
GO:0051170 import into nucleus 4.9180 6 yes
GO:0051898 negative regulation of protein kinase B signaling 4.9180 7 yes
GO:1900077 negative regulation of cellular response to insulin stimulus 4.9180 5 yes
GO:0050918 positive chemotaxis 3.2787 4 yes
GO:0051056 regulation of small GTPase mediated signal transduction 3.2787 6 yes
GO:1901524 regulation of mitophagy 3.2787 8 yes
GO:1901525 negative regulation of mitophagy 3.2787 9 yes
GO:1903146 regulation of autophagy of mitochondrion 3.2787 7 yes
GO:1903147 negative regulation of autophagy of mitochondrion 3.2787 8 yes

Disease

Term Name % Distance from top the of the tree Annotated in TSC2_HUMAN
DOID:331 central nervous system disease 4.9180 3 no
DOID:0050700 cardiomyopathy 4.9180 4 no
DOID:0060036 intrinsic cardiomyopathy 4.9180 5 no
DOID:114 heart disease 4.9180 3 no
DOID:0050161 lower respiratory tract disease 3.2787 3 yes
DOID:0080325 tuberous sclerosis 2 3.2787 3 yes
DOID:3319 lymphangioleiomyomatosis 3.2787 5 yes
DOID:850 lung disease 3.2787 4 yes
DOID:0050686 organ system cancer 3.2787 3 no
DOID:6457 Cowden syndrome 3.2787 3 no
DOID:1289 neurodegenerative disease 3.2787 4 no
DOID:2843 long QT syndrome 3.2787 6 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PLK1_HUMAN [view interactions] Low throughput no yes
PLK2_HUMAN [view interactions] Low throughput no yes
MAPK2_HUMAN [view interactions] Low throughput no yes
NFL_HUMAN [view entry] [view interactions] Low throughput yes yes
CAV1_HUMAN [view interactions] Low throughput no no
RAB5A_HUMAN [view entry] [view interactions] Low throughput yes yes
1433B_HUMAN [view entry] [view interactions] Low throughput yes yes
1433Z_HUMAN [view entry] [view interactions] Low throughput yes yes
TSC1_HUMAN [view entry] [view interactions] Low throughput yes yes
DAPK1_HUMAN [view entry] [view interactions] Low throughput yes yes
CCND1_HUMAN [view interactions] Low throughput no yes
CDK4_HUMAN [view interactions] Low throughput no no
SGK1_HUMAN [view interactions] Low throughput no yes
1433T_HUMAN [view entry] [view interactions] Low throughput yes yes
1433G_HUMAN [view entry] [view interactions] Low throughput yes yes
1433F_HUMAN [view entry] [view interactions] Low throughput yes yes
1433S_HUMAN [view entry] [view interactions] Low throughput yes yes
1433E_HUMAN [view entry] [view interactions] Low throughput yes yes
SIR1_HUMAN [view interactions] Low throughput no yes
GSK3B_HUMAN [view entry] [view interactions] Low throughput yes yes
AAPK1_HUMAN [view interactions] Low throughput no no
KS6B1_HUMAN [view entry] [view interactions] Low throughput yes yes
RHEB_HUMAN [view entry] [view interactions] Low throughput yes yes
AMD_HUMAN [view interactions] Low throughput no yes
RAP1A_HUMAN [view entry] [view interactions] Low throughput yes no
RALA_HUMAN [view entry] [view interactions] Low throughput yes yes
AKT1_HUMAN [view entry] [view interactions] Low throughput yes yes
KS6A1_HUMAN [view interactions] Low throughput no yes
FOXO1_HUMAN [view interactions] Low throughput no yes
AXIN1_HUMAN [view interactions] Low throughput no yes
FAK1_HUMAN [view entry] [view interactions] Low throughput yes yes
MK01_HUMAN [view entry] [view interactions] Low throughput yes yes
CCND2_HUMAN [view interactions] Low throughput no yes
CCND3_HUMAN [view interactions] Low throughput no no
FBXW5_HUMAN [view interactions] Low throughput no no
UBE3A_HUMAN [view interactions] Low throughput no yes
TBCD7_HUMAN [view interactions] Low throughput no no
HERC1_HUMAN [view interactions] Low throughput no no
CDN1B_HUMAN [view interactions] Low throughput no yes
ESR1_HUMAN [view interactions] Low throughput no no
CALM2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM3_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
SMAD2_HUMAN [view interactions] Low throughput no yes
SMAD3_HUMAN [view interactions] Low throughput no yes
RRAGA_HUMAN [view interactions] Low throughput no yes
TSC2_HUMAN [view entry] [view interactions] Low throughput yes yes
CBL_HUMAN [view interactions] Low throughput no yes
TBK1_HUMAN [view entry] [view interactions] High throughput yes yes
LMBRL_HUMAN [view interactions] High throughput no no
PEBB_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
OTUL_HUMAN [view interactions] High throughput no yes
EDEM1_HUMAN [view interactions] High throughput no yes
GP182_HUMAN [view interactions] High throughput no no
CD226_HUMAN [view interactions] High throughput no yes
MO4L1_HUMAN [view interactions] High throughput no yes
TPOR_HUMAN [view interactions] High throughput no no
MUL1_HUMAN [view interactions] High throughput no no
GLPA_HUMAN [view interactions] High throughput no no
CYB5B_HUMAN [view entry] [view interactions] High throughput yes yes
ZP2_HUMAN [view interactions] High throughput no no
TMEM9_HUMAN [view interactions] High throughput no no
GPR17_HUMAN [view interactions] High throughput no no
IDD_HUMAN [view interactions] High throughput no no
NPTN_HUMAN [view entry] [view interactions] High throughput yes yes
SEM4C_HUMAN [view entry] [view interactions] High throughput yes no
TSN10_HUMAN [view interactions] High throughput no no
EFNB1_HUMAN [view interactions] High throughput no yes
HCST_HUMAN [view interactions] High throughput no no
OPALI_HUMAN [view interactions] High throughput no yes
DUS16_HUMAN [view interactions] High throughput no yes
OCAD1_HUMAN [view interactions] High throughput no yes
CC018_HUMAN [view interactions] High throughput no yes
CIA2A_HUMAN [view interactions] High throughput no yes
TMED5_HUMAN [view interactions] High throughput no yes
DNAI2_HUMAN [view interactions] High throughput no no
EFMT3_HUMAN [view interactions] High throughput no no
MCE1_HUMAN [view interactions] High throughput no yes
CCNT1_HUMAN [view interactions] High throughput no yes
CD11A_HUMAN [view interactions] High throughput no yes
B3GN2_HUMAN [view interactions] High throughput no yes
B4GT1_HUMAN [view interactions] High throughput no yes
ARF1_HUMAN [view entry] [view interactions] High throughput yes yes
ARI2_HUMAN [view interactions] High throughput no no
UB2J1_HUMAN [view interactions] High throughput no yes
HDAC8_HUMAN [view interactions] High throughput no yes
BMI1_HUMAN [view interactions] High throughput no yes
SC24A_HUMAN [view interactions] High throughput no no
TPC13_HUMAN [view interactions] High throughput no yes
TPC2L_HUMAN [view interactions] High throughput no yes
DCAF7_HUMAN [view interactions] High throughput no yes
CARM1_HUMAN [view interactions] High throughput no yes
IF2B1_HUMAN [view interactions] High throughput no no
CAND1_HUMAN [view entry] [view interactions] High throughput yes no
VPS53_HUMAN [view entry] [view interactions] High throughput yes yes
MTF2_HUMAN [view interactions] High throughput no no
TPC12_HUMAN [view interactions] High throughput no yes
S39A9_HUMAN [view interactions] High throughput no yes
S23IP_HUMAN [view interactions] High throughput no yes
TPC2A_HUMAN [view interactions] High throughput no yes
RAB1A_HUMAN [view entry] [view interactions] High throughput yes yes
RABX5_HUMAN [view interactions] High throughput no no
S39A7_HUMAN [view interactions] High throughput no yes
RICTR_HUMAN [view interactions] High throughput no yes
SAR1A_HUMAN [view entry] [view interactions] High throughput yes yes
SC24C_HUMAN [view entry] [view interactions] High throughput yes yes
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
FAS_HUMAN [view entry] [view interactions] High throughput yes no
SRBP1_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
PTN11_HUMAN [view entry] [view interactions] High throughput yes yes
SPT6H_HUMAN [view interactions] High throughput no yes
TIGAR_HUMAN [view interactions] High throughput no yes
HAX1_HUMAN [view interactions] High throughput no no
LAMP2_HUMAN [view interactions] High throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
NU155_HUMAN [view interactions] High throughput no yes
RAB9A_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
NEK1_HUMAN [view interactions] High throughput no yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
PIN1_HUMAN [view entry] [view interactions] High throughput yes yes
KITH_HUMAN [view interactions] High throughput no yes
RIPK4_HUMAN [view interactions] High throughput no no
PICK1_HUMAN [view entry] [view interactions] High throughput yes yes
PKHM1_HUMAN [view interactions] High throughput no yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
TN13B_HUMAN [view interactions] High throughput no no
USPL1_HUMAN [view interactions] High throughput no yes
SRB4D_HUMAN [view interactions] High throughput no no
S13A3_HUMAN [view interactions] High throughput no no
NEUS_HUMAN [view interactions] High throughput no yes
RSSA_HUMAN [view entry] [view interactions] High throughput yes yes
RL4_HUMAN [view entry] [view interactions] High throughput yes yes
PHLB1_HUMAN [view entry] [view interactions] High throughput yes yes
RM21_HUMAN [view interactions] High throughput no no
MKRN1_HUMAN [view interactions] High throughput no no
G3P_HUMAN [view entry] [view interactions] High throughput yes yes
ANR35_HUMAN [view interactions] High throughput no no
ACTN2_HUMAN [view entry] [view interactions] High throughput yes yes
SEPT4_HUMAN [view interactions] High throughput no no
TRI63_HUMAN [view interactions] High throughput no no
TRI55_HUMAN [view interactions] High throughput no no
CBY1_HUMAN [view interactions] High throughput no no
LNX1_HUMAN [view interactions] High throughput no yes
MDFI_HUMAN [view interactions] High throughput no no
CBY2_HUMAN [view interactions] High throughput no no
EF1A1_HUMAN [view entry] [view interactions] High throughput yes yes
HECW2_HUMAN [view entry] [view interactions] High throughput yes no
CIAO1_HUMAN [view interactions] High throughput no yes
RRAGB_HUMAN [view interactions] High throughput no yes
RRAGC_HUMAN [view interactions] High throughput no yes
RRAGD_HUMAN [view interactions] High throughput no yes
SPIT2_HUMAN [view interactions] High throughput no yes
PNKD_HUMAN [view entry] [view interactions] High throughput yes yes
XRP2_HUMAN [view entry] [view interactions] High throughput yes no
GLU2B_HUMAN [view interactions] High throughput no yes
AL3A2_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK1_HUMAN [view interactions] High throughput no yes
PO5F1_HUMAN [view interactions] High throughput no yes
COKA1_HUMAN [view interactions] High throughput no no
CD79B_HUMAN [view interactions] High throughput no no
CD83_HUMAN [view interactions] High throughput no yes
SIGL1_HUMAN [view interactions] High throughput no no
P4HA3_HUMAN [view interactions] High throughput no no
F221B_HUMAN [view interactions] High throughput no no
P4HA2_HUMAN [view interactions] High throughput no no
RUVB2_HUMAN [view interactions] High throughput no yes
DAA10_HUMAN [view interactions] High throughput no yes
PIHD1_HUMAN [view interactions] High throughput no yes
RN123_HUMAN [view interactions] High throughput no yes
CTDP1_HUMAN [view interactions] High throughput no yes
APEX1_HUMAN [view interactions] High throughput no yes
DYR1A_HUMAN [view interactions] High throughput no yes
AAKB1_HUMAN [view interactions] Computational no yes
KS6B2_HUMAN [view interactions] Computational no yes
SESN2_HUMAN [view interactions] Computational no no
RPTOR_HUMAN [view interactions] Computational no yes
AAKB2_HUMAN [view interactions] Computational no yes
KS6A3_HUMAN [view entry] [view interactions] Computational yes yes
AKTS1_HUMAN [view interactions] Computational no yes
UBP6_HUMAN [view interactions] Computational no no
MK03_HUMAN [view entry] [view interactions] Computational yes yes
KS6A6_HUMAN [view interactions] Computational no yes
AAKG1_HUMAN [view interactions] Computational no no
RS6_HUMAN [view entry] [view interactions] Computational yes yes
SIN1_HUMAN [view interactions] Computational no yes
MTOR_HUMAN [view entry] [view interactions] Computational yes yes
S38A9_HUMAN [view interactions] Computational no yes
PRR5_HUMAN [view interactions] Computational no yes
SNW1_HUMAN [view interactions] Computational no yes
STK11_HUMAN [view interactions] Computational no yes
AKT2_HUMAN [view entry] [view interactions] Computational yes yes
LTOR4_HUMAN [view interactions] Computational no yes
MK14_HUMAN [view interactions] Computational no yes
PTEN_HUMAN [view entry] [view interactions] Computational yes yes
AAPK2_HUMAN [view interactions] Computational no yes
AAKG3_HUMAN [view interactions] Computational no no
AKT3_HUMAN [view interactions] Computational no yes
AAKG2_HUMAN [view interactions] Computational no yes
MK11_HUMAN [view interactions] Computational no yes
MED1_HUMAN [view interactions] Computational no no
DPTOR_HUMAN [view interactions] Computational no no
LST8_HUMAN [view interactions] Computational no yes
PKD1_HUMAN [view interactions] Computational no yes
TXND9_HUMAN [view interactions] Computational no yes
FOXO3_HUMAN [view interactions] Computational no yes
4EBP1_HUMAN [view entry] [view interactions] Computational yes yes
IKKB_HUMAN [view interactions] Computational no yes
KS6A2_HUMAN [view interactions] Computational no yes
LTOR3_HUMAN [view interactions] Computational no yes
LTOR2_HUMAN [view interactions] Computational no yes
SESN1_HUMAN [view interactions] Computational no no
PDPK1_HUMAN [view entry] [view interactions] Computational yes yes
DDIT4_HUMAN [view interactions] Computational no yes