Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SACS_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
168 Asp Tyr SpasticataxiaCharlevoix-Saguenaytype(SACS) -
201 Thr Lys SpasticataxiaCharlevoix-Saguenaytype(SACS) -
308 Leu Phe SpasticataxiaCharlevoix-Saguenaytype(SACS) -
556 Leu Pro SpasticataxiaCharlevoix-Saguenaytype(SACS) -
802 Leu Pro SpasticataxiaCharlevoix-Saguenaytype(SACS) -
991 Cys Arg SpasticataxiaCharlevoix-Saguenaytype(SACS) -
1054 Phe Ser SpasticataxiaCharlevoix-Saguenaytype(SACS) -
1311 Met Lys SpasticataxiaCharlevoix-Saguenaytype(SACS) -
1575 Arg Pro SpasticataxiaCharlevoix-Saguenaytype(SACS) -
1587 His Arg SpasticataxiaCharlevoix-Saguenaytype(SACS) -
1946 Trp Arg SpasticataxiaCharlevoix-Saguenaytype(SACS) -
2703 Arg Cys SpasticataxiaCharlevoix-Saguenaytype(SACS) -
2798 Pro Gln SpasticataxiaCharlevoix-Saguenaytype(SACS) -
3248 Trp Arg SpasticataxiaCharlevoix-Saguenaytype(SACS) -
3481 Leu Pro SpasticataxiaCharlevoix-Saguenaytype(SACS) -
3636 Arg Gln SpasticataxiaCharlevoix-Saguenaytype(SACS) -
3645 Leu Pro SpasticataxiaCharlevoix-Saguenaytype(SACS) -
3652 Pro Thr SpasticataxiaCharlevoix-Saguenaytype(SACS) -
3653 Phe Ser SpasticataxiaCharlevoix-Saguenaytype(SACS) -
4074 Ala Pro SpasticataxiaCharlevoix-Saguenaytype(SACS) -
4331 Arg Gln SpasticataxiaCharlevoix-Saguenaytype(SACS) -
4343 Glu Lys SpasticataxiaCharlevoix-Saguenaytype(SACS) -
4508 Lys Thr SpasticataxiaCharlevoix-Saguenaytype(SACS) -
4549 Asn Asp SpasticataxiaCharlevoix-Saguenaytype(SACS) -
3702 Thr Ala - -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SACS_HUMAN
GO:0046872 metal ion binding 42.8571 4 no
GO:0030544 Hsp70 protein binding 21.4286 4 yes
GO:0003723 RNA binding 21.4286 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in SACS_HUMAN
GO:0048523 negative regulation of cellular process 57.1429 4 yes
GO:0031323 regulation of cellular metabolic process 57.1429 4 no
GO:0051171 regulation of nitrogen compound metabolic process 57.1429 4 no
GO:0060255 regulation of macromolecule metabolic process 57.1429 4 no
GO:0080090 regulation of primary metabolic process 57.1429 4 no
GO:0048522 positive regulation of cellular process 57.1429 4 no
GO:0051128 regulation of cellular component organization 42.8571 4 yes
GO:0010468 regulation of gene expression 35.7143 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 35.7143 5 no
GO:0051252 regulation of RNA metabolic process 35.7143 5 no
GO:0006996 organelle organization 35.7143 4 no
GO:0007010 cytoskeleton organization 35.7143 5 no
GO:0009889 regulation of biosynthetic process 35.7143 4 no
GO:0009894 regulation of catabolic process 35.7143 4 no
GO:0010556 regulation of macromolecule biosynthetic process 35.7143 5 no
GO:0031326 regulation of cellular biosynthetic process 35.7143 5 no
GO:0051246 regulation of protein metabolic process 35.7143 5 no
GO:0010646 regulation of cell communication 35.7143 4 no
GO:0051129 negative regulation of cellular component organization 28.5714 5 yes
GO:0009893 positive regulation of metabolic process 28.5714 4 no
GO:0010604 positive regulation of macromolecule metabolic process 28.5714 5 no
GO:0031325 positive regulation of cellular metabolic process 28.5714 5 no
GO:0031329 regulation of cellular catabolic process 28.5714 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 28.5714 5 no
GO:0051247 positive regulation of protein metabolic process 28.5714 6 no
GO:0009966 regulation of signal transduction 28.5714 4 no
GO:0009967 positive regulation of signal transduction 28.5714 5 no
GO:0010647 positive regulation of cell communication 28.5714 5 no
GO:0023056 positive regulation of signaling 28.5714 4 no
GO:0048584 positive regulation of response to stimulus 28.5714 4 no
GO:0008104 protein localization 28.5714 4 no
GO:0016192 vesicle-mediated transport 21.4286 4 no
GO:0032091 negative regulation of protein binding 21.4286 5 no
GO:0043393 regulation of protein binding 21.4286 4 no
GO:0050804 modulation of chemical synaptic transmission 21.4286 5 no
GO:0051049 regulation of transport 21.4286 4 no
GO:0051050 positive regulation of transport 21.4286 4 no
GO:0051100 negative regulation of binding 21.4286 4 no
GO:0051130 positive regulation of cellular component organization 21.4286 5 no
GO:0099177 regulation of trans-synaptic signaling 21.4286 4 no
GO:1903506 regulation of nucleic acid-templated transcription 21.4286 7 no
GO:2001141 regulation of RNA biosynthetic process 21.4286 6 no
GO:0006796 phosphate-containing compound metabolic process 21.4286 4 no
GO:0010941 regulation of cell death 21.4286 4 no
GO:0042981 regulation of apoptotic process 21.4286 6 no
GO:0043067 regulation of programmed cell death 21.4286 5 no
GO:0015031 protein transport 21.4286 4 no
GO:0071702 organic substance transport 21.4286 4 no
GO:0071705 nitrogen compound transport 21.4286 4 no
GO:0044087 regulation of cellular component biogenesis 14.2857 4 yes
GO:0090083 regulation of inclusion body assembly 14.2857 5 yes
GO:0090084 negative regulation of inclusion body assembly 14.2857 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in SACS_HUMAN
DOID:0050753 cerebellar ataxia 14.2857 6 yes
DOID:0050946 Charlevoix-Saguenay spastic ataxia 14.2857 8 yes
DOID:0050950 autosomal recessive cerebellar ataxia 14.2857 7 yes
DOID:0050951 hereditary ataxia 14.2857 5 yes
DOID:1289 neurodegenerative disease 14.2857 4 yes
DOID:331 central nervous system disease 14.2857 3 yes

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SACS_HUMAN [view entry] [view interactions] Low throughput yes yes
PSA3_HUMAN [view interactions] Low throughput no no
UBE3A_HUMAN [view interactions] Low throughput no yes
ACTN4_HUMAN [view entry] [view interactions] High throughput yes yes
PICK1_HUMAN [view entry] [view interactions] High throughput yes yes
P63_HUMAN [view interactions] High throughput no no
PLK1_HUMAN [view interactions] High throughput no yes
NAA10_HUMAN [view interactions] High throughput no yes
TRI29_HUMAN [view interactions] High throughput no no
ENPP6_HUMAN [view entry] [view interactions] High throughput yes no
MOCS3_HUMAN [view interactions] High throughput no yes
SODC_HUMAN [view interactions] High throughput no yes
ROA0_HUMAN [view interactions] High throughput no yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
ALBU_HUMAN [view interactions] High throughput no no
PTBP3_HUMAN [view interactions] High throughput no no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
T22D4_HUMAN [view entry] [view interactions] High throughput yes no
RPA12_HUMAN [view interactions] High throughput no yes
ADRB2_HUMAN [view entry] [view interactions] High throughput yes no
MYC_HUMAN [view interactions] High throughput no yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
CCDC8_HUMAN [view interactions] High throughput no yes
ATOH1_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
DRC6_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
CC018_HUMAN [view interactions] High throughput no yes
TACD2_HUMAN [view interactions] High throughput no no
GPR17_HUMAN [view interactions] High throughput no no
EFNB1_HUMAN [view interactions] High throughput no yes
SPSB4_HUMAN [view interactions] High throughput no no
UBP3_HUMAN [view interactions] High throughput no no
FKBP5_HUMAN [view interactions] High throughput no yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
P53_HUMAN [view interactions] High throughput no no
NWD2_HUMAN [view interactions] High throughput no no
P3H2_HUMAN [view interactions] High throughput no yes
P4HA2_HUMAN [view interactions] High throughput no no
DNJA2_HUMAN [view entry] [view interactions] High throughput yes yes
DNJC7_HUMAN [view interactions] High throughput no yes
DYR2_HUMAN [view interactions] High throughput no yes
PERI_HUMAN [view entry] [view interactions] High throughput yes no
VIME_HUMAN [view entry] [view interactions] High throughput yes no