Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PLEK_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Major protein kinase C substrate of platelets. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PLEK_HUMAN
GO:0019900 kinase binding 45.0000 4 yes
GO:0019901 protein kinase binding 45.0000 5 yes
GO:0003779 actin binding 45.0000 4 no
GO:0045296 cadherin binding 35.0000 4 no
GO:0017076 purine nucleotide binding 30.0000 4 no
GO:0032555 purine ribonucleotide binding 30.0000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 30.0000 4 no
GO:0042803 protein homodimerization activity 25.0000 4 yes
GO:0005080 protein kinase C binding 15.0000 6 yes
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 10.0000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PLEK_HUMAN
GO:0048522 positive regulation of cellular process 65.0000 4 yes
GO:0051128 regulation of cellular component organization 65.0000 4 yes
GO:0006996 organelle organization 65.0000 4 yes
GO:0033043 regulation of organelle organization 60.0000 5 yes
GO:0048523 negative regulation of cellular process 55.0000 4 yes
GO:0044087 regulation of cellular component biogenesis 50.0000 4 yes
GO:0080090 regulation of primary metabolic process 50.0000 4 yes
GO:0022607 cellular component assembly 50.0000 4 no
GO:0007010 cytoskeleton organization 50.0000 5 yes
GO:0009893 positive regulation of metabolic process 50.0000 4 yes
GO:0010646 regulation of cell communication 45.0000 4 yes
GO:0031323 regulation of cellular metabolic process 45.0000 4 yes
GO:0051130 positive regulation of cellular component organization 45.0000 5 yes
GO:1902531 regulation of intracellular signal transduction 45.0000 5 yes
GO:0051171 regulation of nitrogen compound metabolic process 45.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 45.0000 4 no
GO:0009966 regulation of signal transduction 45.0000 4 yes
GO:0010638 positive regulation of organelle organization 40.0000 6 yes
GO:0031325 positive regulation of cellular metabolic process 40.0000 5 yes
GO:0032956 regulation of actin cytoskeleton organization 40.0000 5 yes
GO:0032970 regulation of actin filament-based process 40.0000 4 yes
GO:0043254 regulation of protein-containing complex assembly 40.0000 5 yes
GO:0051493 regulation of cytoskeleton organization 40.0000 6 yes
GO:0010468 regulation of gene expression 40.0000 5 no
GO:0010604 positive regulation of macromolecule metabolic process 40.0000 5 no
GO:0030334 regulation of cell migration 40.0000 5 no
GO:0032880 regulation of protein localization 40.0000 5 no
GO:0051049 regulation of transport 40.0000 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 40.0000 5 no
GO:0051246 regulation of protein metabolic process 40.0000 5 no
GO:0060341 regulation of cellular localization 40.0000 4 no
GO:0071310 cellular response to organic substance 40.0000 4 no
GO:2000145 regulation of cell motility 40.0000 4 no
GO:0034330 cell junction organization 40.0000 4 no
GO:0010562 positive regulation of phosphorus metabolic process 35.0000 6 yes
GO:0019220 regulation of phosphate metabolic process 35.0000 6 yes
GO:0031324 negative regulation of cellular metabolic process 35.0000 5 yes
GO:0043085 positive regulation of catalytic activity 35.0000 4 yes
GO:0044089 positive regulation of cellular component biogenesis 35.0000 5 yes
GO:0045937 positive regulation of phosphate metabolic process 35.0000 7 yes
GO:0051174 regulation of phosphorus metabolic process 35.0000 5 yes
GO:0051336 regulation of hydrolase activity 35.0000 4 yes
GO:0110053 regulation of actin filament organization 35.0000 6 yes
GO:1902903 regulation of supramolecular fiber organization 35.0000 5 yes
GO:0010941 regulation of cell death 35.0000 4 no
GO:0042981 regulation of apoptotic process 35.0000 6 no
GO:0043067 regulation of programmed cell death 35.0000 5 no
GO:0030155 regulation of cell adhesion 35.0000 4 no
GO:0031344 regulation of cell projection organization 35.0000 5 no
GO:0045595 regulation of cell differentiation 35.0000 4 no
GO:0051247 positive regulation of protein metabolic process 35.0000 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 35.0000 6 no
GO:0022603 regulation of anatomical structure morphogenesis 35.0000 4 no
GO:0022604 regulation of cell morphogenesis 35.0000 5 no
GO:0007015 actin filament organization 35.0000 5 no
GO:0034329 cell junction assembly 35.0000 5 no
GO:0045216 cell-cell junction organization 35.0000 5 no
GO:0097435 supramolecular fiber organization 35.0000 4 no
GO:0006796 phosphate-containing compound metabolic process 35.0000 4 yes
GO:0008104 protein localization 35.0000 4 yes
GO:0009892 negative regulation of metabolic process 35.0000 4 yes
GO:0030030 cell projection organization 30.0000 4 yes
GO:0031326 regulation of cellular biosynthetic process 30.0000 5 yes
GO:0031334 positive regulation of protein-containing complex assembly 30.0000 6 yes
GO:0032231 regulation of actin filament bundle assembly 30.0000 5 yes
GO:0032535 regulation of cellular component size 30.0000 4 yes
GO:0009894 regulation of catabolic process 30.0000 4 no
GO:0010628 positive regulation of gene expression 30.0000 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 30.0000 5 no
GO:0033674 positive regulation of kinase activity 30.0000 6 no
GO:0036211 protein modification process 30.0000 4 no
GO:0042325 regulation of phosphorylation 30.0000 7 no
GO:0042327 positive regulation of phosphorylation 30.0000 8 no
GO:0043412 macromolecule modification 30.0000 4 no
GO:0043549 regulation of kinase activity 30.0000 5 no
GO:0051050 positive regulation of transport 30.0000 4 no
GO:0051094 positive regulation of developmental process 30.0000 4 no
GO:0051129 negative regulation of cellular component organization 30.0000 5 no
GO:0051338 regulation of transferase activity 30.0000 4 no
GO:0051347 positive regulation of transferase activity 30.0000 5 no
GO:0051726 regulation of cell cycle 30.0000 4 no
GO:1903829 positive regulation of protein localization 30.0000 5 no
GO:0032386 regulation of intracellular transport 30.0000 5 no
GO:0048584 positive regulation of response to stimulus 30.0000 4 no
GO:0009889 regulation of biosynthetic process 30.0000 4 yes
GO:0010648 negative regulation of cell communication 25.0000 5 yes
GO:0023057 negative regulation of signaling 25.0000 4 yes
GO:0030832 regulation of actin filament length 25.0000 5 yes
GO:0030865 cortical cytoskeleton organization 25.0000 6 yes
GO:0048585 negative regulation of response to stimulus 25.0000 4 yes
GO:0051495 positive regulation of cytoskeleton organization 25.0000 7 yes
GO:0120036 plasma membrane bounded cell projection organization 25.0000 5 yes
GO:1902532 negative regulation of intracellular signal transduction 25.0000 6 yes
GO:1902905 positive regulation of supramolecular fiber organization 25.0000 6 yes
GO:0043066 negative regulation of apoptotic process 25.0000 7 no
GO:0043069 negative regulation of programmed cell death 25.0000 6 no
GO:0060548 negative regulation of cell death 25.0000 5 no
GO:0001932 regulation of protein phosphorylation 25.0000 7 no
GO:0001934 positive regulation of protein phosphorylation 25.0000 8 no
GO:0006355 regulation of DNA-templated transcription 25.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 no
GO:0030335 positive regulation of cell migration 25.0000 6 no
GO:0030855 epithelial cell differentiation 25.0000 4 no
GO:0031399 regulation of protein modification process 25.0000 6 no
GO:0031401 positive regulation of protein modification process 25.0000 7 no
GO:0040017 positive regulation of locomotion 25.0000 4 no
GO:0045597 positive regulation of cell differentiation 25.0000 5 no
GO:0045785 positive regulation of cell adhesion 25.0000 5 no
GO:0045787 positive regulation of cell cycle 25.0000 5 no
GO:0045859 regulation of protein kinase activity 25.0000 6 no
GO:0045860 positive regulation of protein kinase activity 25.0000 7 no
GO:0051252 regulation of RNA metabolic process 25.0000 5 no
GO:0060284 regulation of cell development 25.0000 5 no
GO:0080134 regulation of response to stress 25.0000 4 no
GO:1901701 cellular response to oxygen-containing compound 25.0000 4 no
GO:1903506 regulation of nucleic acid-templated transcription 25.0000 7 no
GO:2000147 positive regulation of cell motility 25.0000 5 no
GO:2001141 regulation of RNA biosynthetic process 25.0000 6 no
GO:0002064 epithelial cell development 25.0000 4 no
GO:1902115 regulation of organelle assembly 25.0000 5 no
GO:0009967 positive regulation of signal transduction 25.0000 5 no
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0010810 regulation of cell-substrate adhesion 25.0000 5 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:1902533 positive regulation of intracellular signal transduction 25.0000 6 no
GO:0008064 regulation of actin polymerization or depolymerization 25.0000 6 yes
GO:0008361 regulation of cell size 25.0000 5 yes
GO:0009968 negative regulation of signal transduction 25.0000 5 yes
GO:0016192 vesicle-mediated transport 20.0000 4 yes
GO:0032233 positive regulation of actin filament bundle assembly 20.0000 6 yes
GO:0034109 homotypic cell-cell adhesion 20.0000 4 yes
GO:0035303 regulation of dephosphorylation 20.0000 7 yes
GO:0050865 regulation of cell activation 20.0000 4 yes
GO:0050867 positive regulation of cell activation 20.0000 5 yes
GO:0051345 positive regulation of hydrolase activity 20.0000 5 yes
GO:0070527 platelet aggregation 20.0000 5 yes
GO:0007229 integrin-mediated signaling pathway 20.0000 4 yes
GO:0009890 negative regulation of biosynthetic process 20.0000 5 yes
GO:0010563 negative regulation of phosphorus metabolic process 15.0000 6 yes
GO:0010675 regulation of cellular carbohydrate metabolic process 15.0000 5 yes
GO:0015031 protein transport 15.0000 4 yes
GO:0030834 regulation of actin filament depolymerization 15.0000 7 yes
GO:0030866 cortical actin cytoskeleton organization 15.0000 4 yes
GO:0031327 negative regulation of cellular biosynthetic process 15.0000 6 yes
GO:0031532 actin cytoskeleton reorganization 15.0000 4 yes
GO:0035306 positive regulation of dephosphorylation 15.0000 8 yes
GO:0043244 regulation of protein-containing complex disassembly 15.0000 5 yes
GO:0045936 negative regulation of phosphate metabolic process 15.0000 7 yes
GO:0062012 regulation of small molecule metabolic process 15.0000 4 yes
GO:0071702 organic substance transport 15.0000 4 yes
GO:0071705 nitrogen compound transport 15.0000 4 yes
GO:1901879 regulation of protein depolymerization 15.0000 6 yes
GO:0006109 regulation of carbohydrate metabolic process 15.0000 5 yes
GO:0010921 regulation of phosphatase activity 10.0000 5 yes
GO:0010922 positive regulation of phosphatase activity 10.0000 6 yes
GO:0030836 positive regulation of actin filament depolymerization 10.0000 7 yes
GO:0031529 ruffle organization 10.0000 6 yes
GO:0033623 regulation of integrin activation 10.0000 6 yes
GO:0033625 positive regulation of integrin activation 10.0000 7 yes
GO:0043243 positive regulation of protein-containing complex disassembly 10.0000 6 yes
GO:0043255 regulation of carbohydrate biosynthetic process 10.0000 5 yes
GO:0050848 regulation of calcium-mediated signaling 10.0000 6 yes
GO:0050849 negative regulation of calcium-mediated signaling 10.0000 7 yes
GO:0062014 negative regulation of small molecule metabolic process 10.0000 5 yes
GO:1901881 positive regulation of protein depolymerization 10.0000 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
I5P1_HUMAN [view interactions] Low throughput no yes
PLF4_HUMAN [view interactions] Low throughput no no
ACTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
CAVN2_HUMAN [view interactions] Low throughput no no
TSP1_HUMAN [view interactions] Low throughput no no
MOES_HUMAN [view entry] [view interactions] Low throughput yes no
DHB4_HUMAN [view entry] [view interactions] Low throughput yes yes
RADI_HUMAN [view entry] [view interactions] Low throughput yes yes
WDR75_HUMAN [view interactions] High throughput no no
F13A_HUMAN [view interactions] High throughput no no
TGFR1_HUMAN [view interactions] High throughput no no
ACVR1_HUMAN [view interactions] High throughput no yes
LNX1_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
SARAF_HUMAN [view interactions] High throughput no no
ARHG1_HUMAN [view interactions] High throughput no no
RHOU_HUMAN [view interactions] High throughput no no
IQGA1_HUMAN [view entry] [view interactions] High throughput yes no
PLSL_HUMAN [view entry] [view interactions] High throughput yes no
NHLC2_HUMAN [view interactions] High throughput no yes
MTOR_HUMAN [view entry] [view interactions] Computational yes yes
ANXA5_HUMAN [view entry] [view interactions] Computational yes no
FLNA_HUMAN [view entry] [view interactions] Computational yes no
TLN1_HUMAN [view entry] [view interactions] Computational yes no
LCP2_HUMAN [view interactions] Computational no yes
TBA4A_HUMAN [view entry] [view interactions] Computational yes yes
SODC_HUMAN [view interactions] Computational no yes
RHOA_HUMAN [view entry] [view interactions] Computational yes yes
SRC_HUMAN [view entry] [view interactions] Computational yes no
CDC42_HUMAN [view entry] [view interactions] Computational yes yes
STXB2_HUMAN [view interactions] Computational no no
BRPF3_HUMAN [view interactions] Computational no yes
AKT1_HUMAN [view entry] [view interactions] Computational yes yes
BTK_HUMAN [view interactions] Computational no no
VINC_HUMAN [view entry] [view interactions] Computational yes no
ENDD1_HUMAN [view interactions] Computational no yes
WDR1_HUMAN [view entry] [view interactions] Computational yes yes
MANF_HUMAN [view interactions] Computational no yes
MCF2_HUMAN [view interactions] Computational no no
SUCB2_HUMAN [view interactions] Computational no no
TAGL2_HUMAN [view entry] [view interactions] Computational yes no
ITB2_HUMAN [view interactions] Computational no no
HABP4_HUMAN [view interactions] Computational no yes