VPS11_HUMAN
Evidence for PS localization
Functions
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed, PubMed, PubMed, PubMed, PubMed). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed). Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (PubMed). Involved in the retrograde Shiga toxin transport (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 846 | Cys | Gly | Leukodystrophy,hypomyelinating,12(HLD12) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in VPS11_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 33.3333 | 4 | yes |
| GO:0046872 | metal ion binding | 33.3333 | 5 | yes |
| GO:0043168 | anion binding | 24.2424 | 4 | no |
| GO:0003723 | RNA binding | 24.2424 | 4 | no |
| GO:0000166 | nucleotide binding | 21.2121 | 4 | yes |
| GO:0003779 | actin binding | 21.2121 | 4 | no |
| GO:0019905 | syntaxin binding | 15.1515 | 4 | yes |
| GO:0004842 | ubiquitin-protein transferase activity | 12.1212 | 4 | yes |
| GO:0016755 | aminoacyltransferase activity | 12.1212 | 4 | yes |
| GO:0061630 | ubiquitin protein ligase activity | 12.1212 | 5 | yes |
| GO:0061659 | ubiquitin-like protein ligase activity | 12.1212 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in VPS11_HUMAN |
|---|---|---|---|---|
| GO:0051128 | regulation of cellular component organization | 75.7576 | 4 | yes |
| GO:0008104 | protein localization | 72.7273 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 69.6970 | 4 | yes |
| GO:0015031 | protein transport | 66.6667 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 66.6667 | 4 | yes |
| GO:0071702 | organic substance transport | 66.6667 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 66.6667 | 4 | yes |
| GO:0006996 | organelle organization | 63.6364 | 4 | yes |
| GO:0006886 | intracellular protein transport | 60.6061 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 51.5152 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 51.5152 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 48.4848 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 48.4848 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 45.4545 | 5 | yes |
| GO:0010646 | regulation of cell communication | 45.4545 | 4 | yes |
| GO:0016050 | vesicle organization | 45.4545 | 5 | yes |
| GO:0051049 | regulation of transport | 45.4545 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 45.4545 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 42.4242 | 5 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 42.4242 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 39.3939 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 39.3939 | 5 | yes |
| GO:0061024 | membrane organization | 39.3939 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 39.3939 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 39.3939 | 4 | no |
| GO:0010468 | regulation of gene expression | 39.3939 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 39.3939 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 39.3939 | 5 | no |
| GO:0007034 | vacuolar transport | 36.3636 | 4 | yes |
| GO:0043254 | regulation of protein-containing complex assembly | 36.3636 | 5 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 36.3636 | 6 | yes |
| GO:0022607 | cellular component assembly | 36.3636 | 4 | no |
| GO:0007041 | lysosomal transport | 33.3333 | 5 | yes |
| GO:0009894 | regulation of catabolic process | 33.3333 | 4 | yes |
| GO:0033365 | protein localization to organelle | 33.3333 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 33.3333 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 33.3333 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 33.3333 | 6 | no |
| GO:0006906 | vesicle fusion | 30.3030 | 6 | yes |
| GO:0009896 | positive regulation of catabolic process | 30.3030 | 5 | yes |
| GO:0032880 | regulation of protein localization | 30.3030 | 5 | yes |
| GO:0048284 | organelle fusion | 30.3030 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 30.3030 | 4 | yes |
| GO:0061025 | membrane fusion | 30.3030 | 5 | yes |
| GO:0090174 | organelle membrane fusion | 30.3030 | 6 | yes |
| GO:1902115 | regulation of organelle assembly | 30.3030 | 5 | yes |
| GO:0072594 | establishment of protein localization to organelle | 30.3030 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 30.3030 | 7 | no |
| GO:0010648 | negative regulation of cell communication | 27.2727 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 27.2727 | 4 | yes |
| GO:0036211 | protein modification process | 27.2727 | 4 | yes |
| GO:0043412 | macromolecule modification | 27.2727 | 4 | yes |
| GO:0051050 | positive regulation of transport | 27.2727 | 4 | yes |
| GO:0023056 | positive regulation of signaling | 27.2727 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 27.2727 | 4 | no |
| GO:0098657 | import into cell | 27.2727 | 4 | no |
| GO:0035542 | regulation of SNARE complex assembly | 24.2424 | 6 | yes |
| GO:0042176 | regulation of protein catabolic process | 24.2424 | 5 | yes |
| GO:0045732 | positive regulation of protein catabolic process | 24.2424 | 6 | yes |
| GO:0048585 | negative regulation of response to stimulus | 24.2424 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 24.2424 | 5 | no |
| GO:0030334 | regulation of cell migration | 24.2424 | 5 | no |
| GO:0051726 | regulation of cell cycle | 24.2424 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 24.2424 | 5 | no |
| GO:2000145 | regulation of cell motility | 24.2424 | 4 | no |
| GO:0072657 | protein localization to membrane | 24.2424 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.2424 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 24.2424 | 5 | no |
| GO:0070925 | organelle assembly | 24.2424 | 5 | no |
| GO:0030030 | cell projection organization | 24.2424 | 4 | no |
| GO:0071310 | cellular response to organic substance | 24.2424 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 24.2424 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 21.2121 | 5 | yes |
| GO:0034058 | endosomal vesicle fusion | 21.2121 | 7 | yes |
| GO:0009892 | negative regulation of metabolic process | 21.2121 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 21.2121 | 5 | no |
| GO:0030335 | positive regulation of cell migration | 21.2121 | 6 | no |
| GO:0040017 | positive regulation of locomotion | 21.2121 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 21.2121 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 21.2121 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 21.2121 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 21.2121 | 4 | no |
| GO:2000147 | positive regulation of cell motility | 21.2121 | 5 | no |
| GO:0072659 | protein localization to plasma membrane | 21.2121 | 5 | no |
| GO:1990778 | protein localization to cell periphery | 21.2121 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 21.2121 | 7 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 21.2121 | 4 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 21.2121 | 6 | no |
| GO:0043933 | protein-containing complex organization | 21.2121 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 21.2121 | 5 | no |
| GO:0017157 | regulation of exocytosis | 21.2121 | 5 | no |
| GO:0051046 | regulation of secretion | 21.2121 | 5 | no |
| GO:1903530 | regulation of secretion by cell | 21.2121 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 21.2121 | 4 | no |
| GO:0043687 | post-translational protein modification | 18.1818 | 5 | yes |
| GO:0070647 | protein modification by small protein conjugation or removal | 18.1818 | 6 | yes |
| GO:1903829 | positive regulation of protein localization | 18.1818 | 5 | yes |
| GO:0007032 | endosome organization | 15.1515 | 6 | yes |
| GO:0007033 | vacuole organization | 15.1515 | 5 | yes |
| GO:0032386 | regulation of intracellular transport | 15.1515 | 5 | yes |
| GO:0032446 | protein modification by small protein conjugation | 15.1515 | 7 | yes |
| GO:0048278 | vesicle docking | 15.1515 | 4 | yes |
| GO:0016567 | protein ubiquitination | 12.1212 | 8 | yes |
| GO:0032388 | positive regulation of intracellular transport | 12.1212 | 5 | yes |
| GO:0070201 | regulation of establishment of protein localization | 12.1212 | 6 | yes |
| GO:2000641 | regulation of early endosome to late endosome transport | 12.1212 | 5 | yes |
| GO:2000643 | positive regulation of early endosome to late endosome transport | 12.1212 | 6 | yes |
| GO:1904951 | positive regulation of establishment of protein localization | 9.0909 | 6 | yes |
| GO:0033143 | regulation of intracellular steroid hormone receptor signaling pathway | 6.0606 | 5 | yes |
| GO:0033144 | negative regulation of intracellular steroid hormone receptor signaling pathway | 6.0606 | 6 | yes |
| GO:0033146 | regulation of intracellular estrogen receptor signaling pathway | 6.0606 | 6 | yes |
| GO:0033147 | negative regulation of intracellular estrogen receptor signaling pathway | 6.0606 | 7 | yes |
| GO:1903533 | regulation of protein targeting | 6.0606 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MON1B_HUMAN | [view interactions] | Low throughput | no | yes |
| VPS18_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| VPS39_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| VPS16_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SPE39_HUMAN | [view interactions] | Low throughput | no | yes |
| VP33A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| STX7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VPS41_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TGFA1_HUMAN | [view interactions] | Low throughput | no | no |
| STX17_HUMAN | [view interactions] | Low throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RILP_HUMAN | [view interactions] | Low throughput | no | no |
| RAB5C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ECM29_HUMAN | [view interactions] | Low throughput | no | no |
| EZRI_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PLK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VPS8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RB11A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RADI_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MOES_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GGA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EDNRA_HUMAN | [view interactions] | Low throughput | no | yes |
| LSM1_HUMAN | [view interactions] | High throughput | no | no |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| CAMP3_HUMAN | [view interactions] | High throughput | no | no |
| SCRIB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SAMTR_HUMAN | [view interactions] | High throughput | no | yes |
| ZN263_HUMAN | [view interactions] | High throughput | no | yes |
| PARVA_HUMAN | [view interactions] | High throughput | no | yes |
| BACE1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHM1_HUMAN | [view interactions] | High throughput | no | yes |
| ARL8B_HUMAN | [view interactions] | High throughput | no | yes |
| P55G_HUMAN | [view interactions] | High throughput | no | yes |
| TS101_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE2U_HUMAN | [view interactions] | High throughput | no | no |
| TRI32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN181_HUMAN | [view interactions] | High throughput | no | no |
| LRSM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KR108_HUMAN | [view interactions] | High throughput | no | no |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| GELS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBE2K_HUMAN | [view interactions] | High throughput | no | yes |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PECA1_HUMAN | [view interactions] | High throughput | no | no |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KLF11_HUMAN | [view interactions] | High throughput | no | no |
| SPRE1_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| MARK3_HUMAN | [view interactions] | High throughput | no | yes |
| AP2B_HUMAN | [view interactions] | High throughput | no | no |
| NOTC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KR103_HUMAN | [view interactions] | High throughput | no | no |
| GRSF1_HUMAN | [view interactions] | High throughput | no | yes |
| UVRAG_HUMAN | [view interactions] | High throughput | no | yes |
| VP33B_HUMAN | [view interactions] | High throughput | no | yes |
| STX1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| STX8_HUMAN | [view interactions] | High throughput | no | yes |
| VPS45_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| RN166_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| GTF2I_HUMAN | [view interactions] | High throughput | no | yes |
| ABCG1_HUMAN | [view interactions] | High throughput | no | yes |
| AP3D1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TM266_HUMAN | [view interactions] | High throughput | no | no |
| ISOC2_HUMAN | [view interactions] | High throughput | no | yes |
| ZUP1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| M1IP1_HUMAN | [view interactions] | High throughput | no | yes |
| PARL_HUMAN | [view interactions] | High throughput | no | yes |
| PACE1_HUMAN | [view interactions] | High throughput | no | yes |
| RBX2_HUMAN | [view interactions] | High throughput | no | yes |
| HYPM_HUMAN | [view interactions] | High throughput | no | no |
| PSME1_HUMAN | [view interactions] | High throughput | no | yes |
| CYTA_HUMAN | [view interactions] | High throughput | no | no |
| TTC9C_HUMAN | [view interactions] | High throughput | no | yes |
| CCD92_HUMAN | [view interactions] | High throughput | no | yes |
| LRC61_HUMAN | [view interactions] | High throughput | no | yes |
| S10A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CC018_HUMAN | [view interactions] | High throughput | no | yes |
| THRSP_HUMAN | [view interactions] | High throughput | no | no |
| RLBP1_HUMAN | [view interactions] | High throughput | no | no |
| TCAM1_HUMAN | [view interactions] | High throughput | no | yes |
| BOP_HUMAN | [view interactions] | High throughput | no | no |
| CYS1_HUMAN | [view interactions] | High throughput | no | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| FITM2_HUMAN | [view interactions] | High throughput | no | no |
| UB2L3_HUMAN | [view interactions] | High throughput | no | yes |
| UB2D2_HUMAN | [view interactions] | High throughput | no | yes |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBP17_HUMAN | [view interactions] | High throughput | no | no |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| MON1A_HUMAN | [view interactions] | High throughput | no | no |
| HOOK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HOOK1_HUMAN | [view interactions] | High throughput | no | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |