Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ENPP6_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells (PubMed). Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ENPP6_HUMAN
GO:0008324 monoatomic cation transmembrane transporter activity 33.3333 4 no
GO:0015078 proton transmembrane transporter activity 33.3333 5 no
GO:0015399 primary active transmembrane transporter activity 33.3333 4 no
GO:0015453 oxidoreduction-driven active transmembrane transporter activity 33.3333 5 no
GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 33.3333 4 no
GO:0022853 active monoatomic ion transmembrane transporter activity 33.3333 4 no
GO:0022890 inorganic cation transmembrane transporter activity 33.3333 4 no
GO:0043169 cation binding 25.0000 4 yes
GO:0046872 metal ion binding 25.0000 5 yes
GO:0042578 phosphoric ester hydrolase activity 16.6667 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ENPP6_HUMAN
GO:0022607 cellular component assembly 58.3333 4 no
GO:0006796 phosphate-containing compound metabolic process 58.3333 4 yes
GO:0090407 organophosphate biosynthetic process 41.6667 4 no
GO:0048523 negative regulation of cellular process 41.6667 4 no
GO:0006996 organelle organization 41.6667 4 no
GO:0048522 positive regulation of cellular process 33.3333 4 no
GO:0006120 mitochondrial electron transport, NADH to ubiquinone 33.3333 7 no
GO:0006163 purine nucleotide metabolic process 33.3333 5 no
GO:0006164 purine nucleotide biosynthetic process 33.3333 6 no
GO:0006753 nucleoside phosphate metabolic process 33.3333 4 no
GO:0006754 ATP biosynthetic process 33.3333 8 no
GO:0009060 aerobic respiration 33.3333 6 no
GO:0009117 nucleotide metabolic process 33.3333 5 no
GO:0009141 nucleoside triphosphate metabolic process 33.3333 5 no
GO:0009142 nucleoside triphosphate biosynthetic process 33.3333 6 no
GO:0009144 purine nucleoside triphosphate metabolic process 33.3333 6 no
GO:0009145 purine nucleoside triphosphate biosynthetic process 33.3333 7 no
GO:0009150 purine ribonucleotide metabolic process 33.3333 6 no
GO:0009152 purine ribonucleotide biosynthetic process 33.3333 7 no
GO:0009165 nucleotide biosynthetic process 33.3333 6 no
GO:0009199 ribonucleoside triphosphate metabolic process 33.3333 6 no
GO:0009201 ribonucleoside triphosphate biosynthetic process 33.3333 7 no
GO:0009205 purine ribonucleoside triphosphate metabolic process 33.3333 7 no
GO:0009206 purine ribonucleoside triphosphate biosynthetic process 33.3333 8 no
GO:0009259 ribonucleotide metabolic process 33.3333 5 no
GO:0009260 ribonucleotide biosynthetic process 33.3333 6 no
GO:0015980 energy derivation by oxidation of organic compounds 33.3333 4 no
GO:0015986 proton motive force-driven ATP synthesis 33.3333 9 no
GO:0019646 aerobic electron transport chain 33.3333 6 no
GO:0019693 ribose phosphate metabolic process 33.3333 4 no
GO:0022900 electron transport chain 33.3333 4 no
GO:0022904 respiratory electron transport chain 33.3333 5 no
GO:0034654 nucleobase-containing compound biosynthetic process 33.3333 4 no
GO:0042776 proton motive force-driven mitochondrial ATP synthesis 33.3333 10 no
GO:0043933 protein-containing complex organization 33.3333 4 no
GO:0045333 cellular respiration 33.3333 5 no
GO:0046034 ATP metabolic process 33.3333 7 no
GO:0046390 ribose phosphate biosynthetic process 33.3333 5 no
GO:0065003 protein-containing complex assembly 33.3333 5 no
GO:0072521 purine-containing compound metabolic process 33.3333 4 no
GO:0072522 purine-containing compound biosynthetic process 33.3333 5 no
GO:1901137 carbohydrate derivative biosynthetic process 33.3333 4 no
GO:1901293 nucleoside phosphate biosynthetic process 33.3333 5 no
GO:1901362 organic cyclic compound biosynthetic process 33.3333 4 no
GO:1901566 organonitrogen compound biosynthetic process 33.3333 4 no
GO:0051128 regulation of cellular component organization 33.3333 4 no
GO:0048584 positive regulation of response to stimulus 25.0000 4 no
GO:0061024 membrane organization 25.0000 4 no
GO:0010257 NADH dehydrogenase complex assembly 25.0000 6 no
GO:0032981 mitochondrial respiratory chain complex I assembly 25.0000 7 no
GO:0033108 mitochondrial respiratory chain complex assembly 25.0000 6 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:0051049 regulation of transport 25.0000 4 no
GO:0009893 positive regulation of metabolic process 25.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 25.0000 5 no
GO:0060255 regulation of macromolecule metabolic process 25.0000 4 no
GO:0008104 protein localization 25.0000 4 no
GO:0006644 phospholipid metabolic process 16.6667 4 yes
GO:0006650 glycerophospholipid metabolic process 16.6667 5 yes
GO:0046486 glycerolipid metabolic process 16.6667 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SCAM1_HUMAN [view interactions] High throughput no no
GNPAT_HUMAN [view entry] [view interactions] High throughput yes no
NDUB5_HUMAN [view interactions] High throughput no yes
NDUB3_HUMAN [view interactions] High throughput no yes
NDUB8_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA7_HUMAN [view entry] [view interactions] High throughput yes yes
NU5M_HUMAN [view interactions] High throughput no no
PTN1_HUMAN [view entry] [view interactions] High throughput yes yes
VAMP3_HUMAN [view entry] [view interactions] High throughput yes no
ATRAP_HUMAN [view interactions] High throughput no yes
MEX3B_HUMAN [view interactions] High throughput no no
KAISO_HUMAN [view interactions] High throughput no yes
CRLF3_HUMAN [view interactions] High throughput no yes
GLBL2_HUMAN [view interactions] High throughput no no
GLMN_HUMAN [view interactions] High throughput no no
NUP85_HUMAN [view interactions] High throughput no yes
DIAP3_HUMAN [view interactions] High throughput no no
IMPA3_HUMAN [view interactions] High throughput no yes
SACS_HUMAN [view entry] [view interactions] High throughput yes yes
NDUB9_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
ASPH_HUMAN [view interactions] High throughput no yes
PYRG2_HUMAN [view interactions] High throughput no yes
OCRL_HUMAN [view interactions] High throughput no yes
PIGS_HUMAN [view interactions] High throughput no yes
EMC3_HUMAN [view interactions] High throughput no yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
RUND1_HUMAN [view interactions] High throughput no yes
STEA3_HUMAN [view interactions] High throughput no yes
TMTC3_HUMAN [view interactions] High throughput no yes
LMF1_HUMAN [view interactions] High throughput no no
S26A6_HUMAN [view interactions] High throughput no yes
EMC7_HUMAN [view interactions] High throughput no yes
LMF2_HUMAN [view interactions] High throughput no yes
TEDC1_HUMAN [view interactions] High throughput no no
PACC1_HUMAN [view interactions] High throughput no no
NDUB4_HUMAN [view entry] [view interactions] High throughput yes yes
ALG9_HUMAN [view interactions] High throughput no yes
EMC8_HUMAN [view interactions] High throughput no no
MKS1_HUMAN [view interactions] High throughput no no
UBP22_HUMAN [view interactions] High throughput no yes
KPCD2_HUMAN [view interactions] High throughput no yes
TIF1A_HUMAN [view interactions] High throughput no yes
TOR4A_HUMAN [view interactions] High throughput no yes
ENPP7_HUMAN [view interactions] High throughput no no