ENPP6_HUMAN
Evidence for PS localization
Functions
Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells (PubMed). Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ENPP6_HUMAN |
|---|---|---|---|---|
| GO:0003954 | NADH dehydrogenase activity | 36.3636 | 4 | no |
| GO:0003955 | NAD(P)H dehydrogenase (quinone) activity | 36.3636 | 5 | no |
| GO:0008137 | NADH dehydrogenase (ubiquinone) activity | 36.3636 | 4 | no |
| GO:0015399 | primary active transmembrane transporter activity | 36.3636 | 4 | no |
| GO:0015453 | oxidoreduction-driven active transmembrane transporter activity | 36.3636 | 5 | no |
| GO:0016655 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | 36.3636 | 4 | no |
| GO:0050136 | NADH dehydrogenase (quinone) activity | 36.3636 | 5 | no |
| GO:0046872 | metal ion binding | 18.1818 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ENPP6_HUMAN |
|---|---|---|---|---|
| GO:0022607 | cellular component assembly | 63.6364 | 4 | no |
| GO:0006120 | mitochondrial electron transport, NADH to ubiquinone | 36.3636 | 7 | no |
| GO:0009060 | aerobic respiration | 36.3636 | 6 | no |
| GO:0015980 | energy derivation by oxidation of organic compounds | 36.3636 | 4 | no |
| GO:0019646 | aerobic electron transport chain | 36.3636 | 6 | no |
| GO:0022900 | electron transport chain | 36.3636 | 4 | no |
| GO:0022904 | respiratory electron transport chain | 36.3636 | 5 | no |
| GO:0043933 | protein-containing complex organization | 36.3636 | 4 | no |
| GO:0045333 | cellular respiration | 36.3636 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 36.3636 | 5 | no |
| GO:0048522 | positive regulation of cellular process | 36.3636 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 36.3636 | 4 | no |
| GO:0010257 | NADH dehydrogenase complex assembly | 27.2727 | 6 | no |
| GO:0032981 | mitochondrial respiratory chain complex I assembly | 27.2727 | 7 | no |
| GO:0033108 | mitochondrial respiratory chain complex assembly | 27.2727 | 6 | no |
| GO:0051049 | regulation of transport | 27.2727 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 27.2727 | 4 | no |
| GO:0006996 | organelle organization | 27.2727 | 4 | no |
| GO:0008104 | protein localization | 27.2727 | 4 | no |
| GO:0061024 | membrane organization | 27.2727 | 4 | no |
| GO:0006644 | phospholipid metabolic process | 18.1818 | 4 | yes |
| GO:0006650 | glycerophospholipid metabolic process | 18.1818 | 5 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 18.1818 | 4 | yes |
| GO:0046486 | glycerolipid metabolic process | 18.1818 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NDUB9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SACS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMPA3_HUMAN | [view interactions] | High throughput | no | yes |
| DIAP3_HUMAN | [view interactions] | High throughput | no | no |
| NUP85_HUMAN | [view interactions] | High throughput | no | yes |
| GLMN_HUMAN | [view interactions] | High throughput | no | no |
| GLBL2_HUMAN | [view interactions] | High throughput | no | no |
| CRLF3_HUMAN | [view interactions] | High throughput | no | yes |
| KAISO_HUMAN | [view interactions] | High throughput | no | yes |
| MEX3B_HUMAN | [view interactions] | High throughput | no | no |
| ATRAP_HUMAN | [view interactions] | High throughput | no | yes |
| VAMP3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTN1_HUMAN | [view interactions] | High throughput | no | yes |
| NU5M_HUMAN | [view interactions] | High throughput | no | no |
| NDUA7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUB8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUB3_HUMAN | [view interactions] | High throughput | no | yes |
| NDUB5_HUMAN | [view interactions] | High throughput | no | yes |
| GNPAT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SCAM1_HUMAN | [view interactions] | High throughput | no | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| ASPH_HUMAN | [view interactions] | High throughput | no | yes |
| PYRG2_HUMAN | [view interactions] | High throughput | no | yes |
| OCRL_HUMAN | [view interactions] | High throughput | no | yes |
| PIGS_HUMAN | [view interactions] | High throughput | no | yes |
| EMC3_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RUND1_HUMAN | [view interactions] | High throughput | no | yes |
| STEA3_HUMAN | [view interactions] | High throughput | no | yes |
| TMTC3_HUMAN | [view interactions] | High throughput | no | yes |
| LMF1_HUMAN | [view interactions] | High throughput | no | no |
| S26A6_HUMAN | [view interactions] | High throughput | no | yes |
| EMC7_HUMAN | [view interactions] | High throughput | no | yes |
| LMF2_HUMAN | [view interactions] | High throughput | no | yes |
| TEDC1_HUMAN | [view interactions] | High throughput | no | no |
| PACC1_HUMAN | [view interactions] | High throughput | no | no |
| NDUB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALG9_HUMAN | [view interactions] | High throughput | no | yes |
| EMC8_HUMAN | [view interactions] | High throughput | no | no |
| MKS1_HUMAN | [view interactions] | High throughput | no | no |
| UBP22_HUMAN | [view interactions] | High throughput | no | yes |
| KPCD2_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1A_HUMAN | [view interactions] | High throughput | no | yes |
| TOR4A_HUMAN | [view interactions] | High throughput | no | yes |
| GDPD1_HUMAN | [view interactions] | Computational | no | no |
| GDPD3_HUMAN | [view interactions] | Computational | no | no |
| TM86B_HUMAN | [view interactions] | Computational | no | no |
| LPCT4_HUMAN | [view interactions] | Computational | no | yes |