Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PLEK_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Major protein kinase C substrate of platelets. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PLEK_HUMAN
GO:0003779 actin binding 55.5556 4 no
GO:0043169 cation binding 44.4444 4 no
GO:0046872 metal ion binding 44.4444 5 no
GO:0019900 kinase binding 33.3333 4 yes
GO:0019901 protein kinase binding 33.3333 5 yes
GO:0042803 protein homodimerization activity 33.3333 4 yes
GO:0005509 calcium ion binding 33.3333 6 no
GO:0051020 GTPase binding 33.3333 4 no
GO:0003723 RNA binding 33.3333 4 no
GO:0043168 anion binding 22.2222 4 yes
GO:0045296 cadherin binding 22.2222 4 no
GO:0016755 aminoacyltransferase activity 22.2222 4 no
GO:0003725 double-stranded RNA binding 22.2222 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in PLEK_HUMAN
GO:0048522 positive regulation of cellular process 66.6667 4 yes
GO:0009893 positive regulation of metabolic process 55.5556 4 yes
GO:0031323 regulation of cellular metabolic process 55.5556 4 yes
GO:0031325 positive regulation of cellular metabolic process 55.5556 5 yes
GO:0033043 regulation of organelle organization 44.4444 5 yes
GO:0043254 regulation of protein-containing complex assembly 44.4444 5 yes
GO:0044087 regulation of cellular component biogenesis 44.4444 4 yes
GO:0051128 regulation of cellular component organization 44.4444 4 yes
GO:0080090 regulation of primary metabolic process 44.4444 4 yes
GO:0002064 epithelial cell development 44.4444 4 no
GO:0006996 organelle organization 44.4444 4 yes
GO:0009889 regulation of biosynthetic process 44.4444 4 yes
GO:0031326 regulation of cellular biosynthetic process 44.4444 5 yes
GO:0044089 positive regulation of cellular component biogenesis 33.3333 5 yes
GO:0048523 negative regulation of cellular process 33.3333 4 yes
GO:0051130 positive regulation of cellular component organization 33.3333 5 yes
GO:1902531 regulation of intracellular signal transduction 33.3333 5 yes
GO:0007015 actin filament organization 33.3333 5 no
GO:0010468 regulation of gene expression 33.3333 6 no
GO:0010556 regulation of macromolecule biosynthetic process 33.3333 5 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0051246 regulation of protein metabolic process 33.3333 5 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0060255 regulation of macromolecule metabolic process 33.3333 4 no
GO:0097435 supramolecular fiber organization 33.3333 4 no
GO:0009894 regulation of catabolic process 33.3333 4 no
GO:0009896 positive regulation of catabolic process 33.3333 5 no
GO:0022607 cellular component assembly 33.3333 4 no
GO:0032386 regulation of intracellular transport 33.3333 5 no
GO:0032880 regulation of protein localization 33.3333 5 no
GO:0051049 regulation of transport 33.3333 4 no
GO:0060341 regulation of cellular localization 33.3333 4 no
GO:1902115 regulation of organelle assembly 33.3333 5 no
GO:0007010 cytoskeleton organization 33.3333 5 yes
GO:0008104 protein localization 33.3333 4 yes
GO:0008361 regulation of cell size 33.3333 5 yes
GO:0009966 regulation of signal transduction 33.3333 4 yes
GO:0010638 positive regulation of organelle organization 33.3333 6 yes
GO:0010646 regulation of cell communication 33.3333 4 yes
GO:0031334 positive regulation of protein-containing complex assembly 33.3333 6 yes
GO:0032535 regulation of cellular component size 33.3333 4 yes
GO:0032956 regulation of actin cytoskeleton organization 22.2222 5 yes
GO:0032970 regulation of actin filament-based process 22.2222 4 yes
GO:0035303 regulation of dephosphorylation 22.2222 7 yes
GO:0043085 positive regulation of catalytic activity 22.2222 4 yes
GO:0043244 regulation of protein-containing complex disassembly 22.2222 5 yes
GO:0045936 negative regulation of phosphate metabolic process 22.2222 7 yes
GO:0045937 positive regulation of phosphate metabolic process 22.2222 7 yes
GO:0051174 regulation of phosphorus metabolic process 22.2222 5 yes
GO:0051336 regulation of hydrolase activity 22.2222 4 yes
GO:0051493 regulation of cytoskeleton organization 22.2222 6 yes
GO:0071702 organic substance transport 22.2222 4 yes
GO:0071705 nitrogen compound transport 22.2222 4 yes
GO:0110053 regulation of actin filament organization 22.2222 6 yes
GO:1901879 regulation of protein depolymerization 22.2222 6 yes
GO:1902903 regulation of supramolecular fiber organization 22.2222 5 yes
GO:0007346 regulation of mitotic cell cycle 22.2222 5 no
GO:0036119 response to platelet-derived growth factor 22.2222 4 no
GO:0036120 cellular response to platelet-derived growth factor stimulus 22.2222 5 no
GO:0051726 regulation of cell cycle 22.2222 4 no
GO:0071363 cellular response to growth factor stimulus 22.2222 4 no
GO:0036211 protein modification process 22.2222 4 no
GO:0043412 macromolecule modification 22.2222 4 no
GO:0043687 post-translational protein modification 22.2222 5 no
GO:0001885 endothelial cell development 22.2222 5 no
GO:0009891 positive regulation of biosynthetic process 22.2222 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 22.2222 6 no
GO:0010628 positive regulation of gene expression 22.2222 7 no
GO:0010737 protein kinase A signaling 22.2222 4 no
GO:0022603 regulation of anatomical structure morphogenesis 22.2222 4 no
GO:0022604 regulation of cell morphogenesis 22.2222 5 no
GO:0030334 regulation of cell migration 22.2222 5 no
GO:0031328 positive regulation of cellular biosynthetic process 22.2222 6 no
GO:0032388 positive regulation of intracellular transport 22.2222 5 no
GO:0042176 regulation of protein catabolic process 22.2222 5 no
GO:0045732 positive regulation of protein catabolic process 22.2222 6 no
GO:0051050 positive regulation of transport 22.2222 4 no
GO:0060627 regulation of vesicle-mediated transport 22.2222 4 no
GO:0061028 establishment of endothelial barrier 22.2222 6 no
GO:0071310 cellular response to organic substance 22.2222 4 no
GO:1902965 regulation of protein localization to early endosome 22.2222 7 no
GO:1902966 positive regulation of protein localization to early endosome 22.2222 7 no
GO:1903829 positive regulation of protein localization 22.2222 5 no
GO:1905666 regulation of protein localization to endosome 22.2222 6 no
GO:1905668 positive regulation of protein localization to endosome 22.2222 6 no
GO:2000145 regulation of cell motility 22.2222 4 no
GO:2000641 regulation of early endosome to late endosome transport 22.2222 5 no
GO:2000643 positive regulation of early endosome to late endosome transport 22.2222 6 no
GO:0051017 actin filament bundle assembly 22.2222 5 no
GO:0051639 actin filament network formation 22.2222 6 no
GO:0061572 actin filament bundle organization 22.2222 6 no
GO:0042110 T cell activation 22.2222 4 no
GO:0071801 regulation of podosome assembly 22.2222 6 no
GO:0071803 positive regulation of podosome assembly 22.2222 7 no
GO:1902117 positive regulation of organelle assembly 22.2222 6 no
GO:0006796 phosphate-containing compound metabolic process 22.2222 4 yes
GO:0008064 regulation of actin polymerization or depolymerization 22.2222 6 yes
GO:0009892 negative regulation of metabolic process 22.2222 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 22.2222 6 yes
GO:0010563 negative regulation of phosphorus metabolic process 22.2222 6 yes
GO:0015031 protein transport 22.2222 4 yes
GO:0019220 regulation of phosphate metabolic process 22.2222 6 yes
GO:0030832 regulation of actin filament length 22.2222 5 yes
GO:0030834 regulation of actin filament depolymerization 22.2222 7 yes
GO:0030865 cortical cytoskeleton organization 22.2222 6 yes
GO:0030866 cortical actin cytoskeleton organization 22.2222 4 yes
GO:0031324 negative regulation of cellular metabolic process 22.2222 5 yes
GO:0032231 regulation of actin filament bundle assembly 22.2222 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
I5P1_HUMAN [view interactions] Low throughput no yes
ACTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
PLF4_HUMAN [view interactions] Low throughput no no
TSP1_HUMAN [view interactions] Low throughput no no
CAVN2_HUMAN [view interactions] Low throughput no no
RADI_HUMAN [view entry] [view interactions] Low throughput yes yes
DHB4_HUMAN [view entry] [view interactions] Low throughput yes yes
MOES_HUMAN [view entry] [view interactions] Low throughput yes no
WDR75_HUMAN [view interactions] High throughput no no
F13A_HUMAN [view interactions] High throughput no no
TGFR1_HUMAN [view interactions] High throughput no no
ACVR1_HUMAN [view interactions] High throughput no yes
LNX1_HUMAN [view entry] [view interactions] High throughput yes yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
SARAF_HUMAN [view interactions] High throughput no no
ARHG1_HUMAN [view interactions] High throughput no no
RHOU_HUMAN [view interactions] High throughput no no
IQGA1_HUMAN [view entry] [view interactions] High throughput yes no
PLSL_HUMAN [view entry] [view interactions] High throughput yes no
NHLC2_HUMAN [view interactions] High throughput no yes
STING_HUMAN [view interactions] High throughput no yes