TSC2_HUMAN
In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed, PubMed). Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed). May also play a role in microtubule-mediated protein transport . Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 . [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI002554 | MOD_PKB_1 | MOD | 934 | 942 | - |
| ELMI002555 | MOD_PKB_1 | MOD | 976 | 984 | - |
| ELMI002556 | MOD_PKB_1 | MOD | 1127 | 1135 | - |
| ELMI002557 | MOD_PKB_1 | MOD | 1457 | 1465 | - |
| ELMI002554 | MOD_PKB_1 | MOD | 934 | 942 | - |
| ELMI002555 | MOD_PKB_1 | MOD | 976 | 984 | - |
| ELMI002556 | MOD_PKB_1 | MOD | 1127 | 1135 | - |
| ELMI002557 | MOD_PKB_1 | MOD | 1457 | 1465 | - |
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in TSC2_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 36.0656 | 4 | no |
| GO:0017076 | purine nucleotide binding | 36.0656 | 5 | no |
| GO:0043168 | anion binding | 36.0656 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 34.4262 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 34.4262 | 4 | no |
| GO:0043169 | cation binding | 26.2295 | 4 | no |
| GO:0046872 | metal ion binding | 26.2295 | 5 | no |
| GO:0019900 | kinase binding | 26.2295 | 4 | no |
| GO:0019901 | protein kinase binding | 26.2295 | 5 | no |
| GO:0019902 | phosphatase binding | 14.7541 | 4 | yes |
| GO:0030695 | GTPase regulator activity | 8.1967 | 4 | yes |
| GO:0051020 | GTPase binding | 8.1967 | 4 | yes |
| GO:0031267 | small GTPase binding | 6.5574 | 5 | yes |
| GO:0042803 | protein homodimerization activity | 6.5574 | 4 | yes |
| GO:0005096 | GTPase activator activity | 4.9180 | 4 | yes |
| GO:0051879 | Hsp90 protein binding | 4.9180 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in TSC2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 70.4918 | 4 | yes |
| GO:0010646 | regulation of cell communication | 65.5738 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 62.2951 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 60.6557 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 60.6557 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 59.0164 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 55.7377 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 55.7377 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 49.1803 | 5 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 45.9016 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 44.2623 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 40.9836 | 5 | yes |
| GO:0051049 | regulation of transport | 40.9836 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 39.3443 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 39.3443 | 5 | no |
| GO:0008104 | protein localization | 37.7049 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 37.7049 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 37.7049 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 37.7049 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 36.0656 | 5 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 36.0656 | 5 | no |
| GO:0036211 | protein modification process | 36.0656 | 4 | no |
| GO:0043412 | macromolecule modification | 36.0656 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 34.4262 | 5 | yes |
| GO:0031399 | regulation of protein modification process | 34.4262 | 6 | yes |
| GO:0010468 | regulation of gene expression | 34.4262 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 34.4262 | 5 | no |
| GO:0023056 | positive regulation of signaling | 34.4262 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 32.7869 | 5 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 32.7869 | 6 | yes |
| GO:0023057 | negative regulation of signaling | 32.7869 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 32.7869 | 5 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 32.7869 | 5 | yes |
| GO:0009967 | positive regulation of signal transduction | 32.7869 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 31.1475 | 6 | no |
| GO:0048585 | negative regulation of response to stimulus | 29.5082 | 4 | yes |
| GO:0051726 | regulation of cell cycle | 29.5082 | 4 | yes |
| GO:0141124 | intracellular signaling cassette | 29.5082 | 4 | yes |
| GO:0009894 | regulation of catabolic process | 27.8689 | 4 | yes |
| GO:0071702 | organic substance transport | 27.8689 | 4 | yes |
| GO:0009968 | negative regulation of signal transduction | 26.2295 | 5 | yes |
| GO:0042325 | regulation of phosphorylation | 26.2295 | 7 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 26.2295 | 6 | yes |
| GO:0045595 | regulation of cell differentiation | 24.5902 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 24.5902 | 7 | yes |
| GO:0015031 | protein transport | 24.5902 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 24.5902 | 4 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 24.5902 | 4 | no |
| GO:0006996 | organelle organization | 24.5902 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 24.5902 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 22.9508 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 22.9508 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 22.9508 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 22.9508 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 22.9508 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 22.9508 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 22.9508 | 7 | no |
| GO:0051130 | positive regulation of cellular component organization | 22.9508 | 5 | no |
| GO:0006886 | intracellular protein transport | 22.9508 | 4 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 22.9508 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 22.9508 | 6 | no |
| GO:0051050 | positive regulation of transport | 21.3115 | 4 | no |
| GO:0060341 | regulation of cellular localization | 21.3115 | 4 | no |
| GO:0032006 | regulation of TOR signaling | 21.3115 | 6 | yes |
| GO:0051338 | regulation of transferase activity | 21.3115 | 4 | yes |
| GO:1902532 | negative regulation of intracellular signal transduction | 21.3115 | 6 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 21.3115 | 6 | no |
| GO:0051336 | regulation of hydrolase activity | 21.3115 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 21.3115 | 5 | no |
| GO:1903432 | regulation of TORC1 signaling | 19.6721 | 7 | yes |
| GO:0010506 | regulation of autophagy | 18.0328 | 6 | yes |
| GO:0010563 | negative regulation of phosphorus metabolic process | 18.0328 | 6 | yes |
| GO:0031329 | regulation of cellular catabolic process | 18.0328 | 5 | yes |
| GO:0031400 | negative regulation of protein modification process | 18.0328 | 7 | yes |
| GO:0043549 | regulation of kinase activity | 18.0328 | 5 | yes |
| GO:0045936 | negative regulation of phosphate metabolic process | 18.0328 | 7 | yes |
| GO:0006915 | apoptotic process | 16.3934 | 4 | yes |
| GO:0042127 | regulation of cell population proliferation | 16.3934 | 4 | yes |
| GO:0045859 | regulation of protein kinase activity | 16.3934 | 6 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 16.3934 | 4 | yes |
| GO:0098657 | import into cell | 16.3934 | 4 | yes |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 14.7541 | 4 | yes |
| GO:0007169 | cell surface receptor protein tyrosine kinase signaling pathway | 14.7541 | 5 | yes |
| GO:0009896 | positive regulation of catabolic process | 14.7541 | 5 | yes |
| GO:0043086 | negative regulation of catalytic activity | 14.7541 | 4 | yes |
| GO:0051129 | negative regulation of cellular component organization | 14.7541 | 5 | yes |
| GO:0001933 | negative regulation of protein phosphorylation | 13.1148 | 8 | yes |
| GO:0009267 | cellular response to starvation | 13.1148 | 4 | yes |
| GO:0032007 | negative regulation of TOR signaling | 13.1148 | 7 | yes |
| GO:0042326 | negative regulation of phosphorylation | 13.1148 | 8 | yes |
| GO:0016241 | regulation of macroautophagy | 11.4754 | 7 | yes |
| GO:0033365 | protein localization to organelle | 11.4754 | 5 | yes |
| GO:1904262 | negative regulation of TORC1 signaling | 11.4754 | 8 | yes |
| GO:0010508 | positive regulation of autophagy | 9.8361 | 7 | yes |
| GO:0031331 | positive regulation of cellular catabolic process | 9.8361 | 6 | yes |
| GO:0048009 | insulin-like growth factor receptor signaling pathway | 9.8361 | 6 | yes |
| GO:0051348 | negative regulation of transferase activity | 9.8361 | 5 | yes |
| GO:0072594 | establishment of protein localization to organelle | 9.8361 | 4 | yes |
| GO:0001843 | neural tube closure | 8.1967 | 5 | yes |
| GO:0006469 | negative regulation of protein kinase activity | 8.1967 | 7 | yes |
| GO:0009895 | negative regulation of catabolic process | 8.1967 | 5 | yes |
| GO:0010639 | negative regulation of organelle organization | 8.1967 | 6 | yes |
| GO:0010821 | regulation of mitochondrion organization | 8.1967 | 6 | yes |
| GO:0030100 | regulation of endocytosis | 8.1967 | 5 | yes |
| GO:0030111 | regulation of Wnt signaling pathway | 8.1967 | 5 | yes |
| GO:0033673 | negative regulation of kinase activity | 8.1967 | 6 | yes |
| GO:0043491 | phosphatidylinositol 3-kinase/protein kinase B signal transduction | 8.1967 | 5 | yes |
| GO:0051896 | regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | 8.1967 | 6 | yes |
| GO:0060606 | tube closure | 8.1967 | 4 | yes |
| GO:0006913 | nucleocytoplasmic transport | 6.5574 | 5 | yes |
| GO:0008285 | negative regulation of cell population proliferation | 6.5574 | 5 | yes |
| GO:0010507 | negative regulation of autophagy | 6.5574 | 7 | yes |
| GO:0016242 | negative regulation of macroautophagy | 6.5574 | 8 | yes |
| GO:0031330 | negative regulation of cellular catabolic process | 6.5574 | 6 | yes |
| GO:0034504 | protein localization to nucleus | 6.5574 | 6 | yes |
| GO:0046626 | regulation of insulin receptor signaling pathway | 6.5574 | 5 | yes |
| GO:0051169 | nuclear transport | 6.5574 | 4 | yes |
| GO:1900076 | regulation of cellular response to insulin stimulus | 6.5574 | 4 | yes |
| GO:0006606 | protein import into nucleus | 4.9180 | 5 | yes |
| GO:0007507 | heart development | 4.9180 | 4 | yes |
| GO:0016239 | positive regulation of macroautophagy | 4.9180 | 8 | yes |
| GO:0030178 | negative regulation of Wnt signaling pathway | 4.9180 | 6 | yes |
| GO:0043276 | anoikis | 4.9180 | 5 | yes |
| GO:0046627 | negative regulation of insulin receptor signaling pathway | 4.9180 | 6 | yes |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 4.9180 | 6 | yes |
| GO:0051170 | import into nucleus | 4.9180 | 6 | yes |
| GO:1900077 | negative regulation of cellular response to insulin stimulus | 4.9180 | 5 | yes |
| GO:0050918 | positive chemotaxis | 3.2787 | 4 | yes |
| GO:0051898 | negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | 3.2787 | 7 | yes |
| GO:1901524 | regulation of mitophagy | 3.2787 | 8 | yes |
| GO:1901525 | negative regulation of mitophagy | 3.2787 | 8 | yes |
| GO:1903146 | regulation of autophagy of mitochondrion | 3.2787 | 7 | yes |
| GO:1903147 | negative regulation of autophagy of mitochondrion | 3.2787 | 7 | yes |
Disease
No data found.
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 1433Z_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TSC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DAPK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CCND1_HUMAN | [view interactions] | Low throughput | no | yes |
| CDK4_HUMAN | [view interactions] | Low throughput | no | no |
| SGK1_HUMAN | [view interactions] | Low throughput | no | yes |
| 1433T_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433S_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SIR1_HUMAN | [view interactions] | Low throughput | no | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AAPK1_HUMAN | [view interactions] | Low throughput | no | no |
| KS6B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RHEB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TBCD7_HUMAN | [view interactions] | Low throughput | no | no |
| AMD_HUMAN | [view interactions] | Low throughput | no | yes |
| RAP1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RALA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AKT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KS6A1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FOXO1_HUMAN | [view interactions] | Low throughput | no | yes |
| AXIN1_HUMAN | [view interactions] | Low throughput | no | yes |
| FAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MK01_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CCND2_HUMAN | [view interactions] | Low throughput | no | yes |
| CCND3_HUMAN | [view interactions] | Low throughput | no | no |
| FBXW5_HUMAN | [view interactions] | Low throughput | no | no |
| UBE3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HERC1_HUMAN | [view interactions] | Low throughput | no | no |
| CDN1B_HUMAN | [view interactions] | Low throughput | no | yes |
| ESR1_HUMAN | [view interactions] | Low throughput | no | no |
| CALM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SMAD2_HUMAN | [view interactions] | Low throughput | no | yes |
| SMAD3_HUMAN | [view interactions] | Low throughput | no | yes |
| RRAGA_HUMAN | [view interactions] | Low throughput | no | yes |
| TSC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CBL_HUMAN | [view interactions] | Low throughput | no | yes |
| PLK1_HUMAN | [view interactions] | Low throughput | no | yes |
| CDK1_HUMAN | [view interactions] | Low throughput | no | no |
| CCNB1_HUMAN | [view interactions] | Low throughput | no | no |
| CCNA2_HUMAN | [view interactions] | Low throughput | no | no |
| RHOB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PLK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MAPK2_HUMAN | [view interactions] | Low throughput | no | yes |
| NFL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CAV1_HUMAN | [view interactions] | Low throughput | no | no |
| RAB5A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NEK1_HUMAN | [view interactions] | High throughput | no | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KITH_HUMAN | [view interactions] | High throughput | no | yes |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| PICK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHM1_HUMAN | [view interactions] | High throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TN13B_HUMAN | [view interactions] | High throughput | no | no |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| NEUS_HUMAN | [view interactions] | High throughput | no | yes |
| RSSA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRB4D_HUMAN | [view interactions] | High throughput | no | no |
| USPL1_HUMAN | [view interactions] | High throughput | no | yes |
| SEPT4_HUMAN | [view interactions] | High throughput | no | no |
| ACTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANR35_HUMAN | [view interactions] | High throughput | no | no |
| G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MKRN1_HUMAN | [view interactions] | High throughput | no | no |
| RM21_HUMAN | [view interactions] | High throughput | no | no |
| PHLB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S13A3_HUMAN | [view interactions] | High throughput | no | no |
| CTDP1_HUMAN | [view interactions] | High throughput | no | yes |
| BTG3_HUMAN | [view interactions] | High throughput | no | yes |
| TRI55_HUMAN | [view interactions] | High throughput | no | no |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| CBY1_HUMAN | [view interactions] | High throughput | no | no |
| LNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MDFI_HUMAN | [view interactions] | High throughput | no | no |
| CBY2_HUMAN | [view interactions] | High throughput | no | no |
| EF1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HECW2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CIAO1_HUMAN | [view interactions] | High throughput | no | yes |
| RRAGB_HUMAN | [view interactions] | High throughput | no | yes |
| RRAGC_HUMAN | [view interactions] | High throughput | no | yes |
| RRAGD_HUMAN | [view interactions] | High throughput | no | yes |
| SPIT2_HUMAN | [view interactions] | High throughput | no | yes |
| PNKD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XRP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GLU2B_HUMAN | [view interactions] | High throughput | no | yes |
| AL3A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| PO5F1_HUMAN | [view interactions] | High throughput | no | yes |
| COKA1_HUMAN | [view interactions] | High throughput | no | no |
| CD79B_HUMAN | [view interactions] | High throughput | no | no |
| CD83_HUMAN | [view interactions] | High throughput | no | yes |
| SIGL1_HUMAN | [view interactions] | High throughput | no | no |
| P4HA3_HUMAN | [view interactions] | High throughput | no | no |
| F221B_HUMAN | [view interactions] | High throughput | no | no |
| P4HA2_HUMAN | [view interactions] | High throughput | no | no |
| RUVB2_HUMAN | [view interactions] | High throughput | no | yes |
| DAA10_HUMAN | [view interactions] | High throughput | no | yes |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| RN123_HUMAN | [view interactions] | High throughput | no | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| TBK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| PEBB_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| OTUL_HUMAN | [view interactions] | High throughput | no | yes |
| EDEM1_HUMAN | [view interactions] | High throughput | no | yes |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| CD226_HUMAN | [view interactions] | High throughput | no | yes |
| MO4L1_HUMAN | [view interactions] | High throughput | no | yes |
| TPOR_HUMAN | [view interactions] | High throughput | no | no |
| MUL1_HUMAN | [view interactions] | High throughput | no | no |
| GLPA_HUMAN | [view interactions] | High throughput | no | no |
| CYB5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZP2_HUMAN | [view interactions] | High throughput | no | no |
| TMEM9_HUMAN | [view interactions] | High throughput | no | no |
| GPR17_HUMAN | [view interactions] | High throughput | no | no |
| IDD_HUMAN | [view interactions] | High throughput | no | no |
| NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEM4C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TSN10_HUMAN | [view interactions] | High throughput | no | no |
| EFNB1_HUMAN | [view interactions] | High throughput | no | yes |
| HCST_HUMAN | [view interactions] | High throughput | no | no |
| OPALI_HUMAN | [view interactions] | High throughput | no | yes |
| DUS16_HUMAN | [view interactions] | High throughput | no | yes |
| OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
| CC018_HUMAN | [view interactions] | High throughput | no | yes |
| CIA2A_HUMAN | [view interactions] | High throughput | no | yes |
| TMED5_HUMAN | [view interactions] | High throughput | no | yes |
| DNAI2_HUMAN | [view interactions] | High throughput | no | no |
| EFMT3_HUMAN | [view interactions] | High throughput | no | no |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| PJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CL16A_HUMAN | [view interactions] | High throughput | no | yes |
| MCE1_HUMAN | [view interactions] | High throughput | no | yes |
| CCNT1_HUMAN | [view interactions] | High throughput | no | yes |
| CD11A_HUMAN | [view interactions] | High throughput | no | yes |
| B3GN2_HUMAN | [view interactions] | High throughput | no | yes |
| B4GT1_HUMAN | [view interactions] | High throughput | no | yes |
| ARF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARI2_HUMAN | [view interactions] | High throughput | no | no |
| UB2J1_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC8_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| SC24A_HUMAN | [view interactions] | High throughput | no | no |
| TPC13_HUMAN | [view interactions] | High throughput | no | yes |
| TPC2L_HUMAN | [view interactions] | High throughput | no | yes |
| DCAF7_HUMAN | [view interactions] | High throughput | no | yes |
| CARM1_HUMAN | [view interactions] | High throughput | no | yes |
| IF2B1_HUMAN | [view interactions] | High throughput | no | no |
| CAND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VPS53_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTF2_HUMAN | [view interactions] | High throughput | no | no |
| TPC12_HUMAN | [view interactions] | High throughput | no | yes |
| S39A9_HUMAN | [view interactions] | High throughput | no | yes |
| S23IP_HUMAN | [view interactions] | High throughput | no | yes |
| TPC2A_HUMAN | [view interactions] | High throughput | no | yes |
| RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RABX5_HUMAN | [view interactions] | High throughput | no | no |
| S39A7_HUMAN | [view interactions] | High throughput | no | yes |
| RICTR_HUMAN | [view interactions] | High throughput | no | yes |
| SAR1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC24C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRBP1_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| STK11_HUMAN | [view interactions] | High throughput | no | yes |
| PTN11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPT6H_HUMAN | [view interactions] | High throughput | no | yes |
| TIGAR_HUMAN | [view interactions] | High throughput | no | yes |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NU155_HUMAN | [view interactions] | High throughput | no | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |