QCR7_HUMAN
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. [View more on UniProt]
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No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in QCR7_HUMAN |
---|---|---|---|---|
GO:0015399 | primary active transmembrane transporter activity | 42.8571 | 4 | no |
GO:0015453 | oxidoreduction-driven active transmembrane transporter activity | 41.5584 | 5 | no |
GO:0046872 | metal ion binding | 29.8701 | 4 | no |
GO:0003954 | NADH dehydrogenase activity | 29.8701 | 4 | no |
GO:0003955 | NAD(P)H dehydrogenase (quinone) activity | 29.8701 | 5 | no |
GO:0008137 | NADH dehydrogenase (ubiquinone) activity | 29.8701 | 4 | no |
GO:0016655 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | 29.8701 | 4 | no |
GO:0050136 | NADH dehydrogenase (quinone) activity | 29.8701 | 5 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in QCR7_HUMAN |
---|---|---|---|---|
GO:0009060 | aerobic respiration | 45.4545 | 6 | yes |
GO:0015980 | energy derivation by oxidation of organic compounds | 45.4545 | 4 | yes |
GO:0022900 | electron transport chain | 45.4545 | 4 | yes |
GO:0022904 | respiratory electron transport chain | 45.4545 | 5 | yes |
GO:0045333 | cellular respiration | 45.4545 | 5 | yes |
GO:0019646 | aerobic electron transport chain | 42.8571 | 6 | yes |
GO:0022607 | cellular component assembly | 40.2597 | 4 | no |
GO:0043933 | protein-containing complex organization | 33.7662 | 4 | no |
GO:0065003 | protein-containing complex assembly | 32.4675 | 5 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 31.1688 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 31.1688 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 31.1688 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 29.8701 | 4 | no |
GO:0048522 | positive regulation of cellular process | 29.8701 | 4 | no |
GO:0048523 | negative regulation of cellular process | 28.5714 | 4 | no |
GO:0006120 | mitochondrial electron transport, NADH to ubiquinone | 27.2727 | 7 | no |
GO:0009893 | positive regulation of metabolic process | 25.9740 | 4 | no |
GO:0033108 | mitochondrial respiratory chain complex assembly | 24.6753 | 6 | no |
GO:0009966 | regulation of signal transduction | 23.3766 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 23.3766 | 5 | no |
GO:0010646 | regulation of cell communication | 23.3766 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 23.3766 | 5 | no |
GO:0010257 | NADH dehydrogenase complex assembly | 23.3766 | 6 | no |
GO:0032981 | mitochondrial respiratory chain complex I assembly | 23.3766 | 7 | no |
GO:0031399 | regulation of protein modification process | 20.7792 | 6 | no |
GO:1902531 | regulation of intracellular signal transduction | 20.7792 | 5 | no |
GO:0010941 | regulation of cell death | 20.7792 | 4 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 20.7792 | 5 | no |
GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c | 7.7922 | 7 | yes |
GO:0006119 | oxidative phosphorylation | 6.4935 | 7 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in QCR7_HUMAN |
---|---|---|---|---|
DOID:0050700 | cardiomyopathy | 2.5974 | 4 | no |
DOID:0060036 | intrinsic cardiomyopathy | 2.5974 | 5 | no |
DOID:114 | heart disease | 2.5974 | 3 | no |
DOID:2843 | long QT syndrome | 2.5974 | 6 | no |
DOID:331 | central nervous system disease | 2.5974 | 3 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
QCR8_HUMAN | [view interactions] | Low throughput | no | yes |
CY1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
QCR9_HUMAN | [view interactions] | Low throughput | no | no |
UCRI_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
QCR10_HUMAN | [view interactions] | Low throughput | no | no |
QCR7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
QCR6_HUMAN | [view interactions] | Low throughput | no | yes |
QCR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
QCR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CYB_HUMAN | [view interactions] | Low throughput | no | yes |
COX7R_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CX6B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NMES1_HUMAN | [view interactions] | High throughput | no | no |
NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PTPM1_HUMAN | [view interactions] | High throughput | no | yes |
CISD3_HUMAN | [view interactions] | High throughput | no | yes |
CHC10_HUMAN | [view interactions] | High throughput | no | yes |
OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
MP2K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RINI_HUMAN | [view interactions] | High throughput | no | yes |
SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
1A1L1_HUMAN | [view interactions] | High throughput | no | yes |
ACAP1_HUMAN | [view interactions] | High throughput | no | yes |
MAGB4_HUMAN | [view interactions] | High throughput | no | no |
ZSWM7_HUMAN | [view interactions] | High throughput | no | no |
HPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BECN1_HUMAN | [view interactions] | High throughput | no | yes |
LAP4A_HUMAN | [view interactions] | High throughput | no | yes |
LAR4B_HUMAN | [view interactions] | High throughput | no | yes |
CENPR_HUMAN | [view interactions] | High throughput | no | yes |
PSF3_HUMAN | [view interactions] | High throughput | no | yes |
THAP3_HUMAN | [view interactions] | High throughput | no | yes |
MAGA1_HUMAN | [view interactions] | High throughput | no | no |
LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PARL_HUMAN | [view interactions] | High throughput | no | yes |
CEP76_HUMAN | [view interactions] | High throughput | no | yes |
MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RABL6_HUMAN | [view interactions] | High throughput | no | yes |
MIC27_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZO1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CYTSA_HUMAN | [view interactions] | High throughput | no | yes |
CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GBB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AP2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
TIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FZR1_HUMAN | [view interactions] | High throughput | no | no |
SMAD4_HUMAN | [view interactions] | High throughput | no | yes |
SYLM_HUMAN | [view interactions] | High throughput | no | yes |
NAT8B_HUMAN | [view interactions] | High throughput | no | no |
COX7C_HUMAN | [view interactions] | High throughput | no | yes |
CX6A1_HUMAN | [view interactions] | High throughput | no | yes |
PGES2_HUMAN | [view interactions] | High throughput | no | yes |
COX42_HUMAN | [view interactions] | High throughput | no | no |
HDHD2_HUMAN | [view interactions] | High throughput | no | yes |
COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CX7B2_HUMAN | [view interactions] | High throughput | no | no |
BORC6_HUMAN | [view interactions] | High throughput | no | yes |
ASSY_HUMAN | [view interactions] | High throughput | no | yes |
CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ESTD_HUMAN | [view interactions] | High throughput | no | yes |
FKBP5_HUMAN | [view interactions] | High throughput | no | yes |
HEAT3_HUMAN | [view interactions] | High throughput | no | yes |
SERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSB10_HUMAN | [view interactions] | High throughput | no | no |
ATP68_HUMAN | [view interactions] | High throughput | no | yes |
NDUA8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUA9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUB1_HUMAN | [view interactions] | High throughput | no | yes |
NDUB2_HUMAN | [view interactions] | High throughput | no | yes |
NDUB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DMAC1_HUMAN | [view interactions] | High throughput | no | no |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RIT1_HUMAN | [view interactions] | High throughput | no | yes |
AT5F1_HUMAN | [view interactions] | High throughput | no | yes |
NDUS4_HUMAN | [view interactions] | High throughput | no | yes |
NDUBB_HUMAN | [view interactions] | High throughput | no | yes |
SDHA_HUMAN | [view interactions] | High throughput | no | yes |
NDUB8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COX5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RS10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RL9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RL23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RL11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TIM10_HUMAN | [view interactions] | High throughput | no | yes |
RL14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RS2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
THIL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AL1B1_HUMAN | [view interactions] | High throughput | no | yes |
ML12A_HUMAN | [view interactions] | High throughput | no | no |
RS16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RL6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PM34_HUMAN | [view interactions] | High throughput | no | yes |
OST48_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUAC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AT1B3_HUMAN | [view interactions] | High throughput | no | yes |
NDUAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SDHB_HUMAN | [view interactions] | High throughput | no | yes |
VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SCMC1_HUMAN | [view interactions] | High throughput | no | no |
ODPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATPA_HUMAN | [view interactions] | High throughput | no | yes |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATP5H_HUMAN | [view interactions] | High throughput | no | yes |
IFI44_HUMAN | [view interactions] | High throughput | no | yes |
GRM2B_HUMAN | [view interactions] | High throughput | no | yes |
TMM70_HUMAN | [view interactions] | High throughput | no | yes |
CLPP_HUMAN | [view interactions] | High throughput | no | yes |
SYAM_HUMAN | [view interactions] | High throughput | no | yes |
CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACE2_HUMAN | [view interactions] | High throughput | no | no |
NDUAB_HUMAN | [view interactions] | High throughput | no | no |
MAGA4_HUMAN | [view interactions] | High throughput | no | no |
UHRF1_HUMAN | [view interactions] | High throughput | no | yes |
ACTBL_HUMAN | [view interactions] | High throughput | no | no |
S10AA_HUMAN | [view interactions] | High throughput | no | no |
ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
COX1_HUMAN | [view interactions] | High throughput | no | yes |
COX5B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NDUA5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MCAT_HUMAN | [view interactions] | Computational | no | yes |
NDUV2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NDUB6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NDUB3_HUMAN | [view interactions] | Computational | no | yes |
ATP5E_HUMAN | [view interactions] | Computational | no | no |
NDUBA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NDUV3_HUMAN | [view interactions] | Computational | no | yes |
COX3_HUMAN | [view interactions] | Computational | no | yes |
ATPD_HUMAN | [view interactions] | Computational | no | yes |
NDUC2_HUMAN | [view interactions] | Computational | no | yes |
ATPK_HUMAN | [view interactions] | Computational | no | yes |
NDUA1_HUMAN | [view interactions] | Computational | no | yes |
ATPG_HUMAN | [view interactions] | Computational | no | yes |
NU5M_HUMAN | [view interactions] | Computational | no | no |
NDUAD_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NDUB5_HUMAN | [view interactions] | Computational | no | yes |
ATP5J_HUMAN | [view interactions] | Computational | no | yes |
NDUB7_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NU3M_HUMAN | [view interactions] | Computational | no | yes |
NDUS6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NDUA7_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NDUC1_HUMAN | [view interactions] | Computational | no | yes |
NDUB9_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CYC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NDUA2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NU1M_HUMAN | [view interactions] | Computational | no | yes |
ACPM_HUMAN | [view interactions] | Computational | no | yes |
COA6_HUMAN | [view interactions] | Computational | no | yes |
NU6M_HUMAN | [view interactions] | Computational | no | no |
NDUS5_HUMAN | [view interactions] | Computational | no | yes |
NDUS7_HUMAN | [view entry] [view interactions] | Computational | yes | no |
CX6A2_HUMAN | [view interactions] | Computational | no | no |
COX10_HUMAN | [view interactions] | Computational | no | yes |
NDUS2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ATP5L_HUMAN | [view interactions] | Computational | no | yes |
NU4M_HUMAN | [view interactions] | Computational | no | yes |
RM35_HUMAN | [view interactions] | Computational | no | no |
ATPO_HUMAN | [view interactions] | Computational | no | yes |
NU2M_HUMAN | [view entry] [view interactions] | Computational | yes | no |
UQCC1_HUMAN | [view interactions] | Computational | no | yes |
QCR6L_HUMAN | [view interactions] | Computational | no | yes |
ATP5I_HUMAN | [view interactions] | Computational | no | yes |
COX2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NDUS8_HUMAN | [view interactions] | Computational | no | yes |
NU4LM_HUMAN | [view interactions] | Computational | no | no |
MIC26_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NDUA3_HUMAN | [view interactions] | Computational | no | yes |
COX6C_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
BCS1_HUMAN | [view interactions] | Computational | no | yes |
CX6B2_HUMAN | [view interactions] | Computational | no | no |
ATPMK_HUMAN | [view interactions] | Computational | no | no |
NDUA6_HUMAN | [view interactions] | Computational | no | no |