NDUB6_HUMAN
Evidence for PS localization
Functions
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NDUB6_HUMAN |
|---|---|---|---|---|
| GO:0008324 | monoatomic cation transmembrane transporter activity | 70.5882 | 4 | yes |
| GO:0015078 | proton transmembrane transporter activity | 70.5882 | 5 | yes |
| GO:0015399 | primary active transmembrane transporter activity | 70.5882 | 4 | yes |
| GO:0015453 | oxidoreduction-driven active transmembrane transporter activity | 70.5882 | 5 | yes |
| GO:0022853 | active monoatomic ion transmembrane transporter activity | 70.5882 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 70.5882 | 4 | yes |
| GO:0016655 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | 58.8235 | 4 | yes |
| GO:0043169 | cation binding | 44.1176 | 4 | no |
| GO:0046872 | metal ion binding | 41.1765 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NDUB6_HUMAN |
|---|---|---|---|---|
| GO:0009060 | aerobic respiration | 79.4118 | 6 | yes |
| GO:0015980 | energy derivation by oxidation of organic compounds | 79.4118 | 4 | yes |
| GO:0022900 | electron transport chain | 79.4118 | 4 | yes |
| GO:0022904 | respiratory electron transport chain | 79.4118 | 5 | yes |
| GO:0045333 | cellular respiration | 79.4118 | 5 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 73.5294 | 4 | yes |
| GO:0019646 | aerobic electron transport chain | 73.5294 | 6 | yes |
| GO:0006753 | nucleoside phosphate metabolic process | 67.6471 | 4 | yes |
| GO:0009117 | nucleotide metabolic process | 67.6471 | 5 | yes |
| GO:0006163 | purine nucleotide metabolic process | 64.7059 | 5 | yes |
| GO:0009141 | nucleoside triphosphate metabolic process | 64.7059 | 5 | yes |
| GO:0009144 | purine nucleoside triphosphate metabolic process | 64.7059 | 6 | yes |
| GO:0009150 | purine ribonucleotide metabolic process | 64.7059 | 6 | yes |
| GO:0009199 | ribonucleoside triphosphate metabolic process | 64.7059 | 6 | yes |
| GO:0009205 | purine ribonucleoside triphosphate metabolic process | 64.7059 | 7 | yes |
| GO:0009259 | ribonucleotide metabolic process | 64.7059 | 5 | yes |
| GO:0019693 | ribose phosphate metabolic process | 64.7059 | 4 | yes |
| GO:0046034 | ATP metabolic process | 64.7059 | 7 | yes |
| GO:0072521 | purine-containing compound metabolic process | 64.7059 | 4 | yes |
| GO:1901362 | organic cyclic compound biosynthetic process | 64.7059 | 4 | yes |
| GO:1901566 | organonitrogen compound biosynthetic process | 64.7059 | 4 | yes |
| GO:0006164 | purine nucleotide biosynthetic process | 61.7647 | 6 | yes |
| GO:0006754 | ATP biosynthetic process | 61.7647 | 8 | yes |
| GO:0009142 | nucleoside triphosphate biosynthetic process | 61.7647 | 6 | yes |
| GO:0009145 | purine nucleoside triphosphate biosynthetic process | 61.7647 | 7 | yes |
| GO:0009152 | purine ribonucleotide biosynthetic process | 61.7647 | 7 | yes |
| GO:0009165 | nucleotide biosynthetic process | 61.7647 | 6 | yes |
| GO:0009201 | ribonucleoside triphosphate biosynthetic process | 61.7647 | 7 | yes |
| GO:0009206 | purine ribonucleoside triphosphate biosynthetic process | 61.7647 | 8 | yes |
| GO:0009260 | ribonucleotide biosynthetic process | 61.7647 | 6 | yes |
| GO:0015986 | proton motive force-driven ATP synthesis | 61.7647 | 9 | yes |
| GO:0034654 | nucleobase-containing compound biosynthetic process | 61.7647 | 4 | yes |
| GO:0042776 | proton motive force-driven mitochondrial ATP synthesis | 61.7647 | 10 | yes |
| GO:0046390 | ribose phosphate biosynthetic process | 61.7647 | 5 | yes |
| GO:0072522 | purine-containing compound biosynthetic process | 61.7647 | 5 | yes |
| GO:0090407 | organophosphate biosynthetic process | 61.7647 | 4 | yes |
| GO:1901137 | carbohydrate derivative biosynthetic process | 61.7647 | 4 | yes |
| GO:1901293 | nucleoside phosphate biosynthetic process | 61.7647 | 5 | yes |
| GO:0022607 | cellular component assembly | 58.8235 | 4 | yes |
| GO:0006120 | mitochondrial electron transport, NADH to ubiquinone | 55.8824 | 7 | yes |
| GO:0043933 | protein-containing complex organization | 55.8824 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 55.8824 | 5 | yes |
| GO:0033108 | mitochondrial respiratory chain complex assembly | 52.9412 | 6 | yes |
| GO:0010257 | NADH dehydrogenase complex assembly | 50.0000 | 6 | yes |
| GO:0032981 | mitochondrial respiratory chain complex I assembly | 50.0000 | 7 | yes |
| GO:0009966 | regulation of signal transduction | 23.5294 | 4 | no |
| GO:0010646 | regulation of cell communication | 23.5294 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 23.5294 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 20.5882 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 20.5882 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 20.5882 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 20.5882 | 5 | no |
| GO:0042773 | ATP synthesis coupled electron transport | 14.7059 | 6 | yes |
| GO:0042775 | mitochondrial ATP synthesis coupled electron transport | 14.7059 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NDUS3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUS5_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUAB_HUMAN | [view interactions] | Low throughput | no | no |
| NDUA8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUB5_HUMAN | [view interactions] | Low throughput | no | yes |
| CIA30_HUMAN | [view interactions] | Low throughput | no | yes |
| ACPM_HUMAN | [view interactions] | Low throughput | no | yes |
| YMEL1_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUBB_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUC2_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUB7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUB3_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUA1_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUAD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUBA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUAA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NU3M_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUB9_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NU6M_HUMAN | [view interactions] | Low throughput | no | no |
| NDUS2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUC1_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUA3_HUMAN | [view interactions] | Low throughput | no | yes |
| NU2M_HUMAN | [view interactions] | Low throughput | no | no |
| NU4LM_HUMAN | [view interactions] | Low throughput | no | no |
| NDUB1_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUB8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NU4M_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUB2_HUMAN | [view interactions] | Low throughput | no | yes |
| NU1M_HUMAN | [view interactions] | Low throughput | no | yes |
| NU5M_HUMAN | [view interactions] | Low throughput | no | no |
| NDUB4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUAC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIDC1_HUMAN | [view interactions] | High throughput | no | yes |
| KIF19_HUMAN | [view interactions] | High throughput | no | yes |
| YIPF3_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDUS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FUT1_HUMAN | [view interactions] | High throughput | no | no |
| GALT6_HUMAN | [view interactions] | High throughput | no | yes |
| PON1_HUMAN | [view interactions] | High throughput | no | no |
| G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LFG4_HUMAN | [view interactions] | High throughput | no | no |
| NDUA6_HUMAN | [view interactions] | High throughput | no | no |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB2_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI3_HUMAN | [view interactions] | High throughput | no | yes |
| CREB3_HUMAN | [view interactions] | High throughput | no | no |
| FOXL2_HUMAN | [view interactions] | High throughput | no | no |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| TCTP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| DX39A_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CREL1_HUMAN | [view interactions] | High throughput | no | yes |
| CXA8_HUMAN | [view interactions] | High throughput | no | no |
| NDUA9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUV3_HUMAN | [view interactions] | High throughput | no | yes |
| DJC30_HUMAN | [view interactions] | High throughput | no | no |
| TM192_HUMAN | [view interactions] | High throughput | no | yes |
| EMC3_HUMAN | [view interactions] | High throughput | no | yes |
| SNX17_HUMAN | [view interactions] | High throughput | no | yes |
| NF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STK11_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RT28_HUMAN | [view interactions] | High throughput | no | yes |
| SDHB_HUMAN | [view interactions] | High throughput | no | yes |
| IKIP_HUMAN | [view interactions] | High throughput | no | no |
| MPV17_HUMAN | [view interactions] | High throughput | no | no |
| ABCB7_HUMAN | [view interactions] | High throughput | no | yes |
| ATPD_HUMAN | [view interactions] | High throughput | no | yes |
| IDH3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATP5E_HUMAN | [view interactions] | High throughput | no | no |
| ACBP_HUMAN | [view interactions] | High throughput | no | yes |
| QCR6L_HUMAN | [view interactions] | High throughput | no | yes |
| QCR6_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS4_HUMAN | [view interactions] | High throughput | no | yes |
| T10B_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPA_HUMAN | [view interactions] | High throughput | no | yes |
| CX7A2_HUMAN | [view interactions] | High throughput | no | no |
| ATPG_HUMAN | [view interactions] | High throughput | no | yes |
| ATP5H_HUMAN | [view interactions] | High throughput | no | yes |
| CY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATP5I_HUMAN | [view interactions] | High throughput | no | yes |
| ATPK_HUMAN | [view interactions] | High throughput | no | yes |
| COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CX6B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |