NDUB4_HUMAN
Evidence for PS localization
Functions
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NDUB4_HUMAN |
|---|---|---|---|---|
| GO:0015399 | primary active transmembrane transporter activity | 48.0769 | 4 | yes |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 44.2308 | 4 | yes |
| GO:0015078 | proton transmembrane transporter activity | 44.2308 | 5 | yes |
| GO:0015453 | oxidoreduction-driven active transmembrane transporter activity | 44.2308 | 5 | yes |
| GO:0022853 | active monoatomic ion transmembrane transporter activity | 44.2308 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 44.2308 | 4 | yes |
| GO:0016655 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | 40.3846 | 4 | yes |
| GO:0043169 | cation binding | 28.8462 | 4 | no |
| GO:0046872 | metal ion binding | 26.9231 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NDUB4_HUMAN |
|---|---|---|---|---|
| GO:0006796 | phosphate-containing compound metabolic process | 55.7692 | 4 | yes |
| GO:0022607 | cellular component assembly | 55.7692 | 4 | yes |
| GO:0009060 | aerobic respiration | 48.0769 | 6 | yes |
| GO:0015980 | energy derivation by oxidation of organic compounds | 48.0769 | 4 | yes |
| GO:0022900 | electron transport chain | 48.0769 | 4 | yes |
| GO:0022904 | respiratory electron transport chain | 48.0769 | 5 | yes |
| GO:0043933 | protein-containing complex organization | 48.0769 | 4 | yes |
| GO:0045333 | cellular respiration | 48.0769 | 5 | yes |
| GO:0006163 | purine nucleotide metabolic process | 44.2308 | 5 | yes |
| GO:0006753 | nucleoside phosphate metabolic process | 44.2308 | 4 | yes |
| GO:0009117 | nucleotide metabolic process | 44.2308 | 5 | yes |
| GO:0009150 | purine ribonucleotide metabolic process | 44.2308 | 6 | yes |
| GO:0009259 | ribonucleotide metabolic process | 44.2308 | 5 | yes |
| GO:0019646 | aerobic electron transport chain | 44.2308 | 6 | yes |
| GO:0019693 | ribose phosphate metabolic process | 44.2308 | 4 | yes |
| GO:0072521 | purine-containing compound metabolic process | 44.2308 | 4 | yes |
| GO:1901362 | organic cyclic compound biosynthetic process | 44.2308 | 4 | yes |
| GO:1901566 | organonitrogen compound biosynthetic process | 44.2308 | 4 | yes |
| GO:0009141 | nucleoside triphosphate metabolic process | 42.3077 | 5 | yes |
| GO:0009144 | purine nucleoside triphosphate metabolic process | 42.3077 | 6 | yes |
| GO:0009199 | ribonucleoside triphosphate metabolic process | 42.3077 | 6 | yes |
| GO:0009205 | purine ribonucleoside triphosphate metabolic process | 42.3077 | 7 | yes |
| GO:0034654 | nucleobase-containing compound biosynthetic process | 42.3077 | 4 | yes |
| GO:0046034 | ATP metabolic process | 42.3077 | 7 | yes |
| GO:0065003 | protein-containing complex assembly | 42.3077 | 5 | yes |
| GO:0090407 | organophosphate biosynthetic process | 42.3077 | 4 | yes |
| GO:0006164 | purine nucleotide biosynthetic process | 40.3846 | 6 | yes |
| GO:0006754 | ATP biosynthetic process | 40.3846 | 8 | yes |
| GO:0009142 | nucleoside triphosphate biosynthetic process | 40.3846 | 6 | yes |
| GO:0009145 | purine nucleoside triphosphate biosynthetic process | 40.3846 | 7 | yes |
| GO:0009152 | purine ribonucleotide biosynthetic process | 40.3846 | 7 | yes |
| GO:0009165 | nucleotide biosynthetic process | 40.3846 | 6 | yes |
| GO:0009201 | ribonucleoside triphosphate biosynthetic process | 40.3846 | 7 | yes |
| GO:0009206 | purine ribonucleoside triphosphate biosynthetic process | 40.3846 | 8 | yes |
| GO:0009260 | ribonucleotide biosynthetic process | 40.3846 | 6 | yes |
| GO:0015986 | proton motive force-driven ATP synthesis | 40.3846 | 9 | yes |
| GO:0042776 | proton motive force-driven mitochondrial ATP synthesis | 40.3846 | 10 | yes |
| GO:0046390 | ribose phosphate biosynthetic process | 40.3846 | 5 | yes |
| GO:0072522 | purine-containing compound biosynthetic process | 40.3846 | 5 | yes |
| GO:1901137 | carbohydrate derivative biosynthetic process | 40.3846 | 4 | yes |
| GO:1901293 | nucleoside phosphate biosynthetic process | 40.3846 | 5 | yes |
| GO:0006120 | mitochondrial electron transport, NADH to ubiquinone | 38.4615 | 7 | yes |
| GO:0048523 | negative regulation of cellular process | 36.5385 | 4 | no |
| GO:0033108 | mitochondrial respiratory chain complex assembly | 34.6154 | 6 | yes |
| GO:0010257 | NADH dehydrogenase complex assembly | 32.6923 | 6 | yes |
| GO:0032981 | mitochondrial respiratory chain complex I assembly | 32.6923 | 7 | yes |
| GO:0006996 | organelle organization | 32.6923 | 4 | no |
| GO:0010646 | regulation of cell communication | 32.6923 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 32.6923 | 4 | no |
| GO:0009966 | regulation of signal transduction | 30.7692 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 30.7692 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 30.7692 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 26.9231 | 4 | no |
| GO:0008104 | protein localization | 25.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 25.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 25.0000 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 23.0769 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 23.0769 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 23.0769 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 23.0769 | 5 | no |
| GO:0071702 | organic substance transport | 21.1538 | 4 | no |
| GO:0043066 | negative regulation of apoptotic process | 21.1538 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 21.1538 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 21.1538 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 21.1538 | 5 | no |
| GO:0009894 | regulation of catabolic process | 21.1538 | 4 | no |
| GO:0010468 | regulation of gene expression | 21.1538 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 21.1538 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 21.1538 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 21.1538 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 21.1538 | 5 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 21.1538 | 6 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NDUS5_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUAB_HUMAN | [view interactions] | Low throughput | no | no |
| ACPM_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUA8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUBB_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUB3_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUA1_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUB1_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUA3_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUC2_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUS2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUBA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUAA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUB7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUB5_HUMAN | [view interactions] | Low throughput | no | yes |
| NU3M_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUB9_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NU6M_HUMAN | [view interactions] | Low throughput | no | no |
| NDUB6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUC1_HUMAN | [view interactions] | Low throughput | no | yes |
| NU2M_HUMAN | [view interactions] | Low throughput | no | no |
| NU4LM_HUMAN | [view interactions] | Low throughput | no | no |
| NDUB8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NU4M_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUB2_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUAD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NU1M_HUMAN | [view interactions] | Low throughput | no | yes |
| NU5M_HUMAN | [view interactions] | Low throughput | no | no |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| NDUAC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS4_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIDC1_HUMAN | [view interactions] | High throughput | no | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMES1_HUMAN | [view interactions] | High throughput | no | no |
| CX6B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COQ9_HUMAN | [view interactions] | High throughput | no | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NEP_HUMAN | [view interactions] | High throughput | no | no |
| NDUA6_HUMAN | [view interactions] | High throughput | no | no |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| KCNQ1_HUMAN | [view interactions] | High throughput | no | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| TFE2_HUMAN | [view interactions] | High throughput | no | no |
| ENPP6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PP4R1_HUMAN | [view interactions] | High throughput | no | yes |
| GOT1B_HUMAN | [view interactions] | High throughput | no | yes |
| BMR1A_HUMAN | [view interactions] | High throughput | no | no |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMED2_HUMAN | [view interactions] | High throughput | no | yes |
| RMD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCTD5_HUMAN | [view interactions] | High throughput | no | no |
| CDC16_HUMAN | [view interactions] | High throughput | no | yes |
| ERC6L_HUMAN | [view interactions] | High throughput | no | yes |
| KC1A_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| DX39A_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FRIL_HUMAN | [view interactions] | High throughput | no | yes |
| NDUV3_HUMAN | [view interactions] | High throughput | no | yes |
| FUT1_HUMAN | [view interactions] | High throughput | no | no |
| SCAR3_HUMAN | [view interactions] | High throughput | no | yes |
| FFAR1_HUMAN | [view interactions] | High throughput | no | no |
| DRB1_HUMAN | [view interactions] | High throughput | no | no |
| DJC30_HUMAN | [view interactions] | High throughput | no | no |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FOXA1_HUMAN | [view interactions] | High throughput | no | no |
| AURKA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| SNIP1_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| PRRT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPTOR_HUMAN | [view interactions] | High throughput | no | no |
| AFG32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| T2EA_HUMAN | [view interactions] | High throughput | no | yes |
| BACD3_HUMAN | [view interactions] | High throughput | no | yes |
| C560_HUMAN | [view interactions] | High throughput | no | no |
| QCR7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ML12A_HUMAN | [view interactions] | High throughput | no | no |
| MPV17_HUMAN | [view interactions] | High throughput | no | no |
| MPRD_HUMAN | [view interactions] | High throughput | no | yes |
| TOM20_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LTOR3_HUMAN | [view interactions] | High throughput | no | yes |
| MARC1_HUMAN | [view interactions] | High throughput | no | yes |
| ABCD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOM5_HUMAN | [view interactions] | High throughput | no | yes |
| WFS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUCR_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDUA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUP35_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |