RAB4B_HUMAN
Evidence for PS localization
Functions
Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state . Protein transport. Probably involved in vesicular traffic . Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RAB4B_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 35.2941 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 35.2941 | 5 | yes |
| GO:0043168 | anion binding | 35.2941 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 32.3529 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 29.4118 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 26.4706 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 26.4706 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 26.4706 | 6 | yes |
| GO:0042803 | protein homodimerization activity | 23.5294 | 4 | no |
| GO:0005525 | GTP binding | 20.5882 | 5 | yes |
| GO:0019001 | guanyl nucleotide binding | 20.5882 | 6 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 20.5882 | 5 | yes |
| GO:0051020 | GTPase binding | 20.5882 | 4 | no |
| GO:0045296 | cadherin binding | 20.5882 | 4 | no |
| GO:0003924 | GTPase activity | 17.6471 | 7 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RAB4B_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 55.8824 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 44.1176 | 4 | yes |
| GO:0071702 | organic substance transport | 44.1176 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 44.1176 | 4 | no |
| GO:0071705 | nitrogen compound transport | 41.1765 | 4 | yes |
| GO:0006996 | organelle organization | 41.1765 | 4 | no |
| GO:0015031 | protein transport | 38.2353 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 38.2353 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 38.2353 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 38.2353 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 38.2353 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 38.2353 | 4 | no |
| GO:0051049 | regulation of transport | 35.2941 | 4 | yes |
| GO:0010646 | regulation of cell communication | 35.2941 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 35.2941 | 4 | no |
| GO:0009966 | regulation of signal transduction | 32.3529 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 32.3529 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 32.3529 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 32.3529 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 32.3529 | 5 | no |
| GO:0022607 | cellular component assembly | 29.4118 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 29.4118 | 5 | no |
| GO:0010468 | regulation of gene expression | 29.4118 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 29.4118 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 29.4118 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 29.4118 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 29.4118 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.4706 | 5 | no |
| GO:0072657 | protein localization to membrane | 26.4706 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 26.4706 | 4 | no |
| GO:0032880 | regulation of protein localization | 26.4706 | 5 | no |
| GO:0060341 | regulation of cellular localization | 26.4706 | 4 | no |
| GO:0080134 | regulation of response to stress | 26.4706 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 23.5294 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 23.5294 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 23.5294 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 23.5294 | 4 | no |
| GO:0061024 | membrane organization | 23.5294 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 23.5294 | 5 | no |
| GO:0043933 | protein-containing complex organization | 23.5294 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 23.5294 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 23.5294 | 4 | no |
| GO:0023056 | positive regulation of signaling | 23.5294 | 4 | no |
| GO:0006915 | apoptotic process | 20.5882 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 20.5882 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 20.5882 | 5 | no |
| GO:0023057 | negative regulation of signaling | 20.5882 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 20.5882 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 20.5882 | 5 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 20.5882 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 20.5882 | 6 | no |
| GO:1990778 | protein localization to cell periphery | 20.5882 | 5 | no |
| GO:0009890 | negative regulation of biosynthetic process | 20.5882 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 20.5882 | 5 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 20.5882 | 6 | no |
| GO:0098657 | import into cell | 20.5882 | 4 | no |
| GO:0006886 | intracellular protein transport | 20.5882 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 20.5882 | 7 | no |
| GO:0031347 | regulation of defense response | 20.5882 | 5 | no |
| GO:0032101 | regulation of response to external stimulus | 20.5882 | 4 | no |
| GO:0033365 | protein localization to organelle | 20.5882 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 20.5882 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 20.5882 | 5 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 17.6471 | 4 | yes |
| GO:0141124 | intracellular signaling cassette | 14.7059 | 4 | yes |
| GO:0007264 | small GTPase-mediated signal transduction | 11.7647 | 5 | yes |
| GO:0030100 | regulation of endocytosis | 8.8235 | 5 | yes |
| GO:0032482 | Rab protein signal transduction | 8.8235 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RAB3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRPF3_HUMAN | [view interactions] | High throughput | no | yes |
| NECP1_HUMAN | [view interactions] | High throughput | no | no |
| SFXN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHD8_HUMAN | [view interactions] | High throughput | no | no |
| TFB2M_HUMAN | [view interactions] | High throughput | no | no |
| SKI2_HUMAN | [view interactions] | High throughput | no | yes |
| TAF11_HUMAN | [view interactions] | High throughput | no | no |
| U520_HUMAN | [view interactions] | High throughput | no | yes |
| PRDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAB2P_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRP6_HUMAN | [view interactions] | High throughput | no | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NISCH_HUMAN | [view interactions] | High throughput | no | yes |
| EXOC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RABE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPS52_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GAR6_HUMAN | [view interactions] | High throughput | no | no |
| CDC45_HUMAN | [view interactions] | High throughput | no | no |
| LIMD1_HUMAN | [view interactions] | High throughput | no | yes |
| MYP2_HUMAN | [view interactions] | High throughput | no | no |
| GLMP_HUMAN | [view interactions] | High throughput | no | no |
| A16A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GAPD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| WDR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMU1_HUMAN | [view interactions] | High throughput | no | yes |
| ACY1_HUMAN | [view interactions] | High throughput | no | no |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| C1TM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RU2A_HUMAN | [view interactions] | High throughput | no | yes |
| TPIS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD44_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSPC1_HUMAN | [view interactions] | High throughput | no | yes |
| RTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
| AFAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHX15_HUMAN | [view interactions] | High throughput | no | yes |
| FA98A_HUMAN | [view interactions] | High throughput | no | no |
| DJB11_HUMAN | [view interactions] | High throughput | no | yes |
| P5CS_HUMAN | [view interactions] | High throughput | no | yes |
| CRNL1_HUMAN | [view interactions] | High throughput | no | no |
| VPS35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SF3B4_HUMAN | [view interactions] | High throughput | no | yes |
| AT1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SF3A3_HUMAN | [view interactions] | High throughput | no | yes |
| RB39B_HUMAN | [view interactions] | High throughput | no | no |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BOLA2_HUMAN | [view interactions] | High throughput | no | yes |
| NSF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG39_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RN170_HUMAN | [view interactions] | High throughput | no | yes |
| LCOR_HUMAN | [view interactions] | High throughput | no | yes |
| GDIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| RIN3_HUMAN | [view interactions] | High throughput | no | yes |
| DX39A_HUMAN | [view interactions] | High throughput | no | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| PICAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SENP8_HUMAN | [view interactions] | High throughput | no | yes |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |