PNKD_HUMAN
Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway. [View more on UniProt]
Interacting region for partners were not defined.
Position | Amino acid | Mutation | Disease | Overlap with binding region |
---|---|---|---|---|
7 | Ala | Val | Dystonia8(DYT8) | - |
9 | Ala | Val | Dystonia8(DYT8) | - |
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in PNKD_HUMAN |
---|---|---|---|---|
GO:0043168 | anion binding | 30.4348 | 4 | no |
GO:0043169 | cation binding | 26.0870 | 4 | yes |
GO:0046872 | metal ion binding | 26.0870 | 5 | yes |
GO:0000166 | nucleotide binding | 26.0870 | 4 | no |
GO:0017076 | purine nucleotide binding | 26.0870 | 5 | no |
GO:0032555 | purine ribonucleotide binding | 26.0870 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 26.0870 | 4 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in PNKD_HUMAN |
---|---|---|---|---|
GO:0080090 | regulation of primary metabolic process | 47.8261 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 47.8261 | 4 | no |
GO:0048523 | negative regulation of cellular process | 43.4783 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 43.4783 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 43.4783 | 4 | no |
GO:0071702 | organic substance transport | 34.7826 | 4 | no |
GO:0071705 | nitrogen compound transport | 34.7826 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 34.7826 | 4 | no |
GO:0010468 | regulation of gene expression | 34.7826 | 6 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 34.7826 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 34.7826 | 5 | no |
GO:0006996 | organelle organization | 34.7826 | 4 | no |
GO:0051128 | regulation of cellular component organization | 34.7826 | 4 | no |
GO:0010646 | regulation of cell communication | 30.4348 | 4 | yes |
GO:0009892 | negative regulation of metabolic process | 30.4348 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 30.4348 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.4348 | 5 | no |
GO:0051252 | regulation of RNA metabolic process | 30.4348 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 30.4348 | 5 | no |
GO:0051049 | regulation of transport | 26.0870 | 4 | yes |
GO:0008104 | protein localization | 26.0870 | 4 | no |
GO:0009894 | regulation of catabolic process | 26.0870 | 4 | no |
GO:0015031 | protein transport | 26.0870 | 4 | no |
GO:0006355 | regulation of DNA-templated transcription | 26.0870 | 7 | no |
GO:0009966 | regulation of signal transduction | 26.0870 | 4 | no |
GO:0031324 | negative regulation of cellular metabolic process | 26.0870 | 5 | no |
GO:0042127 | regulation of cell population proliferation | 26.0870 | 4 | no |
GO:2001141 | regulation of RNA biosynthetic process | 26.0870 | 6 | no |
GO:0022607 | cellular component assembly | 26.0870 | 4 | no |
GO:0051338 | regulation of transferase activity | 26.0870 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 21.7391 | 4 | no |
GO:0045595 | regulation of cell differentiation | 21.7391 | 4 | no |
GO:0051094 | positive regulation of developmental process | 21.7391 | 4 | no |
GO:0006357 | regulation of transcription by RNA polymerase II | 21.7391 | 8 | no |
GO:0090304 | nucleic acid metabolic process | 21.7391 | 4 | no |
GO:0001932 | regulation of protein phosphorylation | 21.7391 | 7 | no |
GO:0009893 | positive regulation of metabolic process | 21.7391 | 4 | no |
GO:0019220 | regulation of phosphate metabolic process | 21.7391 | 6 | no |
GO:0031325 | positive regulation of cellular metabolic process | 21.7391 | 5 | no |
GO:0031399 | regulation of protein modification process | 21.7391 | 6 | no |
GO:0042325 | regulation of phosphorylation | 21.7391 | 7 | no |
GO:0043549 | regulation of kinase activity | 21.7391 | 5 | no |
GO:0045859 | regulation of protein kinase activity | 21.7391 | 6 | no |
GO:0051174 | regulation of phosphorus metabolic process | 21.7391 | 5 | no |
GO:0050804 | modulation of chemical synaptic transmission | 13.0435 | 5 | yes |
GO:0099177 | regulation of trans-synaptic signaling | 13.0435 | 4 | yes |
GO:0050905 | neuromuscular process | 8.6957 | 4 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
MK03_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
COA3_HUMAN | [view interactions] | High throughput | no | yes |
MD2L2_HUMAN | [view interactions] | High throughput | no | yes |
FARP2_HUMAN | [view interactions] | High throughput | no | yes |
NPC1_HUMAN | [view interactions] | High throughput | no | yes |
ACADM_HUMAN | [view interactions] | High throughput | no | yes |
KCTD9_HUMAN | [view interactions] | High throughput | no | no |
MAGAB_HUMAN | [view interactions] | High throughput | no | no |
ILK_HUMAN | [view interactions] | High throughput | no | no |
ESR1_HUMAN | [view interactions] | High throughput | no | no |
COX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBB5_HUMAN | [view interactions] | High throughput | no | yes |
PEX19_HUMAN | [view interactions] | High throughput | no | yes |
BTAF1_HUMAN | [view interactions] | High throughput | no | no |
RTF2_HUMAN | [view interactions] | High throughput | no | yes |
EI2BE_HUMAN | [view interactions] | High throughput | no | yes |
IF4G3_HUMAN | [view interactions] | High throughput | no | yes |
SETX_HUMAN | [view interactions] | High throughput | no | yes |
TBC15_HUMAN | [view interactions] | High throughput | no | yes |
TFP11_HUMAN | [view interactions] | High throughput | no | no |
IPO8_HUMAN | [view interactions] | High throughput | no | no |
EI2BD_HUMAN | [view interactions] | High throughput | no | yes |
KCC1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HEAT3_HUMAN | [view interactions] | High throughput | no | yes |
NU160_HUMAN | [view interactions] | High throughput | no | no |
TNPO2_HUMAN | [view interactions] | High throughput | no | yes |
RNBP6_HUMAN | [view interactions] | High throughput | no | yes |
CND1_HUMAN | [view interactions] | High throughput | no | yes |
IPO9_HUMAN | [view interactions] | High throughput | no | no |
FDFT_HUMAN | [view interactions] | High throughput | no | yes |
SAAL1_HUMAN | [view interactions] | High throughput | no | yes |
CIP2A_HUMAN | [view interactions] | High throughput | no | yes |
CNDD3_HUMAN | [view interactions] | High throughput | no | no |
KBP_HUMAN | [view interactions] | High throughput | no | yes |
DIAP3_HUMAN | [view interactions] | High throughput | no | no |
GBF1_HUMAN | [view interactions] | High throughput | no | yes |
GOLP3_HUMAN | [view interactions] | High throughput | no | no |
GLP3L_HUMAN | [view interactions] | High throughput | no | no |
TSC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PP6R2_HUMAN | [view interactions] | High throughput | no | no |
NUP98_HUMAN | [view interactions] | High throughput | no | no |
XPO4_HUMAN | [view interactions] | High throughput | no | no |
PRGC2_HUMAN | [view interactions] | High throughput | no | no |
LIPB1_HUMAN | [view interactions] | High throughput | no | yes |
EXOC7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DICER_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AP1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NUP85_HUMAN | [view interactions] | High throughput | no | yes |
CETN3_HUMAN | [view interactions] | High throughput | no | yes |
SOSSC_HUMAN | [view interactions] | High throughput | no | yes |
STAG1_HUMAN | [view interactions] | High throughput | no | yes |
STAG2_HUMAN | [view interactions] | High throughput | no | yes |
ANM9_HUMAN | [view interactions] | High throughput | no | no |
IPO11_HUMAN | [view interactions] | High throughput | no | yes |
DCNL5_HUMAN | [view interactions] | High throughput | no | yes |
PBIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RRP1_HUMAN | [view interactions] | High throughput | no | yes |
HOOK2_HUMAN | [view interactions] | High throughput | no | yes |
TAF12_HUMAN | [view interactions] | High throughput | no | yes |
NU107_HUMAN | [view interactions] | High throughput | no | no |
STOM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ECD_HUMAN | [view interactions] | High throughput | no | yes |
PP6R1_HUMAN | [view interactions] | High throughput | no | no |
KIF14_HUMAN | [view interactions] | High throughput | no | no |
GEMI_HUMAN | [view interactions] | High throughput | no | no |
ASAH1_HUMAN | [view interactions] | High throughput | no | yes |
EIF3J_HUMAN | [view interactions] | High throughput | no | yes |
RADIL_HUMAN | [view interactions] | High throughput | no | no |
FBX30_HUMAN | [view interactions] | High throughput | no | yes |
EI2BB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CNDH2_HUMAN | [view interactions] | High throughput | no | no |
INT3_HUMAN | [view interactions] | High throughput | no | yes |
MLXIP_HUMAN | [view interactions] | High throughput | no | yes |
MIGA1_HUMAN | [view interactions] | High throughput | no | yes |
EI2BG_HUMAN | [view interactions] | High throughput | no | yes |
VPS8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PJA1_HUMAN | [view interactions] | High throughput | no | yes |
ARMX3_HUMAN | [view interactions] | High throughput | no | no |
EXOC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DCA11_HUMAN | [view interactions] | High throughput | no | yes |
LSS_HUMAN | [view interactions] | High throughput | no | yes |
AL14E_HUMAN | [view interactions] | High throughput | no | yes |
HAUS7_HUMAN | [view interactions] | High throughput | no | no |
GEMI2_HUMAN | [view interactions] | High throughput | no | yes |
AR2BP_HUMAN | [view interactions] | High throughput | no | yes |
BIG3_HUMAN | [view interactions] | High throughput | no | yes |
TRBP2_HUMAN | [view interactions] | High throughput | no | yes |
P4R3B_HUMAN | [view interactions] | High throughput | no | yes |
NUP37_HUMAN | [view interactions] | High throughput | no | yes |
DYM_HUMAN | [view interactions] | High throughput | no | yes |
ATRIP_HUMAN | [view interactions] | High throughput | no | yes |
GON4L_HUMAN | [view interactions] | High throughput | no | yes |
SCRB2_HUMAN | [view interactions] | High throughput | no | yes |
NICA_HUMAN | [view interactions] | High throughput | no | yes |
ARMC6_HUMAN | [view interactions] | High throughput | no | yes |
BUB1_HUMAN | [view interactions] | High throughput | no | no |
SMN_HUMAN | [view interactions] | High throughput | no | yes |
TBG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CLSPN_HUMAN | [view interactions] | High throughput | no | no |
OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
EYA2_HUMAN | [view interactions] | High throughput | no | yes |
FHI2A_HUMAN | [view interactions] | High throughput | no | yes |
HIF1N_HUMAN | [view interactions] | High throughput | no | yes |
EGLN3_HUMAN | [view interactions] | High throughput | no | no |
MK06_HUMAN | [view interactions] | High throughput | no | yes |
RNF31_HUMAN | [view interactions] | High throughput | no | yes |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
KIF23_HUMAN | [view interactions] | High throughput | no | yes |
DX39A_HUMAN | [view interactions] | High throughput | no | yes |
GREB1_HUMAN | [view interactions] | High throughput | no | yes |
DCAF7_HUMAN | [view interactions] | High throughput | no | yes |
T10B_HUMAN | [view interactions] | High throughput | no | yes |
TIM10_HUMAN | [view interactions] | High throughput | no | yes |
NR6A1_HUMAN | [view interactions] | High throughput | no | no |
TBCD5_HUMAN | [view interactions] | High throughput | no | yes |
LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GRB1L_HUMAN | [view interactions] | High throughput | no | no |
ADDA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ADDB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBR3_HUMAN | [view interactions] | High throughput | no | yes |
AL3B2_HUMAN | [view interactions] | High throughput | no | yes |
RAMP3_HUMAN | [view interactions] | High throughput | no | no |
TBB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ESPN_HUMAN | [view interactions] | High throughput | no | yes |
KLH22_HUMAN | [view interactions] | High throughput | no | no |
CCNF_HUMAN | [view interactions] | High throughput | no | no |
ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PPIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SFXN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |