RAB4B_HUMAN
Evidence for PS localization
Functions
Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state . Protein transport. Probably involved in vesicular traffic . Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RAB4B_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 36.3636 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 36.3636 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 36.3636 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 27.2727 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 27.2727 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 27.2727 | 6 | yes |
| GO:0003924 | GTPase activity | 21.2121 | 7 | yes |
| GO:0005525 | GTP binding | 21.2121 | 5 | yes |
| GO:0019001 | guanyl nucleotide binding | 21.2121 | 5 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 21.2121 | 5 | yes |
| GO:0042803 | protein homodimerization activity | 21.2121 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RAB4B_HUMAN |
|---|---|---|---|---|
| GO:0071702 | organic substance transport | 51.5152 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 51.5152 | 4 | yes |
| GO:0008104 | protein localization | 51.5152 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 48.4848 | 4 | no |
| GO:0015031 | protein transport | 48.4848 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 45.4545 | 4 | yes |
| GO:0010646 | regulation of cell communication | 42.4242 | 4 | no |
| GO:0006996 | organelle organization | 42.4242 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 42.4242 | 4 | no |
| GO:0009966 | regulation of signal transduction | 39.3939 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 39.3939 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 39.3939 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 39.3939 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 36.3636 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 36.3636 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 36.3636 | 4 | no |
| GO:0051049 | regulation of transport | 33.3333 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 33.3333 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 33.3333 | 5 | no |
| GO:0010468 | regulation of gene expression | 30.3030 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 30.3030 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 30.3030 | 6 | no |
| GO:0022607 | cellular component assembly | 30.3030 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 27.2727 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 27.2727 | 5 | no |
| GO:0098876 | vesicle-mediated transport to the plasma membrane | 27.2727 | 4 | no |
| GO:0006886 | intracellular protein transport | 27.2727 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 24.2424 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 24.2424 | 4 | no |
| GO:0023056 | positive regulation of signaling | 24.2424 | 4 | no |
| GO:0030030 | cell projection organization | 24.2424 | 4 | no |
| GO:0032880 | regulation of protein localization | 24.2424 | 5 | no |
| GO:0060341 | regulation of cellular localization | 24.2424 | 4 | no |
| GO:0033365 | protein localization to organelle | 24.2424 | 5 | no |
| GO:0072657 | protein localization to membrane | 24.2424 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 21.2121 | 4 | no |
| GO:0009894 | regulation of catabolic process | 21.2121 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 21.2121 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 21.2121 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 21.2121 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 21.2121 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 21.2121 | 5 | no |
| GO:0042176 | regulation of protein catabolic process | 21.2121 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 21.2121 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 21.2121 | 4 | no |
| GO:0050776 | regulation of immune response | 21.2121 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 21.2121 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 21.2121 | 5 | no |
| GO:0071310 | cellular response to organic substance | 21.2121 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 21.2121 | 6 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 21.2121 | 4 | no |
| GO:0048193 | Golgi vesicle transport | 21.2121 | 5 | no |
| GO:0033043 | regulation of organelle organization | 21.2121 | 5 | no |
| GO:1990778 | protein localization to cell periphery | 21.2121 | 5 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 18.1818 | 4 | yes |
| GO:0007264 | small GTPase mediated signal transduction | 15.1515 | 4 | yes |
| GO:0007265 | Ras protein signal transduction | 15.1515 | 5 | yes |
| GO:0030100 | regulation of endocytosis | 9.0909 | 5 | yes |
| GO:0032482 | Rab protein signal transduction | 9.0909 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RAB3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRP6_HUMAN | [view interactions] | High throughput | no | yes |
| DAB2P_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| U520_HUMAN | [view interactions] | High throughput | no | yes |
| TAF11_HUMAN | [view interactions] | High throughput | no | no |
| SKIV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TFB2M_HUMAN | [view interactions] | High throughput | no | no |
| CHD8_HUMAN | [view interactions] | High throughput | no | no |
| SFXN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NECP1_HUMAN | [view interactions] | High throughput | no | no |
| PRPF3_HUMAN | [view interactions] | High throughput | no | yes |
| NISCH_HUMAN | [view interactions] | High throughput | no | yes |
| EXOC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RABE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPS52_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FA71C_HUMAN | [view interactions] | High throughput | no | no |
| CDC45_HUMAN | [view interactions] | High throughput | no | no |
| SF3A3_HUMAN | [view interactions] | High throughput | no | yes |
| P5CS_HUMAN | [view interactions] | High throughput | no | yes |
| DJB11_HUMAN | [view interactions] | High throughput | no | yes |
| FA98A_HUMAN | [view interactions] | High throughput | no | no |
| DHX15_HUMAN | [view interactions] | High throughput | no | yes |
| CD44_HUMAN | [view interactions] | High throughput | no | yes |
| ACY1_HUMAN | [view interactions] | High throughput | no | no |
| SMU1_HUMAN | [view interactions] | High throughput | no | yes |
| GAPD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A16A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GLMP_HUMAN | [view interactions] | High throughput | no | no |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB39B_HUMAN | [view interactions] | High throughput | no | no |
| AT1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SF3B4_HUMAN | [view interactions] | High throughput | no | yes |
| VPS35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRNL1_HUMAN | [view interactions] | High throughput | no | no |
| AFAD_HUMAN | [view interactions] | High throughput | no | yes |
| NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
| RTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSPC1_HUMAN | [view interactions] | High throughput | no | yes |
| PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPIS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RU2A_HUMAN | [view interactions] | High throughput | no | yes |
| C1TM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| MYP2_HUMAN | [view interactions] | High throughput | no | no |
| LIMD1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BOLA2_HUMAN | [view interactions] | High throughput | no | yes |
| NSF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG39_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RN170_HUMAN | [view interactions] | High throughput | no | yes |
| LCOR_HUMAN | [view interactions] | High throughput | no | yes |
| GDIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| RIN3_HUMAN | [view interactions] | High throughput | no | yes |
| DX39A_HUMAN | [view interactions] | High throughput | no | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| GRB2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CRKL_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GAB1_HUMAN | [view interactions] | Computational | no | yes |
| ARF6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MET_HUMAN | [view interactions] | Computational | no | yes |
| CRK_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GGA3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| HGF_HUMAN | [view interactions] | Computational | no | yes |