Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SACS_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
168 Asp Tyr SpasticataxiaCharlevoix-Saguenaytype(SACS) -
201 Thr Lys SpasticataxiaCharlevoix-Saguenaytype(SACS) -
308 Leu Phe SpasticataxiaCharlevoix-Saguenaytype(SACS) -
556 Leu Pro SpasticataxiaCharlevoix-Saguenaytype(SACS) -
802 Leu Pro SpasticataxiaCharlevoix-Saguenaytype(SACS) -
991 Cys Arg SpasticataxiaCharlevoix-Saguenaytype(SACS) -
1054 Phe Ser SpasticataxiaCharlevoix-Saguenaytype(SACS) -
1311 Met Lys SpasticataxiaCharlevoix-Saguenaytype(SACS) -
1575 Arg Pro SpasticataxiaCharlevoix-Saguenaytype(SACS) -
1587 His Arg SpasticataxiaCharlevoix-Saguenaytype(SACS) -
1946 Trp Arg SpasticataxiaCharlevoix-Saguenaytype(SACS) -
2703 Arg Cys SpasticataxiaCharlevoix-Saguenaytype(SACS) -
2798 Pro Gln SpasticataxiaCharlevoix-Saguenaytype(SACS) -
3248 Trp Arg SpasticataxiaCharlevoix-Saguenaytype(SACS) -
3481 Leu Pro SpasticataxiaCharlevoix-Saguenaytype(SACS) -
3636 Arg Gln SpasticataxiaCharlevoix-Saguenaytype(SACS) -
3645 Leu Pro SpasticataxiaCharlevoix-Saguenaytype(SACS) -
3652 Pro Thr SpasticataxiaCharlevoix-Saguenaytype(SACS) -
3653 Phe Ser SpasticataxiaCharlevoix-Saguenaytype(SACS) -
4074 Ala Pro SpasticataxiaCharlevoix-Saguenaytype(SACS) -
4331 Arg Gln SpasticataxiaCharlevoix-Saguenaytype(SACS) -
4343 Glu Lys SpasticataxiaCharlevoix-Saguenaytype(SACS) -
4508 Lys Thr SpasticataxiaCharlevoix-Saguenaytype(SACS) -
4549 Asn Asp SpasticataxiaCharlevoix-Saguenaytype(SACS) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SACS_HUMAN
GO:0043169 cation binding 57.8947 4 no
GO:0046872 metal ion binding 52.6316 5 no
GO:0030544 Hsp70 protein binding 26.3158 4 yes
GO:0003723 RNA binding 21.0526 4 no
GO:0003779 actin binding 21.0526 4 no
GO:0019900 kinase binding 21.0526 4 no
GO:0019901 protein kinase binding 21.0526 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in SACS_HUMAN
GO:0060255 regulation of macromolecule metabolic process 73.6842 4 no
GO:0048523 negative regulation of cellular process 68.4211 4 yes
GO:0031323 regulation of cellular metabolic process 68.4211 4 no
GO:0080090 regulation of primary metabolic process 68.4211 4 no
GO:0009889 regulation of biosynthetic process 63.1579 4 no
GO:0010468 regulation of gene expression 63.1579 6 no
GO:0010556 regulation of macromolecule biosynthetic process 63.1579 5 no
GO:0031326 regulation of cellular biosynthetic process 63.1579 5 no
GO:0048522 positive regulation of cellular process 63.1579 4 no
GO:0051128 regulation of cellular component organization 57.8947 4 yes
GO:0051129 negative regulation of cellular component organization 47.3684 5 yes
GO:0009894 regulation of catabolic process 47.3684 4 no
GO:0051246 regulation of protein metabolic process 47.3684 5 no
GO:0009893 positive regulation of metabolic process 47.3684 4 no
GO:0010604 positive regulation of macromolecule metabolic process 47.3684 5 no
GO:0010646 regulation of cell communication 47.3684 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 47.3684 5 no
GO:0051252 regulation of RNA metabolic process 47.3684 5 no
GO:0006996 organelle organization 42.1053 4 no
GO:0009966 regulation of signal transduction 42.1053 4 no
GO:0010647 positive regulation of cell communication 42.1053 5 no
GO:0023056 positive regulation of signaling 42.1053 4 no
GO:0031325 positive regulation of cellular metabolic process 42.1053 5 no
GO:0048584 positive regulation of response to stimulus 42.1053 4 no
GO:0042981 regulation of apoptotic process 36.8421 5 no
GO:0043067 regulation of programmed cell death 36.8421 4 no
GO:0006355 regulation of DNA-templated transcription 36.8421 7 no
GO:0006357 regulation of transcription by RNA polymerase II 36.8421 8 no
GO:0009891 positive regulation of biosynthetic process 36.8421 5 no
GO:0009967 positive regulation of signal transduction 36.8421 5 no
GO:0031328 positive regulation of cellular biosynthetic process 36.8421 6 no
GO:2001141 regulation of RNA biosynthetic process 36.8421 6 no
GO:0051247 positive regulation of protein metabolic process 36.8421 6 no
GO:0009892 negative regulation of metabolic process 31.5789 4 no
GO:0010605 negative regulation of macromolecule metabolic process 31.5789 5 no
GO:0031399 regulation of protein modification process 31.5789 6 no
GO:0033043 regulation of organelle organization 31.5789 5 no
GO:0036211 protein modification process 31.5789 4 no
GO:0043412 macromolecule modification 31.5789 4 no
GO:0043933 protein-containing complex organization 31.5789 4 no
GO:0048585 negative regulation of response to stimulus 31.5789 4 no
GO:0051049 regulation of transport 31.5789 4 no
GO:0051050 positive regulation of transport 31.5789 4 no
GO:0008104 protein localization 31.5789 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 31.5789 6 no
GO:0010648 negative regulation of cell communication 31.5789 5 no
GO:0023057 negative regulation of signaling 31.5789 4 no
GO:0050804 modulation of chemical synaptic transmission 31.5789 5 no
GO:0099177 regulation of trans-synaptic signaling 31.5789 4 no
GO:0044087 regulation of cellular component biogenesis 26.3158 4 yes
GO:0009890 negative regulation of biosynthetic process 26.3158 5 no
GO:0010038 response to metal ion 26.3158 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 26.3158 6 no
GO:0022607 cellular component assembly 26.3158 4 no
GO:0031324 negative regulation of cellular metabolic process 26.3158 5 no
GO:0031327 negative regulation of cellular biosynthetic process 26.3158 6 no
GO:0045893 positive regulation of DNA-templated transcription 26.3158 8 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 26.3158 5 no
GO:0045944 positive regulation of transcription by RNA polymerase II 26.3158 9 no
GO:0051254 positive regulation of RNA metabolic process 26.3158 6 no
GO:0071702 organic substance transport 26.3158 4 no
GO:0071705 nitrogen compound transport 26.3158 4 no
GO:1902531 regulation of intracellular signal transduction 26.3158 5 no
GO:1902533 positive regulation of intracellular signal transduction 26.3158 6 no
GO:1902680 positive regulation of RNA biosynthetic process 26.3158 7 no
GO:0009968 negative regulation of signal transduction 26.3158 5 no
GO:0010243 response to organonitrogen compound 26.3158 4 no
GO:0019220 regulation of phosphate metabolic process 26.3158 6 no
GO:0031401 positive regulation of protein modification process 26.3158 7 no
GO:0051130 positive regulation of cellular component organization 26.3158 5 no
GO:0051174 regulation of phosphorus metabolic process 26.3158 5 no
GO:0006796 phosphate-containing compound metabolic process 26.3158 4 no
GO:0007005 mitochondrion organization 21.0526 5 no
GO:0009057 macromolecule catabolic process 21.0526 4 no
GO:0010506 regulation of autophagy 21.0526 6 no
GO:0010959 regulation of metal ion transport 21.0526 6 no
GO:0016070 RNA metabolic process 21.0526 5 no
GO:0030100 regulation of endocytosis 21.0526 5 no
GO:0031329 regulation of cellular catabolic process 21.0526 5 no
GO:0031344 regulation of cell projection organization 21.0526 5 no
GO:0034762 regulation of transmembrane transport 21.0526 4 no
GO:0034765 regulation of monoatomic ion transmembrane transport 21.0526 5 no
GO:0043066 negative regulation of apoptotic process 21.0526 6 no
GO:0043069 negative regulation of programmed cell death 21.0526 5 no
GO:0043269 regulation of monoatomic ion transport 21.0526 5 no
GO:0043687 post-translational protein modification 21.0526 5 no
GO:0051046 regulation of secretion 21.0526 5 no
GO:0051240 positive regulation of multicellular organismal process 21.0526 4 no
GO:0051248 negative regulation of protein metabolic process 21.0526 6 no
GO:0060627 regulation of vesicle-mediated transport 21.0526 4 no
GO:0062197 cellular response to chemical stress 21.0526 4 no
GO:0080134 regulation of response to stress 21.0526 4 no
GO:0090304 nucleic acid metabolic process 21.0526 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 21.0526 6 no
GO:1901362 organic cyclic compound biosynthetic process 21.0526 4 no
GO:0007010 cytoskeleton organization 21.0526 5 no
GO:0000122 negative regulation of transcription by RNA polymerase II 21.0526 9 no
GO:0001932 regulation of protein phosphorylation 21.0526 7 no
GO:0006508 proteolysis 21.0526 4 no
GO:0009896 positive regulation of catabolic process 21.0526 5 no
GO:0010639 negative regulation of organelle organization 21.0526 6 no
GO:0030162 regulation of proteolysis 21.0526 6 no
GO:0032880 regulation of protein localization 21.0526 5 no
GO:0042325 regulation of phosphorylation 21.0526 7 no
GO:0043393 regulation of protein binding 21.0526 4 no
GO:0043523 regulation of neuron apoptotic process 21.0526 6 no
GO:0043549 regulation of kinase activity 21.0526 5 no
GO:0045892 negative regulation of DNA-templated transcription 21.0526 8 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 21.0526 5 no
GO:0051093 negative regulation of developmental process 21.0526 4 no
GO:0051094 positive regulation of developmental process 21.0526 4 no
GO:0051253 negative regulation of RNA metabolic process 21.0526 6 no
GO:0051338 regulation of transferase activity 21.0526 4 no
GO:0060341 regulation of cellular localization 21.0526 4 no
GO:0071310 cellular response to organic substance 21.0526 4 no
GO:0071417 cellular response to organonitrogen compound 21.0526 4 no
GO:0098657 import into cell 21.0526 4 no
GO:1901699 cellular response to nitrogen compound 21.0526 4 no
GO:1901701 cellular response to oxygen-containing compound 21.0526 4 no
GO:1902679 negative regulation of RNA biosynthetic process 21.0526 7 no
GO:0033993 response to lipid 21.0526 4 no
GO:0090083 regulation of inclusion body assembly 10.5263 5 yes
GO:0090084 negative regulation of inclusion body assembly 10.5263 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SACS_HUMAN [view entry] [view interactions] Low throughput yes yes
PSA3_HUMAN [view interactions] Low throughput no no
UBE3A_HUMAN [view entry] [view interactions] Low throughput yes yes
SODC_HUMAN [view interactions] High throughput no yes
ROA0_HUMAN [view interactions] High throughput no yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
ALBU_HUMAN [view interactions] High throughput no no
PTBP3_HUMAN [view interactions] High throughput no no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
BICD1_HUMAN [view interactions] High throughput no yes
DYR1A_HUMAN [view interactions] High throughput no yes
T22D4_HUMAN [view entry] [view interactions] High throughput yes no
RPA12_HUMAN [view interactions] High throughput no yes
ADRB2_HUMAN [view entry] [view interactions] High throughput yes no
MYC_HUMAN [view interactions] High throughput no yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
DSCAM_HUMAN [view interactions] High throughput no yes
CCDC8_HUMAN [view interactions] High throughput no yes
ATOH1_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
FXL13_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
CC018_HUMAN [view interactions] High throughput no yes
TACD2_HUMAN [view interactions] High throughput no no
GPR17_HUMAN [view interactions] High throughput no no
EFNB1_HUMAN [view interactions] High throughput no yes
SPSB4_HUMAN [view interactions] High throughput no no
UBP3_HUMAN [view interactions] High throughput no no
FKBP5_HUMAN [view interactions] High throughput no yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
ATG5_HUMAN [view entry] [view interactions] High throughput yes no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
PARPT_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
MYO10_HUMAN [view interactions] High throughput no no
P53_HUMAN [view interactions] High throughput no no
ELOF1_HUMAN [view interactions] High throughput no yes
NWD2_HUMAN [view interactions] High throughput no no
P3H2_HUMAN [view interactions] High throughput no yes
P4HA2_HUMAN [view interactions] High throughput no no
DNJA2_HUMAN [view entry] [view interactions] High throughput yes yes
DNJC7_HUMAN [view interactions] High throughput no yes
DYR2_HUMAN [view interactions] High throughput no yes
PERI_HUMAN [view entry] [view interactions] High throughput yes no
VIME_HUMAN [view entry] [view interactions] High throughput yes no
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
STING_HUMAN [view interactions] High throughput no yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
ACTN4_HUMAN [view entry] [view interactions] High throughput yes yes
PICK1_HUMAN [view entry] [view interactions] High throughput yes yes
P63_HUMAN [view interactions] High throughput no no
PLK1_HUMAN [view interactions] High throughput no yes
NAA10_HUMAN [view interactions] High throughput no yes
TRI29_HUMAN [view interactions] High throughput no no
ENPP6_HUMAN [view entry] [view interactions] High throughput yes no
MOCS3_HUMAN [view interactions] High throughput no yes