Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PLK2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CENPJ and NPM1, respectively. Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PLK2_HUMAN
GO:0000166 nucleotide binding 32.1429 4 yes
GO:0043168 anion binding 32.1429 4 yes
GO:0017076 purine nucleotide binding 28.5714 5 yes
GO:0032555 purine ribonucleotide binding 28.5714 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 25.0000 4 yes
GO:0030554 adenyl nucleotide binding 21.4286 6 yes
GO:0032559 adenyl ribonucleotide binding 21.4286 5 yes
GO:0043169 cation binding 21.4286 4 no
GO:0046872 metal ion binding 21.4286 5 no
GO:0005524 ATP binding 17.8571 5 yes
GO:0004674 protein serine/threonine kinase activity 14.2857 4 yes
GO:0016301 kinase activity 14.2857 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 14.2857 4 yes
GO:0106310 protein serine kinase activity 14.2857 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PLK2_HUMAN
GO:0048522 positive regulation of cellular process 71.4286 4 yes
GO:0048523 negative regulation of cellular process 67.8571 4 yes
GO:0051128 regulation of cellular component organization 64.2857 4 yes
GO:0060255 regulation of macromolecule metabolic process 60.7143 4 yes
GO:0080090 regulation of primary metabolic process 60.7143 4 yes
GO:0051246 regulation of protein metabolic process 57.1429 5 yes
GO:0051049 regulation of transport 57.1429 4 no
GO:0010646 regulation of cell communication 57.1429 4 yes
GO:0031323 regulation of cellular metabolic process 57.1429 4 yes
GO:0008104 protein localization 42.8571 4 no
GO:0051050 positive regulation of transport 42.8571 4 no
GO:0006996 organelle organization 42.8571 4 yes
GO:0009892 negative regulation of metabolic process 42.8571 4 yes
GO:0009893 positive regulation of metabolic process 42.8571 4 yes
GO:0009894 regulation of catabolic process 42.8571 4 yes
GO:0009966 regulation of signal transduction 42.8571 4 yes
GO:0031324 negative regulation of cellular metabolic process 42.8571 5 yes
GO:0044087 regulation of cellular component biogenesis 42.8571 4 yes
GO:0048585 negative regulation of response to stimulus 42.8571 4 yes
GO:0071702 organic substance transport 39.2857 4 no
GO:0019220 regulation of phosphate metabolic process 39.2857 6 no
GO:0051174 regulation of phosphorus metabolic process 39.2857 5 no
GO:0010648 negative regulation of cell communication 39.2857 5 yes
GO:0023057 negative regulation of signaling 39.2857 4 yes
GO:0071705 nitrogen compound transport 35.7143 4 no
GO:0010605 negative regulation of macromolecule metabolic process 35.7143 5 no
GO:0031399 regulation of protein modification process 35.7143 6 no
GO:0010604 positive regulation of macromolecule metabolic process 35.7143 5 yes
GO:0031325 positive regulation of cellular metabolic process 35.7143 5 yes
GO:0051247 positive regulation of protein metabolic process 32.1429 6 yes
GO:1902531 regulation of intracellular signal transduction 32.1429 5 yes
GO:0006886 intracellular protein transport 32.1429 4 no
GO:0015031 protein transport 32.1429 4 no
GO:0060341 regulation of cellular localization 32.1429 4 no
GO:0010647 positive regulation of cell communication 32.1429 5 yes
GO:0023056 positive regulation of signaling 32.1429 4 yes
GO:0031329 regulation of cellular catabolic process 32.1429 5 yes
GO:0051726 regulation of cell cycle 28.5714 4 yes
GO:0080134 regulation of response to stress 28.5714 4 yes
GO:0099177 regulation of trans-synaptic signaling 28.5714 4 yes
GO:0042325 regulation of phosphorylation 28.5714 7 no
GO:0032880 regulation of protein localization 28.5714 5 no
GO:0009968 negative regulation of signal transduction 28.5714 5 no
GO:0051248 negative regulation of protein metabolic process 28.5714 6 no
GO:0060627 regulation of vesicle-mediated transport 28.5714 4 no
GO:0009889 regulation of biosynthetic process 28.5714 4 no
GO:0010468 regulation of gene expression 28.5714 6 no
GO:0010556 regulation of macromolecule biosynthetic process 28.5714 5 no
GO:0031326 regulation of cellular biosynthetic process 28.5714 5 no
GO:0009896 positive regulation of catabolic process 28.5714 5 yes
GO:0010506 regulation of autophagy 28.5714 6 yes
GO:0032101 regulation of response to external stimulus 28.5714 4 yes
GO:0033043 regulation of organelle organization 28.5714 5 yes
GO:0042981 regulation of apoptotic process 28.5714 5 yes
GO:0043067 regulation of programmed cell death 28.5714 4 yes
GO:0050804 modulation of chemical synaptic transmission 28.5714 5 yes
GO:0043549 regulation of kinase activity 25.0000 5 no
GO:0051338 regulation of transferase activity 25.0000 4 no
GO:0070201 regulation of establishment of protein localization 25.0000 6 no
GO:0001932 regulation of protein phosphorylation 25.0000 7 no
GO:0008285 negative regulation of cell population proliferation 25.0000 5 no
GO:0042127 regulation of cell population proliferation 25.0000 4 no
GO:0009890 negative regulation of biosynthetic process 25.0000 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0031327 negative regulation of cellular biosynthetic process 25.0000 6 no
GO:0051252 regulation of RNA metabolic process 25.0000 5 no
GO:1903829 positive regulation of protein localization 25.0000 5 no
GO:0051046 regulation of secretion 25.0000 5 no
GO:1903530 regulation of secretion by cell 25.0000 4 no
GO:0031347 regulation of defense response 25.0000 5 yes
GO:0036211 protein modification process 25.0000 4 yes
GO:0042176 regulation of protein catabolic process 25.0000 5 yes
GO:0043066 negative regulation of apoptotic process 25.0000 6 yes
GO:0043069 negative regulation of programmed cell death 25.0000 5 yes
GO:0043412 macromolecule modification 25.0000 4 yes
GO:0048584 positive regulation of response to stimulus 25.0000 4 yes
GO:0016050 vesicle organization 21.4286 5 no
GO:0035542 regulation of SNARE complex assembly 21.4286 6 no
GO:0043254 regulation of protein-containing complex assembly 21.4286 5 no
GO:0061024 membrane organization 21.4286 4 no
GO:0010562 positive regulation of phosphorus metabolic process 21.4286 6 no
GO:0045937 positive regulation of phosphate metabolic process 21.4286 7 no
GO:0051223 regulation of protein transport 21.4286 5 no
GO:0006915 apoptotic process 21.4286 4 no
GO:0010563 negative regulation of phosphorus metabolic process 21.4286 6 no
GO:0031400 negative regulation of protein modification process 21.4286 7 no
GO:0045859 regulation of protein kinase activity 21.4286 6 no
GO:0045936 negative regulation of phosphate metabolic process 21.4286 7 no
GO:0098657 import into cell 21.4286 4 no
GO:0006355 regulation of DNA-templated transcription 21.4286 7 no
GO:0006357 regulation of transcription by RNA polymerase II 21.4286 8 no
GO:1904951 positive regulation of establishment of protein localization 21.4286 6 no
GO:2001141 regulation of RNA biosynthetic process 21.4286 6 no
GO:0022607 cellular component assembly 21.4286 4 no
GO:0006796 phosphate-containing compound metabolic process 21.4286 4 yes
GO:0050806 positive regulation of synaptic transmission 17.8571 5 yes
GO:0141124 intracellular signaling cassette 17.8571 4 yes
GO:0009967 positive regulation of signal transduction 17.8571 5 yes
GO:0016310 phosphorylation 17.8571 5 yes
GO:0031331 positive regulation of cellular catabolic process 17.8571 6 yes
GO:0050727 regulation of inflammatory response 17.8571 5 yes
GO:0050890 cognition 14.2857 4 yes
GO:0051241 negative regulation of multicellular organismal process 14.2857 4 yes
GO:1902533 positive regulation of intracellular signal transduction 14.2857 6 yes
GO:2000026 regulation of multicellular organismal development 14.2857 4 yes
GO:2000145 regulation of cell motility 14.2857 4 yes
GO:0006468 protein phosphorylation 14.2857 5 yes
GO:0006974 DNA damage response 14.2857 4 yes
GO:0007010 cytoskeleton organization 14.2857 5 yes
GO:0007346 regulation of mitotic cell cycle 14.2857 5 yes
GO:0010564 regulation of cell cycle process 14.2857 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 14.2857 4 yes
GO:0030334 regulation of cell migration 14.2857 5 yes
GO:0032102 negative regulation of response to external stimulus 14.2857 5 yes
GO:0032886 regulation of microtubule-based process 14.2857 4 yes
GO:0045732 positive regulation of protein catabolic process 14.2857 6 yes
GO:0050776 regulation of immune response 14.2857 4 yes
GO:0051093 negative regulation of developmental process 10.7143 4 yes
GO:0060291 long-term synaptic potentiation 10.7143 4 yes
GO:0060292 long-term synaptic depression 10.7143 4 yes
GO:1901987 regulation of cell cycle phase transition 10.7143 6 yes
GO:1901990 regulation of mitotic cell cycle phase transition 10.7143 6 yes
GO:1902115 regulation of organelle assembly 10.7143 5 yes
GO:2000147 positive regulation of cell motility 10.7143 5 yes
GO:0002683 negative regulation of immune system process 10.7143 4 yes
GO:0010508 positive regulation of autophagy 10.7143 7 yes
GO:0010824 regulation of centrosome duplication 10.7143 6 yes
GO:0018105 peptidyl-serine phosphorylation 10.7143 6 yes
GO:0018193 peptidyl-amino acid modification 10.7143 5 yes
GO:0018209 peptidyl-serine modification 10.7143 6 yes
GO:0030335 positive regulation of cell migration 10.7143 6 yes
GO:0031348 negative regulation of defense response 10.7143 5 yes
GO:0040017 positive regulation of locomotion 10.7143 4 yes
GO:0044772 mitotic cell cycle phase transition 10.7143 4 yes
GO:0046605 regulation of centrosome cycle 10.7143 5 yes
GO:0050728 negative regulation of inflammatory response 10.7143 6 yes
GO:0050805 negative regulation of synaptic transmission 10.7143 5 yes
GO:0071865 regulation of apoptotic process in bone marrow cell 7.1429 6 yes
GO:0071866 negative regulation of apoptotic process in bone marrow cell 7.1429 7 yes
GO:0072331 signal transduction by p53 class mediator 7.1429 4 yes
GO:0090049 regulation of cell migration involved in sprouting angiogenesis 7.1429 7 yes
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis 7.1429 8 yes
GO:1901342 regulation of vasculature development 7.1429 5 yes
GO:1901343 negative regulation of vasculature development 7.1429 5 yes
GO:1901988 negative regulation of cell cycle phase transition 7.1429 7 yes
GO:1901991 negative regulation of mitotic cell cycle phase transition 7.1429 7 yes
GO:1902806 regulation of cell cycle G1/S phase transition 7.1429 7 yes
GO:1902807 negative regulation of cell cycle G1/S phase transition 7.1429 8 yes
GO:1902850 microtubule cytoskeleton organization involved in mitosis 7.1429 4 yes
GO:2000045 regulation of G1/S transition of mitotic cell cycle 7.1429 7 yes
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle 7.1429 8 yes
GO:2000181 negative regulation of blood vessel morphogenesis 7.1429 5 yes
GO:2000772 regulation of cellular senescence 7.1429 5 yes
GO:2000773 negative regulation of cellular senescence 7.1429 6 yes
GO:0000075 cell cycle checkpoint signaling 7.1429 4 yes
GO:0000077 DNA damage checkpoint signaling 7.1429 5 yes
GO:0000082 G1/S transition of mitotic cell cycle 7.1429 5 yes
GO:0002861 regulation of inflammatory response to antigenic stimulus 7.1429 5 yes
GO:0002862 negative regulation of inflammatory response to antigenic stimulus 7.1429 6 yes
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 7.1429 6 yes
GO:0007052 mitotic spindle organization 7.1429 4 yes
GO:0007093 mitotic cell cycle checkpoint signaling 7.1429 4 yes
GO:0007264 small GTPase-mediated signal transduction 7.1429 5 yes
GO:0007265 Ras protein signal transduction 7.1429 6 yes
GO:0007613 memory 7.1429 4 yes
GO:0010594 regulation of endothelial cell migration 7.1429 5 yes
GO:0010595 positive regulation of endothelial cell migration 7.1429 6 yes
GO:0010632 regulation of epithelial cell migration 7.1429 4 yes
GO:0010634 positive regulation of epithelial cell migration 7.1429 5 yes
GO:0010948 negative regulation of cell cycle process 7.1429 6 yes
GO:0016525 negative regulation of angiogenesis 7.1429 6 yes
GO:0030330 DNA damage response, signal transduction by p53 class mediator 7.1429 5 yes
GO:0031570 DNA integrity checkpoint signaling 7.1429 5 yes
GO:0031571 mitotic G1 DNA damage checkpoint signaling 7.1429 6 yes
GO:0032486 Rap protein signal transduction 7.1429 6 yes
GO:0042770 signal transduction in response to DNA damage 7.1429 4 yes
GO:0043122 regulation of canonical NF-kappaB signal transduction 7.1429 6 yes
GO:0043123 positive regulation of canonical NF-kappaB signal transduction 7.1429 7 yes
GO:0043535 regulation of blood vessel endothelial cell migration 7.1429 6 yes
GO:0043536 positive regulation of blood vessel endothelial cell migration 7.1429 7 yes
GO:0044773 mitotic DNA damage checkpoint signaling 7.1429 6 yes
GO:0044774 mitotic DNA integrity checkpoint signaling 7.1429 5 yes
GO:0044819 mitotic G1/S transition checkpoint signaling 7.1429 5 yes
GO:0044843 cell cycle G1/S phase transition 7.1429 4 yes
GO:0045765 regulation of angiogenesis 7.1429 5 yes
GO:0045786 negative regulation of cell cycle 7.1429 5 yes
GO:0045930 negative regulation of mitotic cell cycle 7.1429 6 yes
GO:0046599 regulation of centriole replication 7.1429 6 yes
GO:0050777 negative regulation of immune response 7.1429 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MAGI2_HUMAN [view entry] [view interactions] Low throughput yes yes
CENPJ_HUMAN [view interactions] Low throughput no no
PLK1_HUMAN [view interactions] Low throughput no yes
PLK2_HUMAN [view entry] [view interactions] Low throughput yes yes
CIB1_HUMAN [view interactions] Low throughput no no
VPS18_HUMAN [view entry] [view interactions] Low throughput yes no
VPS16_HUMAN [view entry] [view interactions] Low throughput yes yes
VP33A_HUMAN [view entry] [view interactions] Low throughput yes no
VPS11_HUMAN [view entry] [view interactions] Low throughput yes no
FBXW7_HUMAN [view interactions] Low throughput no yes
TSC1_HUMAN [view entry] [view interactions] Low throughput yes yes
RN180_HUMAN [view interactions] Low throughput no yes
SKP1_HUMAN [view interactions] Low throughput no yes
SYUA_HUMAN [view entry] [view interactions] Low throughput yes no
TSC2_HUMAN [view entry] [view interactions] Low throughput yes yes
CENPU_HUMAN [view interactions] Low throughput no no
MY18A_HUMAN [view entry] [view interactions] High throughput yes yes
STXB1_HUMAN [view entry] [view interactions] High throughput yes yes
RBBP6_HUMAN [view interactions] High throughput no yes
CA2D1_HUMAN [view entry] [view interactions] High throughput yes yes
NEST_HUMAN [view interactions] High throughput no no
RBM27_HUMAN [view interactions] High throughput no yes
TR150_HUMAN [view interactions] High throughput no yes
MFN1_HUMAN [view interactions] High throughput no yes
TDIF1_HUMAN [view interactions] High throughput no no
PCGF5_HUMAN [view interactions] High throughput no yes
IRGQ_HUMAN [view entry] [view interactions] High throughput yes yes
CATZ_HUMAN [view interactions] High throughput no yes
LENG1_HUMAN [view interactions] High throughput no no
RT4I1_HUMAN [view interactions] High throughput no yes
CA226_HUMAN [view interactions] High throughput no yes
ANR28_HUMAN [view interactions] High throughput no no
CATL2_HUMAN [view interactions] High throughput no yes
SPB7_HUMAN [view interactions] High throughput no no
IGKC_HUMAN [view interactions] High throughput no no
PAK2_HUMAN [view entry] [view interactions] High throughput yes no
SPA12_HUMAN [view interactions] High throughput no no
SUGP1_HUMAN [view interactions] High throughput no yes
DR9C7_HUMAN [view interactions] High throughput no no
POF1B_HUMAN [view interactions] High throughput no no
RNAS7_HUMAN [view interactions] High throughput no no
CBPA4_HUMAN [view interactions] High throughput no no
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
H2AZ_HUMAN [view interactions] High throughput no yes
KAP0_HUMAN [view entry] [view interactions] High throughput yes yes
H2A2C_HUMAN [view interactions] High throughput no yes
CSKP_HUMAN [view entry] [view interactions] High throughput yes yes
CD20B_HUMAN [view interactions] High throughput no no
MPP3_HUMAN [view entry] [view interactions] High throughput yes yes
ELP1_HUMAN [view interactions] High throughput no yes
DLGP4_HUMAN [view entry] [view interactions] High throughput yes yes
NRIP1_HUMAN [view interactions] High throughput no yes
KLK7_HUMAN [view interactions] High throughput no no
IF2P_HUMAN [view interactions] High throughput no yes
TAF8_HUMAN [view interactions] High throughput no yes
CCD12_HUMAN [view interactions] High throughput no yes
EF1A2_HUMAN [view entry] [view interactions] High throughput yes yes
RABL6_HUMAN [view interactions] High throughput no yes
ANR44_HUMAN [view interactions] High throughput no no
SAR1B_HUMAN [view interactions] High throughput no yes
CSTF1_HUMAN [view interactions] High throughput no yes
A1AT_HUMAN [view interactions] High throughput no no
UNK_HUMAN [view interactions] High throughput no yes
ITPR1_HUMAN [view entry] [view interactions] High throughput yes yes
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
FGD6_HUMAN [view interactions] High throughput no yes
CALD1_HUMAN [view entry] [view interactions] High throughput yes no
HEM2_HUMAN [view interactions] High throughput no no
RNF4_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
LOXE3_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes