VPS11_HUMAN
Evidence for PS localization
Functions
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed, PubMed, PubMed, PubMed, PubMed). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed). Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (PubMed). Involved in the retrograde Shiga toxin transport (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 846 | Cys | Gly | Leukodystrophy,hypomyelinating,12(HLD12) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in VPS11_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 34.4828 | 4 | yes |
| GO:0003723 | RNA binding | 27.5862 | 4 | no |
| GO:0003779 | actin binding | 24.1379 | 4 | no |
| GO:0004842 | ubiquitin-protein transferase activity | 13.7931 | 4 | yes |
| GO:0019905 | syntaxin binding | 13.7931 | 4 | yes |
| GO:0061630 | ubiquitin protein ligase activity | 13.7931 | 5 | yes |
| GO:0061659 | ubiquitin-like protein ligase activity | 13.7931 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in VPS11_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 72.4138 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 68.9655 | 4 | yes |
| GO:0071702 | organic substance transport | 68.9655 | 4 | yes |
| GO:0015031 | protein transport | 65.5172 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 65.5172 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 65.5172 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 58.6207 | 4 | yes |
| GO:0006886 | intracellular protein transport | 55.1724 | 4 | yes |
| GO:0006996 | organelle organization | 55.1724 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 51.7241 | 4 | yes |
| GO:0051049 | regulation of transport | 51.7241 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 51.7241 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 48.2759 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 48.2759 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 48.2759 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 48.2759 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 44.8276 | 5 | yes |
| GO:0010646 | regulation of cell communication | 44.8276 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 44.8276 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 44.8276 | 5 | yes |
| GO:0033043 | regulation of organelle organization | 41.3793 | 5 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 41.3793 | 5 | yes |
| GO:0010468 | regulation of gene expression | 41.3793 | 5 | no |
| GO:0009966 | regulation of signal transduction | 37.9310 | 4 | yes |
| GO:0016050 | vesicle organization | 37.9310 | 5 | yes |
| GO:0051050 | positive regulation of transport | 37.9310 | 4 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 37.9310 | 6 | yes |
| GO:0031323 | regulation of cellular metabolic process | 37.9310 | 4 | no |
| GO:0007034 | vacuolar transport | 34.4828 | 4 | yes |
| GO:0007041 | lysosomal transport | 34.4828 | 5 | yes |
| GO:0009894 | regulation of catabolic process | 34.4828 | 4 | yes |
| GO:0032880 | regulation of protein localization | 34.4828 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 34.4828 | 4 | yes |
| GO:0022607 | cellular component assembly | 34.4828 | 4 | no |
| GO:0008333 | endosome to lysosome transport | 31.0345 | 5 | yes |
| GO:0009896 | positive regulation of catabolic process | 31.0345 | 5 | yes |
| GO:0048284 | organelle fusion | 31.0345 | 5 | yes |
| GO:0061024 | membrane organization | 31.0345 | 4 | yes |
| GO:0010628 | positive regulation of gene expression | 31.0345 | 6 | no |
| GO:0006897 | endocytosis | 31.0345 | 5 | no |
| GO:0043933 | protein-containing complex organization | 31.0345 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 27.5862 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 27.5862 | 4 | yes |
| GO:0036211 | protein modification process | 27.5862 | 4 | yes |
| GO:0042176 | regulation of protein catabolic process | 27.5862 | 5 | yes |
| GO:0043412 | macromolecule modification | 27.5862 | 4 | yes |
| GO:0045732 | positive regulation of protein catabolic process | 27.5862 | 6 | yes |
| GO:1902115 | regulation of organelle assembly | 27.5862 | 5 | yes |
| GO:0072657 | protein localization to membrane | 27.5862 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 27.5862 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 27.5862 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 27.5862 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 27.5862 | 5 | no |
| GO:0006906 | vesicle fusion | 24.1379 | 6 | yes |
| GO:0009968 | negative regulation of signal transduction | 24.1379 | 5 | yes |
| GO:0048585 | negative regulation of response to stimulus | 24.1379 | 4 | yes |
| GO:0061025 | membrane fusion | 24.1379 | 5 | yes |
| GO:0070647 | protein modification by small protein conjugation or removal | 24.1379 | 5 | yes |
| GO:0090174 | organelle membrane fusion | 24.1379 | 6 | yes |
| GO:1903829 | positive regulation of protein localization | 24.1379 | 5 | yes |
| GO:0051129 | negative regulation of cellular component organization | 24.1379 | 5 | no |
| GO:0071310 | cellular response to organic substance | 24.1379 | 4 | no |
| GO:0023056 | positive regulation of signaling | 24.1379 | 4 | no |
| GO:0051046 | regulation of secretion | 24.1379 | 5 | no |
| GO:1903530 | regulation of secretion by cell | 24.1379 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.1379 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 24.1379 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 24.1379 | 5 | no |
| GO:0032446 | protein modification by small protein conjugation | 20.6897 | 6 | yes |
| GO:0051223 | regulation of protein transport | 20.6897 | 5 | yes |
| GO:0070201 | regulation of establishment of protein localization | 20.6897 | 6 | yes |
| GO:0031344 | regulation of cell projection organization | 20.6897 | 5 | no |
| GO:0051726 | regulation of cell cycle | 20.6897 | 4 | no |
| GO:0072659 | protein localization to plasma membrane | 20.6897 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 20.6897 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 20.6897 | 5 | no |
| GO:1990778 | protein localization to cell periphery | 20.6897 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 20.6897 | 5 | no |
| GO:0017157 | regulation of exocytosis | 20.6897 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 20.6897 | 5 | no |
| GO:0051047 | positive regulation of secretion | 20.6897 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 20.6897 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 20.6897 | 4 | no |
| GO:1903532 | positive regulation of secretion by cell | 20.6897 | 5 | no |
| GO:0033365 | protein localization to organelle | 20.6897 | 5 | no |
| GO:0072594 | establishment of protein localization to organelle | 20.6897 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 20.6897 | 6 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 20.6897 | 4 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 20.6897 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 20.6897 | 6 | no |
| GO:0034097 | response to cytokine | 20.6897 | 4 | no |
| GO:0030100 | regulation of endocytosis | 20.6897 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 20.6897 | 5 | no |
| GO:0010941 | regulation of cell death | 20.6897 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 20.6897 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 20.6897 | 5 | no |
| GO:0016567 | protein ubiquitination | 17.2414 | 7 | yes |
| GO:0032386 | regulation of intracellular transport | 17.2414 | 5 | yes |
| GO:0032388 | positive regulation of intracellular transport | 17.2414 | 5 | yes |
| GO:0048278 | vesicle docking | 17.2414 | 4 | yes |
| GO:0051222 | positive regulation of protein transport | 17.2414 | 5 | yes |
| GO:1904951 | positive regulation of establishment of protein localization | 17.2414 | 6 | yes |
| GO:0007033 | vacuole organization | 13.7931 | 5 | yes |
| GO:0034058 | endosomal vesicle fusion | 13.7931 | 7 | yes |
| GO:1903649 | regulation of cytoplasmic transport | 13.7931 | 6 | yes |
| GO:1903651 | positive regulation of cytoplasmic transport | 13.7931 | 6 | yes |
| GO:2000641 | regulation of early endosome to late endosome transport | 13.7931 | 5 | yes |
| GO:2000643 | positive regulation of early endosome to late endosome transport | 13.7931 | 6 | yes |
| GO:0007032 | endosome organization | 10.3448 | 6 | yes |
| GO:0033143 | regulation of intracellular steroid hormone receptor signaling pathway | 6.8966 | 5 | yes |
| GO:0033144 | negative regulation of intracellular steroid hormone receptor signaling pathway | 6.8966 | 6 | yes |
| GO:0033146 | regulation of intracellular estrogen receptor signaling pathway | 6.8966 | 6 | yes |
| GO:0033147 | negative regulation of intracellular estrogen receptor signaling pathway | 6.8966 | 7 | yes |
| GO:0033157 | regulation of intracellular protein transport | 6.8966 | 6 | yes |
| GO:0090316 | positive regulation of intracellular protein transport | 6.8966 | 6 | yes |
| GO:1903533 | regulation of protein targeting | 6.8966 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MON1B_HUMAN | [view interactions] | Low throughput | no | yes |
| VPS18_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| VPS39_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| VPS16_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SPE39_HUMAN | [view interactions] | Low throughput | no | yes |
| VP33A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| STX7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VPS41_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TGFA1_HUMAN | [view interactions] | Low throughput | no | no |
| STX17_HUMAN | [view interactions] | Low throughput | no | yes |
| RILP_HUMAN | [view interactions] | Low throughput | no | no |
| RAB5C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ECM29_HUMAN | [view interactions] | Low throughput | no | no |
| EZRI_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PLK2_HUMAN | [view interactions] | Low throughput | no | yes |
| VPS8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RADI_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MOES_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GGA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EDNRA_HUMAN | [view interactions] | Low throughput | no | yes |
| LSM1_HUMAN | [view interactions] | High throughput | no | no |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| SCRIB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAMP3_HUMAN | [view interactions] | High throughput | no | no |
| SAMTR_HUMAN | [view interactions] | High throughput | no | yes |
| ZN263_HUMAN | [view interactions] | High throughput | no | yes |
| PARVA_HUMAN | [view interactions] | High throughput | no | yes |
| BACE1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHM1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARL8B_HUMAN | [view interactions] | High throughput | no | yes |
| P55G_HUMAN | [view interactions] | High throughput | no | yes |
| TS101_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE2U_HUMAN | [view interactions] | High throughput | no | no |
| TRI32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN181_HUMAN | [view interactions] | High throughput | no | no |
| LRSM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KR108_HUMAN | [view interactions] | High throughput | no | no |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| GELS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBE2K_HUMAN | [view interactions] | High throughput | no | yes |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PECA1_HUMAN | [view interactions] | High throughput | no | no |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KLF11_HUMAN | [view interactions] | High throughput | no | no |
| SPRE1_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| MARK3_HUMAN | [view interactions] | High throughput | no | yes |
| AP2B_HUMAN | [view interactions] | High throughput | no | no |
| NOTC1_HUMAN | [view interactions] | High throughput | no | yes |
| KR103_HUMAN | [view interactions] | High throughput | no | no |
| GRSF1_HUMAN | [view interactions] | High throughput | no | yes |
| UVRAG_HUMAN | [view interactions] | High throughput | no | yes |
| VP33B_HUMAN | [view interactions] | High throughput | no | yes |
| STX1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| STX8_HUMAN | [view interactions] | High throughput | no | yes |
| VPS45_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| RN166_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| GTF2I_HUMAN | [view interactions] | High throughput | no | yes |
| ABCG1_HUMAN | [view interactions] | High throughput | no | yes |
| AP3D1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TM266_HUMAN | [view interactions] | High throughput | no | no |
| ISOC2_HUMAN | [view interactions] | High throughput | no | yes |
| ZUP1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| M1IP1_HUMAN | [view interactions] | High throughput | no | yes |
| PARL_HUMAN | [view interactions] | High throughput | no | yes |
| PACE1_HUMAN | [view interactions] | High throughput | no | yes |
| RBX2_HUMAN | [view interactions] | High throughput | no | yes |
| HYPM_HUMAN | [view interactions] | High throughput | no | no |
| PSME1_HUMAN | [view interactions] | High throughput | no | yes |
| CYTA_HUMAN | [view interactions] | High throughput | no | no |
| TTC9C_HUMAN | [view interactions] | High throughput | no | yes |
| CCD92_HUMAN | [view interactions] | High throughput | no | yes |
| LRC61_HUMAN | [view interactions] | High throughput | no | yes |
| S10A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CC018_HUMAN | [view interactions] | High throughput | no | yes |
| THRSP_HUMAN | [view interactions] | High throughput | no | no |
| RLBP1_HUMAN | [view interactions] | High throughput | no | no |
| TCAM1_HUMAN | [view interactions] | High throughput | no | yes |
| BOP_HUMAN | [view interactions] | High throughput | no | no |
| CYS1_HUMAN | [view interactions] | High throughput | no | no |
| FITM2_HUMAN | [view interactions] | High throughput | no | no |
| UB2L3_HUMAN | [view interactions] | High throughput | no | yes |
| UB2D2_HUMAN | [view interactions] | High throughput | no | yes |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBP17_HUMAN | [view interactions] | High throughput | no | no |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| MON1A_HUMAN | [view interactions] | High throughput | no | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |