Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

VPS41_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (PubMed). Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo (PubMed, PubMed, PubMed, PubMed). Required for fusion of autophagosomes with lysosomes (PubMed). Links the HOPS complex to endosomal Rab7 via its association with RILP and to lysosomal membranes via its association with ARL8B, suggesting that these interactions may bring the compartments to close proximity for fusion (PubMed, PubMed, PubMed). Involved in the direct trans-Golgi network to late endosomes transport of lysosomal membrane proteins independently of HOPS (PubMed). Involved in sorting to the regulated secretory pathway presumably implicating the AP-3 adaptor complex . May play a role in HOPS-independent function in the regulated secretory pathway (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
285 Ser Pro Spinocerebellarataxia,autosomalrecessive,29(SCAR29) -
791 Cys Phe Spinocerebellarataxia,autosomalrecessive,29(SCAR29) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in VPS41_HUMAN
GO:0043169 cation binding 31.5789 4 yes
GO:0046872 metal ion binding 31.5789 5 yes
GO:0015631 tubulin binding 21.0526 4 yes
GO:0003779 actin binding 21.0526 4 no
GO:0000166 nucleotide binding 21.0526 4 no
GO:0051020 GTPase binding 21.0526 4 no
GO:0008017 microtubule binding 15.7895 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in VPS41_HUMAN
GO:0008104 protein localization 78.9474 4 yes
GO:0071702 organic substance transport 78.9474 4 yes
GO:0071705 nitrogen compound transport 78.9474 4 yes
GO:0015031 protein transport 73.6842 4 yes
GO:0006886 intracellular protein transport 68.4211 4 yes
GO:0006996 organelle organization 68.4211 4 yes
GO:0007034 vacuolar transport 68.4211 4 yes
GO:0007041 lysosomal transport 68.4211 5 yes
GO:0051128 regulation of cellular component organization 63.1579 4 yes
GO:0044087 regulation of cellular component biogenesis 57.8947 4 yes
GO:0016050 vesicle organization 52.6316 5 yes
GO:0061024 membrane organization 52.6316 4 yes
GO:0006906 vesicle fusion 42.1053 6 yes
GO:0043254 regulation of protein-containing complex assembly 42.1053 5 yes
GO:0048284 organelle fusion 42.1053 5 yes
GO:0061025 membrane fusion 42.1053 5 yes
GO:0090174 organelle membrane fusion 42.1053 6 yes
GO:0048522 positive regulation of cellular process 36.8421 4 no
GO:0060255 regulation of macromolecule metabolic process 36.8421 4 no
GO:0080090 regulation of primary metabolic process 36.8421 4 no
GO:0033365 protein localization to organelle 36.8421 5 yes
GO:0034058 endosomal vesicle fusion 36.8421 7 yes
GO:0035542 regulation of SNARE complex assembly 36.8421 6 yes
GO:0048523 negative regulation of cellular process 36.8421 4 no
GO:0009893 positive regulation of metabolic process 36.8421 4 no
GO:0010604 positive regulation of macromolecule metabolic process 36.8421 5 no
GO:0022607 cellular component assembly 36.8421 4 no
GO:0043933 protein-containing complex organization 31.5789 4 no
GO:0051049 regulation of transport 31.5789 4 no
GO:0051246 regulation of protein metabolic process 31.5789 5 no
GO:0051247 positive regulation of protein metabolic process 31.5789 6 no
GO:0009894 regulation of catabolic process 31.5789 4 no
GO:0009966 regulation of signal transduction 31.5789 4 no
GO:0010646 regulation of cell communication 31.5789 4 no
GO:0031326 regulation of cellular biosynthetic process 26.3158 5 no
GO:0031328 positive regulation of cellular biosynthetic process 26.3158 6 no
GO:0042176 regulation of protein catabolic process 26.3158 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 26.3158 5 no
GO:0016236 macroautophagy 26.3158 4 yes
GO:0072594 establishment of protein localization to organelle 26.3158 4 yes
GO:0007033 vacuole organization 26.3158 5 no
GO:0097435 supramolecular fiber organization 26.3158 4 no
GO:0009889 regulation of biosynthetic process 26.3158 4 no
GO:0009891 positive regulation of biosynthetic process 26.3158 5 no
GO:0009896 positive regulation of catabolic process 26.3158 5 no
GO:0010556 regulation of macromolecule biosynthetic process 26.3158 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 26.3158 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 26.3158 5 no
GO:0031323 regulation of cellular metabolic process 26.3158 4 no
GO:0031325 positive regulation of cellular metabolic process 26.3158 5 no
GO:0031399 regulation of protein modification process 21.0526 6 no
GO:0031401 positive regulation of protein modification process 21.0526 7 no
GO:0032880 regulation of protein localization 21.0526 5 no
GO:0033043 regulation of organelle organization 21.0526 5 no
GO:0036211 protein modification process 21.0526 4 no
GO:0042325 regulation of phosphorylation 21.0526 7 no
GO:0043412 macromolecule modification 21.0526 4 no
GO:0043549 regulation of kinase activity 21.0526 5 no
GO:0045732 positive regulation of protein catabolic process 21.0526 6 no
GO:0048584 positive regulation of response to stimulus 21.0526 4 no
GO:0048585 negative regulation of response to stimulus 21.0526 4 no
GO:0051050 positive regulation of transport 21.0526 4 no
GO:0051174 regulation of phosphorus metabolic process 21.0526 5 no
GO:0051338 regulation of transferase activity 21.0526 4 no
GO:0060341 regulation of cellular localization 21.0526 4 no
GO:0060627 regulation of vesicle-mediated transport 21.0526 4 no
GO:0065003 protein-containing complex assembly 21.0526 5 no
GO:0098657 import into cell 21.0526 4 no
GO:1901565 organonitrogen compound catabolic process 21.0526 4 no
GO:1903829 positive regulation of protein localization 21.0526 5 no
GO:0006605 protein targeting 21.0526 4 yes
GO:0006623 protein targeting to vacuole 21.0526 5 yes
GO:0072665 protein localization to vacuole 21.0526 6 yes
GO:0072666 establishment of protein localization to vacuole 21.0526 5 yes
GO:0045595 regulation of cell differentiation 21.0526 4 no
GO:0001932 regulation of protein phosphorylation 21.0526 7 no
GO:0009057 macromolecule catabolic process 21.0526 4 no
GO:0009968 negative regulation of signal transduction 21.0526 5 no
GO:0010243 response to organonitrogen compound 21.0526 4 no
GO:0010468 regulation of gene expression 21.0526 6 no
GO:0010648 negative regulation of cell communication 21.0526 5 no
GO:0019220 regulation of phosphate metabolic process 21.0526 6 no
GO:0023057 negative regulation of signaling 21.0526 4 no
GO:0030163 protein catabolic process 21.0526 4 no
GO:1902774 late endosome to lysosome transport 15.7895 6 yes
GO:0009267 cellular response to starvation 10.5263 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
VPS41_HUMAN [view entry] [view interactions] Low throughput yes yes
VPS18_HUMAN [view entry] [view interactions] Low throughput yes no
SPE39_HUMAN [view interactions] Low throughput no yes
VP33A_HUMAN [view entry] [view interactions] Low throughput yes no
VPS11_HUMAN [view entry] [view interactions] Low throughput yes no
VP33B_HUMAN [view interactions] Low throughput no yes
STX17_HUMAN [view interactions] Low throughput no yes
PKHM1_HUMAN [view interactions] Low throughput no yes
ARL8B_HUMAN [view interactions] Low throughput no yes
MON1B_HUMAN [view interactions] Low throughput no yes
RILP_HUMAN [view interactions] Low throughput no no
ESR2_HUMAN [view interactions] High throughput no no
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
HOOK1_HUMAN [view interactions] High throughput no no
HOOK2_HUMAN [view interactions] High throughput no yes
HOOK3_HUMAN [view entry] [view interactions] High throughput yes yes
AKTIP_HUMAN [view interactions] High throughput no yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
EED_HUMAN [view interactions] High throughput no yes
CT55_HUMAN [view interactions] High throughput no no
F111B_HUMAN [view interactions] High throughput no no
AP3D1_HUMAN [view entry] [view interactions] High throughput yes no
CLCB_HUMAN [view entry] [view interactions] High throughput yes yes
TCPR2_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
ZUP1_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
PRC1_HUMAN [view interactions] High throughput no yes
CTDS2_HUMAN [view interactions] High throughput no yes
BICD2_HUMAN [view interactions] High throughput no yes
GGTL1_HUMAN [view interactions] High throughput no no
UBXN6_HUMAN [view entry] [view interactions] High throughput yes yes
INF2_HUMAN [view entry] [view interactions] High throughput yes yes
ST1C4_HUMAN [view interactions] High throughput no no
RFXK_HUMAN [view interactions] High throughput no yes
PLBL1_HUMAN [view interactions] High throughput no no
D2HDH_HUMAN [view interactions] High throughput no no
EFMT3_HUMAN [view interactions] High throughput no no
CIA2A_HUMAN [view interactions] High throughput no yes
TRI35_HUMAN [view interactions] High throughput no yes
MTU1_HUMAN [view interactions] High throughput no no
PKHG7_HUMAN [view interactions] High throughput no no
SNX27_HUMAN [view entry] [view interactions] High throughput yes no
RBM25_HUMAN [view interactions] High throughput no yes
PR40A_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
PTAR1_HUMAN [view interactions] High throughput no yes
FITM2_HUMAN [view interactions] High throughput no no
ATG12_HUMAN [view interactions] High throughput no yes
SPRNG_HUMAN [view interactions] High throughput no yes
ATG7_HUMAN [view interactions] High throughput no yes
ATG10_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
UTP20_HUMAN [view interactions] High throughput no no
XRCC4_HUMAN [view interactions] High throughput no yes
Z512B_HUMAN [view interactions] High throughput no yes
TCAL4_HUMAN [view interactions] High throughput no no
KDM5C_HUMAN [view interactions] High throughput no no
VPS16_HUMAN [view entry] [view interactions] High throughput yes yes
DDX41_HUMAN [view interactions] High throughput no yes
BABA1_HUMAN [view interactions] High throughput no yes
TGFA1_HUMAN [view interactions] High throughput no no
MAX_HUMAN [view interactions] High throughput no yes
SOSB1_HUMAN [view interactions] High throughput no yes
XPO7_HUMAN [view entry] [view interactions] High throughput yes yes
VPS39_HUMAN [view entry] [view interactions] High throughput yes no
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
H2B2C_HUMAN [view interactions] High throughput no no
UBE2U_HUMAN [view interactions] High throughput no no