Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PNKD_HUMAN

Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway. [View more on UniProt]

Interacting region for partners were not defined.

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Position Amino acid Mutation Disease Overlap with binding region
7 Ala Val Dystonia8(DYT8) -
9 Ala Val Dystonia8(DYT8) -

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in PNKD_HUMAN
GO:0043168 anion binding 30.4348 4 no
GO:0043169 cation binding 26.0870 4 yes
GO:0046872 metal ion binding 26.0870 5 yes
GO:0000166 nucleotide binding 26.0870 4 no
GO:0017076 purine nucleotide binding 26.0870 5 no
GO:0032555 purine ribonucleotide binding 26.0870 4 no
GO:0035639 purine ribonucleoside triphosphate binding 26.0870 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in PNKD_HUMAN
GO:0080090 regulation of primary metabolic process 47.8261 4 yes
GO:0031323 regulation of cellular metabolic process 47.8261 4 no
GO:0048523 negative regulation of cellular process 43.4783 4 yes
GO:0048522 positive regulation of cellular process 43.4783 4 no
GO:0060255 regulation of macromolecule metabolic process 43.4783 4 no
GO:0071702 organic substance transport 34.7826 4 no
GO:0071705 nitrogen compound transport 34.7826 4 no
GO:0009889 regulation of biosynthetic process 34.7826 4 no
GO:0010468 regulation of gene expression 34.7826 6 no
GO:0010556 regulation of macromolecule biosynthetic process 34.7826 5 no
GO:0031326 regulation of cellular biosynthetic process 34.7826 5 no
GO:0006996 organelle organization 34.7826 4 no
GO:0051128 regulation of cellular component organization 34.7826 4 no
GO:0010646 regulation of cell communication 30.4348 4 yes
GO:0009892 negative regulation of metabolic process 30.4348 4 no
GO:0010605 negative regulation of macromolecule metabolic process 30.4348 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 30.4348 5 no
GO:0051252 regulation of RNA metabolic process 30.4348 5 no
GO:0051246 regulation of protein metabolic process 30.4348 5 no
GO:0051049 regulation of transport 26.0870 4 yes
GO:0008104 protein localization 26.0870 4 no
GO:0009894 regulation of catabolic process 26.0870 4 no
GO:0015031 protein transport 26.0870 4 no
GO:0006355 regulation of DNA-templated transcription 26.0870 7 no
GO:0009966 regulation of signal transduction 26.0870 4 no
GO:0031324 negative regulation of cellular metabolic process 26.0870 5 no
GO:0042127 regulation of cell population proliferation 26.0870 4 no
GO:2001141 regulation of RNA biosynthetic process 26.0870 6 no
GO:0022607 cellular component assembly 26.0870 4 no
GO:0051338 regulation of transferase activity 26.0870 4 no
GO:0048584 positive regulation of response to stimulus 21.7391 4 no
GO:0045595 regulation of cell differentiation 21.7391 4 no
GO:0051094 positive regulation of developmental process 21.7391 4 no
GO:0006357 regulation of transcription by RNA polymerase II 21.7391 8 no
GO:0090304 nucleic acid metabolic process 21.7391 4 no
GO:0001932 regulation of protein phosphorylation 21.7391 7 no
GO:0009893 positive regulation of metabolic process 21.7391 4 no
GO:0019220 regulation of phosphate metabolic process 21.7391 6 no
GO:0031325 positive regulation of cellular metabolic process 21.7391 5 no
GO:0031399 regulation of protein modification process 21.7391 6 no
GO:0042325 regulation of phosphorylation 21.7391 7 no
GO:0043549 regulation of kinase activity 21.7391 5 no
GO:0045859 regulation of protein kinase activity 21.7391 6 no
GO:0051174 regulation of phosphorus metabolic process 21.7391 5 no
GO:0050804 modulation of chemical synaptic transmission 13.0435 5 yes
GO:0099177 regulation of trans-synaptic signaling 13.0435 4 yes
GO:0050905 neuromuscular process 8.6957 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MK03_HUMAN [view entry] [view interactions] Low throughput yes yes
COA3_HUMAN [view interactions] High throughput no yes
MD2L2_HUMAN [view interactions] High throughput no yes
FARP2_HUMAN [view interactions] High throughput no yes
NPC1_HUMAN [view interactions] High throughput no yes
ACADM_HUMAN [view interactions] High throughput no yes
KCTD9_HUMAN [view interactions] High throughput no no
MAGAB_HUMAN [view interactions] High throughput no no
ILK_HUMAN [view interactions] High throughput no no
ESR1_HUMAN [view interactions] High throughput no no
COX2_HUMAN [view entry] [view interactions] High throughput yes yes
TBB5_HUMAN [view interactions] High throughput no yes
PEX19_HUMAN [view interactions] High throughput no yes
BTAF1_HUMAN [view interactions] High throughput no no
RTF2_HUMAN [view interactions] High throughput no yes
EI2BE_HUMAN [view interactions] High throughput no yes
IF4G3_HUMAN [view interactions] High throughput no yes
SETX_HUMAN [view interactions] High throughput no yes
TBC15_HUMAN [view interactions] High throughput no yes
TFP11_HUMAN [view interactions] High throughput no no
IPO8_HUMAN [view interactions] High throughput no no
EI2BD_HUMAN [view interactions] High throughput no yes
KCC1A_HUMAN [view entry] [view interactions] High throughput yes yes
IPO7_HUMAN [view entry] [view interactions] High throughput yes yes
HEAT3_HUMAN [view interactions] High throughput no yes
NU160_HUMAN [view interactions] High throughput no no
TNPO2_HUMAN [view interactions] High throughput no yes
RNBP6_HUMAN [view interactions] High throughput no yes
CND1_HUMAN [view interactions] High throughput no yes
IPO9_HUMAN [view interactions] High throughput no no
FDFT_HUMAN [view interactions] High throughput no yes
SAAL1_HUMAN [view interactions] High throughput no yes
CIP2A_HUMAN [view interactions] High throughput no yes
CNDD3_HUMAN [view interactions] High throughput no no
KBP_HUMAN [view interactions] High throughput no yes
DIAP3_HUMAN [view interactions] High throughput no no
GBF1_HUMAN [view interactions] High throughput no yes
GOLP3_HUMAN [view interactions] High throughput no no
GLP3L_HUMAN [view interactions] High throughput no no
TSC2_HUMAN [view entry] [view interactions] High throughput yes yes
PP6R2_HUMAN [view interactions] High throughput no no
NUP98_HUMAN [view interactions] High throughput no no
XPO4_HUMAN [view interactions] High throughput no no
PRGC2_HUMAN [view interactions] High throughput no no
LIPB1_HUMAN [view interactions] High throughput no yes
EXOC7_HUMAN [view entry] [view interactions] High throughput yes yes
DICER_HUMAN [view entry] [view interactions] High throughput yes yes
AP1B1_HUMAN [view entry] [view interactions] High throughput yes yes
NUP85_HUMAN [view interactions] High throughput no yes
CETN3_HUMAN [view interactions] High throughput no yes
SOSSC_HUMAN [view interactions] High throughput no yes
STAG1_HUMAN [view interactions] High throughput no yes
STAG2_HUMAN [view interactions] High throughput no yes
ANM9_HUMAN [view interactions] High throughput no no
IPO11_HUMAN [view interactions] High throughput no yes
DCNL5_HUMAN [view interactions] High throughput no yes
PBIP1_HUMAN [view entry] [view interactions] High throughput yes no
RRP1_HUMAN [view interactions] High throughput no yes
HOOK2_HUMAN [view interactions] High throughput no yes
TAF12_HUMAN [view interactions] High throughput no yes
NU107_HUMAN [view interactions] High throughput no no
STOM_HUMAN [view entry] [view interactions] High throughput yes yes
ECD_HUMAN [view interactions] High throughput no yes
PP6R1_HUMAN [view interactions] High throughput no no
KIF14_HUMAN [view interactions] High throughput no no
GEMI_HUMAN [view interactions] High throughput no no
ASAH1_HUMAN [view interactions] High throughput no yes
EIF3J_HUMAN [view interactions] High throughput no yes
RADIL_HUMAN [view interactions] High throughput no no
FBX30_HUMAN [view interactions] High throughput no yes
EI2BB_HUMAN [view entry] [view interactions] High throughput yes yes
CNDH2_HUMAN [view interactions] High throughput no no
INT3_HUMAN [view interactions] High throughput no yes
MLXIP_HUMAN [view interactions] High throughput no yes
MIGA1_HUMAN [view interactions] High throughput no yes
EI2BG_HUMAN [view interactions] High throughput no yes
VPS8_HUMAN [view entry] [view interactions] High throughput yes yes
PJA1_HUMAN [view interactions] High throughput no yes
ARMX3_HUMAN [view interactions] High throughput no no
EXOC5_HUMAN [view entry] [view interactions] High throughput yes yes
DCA11_HUMAN [view interactions] High throughput no yes
LSS_HUMAN [view interactions] High throughput no yes
AL14E_HUMAN [view interactions] High throughput no yes
HAUS7_HUMAN [view interactions] High throughput no no
GEMI2_HUMAN [view interactions] High throughput no yes
AR2BP_HUMAN [view interactions] High throughput no yes
BIG3_HUMAN [view interactions] High throughput no yes
TRBP2_HUMAN [view interactions] High throughput no yes
P4R3B_HUMAN [view interactions] High throughput no yes
NUP37_HUMAN [view interactions] High throughput no yes
DYM_HUMAN [view interactions] High throughput no yes
ATRIP_HUMAN [view interactions] High throughput no yes
GON4L_HUMAN [view interactions] High throughput no yes
SCRB2_HUMAN [view interactions] High throughput no yes
NICA_HUMAN [view interactions] High throughput no yes
ARMC6_HUMAN [view interactions] High throughput no yes
BUB1_HUMAN [view interactions] High throughput no no
SMN_HUMAN [view interactions] High throughput no yes
TBG1_HUMAN [view entry] [view interactions] High throughput yes yes
CLSPN_HUMAN [view interactions] High throughput no no
OTUB1_HUMAN [view interactions] High throughput no yes
EYA2_HUMAN [view interactions] High throughput no yes
FHI2A_HUMAN [view interactions] High throughput no yes
HIF1N_HUMAN [view interactions] High throughput no yes
EGLN3_HUMAN [view interactions] High throughput no no
MK06_HUMAN [view interactions] High throughput no yes
RNF31_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA4_HUMAN [view interactions] High throughput no yes
KIF23_HUMAN [view interactions] High throughput no yes
DX39A_HUMAN [view interactions] High throughput no yes
GREB1_HUMAN [view interactions] High throughput no yes
DCAF7_HUMAN [view interactions] High throughput no yes
T10B_HUMAN [view interactions] High throughput no yes
TIM10_HUMAN [view interactions] High throughput no yes
NR6A1_HUMAN [view interactions] High throughput no no
TBCD5_HUMAN [view interactions] High throughput no yes
LPPRC_HUMAN [view entry] [view interactions] High throughput yes yes
GRB1L_HUMAN [view interactions] High throughput no no
ADDA_HUMAN [view entry] [view interactions] High throughput yes yes
ADDB_HUMAN [view entry] [view interactions] High throughput yes yes
UBR3_HUMAN [view interactions] High throughput no yes
AL3B2_HUMAN [view interactions] High throughput no yes
RAMP3_HUMAN [view interactions] High throughput no no
TBB2A_HUMAN [view entry] [view interactions] High throughput yes yes
ESPN_HUMAN [view interactions] High throughput no yes
KLH22_HUMAN [view interactions] High throughput no no
CCNF_HUMAN [view interactions] High throughput no no
ZRAN1_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
PPIB_HUMAN [view entry] [view interactions] High throughput yes yes
SFXN1_HUMAN [view entry] [view interactions] High throughput yes yes