IDH3A_HUMAN
Evidence for PS localization
Functions
Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in IDH3A_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 35.0000 | 4 | yes |
| GO:0046872 | metal ion binding | 33.7500 | 5 | yes |
| GO:0000166 | nucleotide binding | 27.5000 | 4 | yes |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 27.5000 | 4 | no |
| GO:0022890 | inorganic cation transmembrane transporter activity | 27.5000 | 4 | no |
| GO:0017076 | purine nucleotide binding | 25.0000 | 5 | yes |
| GO:0015078 | proton transmembrane transporter activity | 25.0000 | 5 | no |
| GO:0022853 | active monoatomic ion transmembrane transporter activity | 25.0000 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 23.7500 | 6 | yes |
| GO:0015399 | primary active transmembrane transporter activity | 22.5000 | 4 | no |
| GO:0003723 | RNA binding | 22.5000 | 4 | no |
| GO:0043168 | anion binding | 21.2500 | 4 | no |
| GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | 8.7500 | 4 | yes |
| GO:0000287 | magnesium ion binding | 7.5000 | 6 | yes |
| GO:0051287 | NAD binding | 7.5000 | 7 | yes |
| GO:0004448 | isocitrate dehydrogenase [NAD(P)+] activity | 6.2500 | 5 | yes |
| GO:0004449 | isocitrate dehydrogenase (NAD+) activity | 5.0000 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in IDH3A_HUMAN |
|---|---|---|---|---|
| GO:0006796 | phosphate-containing compound metabolic process | 38.7500 | 4 | no |
| GO:0022607 | cellular component assembly | 37.5000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 33.7500 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 32.5000 | 4 | no |
| GO:0006753 | nucleoside phosphate metabolic process | 32.5000 | 4 | no |
| GO:0009117 | nucleotide metabolic process | 32.5000 | 5 | no |
| GO:0010646 | regulation of cell communication | 32.5000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 32.5000 | 4 | no |
| GO:0006163 | purine nucleotide metabolic process | 31.2500 | 5 | no |
| GO:0072521 | purine-containing compound metabolic process | 31.2500 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 31.2500 | 4 | no |
| GO:0009259 | ribonucleotide metabolic process | 30.0000 | 5 | no |
| GO:0019693 | ribose phosphate metabolic process | 30.0000 | 4 | no |
| GO:0043933 | protein-containing complex organization | 30.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 30.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 28.7500 | 4 | no |
| GO:0009150 | purine ribonucleotide metabolic process | 28.7500 | 6 | no |
| GO:0065003 | protein-containing complex assembly | 28.7500 | 5 | no |
| GO:1901362 | organic cyclic compound biosynthetic process | 27.5000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 27.5000 | 4 | no |
| GO:0015980 | energy derivation by oxidation of organic compounds | 26.2500 | 4 | no |
| GO:1901566 | organonitrogen compound biosynthetic process | 26.2500 | 4 | no |
| GO:0009060 | aerobic respiration | 25.0000 | 6 | no |
| GO:0045333 | cellular respiration | 25.0000 | 5 | no |
| GO:0006996 | organelle organization | 25.0000 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 25.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 25.0000 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.0000 | 5 | no |
| GO:0019752 | carboxylic acid metabolic process | 23.7500 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 23.7500 | 4 | yes |
| GO:0022900 | electron transport chain | 23.7500 | 4 | no |
| GO:0022904 | respiratory electron transport chain | 23.7500 | 5 | no |
| GO:0034654 | nucleobase-containing compound biosynthetic process | 23.7500 | 4 | no |
| GO:0090407 | organophosphate biosynthetic process | 23.7500 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 22.5000 | 5 | no |
| GO:0009165 | nucleotide biosynthetic process | 22.5000 | 6 | no |
| GO:0009260 | ribonucleotide biosynthetic process | 22.5000 | 6 | no |
| GO:0019646 | aerobic electron transport chain | 22.5000 | 6 | no |
| GO:0046390 | ribose phosphate biosynthetic process | 22.5000 | 5 | no |
| GO:1901137 | carbohydrate derivative biosynthetic process | 22.5000 | 4 | no |
| GO:1901293 | nucleoside phosphate biosynthetic process | 22.5000 | 5 | no |
| GO:0010468 | regulation of gene expression | 22.5000 | 6 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 22.5000 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 22.5000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 22.5000 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 22.5000 | 5 | no |
| GO:0006164 | purine nucleotide biosynthetic process | 21.2500 | 6 | no |
| GO:0009141 | nucleoside triphosphate metabolic process | 21.2500 | 5 | no |
| GO:0009152 | purine ribonucleotide biosynthetic process | 21.2500 | 7 | no |
| GO:0009199 | ribonucleoside triphosphate metabolic process | 21.2500 | 6 | no |
| GO:0072522 | purine-containing compound biosynthetic process | 21.2500 | 5 | no |
| GO:0072350 | tricarboxylic acid metabolic process | 8.7500 | 6 | yes |
| GO:0006102 | isocitrate metabolic process | 7.5000 | 5 | yes |
| GO:1902652 | secondary alcohol metabolic process | 7.5000 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| IDH3G_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GLYC_HUMAN | [view interactions] | Low throughput | no | no |
| IDH3B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IDH3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DMWD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DDA1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SIM26_HUMAN | [view interactions] | High throughput | no | no |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDHA_HUMAN | [view interactions] | High throughput | no | yes |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| KCNQ1_HUMAN | [view interactions] | High throughput | no | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| RD3_HUMAN | [view interactions] | High throughput | no | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| MBNL1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NEMO_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD3_HUMAN | [view interactions] | High throughput | no | yes |
| KDM3B_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOX4_HUMAN | [view interactions] | High throughput | no | yes |
| MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDK1_HUMAN | [view interactions] | High throughput | no | yes |
| IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
| PRP6_HUMAN | [view interactions] | High throughput | no | yes |
| SF01_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD4_HUMAN | [view interactions] | High throughput | no | yes |
| TERF1_HUMAN | [view interactions] | High throughput | no | no |
| TERF2_HUMAN | [view interactions] | High throughput | no | yes |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| RDH13_HUMAN | [view interactions] | High throughput | no | no |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NFAC2_HUMAN | [view interactions] | High throughput | no | yes |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCND1_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| TM129_HUMAN | [view interactions] | High throughput | no | no |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| DHCR7_HUMAN | [view interactions] | High throughput | no | yes |
| TLS1_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| CL16A_HUMAN | [view interactions] | High throughput | no | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RICTR_HUMAN | [view interactions] | High throughput | no | yes |
| S10AG_HUMAN | [view interactions] | High throughput | no | no |
| SUCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MRP1_HUMAN | [view interactions] | High throughput | no | no |
| MRP3_HUMAN | [view interactions] | High throughput | no | no |
| ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDHD1_HUMAN | [view interactions] | High throughput | no | yes |
| IDHC_HUMAN | [view interactions] | High throughput | no | no |
| ACADM_HUMAN | [view interactions] | High throughput | no | yes |
| PYR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPW_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLH2_HUMAN | [view interactions] | High throughput | no | no |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYEP_HUMAN | [view interactions] | High throughput | no | yes |
| ETFA_HUMAN | [view interactions] | High throughput | no | yes |
| IDHP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRS8_HUMAN | [view interactions] | High throughput | no | yes |
| RLA0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S25A3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SUCB2_HUMAN | [view interactions] | High throughput | no | no |
| IPO9_HUMAN | [view interactions] | High throughput | no | no |
| PSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE2N_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAOM_HUMAN | [view interactions] | High throughput | no | yes |
| P5CR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHX9_HUMAN | [view interactions] | High throughput | no | yes |
| NDUB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS4_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHSD_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIC26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPA_HUMAN | [view interactions] | High throughput | no | yes |
| ATPG_HUMAN | [view interactions] | High throughput | no | yes |
| ATP5I_HUMAN | [view interactions] | High throughput | no | yes |
| AT5L2_HUMAN | [view interactions] | High throughput | no | no |
| ATP5L_HUMAN | [view interactions] | High throughput | no | yes |
| COQ9_HUMAN | [view interactions] | High throughput | no | yes |
| CY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |
| NDUAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACPM_HUMAN | [view interactions] | High throughput | no | yes |
| NDUB7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDUS2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PFKAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDHB_HUMAN | [view interactions] | High throughput | no | yes |
| QCR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ISCA1_HUMAN | [view interactions] | High throughput | no | yes |
| LETM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUBA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SUCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIC19_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CISD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUAC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDHF3_HUMAN | [view interactions] | High throughput | no | yes |
| ADT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QRIC1_HUMAN | [view interactions] | High throughput | no | yes |
| MRM1_HUMAN | [view interactions] | High throughput | no | no |
| DPPA3_HUMAN | [view interactions] | High throughput | no | no |
| C1QBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | no |
| MRES1_HUMAN | [view interactions] | High throughput | no | yes |
| HINT2_HUMAN | [view interactions] | High throughput | no | yes |
| LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RRFM_HUMAN | [view interactions] | High throughput | no | yes |
| MTG2_HUMAN | [view interactions] | High throughput | no | yes |
| EFTS_HUMAN | [view interactions] | High throughput | no | no |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAOK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |