EXOC5_HUMAN
Evidence for PS localization
Functions
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in EXOC5_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 32.0755 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 32.0755 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 32.0755 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 22.6415 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 22.6415 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 22.6415 | 6 | no |
| GO:0019900 | kinase binding | 22.6415 | 4 | no |
| GO:0003924 | GTPase activity | 20.7547 | 7 | no |
| GO:0005525 | GTP binding | 20.7547 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 20.7547 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 20.7547 | 5 | no |
| GO:0031267 | small GTPase binding | 13.2075 | 5 | yes |
| GO:0051020 | GTPase binding | 13.2075 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in EXOC5_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 62.2642 | 4 | yes |
| GO:0071702 | organic substance transport | 58.4906 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 58.4906 | 4 | yes |
| GO:0015031 | protein transport | 52.8302 | 4 | yes |
| GO:0051049 | regulation of transport | 52.8302 | 4 | no |
| GO:0006996 | organelle organization | 50.9434 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 50.9434 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 47.1698 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 47.1698 | 4 | no |
| GO:0010646 | regulation of cell communication | 45.2830 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 45.2830 | 4 | no |
| GO:0022607 | cellular component assembly | 41.5094 | 4 | yes |
| GO:0046903 | secretion | 39.6226 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 39.6226 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 37.7358 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 37.7358 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 37.7358 | 4 | no |
| GO:0006887 | exocytosis | 35.8491 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 35.8491 | 4 | no |
| GO:0009966 | regulation of signal transduction | 35.8491 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 33.9623 | 4 | no |
| GO:0051046 | regulation of secretion | 32.0755 | 5 | no |
| GO:1903530 | regulation of secretion by cell | 32.0755 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 32.0755 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 32.0755 | 5 | no |
| GO:0023056 | positive regulation of signaling | 32.0755 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 30.1887 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 30.1887 | 4 | no |
| GO:0030030 | cell projection organization | 28.3019 | 4 | yes |
| GO:0098876 | vesicle-mediated transport to the plasma membrane | 28.3019 | 4 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 28.3019 | 5 | no |
| GO:0048193 | Golgi vesicle transport | 26.4151 | 5 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 26.4151 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 26.4151 | 4 | no |
| GO:0010468 | regulation of gene expression | 26.4151 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.4151 | 5 | no |
| GO:0009894 | regulation of catabolic process | 26.4151 | 4 | no |
| GO:0061024 | membrane organization | 26.4151 | 4 | no |
| GO:0006892 | post-Golgi vesicle-mediated transport | 24.5283 | 6 | yes |
| GO:0072657 | protein localization to membrane | 24.5283 | 4 | yes |
| GO:0010941 | regulation of cell death | 24.5283 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 24.5283 | 5 | no |
| GO:0060341 | regulation of cellular localization | 24.5283 | 4 | no |
| GO:1990778 | protein localization to cell periphery | 22.6415 | 5 | yes |
| GO:0010243 | response to organonitrogen compound | 22.6415 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 22.6415 | 5 | no |
| GO:0031399 | regulation of protein modification process | 22.6415 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 22.6415 | 6 | no |
| GO:0017157 | regulation of exocytosis | 22.6415 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 22.6415 | 5 | no |
| GO:0032880 | regulation of protein localization | 22.6415 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 22.6415 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 22.6415 | 6 | no |
| GO:0071310 | cellular response to organic substance | 22.6415 | 4 | no |
| GO:0006886 | intracellular protein transport | 22.6415 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 20.7547 | 5 | no |
| GO:0023057 | negative regulation of signaling | 20.7547 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 20.7547 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 20.7547 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 20.7547 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 20.7547 | 5 | no |
| GO:0051050 | positive regulation of transport | 20.7547 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 20.7547 | 5 | no |
| GO:0031329 | regulation of cellular catabolic process | 20.7547 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 20.7547 | 5 | no |
| GO:0007010 | cytoskeleton organization | 20.7547 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 20.7547 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 20.7547 | 4 | no |
| GO:0006893 | Golgi to plasma membrane transport | 18.8679 | 5 | yes |
| GO:0070925 | organelle assembly | 18.8679 | 5 | yes |
| GO:0072659 | protein localization to plasma membrane | 16.9811 | 5 | yes |
| GO:0030031 | cell projection assembly | 15.0943 | 5 | yes |
| GO:0120031 | plasma membrane bounded cell projection assembly | 15.0943 | 6 | yes |
| GO:0006915 | apoptotic process | 13.2075 | 4 | yes |
| GO:0044782 | cilium organization | 9.4340 | 5 | yes |
| GO:0060271 | cilium assembly | 9.4340 | 6 | yes |
| GO:1904019 | epithelial cell apoptotic process | 5.6604 | 5 | yes |
| GO:0001736 | establishment of planar polarity | 3.7736 | 4 | yes |
| GO:1905515 | non-motile cilium assembly | 3.7736 | 7 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in EXOC5_HUMAN |
|---|---|---|---|---|
| DOID:0050155 | sensory system disease | 5.6604 | 3 | no |
| DOID:0050563 | nonsyndromic deafness | 3.7736 | 5 | no |
| DOID:0050564 | autosomal dominant nonsyndromic deafness | 3.7736 | 6 | no |
| DOID:110 | lens disease | 3.7736 | 5 | no |
| DOID:2742 | auditory system disease | 3.7736 | 4 | no |
| DOID:5614 | eye disease | 3.7736 | 4 | no |
| DOID:83 | cataract | 3.7736 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| EXOC3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EXOC4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SC61B_HUMAN | [view interactions] | Low throughput | no | yes |
| KPCG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNPO2_HUMAN | [view interactions] | High throughput | no | yes |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| NPY2R_HUMAN | [view interactions] | High throughput | no | no |
| EPHA1_HUMAN | [view interactions] | High throughput | no | yes |
| STX11_HUMAN | [view interactions] | High throughput | no | yes |
| IL1R2_HUMAN | [view interactions] | High throughput | no | no |
| CAH14_HUMAN | [view interactions] | High throughput | no | yes |
| ERP29_HUMAN | [view interactions] | High throughput | no | yes |
| SCN2B_HUMAN | [view interactions] | High throughput | no | no |
| EXOC6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DSN1_HUMAN | [view interactions] | High throughput | no | yes |
| COG6_HUMAN | [view interactions] | High throughput | no | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| UN93B_HUMAN | [view interactions] | High throughput | no | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| CADH2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ICA69_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SOX10_HUMAN | [view interactions] | High throughput | no | yes |
| TBX21_HUMAN | [view interactions] | High throughput | no | no |
| ADCK1_HUMAN | [view interactions] | High throughput | no | no |
| ARP3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DEUP1_HUMAN | [view interactions] | High throughput | no | no |
| OAS1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB4B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TXN4A_HUMAN | [view interactions] | High throughput | no | no |
| PTK6_HUMAN | [view interactions] | High throughput | no | yes |
| BRM1L_HUMAN | [view interactions] | High throughput | no | no |
| C102B_HUMAN | [view interactions] | High throughput | no | yes |
| MAGA6_HUMAN | [view interactions] | High throughput | no | no |
| TXLNB_HUMAN | [view interactions] | High throughput | no | no |
| KXDL1_HUMAN | [view interactions] | High throughput | no | yes |
| MESH1_HUMAN | [view interactions] | High throughput | no | yes |
| SACA9_HUMAN | [view interactions] | High throughput | no | no |
| FRMD6_HUMAN | [view interactions] | High throughput | no | no |
| BARD1_HUMAN | [view interactions] | High throughput | no | yes |
| ASC_HUMAN | [view interactions] | High throughput | no | no |
| EXOC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HGS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFT57_HUMAN | [view interactions] | High throughput | no | yes |
| MAGA3_HUMAN | [view interactions] | High throughput | no | no |
| CRBB1_HUMAN | [view interactions] | High throughput | no | no |
| THOC1_HUMAN | [view interactions] | High throughput | no | yes |
| CA216_HUMAN | [view interactions] | High throughput | no | yes |
| EXC6B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP2_HUMAN | [view interactions] | High throughput | no | yes |
| CRYAB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WFS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPRE1_HUMAN | [view interactions] | High throughput | no | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TADBP_HUMAN | [view interactions] | High throughput | no | yes |
| EXOC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN609_HUMAN | [view interactions] | High throughput | no | yes |
| EXOC2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NSF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOC7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STIM1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENOG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EDRF1_HUMAN | [view interactions] | High throughput | no | no |
| TT23L_HUMAN | [view interactions] | High throughput | no | no |
| PPIP1_HUMAN | [view interactions] | High throughput | no | no |
| DAAF4_HUMAN | [view interactions] | High throughput | no | yes |
| KIFC3_HUMAN | [view interactions] | High throughput | no | no |
| FIBA_HUMAN | [view interactions] | High throughput | no | no |
| CBP_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| PNKD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SETB1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| OPRM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EDNRB_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| HECD1_HUMAN | [view interactions] | High throughput | no | yes |
| K1C17_HUMAN | [view interactions] | High throughput | no | no |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| PD1L1_HUMAN | [view interactions] | High throughput | no | no |
| EFNB1_HUMAN | [view interactions] | High throughput | no | yes |
| MTX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQIP1_HUMAN | [view interactions] | High throughput | no | yes |
| SCHI1_HUMAN | [view interactions] | High throughput | no | yes |
| SEM4C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VMAT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LURA1_HUMAN | [view interactions] | High throughput | no | yes |
| F234A_HUMAN | [view interactions] | High throughput | no | yes |
| GPR17_HUMAN | [view interactions] | High throughput | no | no |
| TACD2_HUMAN | [view interactions] | High throughput | no | no |
| GLPA_HUMAN | [view interactions] | High throughput | no | no |
| CC018_HUMAN | [view interactions] | High throughput | no | yes |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| IFT20_HUMAN | [view interactions] | High throughput | no | yes |
| GLR_HUMAN | [view interactions] | High throughput | no | no |
| CML1_HUMAN | [view interactions] | High throughput | no | yes |
| EX3L1_HUMAN | [view interactions] | High throughput | no | yes |
| TNR5_HUMAN | [view interactions] | High throughput | no | no |
| GGA1_HUMAN | [view interactions] | High throughput | no | yes |
| CD70_HUMAN | [view interactions] | High throughput | no | no |
| MIC19_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KT222_HUMAN | [view interactions] | High throughput | no | no |
| GPR45_HUMAN | [view interactions] | High throughput | no | no |
| DVL2_HUMAN | [view interactions] | High throughput | no | yes |
| CBX1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STXB3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAB3I_HUMAN | [view interactions] | Computational | no | no |
| CDC42_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SKP1_HUMAN | [view interactions] | Computational | no | yes |
| PKD2_HUMAN | [view interactions] | Computational | no | yes |
| C2CD5_HUMAN | [view interactions] | Computational | no | yes |
| RHOQ_HUMAN | [view interactions] | Computational | no | no |
| STX4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| MYH9_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| RAB10_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SNP23_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| MYO5A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CIP4_HUMAN | [view interactions] | Computational | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| RAB13_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RALA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |