PNKD_HUMAN
Evidence for PS localization
Functions
Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 7 | Ala | Val | Dystonia8(DYT8) | - |
| 9 | Ala | Val | Dystonia8(DYT8) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PNKD_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 26.0870 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 26.0870 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 26.0870 | 4 | no |
| GO:0046872 | metal ion binding | 21.7391 | 4 | yes |
| GO:0042803 | protein homodimerization activity | 21.7391 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PNKD_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 52.1739 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 47.8261 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 47.8261 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 43.4783 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 43.4783 | 4 | no |
| GO:0071702 | organic substance transport | 39.1304 | 4 | no |
| GO:0071705 | nitrogen compound transport | 39.1304 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 39.1304 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 34.7826 | 4 | no |
| GO:0010468 | regulation of gene expression | 34.7826 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 34.7826 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 34.7826 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 34.7826 | 5 | no |
| GO:0006996 | organelle organization | 30.4348 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 30.4348 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 30.4348 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.4348 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 30.4348 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 30.4348 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 30.4348 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 30.4348 | 5 | no |
| GO:0051049 | regulation of transport | 26.0870 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 26.0870 | 7 | no |
| GO:0006355 | regulation of DNA-templated transcription | 26.0870 | 6 | no |
| GO:0009894 | regulation of catabolic process | 26.0870 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 26.0870 | 6 | no |
| GO:0031399 | regulation of protein modification process | 26.0870 | 6 | no |
| GO:0036211 | protein modification process | 26.0870 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 26.0870 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 26.0870 | 7 | no |
| GO:0043412 | macromolecule modification | 26.0870 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 26.0870 | 5 | no |
| GO:0051338 | regulation of transferase activity | 26.0870 | 4 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 26.0870 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 26.0870 | 6 | no |
| GO:0008104 | protein localization | 26.0870 | 4 | no |
| GO:0015031 | protein transport | 26.0870 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 26.0870 | 4 | no |
| GO:0010646 | regulation of cell communication | 26.0870 | 4 | yes |
| GO:0006357 | regulation of transcription by RNA polymerase II | 21.7391 | 7 | no |
| GO:0009893 | positive regulation of metabolic process | 21.7391 | 4 | no |
| GO:0009966 | regulation of signal transduction | 21.7391 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 21.7391 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 21.7391 | 4 | no |
| GO:0043549 | regulation of kinase activity | 21.7391 | 5 | no |
| GO:0045859 | regulation of protein kinase activity | 21.7391 | 6 | no |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 21.7391 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 21.7391 | 4 | no |
| GO:0051253 | negative regulation of RNA metabolic process | 21.7391 | 6 | no |
| GO:0031329 | regulation of cellular catabolic process | 21.7391 | 5 | no |
| GO:0033043 | regulation of organelle organization | 21.7391 | 5 | no |
| GO:0022607 | cellular component assembly | 21.7391 | 4 | no |
| GO:0043393 | regulation of protein binding | 21.7391 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 21.7391 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 17.3913 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 17.3913 | 4 | yes |
| GO:0043436 | oxoacid metabolic process | 8.6957 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 8.6957 | 5 | yes |
| GO:0050905 | neuromuscular process | 8.6957 | 4 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 8.6957 | 4 | yes |
| GO:0019752 | carboxylic acid metabolic process | 8.6957 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MK03_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GEMI2_HUMAN | [view interactions] | High throughput | no | yes |
| AR2BP_HUMAN | [view interactions] | High throughput | no | yes |
| BIG3_HUMAN | [view interactions] | High throughput | no | yes |
| TRBP2_HUMAN | [view interactions] | High throughput | no | yes |
| P4R3B_HUMAN | [view interactions] | High throughput | no | yes |
| NUP37_HUMAN | [view interactions] | High throughput | no | yes |
| DYM_HUMAN | [view interactions] | High throughput | no | yes |
| ATRIP_HUMAN | [view interactions] | High throughput | no | yes |
| GON4L_HUMAN | [view interactions] | High throughput | no | yes |
| SCRB2_HUMAN | [view interactions] | High throughput | no | yes |
| NICA_HUMAN | [view interactions] | High throughput | no | yes |
| ARMC6_HUMAN | [view interactions] | High throughput | no | yes |
| BUB1_HUMAN | [view interactions] | High throughput | no | no |
| SMN_HUMAN | [view interactions] | High throughput | no | yes |
| TBG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLSPN_HUMAN | [view interactions] | High throughput | no | no |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| EYA2_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2A_HUMAN | [view interactions] | High throughput | no | yes |
| HIF1N_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| MK06_HUMAN | [view interactions] | High throughput | no | yes |
| RNF31_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| DX39A_HUMAN | [view interactions] | High throughput | no | yes |
| GREB1_HUMAN | [view interactions] | High throughput | no | yes |
| DCAF7_HUMAN | [view interactions] | High throughput | no | yes |
| T10B_HUMAN | [view interactions] | High throughput | no | yes |
| TIM10_HUMAN | [view interactions] | High throughput | no | yes |
| NR6A1_HUMAN | [view interactions] | High throughput | no | no |
| TBCD5_HUMAN | [view interactions] | High throughput | no | yes |
| LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRB1L_HUMAN | [view interactions] | High throughput | no | no |
| ADDA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADDB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBR3_HUMAN | [view interactions] | High throughput | no | yes |
| AL3B2_HUMAN | [view interactions] | High throughput | no | yes |
| RAMP3_HUMAN | [view interactions] | High throughput | no | no |
| TBB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESPN_HUMAN | [view interactions] | High throughput | no | yes |
| KLH22_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SFXN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COA3_HUMAN | [view interactions] | High throughput | no | yes |
| MD2L2_HUMAN | [view interactions] | High throughput | no | yes |
| FARP2_HUMAN | [view interactions] | High throughput | no | yes |
| ACADM_HUMAN | [view interactions] | High throughput | no | yes |
| KCTD9_HUMAN | [view interactions] | High throughput | no | no |
| MAGAB_HUMAN | [view interactions] | High throughput | no | no |
| ILK_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| CMC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| PEX19_HUMAN | [view interactions] | High throughput | no | yes |
| BTAF1_HUMAN | [view interactions] | High throughput | no | no |
| RTF2_HUMAN | [view interactions] | High throughput | no | yes |
| EI2BE_HUMAN | [view interactions] | High throughput | no | yes |
| IF4G3_HUMAN | [view interactions] | High throughput | no | yes |
| SETX_HUMAN | [view interactions] | High throughput | no | yes |
| TBC15_HUMAN | [view interactions] | High throughput | no | yes |
| TFP11_HUMAN | [view interactions] | High throughput | no | no |
| IPO8_HUMAN | [view interactions] | High throughput | no | no |
| EI2BD_HUMAN | [view interactions] | High throughput | no | yes |
| KCC1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HEAT3_HUMAN | [view interactions] | High throughput | no | yes |
| NU160_HUMAN | [view interactions] | High throughput | no | no |
| TNPO2_HUMAN | [view interactions] | High throughput | no | yes |
| RNBP6_HUMAN | [view interactions] | High throughput | no | yes |
| CND1_HUMAN | [view interactions] | High throughput | no | yes |
| IPO9_HUMAN | [view interactions] | High throughput | no | no |
| FDFT_HUMAN | [view interactions] | High throughput | no | yes |
| SAAL1_HUMAN | [view interactions] | High throughput | no | yes |
| CIP2A_HUMAN | [view interactions] | High throughput | no | yes |
| CNDD3_HUMAN | [view interactions] | High throughput | no | no |
| KBP_HUMAN | [view interactions] | High throughput | no | yes |
| DIAP3_HUMAN | [view interactions] | High throughput | no | no |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| GOLP3_HUMAN | [view interactions] | High throughput | no | no |
| GLP3L_HUMAN | [view interactions] | High throughput | no | no |
| TSC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP6R2_HUMAN | [view interactions] | High throughput | no | no |
| NUP98_HUMAN | [view interactions] | High throughput | no | no |
| XPO4_HUMAN | [view interactions] | High throughput | no | no |
| PRGC2_HUMAN | [view interactions] | High throughput | no | no |
| LIPB1_HUMAN | [view interactions] | High throughput | no | yes |
| EXOC7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DICER_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUP85_HUMAN | [view interactions] | High throughput | no | yes |
| CETN3_HUMAN | [view interactions] | High throughput | no | yes |
| SOSSC_HUMAN | [view interactions] | High throughput | no | yes |
| STAG1_HUMAN | [view interactions] | High throughput | no | yes |
| STAG2_HUMAN | [view interactions] | High throughput | no | yes |
| ANM9_HUMAN | [view interactions] | High throughput | no | no |
| IPO11_HUMAN | [view interactions] | High throughput | no | yes |
| DCNL5_HUMAN | [view interactions] | High throughput | no | yes |
| PBIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RRP1_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK2_HUMAN | [view interactions] | High throughput | no | yes |
| TAF12_HUMAN | [view interactions] | High throughput | no | yes |
| NU107_HUMAN | [view interactions] | High throughput | no | no |
| STOM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECD_HUMAN | [view interactions] | High throughput | no | yes |
| PP6R1_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| GEMI_HUMAN | [view interactions] | High throughput | no | no |
| ASAH1_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3J_HUMAN | [view interactions] | High throughput | no | yes |
| RADIL_HUMAN | [view interactions] | High throughput | no | no |
| FBX30_HUMAN | [view interactions] | High throughput | no | yes |
| EI2BB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNDH2_HUMAN | [view interactions] | High throughput | no | no |
| INT3_HUMAN | [view interactions] | High throughput | no | yes |
| MLXIP_HUMAN | [view interactions] | High throughput | no | yes |
| MIGA1_HUMAN | [view interactions] | High throughput | no | yes |
| EI2BG_HUMAN | [view interactions] | High throughput | no | yes |
| VPS8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PJA1_HUMAN | [view interactions] | High throughput | no | yes |
| ARMX3_HUMAN | [view interactions] | High throughput | no | no |
| EXOC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCA11_HUMAN | [view interactions] | High throughput | no | yes |
| LSS_HUMAN | [view interactions] | High throughput | no | yes |
| AL14E_HUMAN | [view interactions] | High throughput | no | yes |
| HAUS7_HUMAN | [view interactions] | High throughput | no | no |
| ASIC4_HUMAN | [view interactions] | Computational | no | no |