GNPAT_HUMAN
Evidence for PS localization
Functions
Dihydroxyacetonephosphate acyltransferase involved in plasmalogen biosynthesis. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 211 | Arg | Cys | Rhizomelicchondrodysplasiapunctata2(RCDP2) | - |
| 211 | Arg | His | Rhizomelicchondrodysplasiapunctata2(RCDP2) | - |
| 519 | Asp | Gly | Rhizomelicchondrodysplasiapunctata2(RCDP2) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GNPAT_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 26.0870 | 4 | no |
| GO:0008374 | O-acyltransferase activity | 17.3913 | 5 | yes |
| GO:0016747 | acyltransferase activity, transferring groups other than amino-acyl groups | 17.3913 | 4 | yes |
| GO:0016407 | acetyltransferase activity | 13.0435 | 5 | yes |
| GO:0016413 | O-acetyltransferase activity | 13.0435 | 6 | yes |
| GO:0016287 | glycerone-phosphate O-acyltransferase activity | 8.6957 | 7 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GNPAT_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 43.4783 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 39.1304 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 39.1304 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 34.7826 | 4 | no |
| GO:0009966 | regulation of signal transduction | 34.7826 | 4 | no |
| GO:0010646 | regulation of cell communication | 34.7826 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 34.7826 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 34.7826 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 34.7826 | 5 | no |
| GO:0010468 | regulation of gene expression | 30.4348 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 30.4348 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 30.4348 | 5 | no |
| GO:0008104 | protein localization | 30.4348 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 26.0870 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.0870 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 26.0870 | 5 | no |
| GO:0023056 | positive regulation of signaling | 26.0870 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 26.0870 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 26.0870 | 6 | no |
| GO:0048523 | negative regulation of cellular process | 26.0870 | 4 | no |
| GO:0006631 | fatty acid metabolic process | 26.0870 | 4 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 26.0870 | 4 | yes |
| GO:0019752 | carboxylic acid metabolic process | 26.0870 | 5 | yes |
| GO:0032787 | monocarboxylic acid metabolic process | 26.0870 | 6 | yes |
| GO:0043436 | oxoacid metabolic process | 26.0870 | 4 | yes |
| GO:0046486 | glycerolipid metabolic process | 21.7391 | 4 | yes |
| GO:0001817 | regulation of cytokine production | 21.7391 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 21.7391 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 21.7391 | 5 | no |
| GO:0030030 | cell projection organization | 21.7391 | 4 | no |
| GO:0031175 | neuron projection development | 21.7391 | 6 | no |
| GO:0051130 | positive regulation of cellular component organization | 21.7391 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 21.7391 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 21.7391 | 5 | no |
| GO:0071702 | organic substance transport | 21.7391 | 4 | no |
| GO:0071705 | nitrogen compound transport | 21.7391 | 4 | no |
| GO:0016042 | lipid catabolic process | 21.7391 | 4 | no |
| GO:0044242 | cellular lipid catabolic process | 21.7391 | 4 | no |
| GO:0051049 | regulation of transport | 21.7391 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 21.7391 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 21.7391 | 5 | no |
| GO:0010941 | regulation of cell death | 21.7391 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 21.7391 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 21.7391 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 21.7391 | 5 | no |
| GO:0008610 | lipid biosynthetic process | 21.7391 | 4 | yes |
| GO:0022607 | cellular component assembly | 21.7391 | 4 | yes |
| GO:0006644 | phospholipid metabolic process | 17.3913 | 4 | yes |
| GO:0006650 | glycerophospholipid metabolic process | 17.3913 | 5 | yes |
| GO:0033993 | response to lipid | 17.3913 | 4 | yes |
| GO:0045017 | glycerolipid biosynthetic process | 13.0435 | 4 | yes |
| GO:0046473 | phosphatidic acid metabolic process | 13.0435 | 6 | yes |
| GO:0046474 | glycerophospholipid biosynthetic process | 13.0435 | 5 | yes |
| GO:0050808 | synapse organization | 13.0435 | 5 | yes |
| GO:0070542 | response to fatty acid | 13.0435 | 4 | yes |
| GO:0090407 | organophosphate biosynthetic process | 13.0435 | 4 | yes |
| GO:0006654 | phosphatidic acid biosynthetic process | 13.0435 | 6 | yes |
| GO:0007416 | synapse assembly | 13.0435 | 6 | yes |
| GO:0008654 | phospholipid biosynthetic process | 13.0435 | 4 | yes |
| GO:0031667 | response to nutrient levels | 13.0435 | 4 | yes |
| GO:0034329 | cell junction assembly | 13.0435 | 5 | yes |
| GO:0034330 | cell junction organization | 13.0435 | 4 | yes |
| GO:0045216 | cell-cell junction organization | 8.6957 | 5 | yes |
| GO:0046485 | ether lipid metabolic process | 8.6957 | 4 | yes |
| GO:0046504 | glycerol ether biosynthetic process | 8.6957 | 4 | yes |
| GO:0061024 | membrane organization | 8.6957 | 4 | yes |
| GO:0097384 | cellular lipid biosynthetic process | 8.6957 | 4 | yes |
| GO:1901503 | ether biosynthetic process | 8.6957 | 4 | yes |
| GO:0006662 | glycerol ether metabolic process | 8.6957 | 4 | yes |
| GO:0007043 | cell-cell junction assembly | 8.6957 | 6 | yes |
| GO:0008611 | ether lipid biosynthetic process | 8.6957 | 5 | yes |
| GO:0030913 | paranodal junction assembly | 8.6957 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in GNPAT_HUMAN |
|---|---|---|---|---|
| DOID:0110852 | rhizomelic chondrodysplasia punctata type 2 | 8.6957 | 4 | yes |
| DOID:2580 | rhizomelic chondrodysplasia punctata | 8.6957 | 3 | yes |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ADAS_HUMAN | [view interactions] | Low throughput | no | yes |
| ARRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SLX4_HUMAN | [view interactions] | High throughput | no | yes |
| SL7A1_HUMAN | [view interactions] | High throughput | no | no |
| C3AR_HUMAN | [view interactions] | High throughput | no | no |
| PRSR2_HUMAN | [view interactions] | High throughput | no | yes |
| DAAF8_HUMAN | [view interactions] | High throughput | no | no |
| PACC1_HUMAN | [view interactions] | High throughput | no | no |
| LYPD3_HUMAN | [view interactions] | High throughput | no | no |
| GRPR_HUMAN | [view interactions] | High throughput | no | no |
| C1QT2_HUMAN | [view interactions] | High throughput | no | yes |
| IL1R2_HUMAN | [view interactions] | High throughput | no | no |
| F131B_HUMAN | [view interactions] | High throughput | no | no |
| ENPP6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FANCE_HUMAN | [view interactions] | High throughput | no | yes |
| ODAD4_HUMAN | [view interactions] | High throughput | no | no |
| DCA11_HUMAN | [view interactions] | High throughput | no | yes |
| ZN544_HUMAN | [view interactions] | High throughput | no | yes |
| IFTAP_HUMAN | [view interactions] | High throughput | no | no |
| PEX14_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| PTPS_HUMAN | [view interactions] | High throughput | no | yes |
| GPR3_HUMAN | [view interactions] | High throughput | no | no |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CATA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
| VDR_HUMAN | [view interactions] | High throughput | no | no |
| BARD1_HUMAN | [view interactions] | High throughput | no | yes |
| PEX5_HUMAN | [view interactions] | High throughput | no | yes |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PMF1_HUMAN | [view interactions] | High throughput | no | no |
| S39A4_HUMAN | [view interactions] | High throughput | no | no |
| MINY2_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| SG2A2_HUMAN | [view interactions] | High throughput | no | no |
| PVR_HUMAN | [view interactions] | High throughput | no | yes |
| HDA10_HUMAN | [view interactions] | High throughput | no | yes |
| LYPD4_HUMAN | [view interactions] | High throughput | no | no |
| ATX3_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| HYPM_HUMAN | [view interactions] | High throughput | no | no |
| IFT20_HUMAN | [view interactions] | High throughput | no | yes |
| SAAL1_HUMAN | [view interactions] | High throughput | no | yes |
| NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AR2BP_HUMAN | [view interactions] | High throughput | no | yes |
| GPC3_HUMAN | [view interactions] | High throughput | no | no |
| APOA2_HUMAN | [view interactions] | High throughput | no | no |
| S10A9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GIP_HUMAN | [view interactions] | High throughput | no | no |
| HCST_HUMAN | [view interactions] | High throughput | no | no |
| GHRL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DLL1_HUMAN | [view interactions] | High throughput | no | no |
| TSN10_HUMAN | [view interactions] | High throughput | no | no |
| RU1C_HUMAN | [view interactions] | High throughput | no | yes |
| BNIP5_HUMAN | [view interactions] | High throughput | no | no |
| AT7L1_HUMAN | [view interactions] | High throughput | no | yes |
| CYB5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGFA_HUMAN | [view interactions] | High throughput | no | yes |
| PAHX_HUMAN | [view interactions] | High throughput | no | yes |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| GALA_HUMAN | [view interactions] | High throughput | no | no |
| FFAR1_HUMAN | [view interactions] | High throughput | no | no |
| NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBCC1_HUMAN | [view interactions] | High throughput | no | no |
| GNPAT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SAE2_HUMAN | [view interactions] | High throughput | no | yes |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| HEBP1_HUMAN | [view interactions] | High throughput | no | yes |
| COIL_HUMAN | [view interactions] | High throughput | no | yes |
| FACR2_HUMAN | [view interactions] | Computational | no | yes |
| TKFC_HUMAN | [view interactions] | Computational | no | no |
| DECR2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| NUDT7_HUMAN | [view interactions] | Computational | no | yes |
| PLPP5_HUMAN | [view interactions] | Computational | no | no |
| GPDM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| S27A2_HUMAN | [view interactions] | Computational | no | no |
| IDHC_HUMAN | [view interactions] | Computational | no | no |
| LCLT1_HUMAN | [view interactions] | Computational | no | no |
| HACL1_HUMAN | [view interactions] | Computational | no | no |
| PEX5R_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MPV17_HUMAN | [view interactions] | Computational | no | no |
| GPD1L_HUMAN | [view interactions] | Computational | no | no |
| PLCD_HUMAN | [view interactions] | Computational | no | yes |
| ACOX1_HUMAN | [view interactions] | Computational | no | yes |
| HMGCL_HUMAN | [view interactions] | Computational | no | yes |
| LPIN3_HUMAN | [view interactions] | Computational | no | yes |
| PECR_HUMAN | [view interactions] | Computational | no | yes |
| ACOX3_HUMAN | [view interactions] | Computational | no | yes |
| NUD19_HUMAN | [view interactions] | Computational | no | no |
| LPIN1_HUMAN | [view interactions] | Computational | no | no |
| PAOX_HUMAN | [view interactions] | Computational | no | no |
| AMACR_HUMAN | [view interactions] | Computational | no | yes |
| LONP2_HUMAN | [view interactions] | Computational | no | yes |
| HAOX2_HUMAN | [view interactions] | Computational | no | no |
| PLCA_HUMAN | [view interactions] | Computational | no | yes |
| ECHP_HUMAN | [view interactions] | Computational | no | no |
| PLCB_HUMAN | [view interactions] | Computational | no | yes |
| PEX7_HUMAN | [view interactions] | Computational | no | yes |
| FACR1_HUMAN | [view interactions] | Computational | no | yes |
| MBOA1_HUMAN | [view interactions] | Computational | no | no |
| BAAT_HUMAN | [view interactions] | Computational | no | no |
| ECI2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SOX_HUMAN | [view interactions] | Computational | no | no |
| ACOT2_HUMAN | [view interactions] | Computational | no | yes |
| CACP_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PEX2_HUMAN | [view interactions] | Computational | no | yes |
| ECH1_HUMAN | [view interactions] | Computational | no | yes |
| OCTC_HUMAN | [view interactions] | Computational | no | yes |
| OXDA_HUMAN | [view interactions] | Computational | no | no |
| HYES_HUMAN | [view interactions] | Computational | no | no |
| ACOT4_HUMAN | [view interactions] | Computational | no | yes |
| OXDD_HUMAN | [view interactions] | Computational | no | yes |
| PLPP4_HUMAN | [view interactions] | Computational | no | yes |
| GPDA_HUMAN | [view interactions] | Computational | no | yes |
| HAOX1_HUMAN | [view interactions] | Computational | no | no |
| TYSD1_HUMAN | [view interactions] | Computational | no | yes |
| MBOA2_HUMAN | [view interactions] | Computational | no | yes |
| ACOX2_HUMAN | [view interactions] | Computational | no | yes |
| DHRS4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PLPP2_HUMAN | [view interactions] | Computational | no | yes |
| NOS2_HUMAN | [view interactions] | Computational | no | yes |
| PLCE_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SCP2_HUMAN | [view interactions] | Computational | no | no |
| LPIN2_HUMAN | [view interactions] | Computational | no | yes |
| PLPP3_HUMAN | [view interactions] | Computational | no | no |
| DCMC_HUMAN | [view interactions] | Computational | no | no |
| SPYA_HUMAN | [view interactions] | Computational | no | no |
| GSTK1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ACOT8_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PLCC_HUMAN | [view interactions] | Computational | no | no |
| IDE_HUMAN | [view interactions] | Computational | no | yes |