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LPAR1_HUMAN

GO
G2C
SynaptomeDB

Receptor for lysophosphatidic acid (LPA) (PubMed, PubMed, PubMed, PubMed). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed). Signaling triggers an increase of cytoplasmic Ca(2+) levels (PubMed, PubMed, PubMed). Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate (PubMed). Signaling mediates activation of down-stream MAP kinases . Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed). Promotes the activation of Rho and the formation of actin stress fibers (PubMed). Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 . Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed, PubMed, PubMed). Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain . [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in LPAR1_HUMAN
GO:0043168 anion binding 20.5882 4 yes
GO:0043169 cation binding 20.5882 4 no
GO:0004930 G protein-coupled receptor activity 17.6471 4 yes
GO:0030165 PDZ domain binding 5.8824 4 yes
GO:0045125 bioactive lipid receptor activity 5.8824 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in LPAR1_HUMAN
GO:0048522 positive regulation of cellular process 52.9412 4 yes
GO:0010646 regulation of cell communication 47.0588 4 yes
GO:0051049 regulation of transport 38.2353 4 yes
GO:0009966 regulation of signal transduction 38.2353 4 yes
GO:0060341 regulation of cellular localization 35.2941 4 no
GO:0071702 organic substance transport 35.2941 4 no
GO:0022607 cellular component assembly 35.2941 4 yes
GO:0008104 protein localization 32.3529 4 no
GO:0071705 nitrogen compound transport 32.3529 4 no
GO:0060255 regulation of macromolecule metabolic process 32.3529 4 no
GO:0032880 regulation of protein localization 29.4118 5 no
GO:0009893 positive regulation of metabolic process 29.4118 4 no
GO:0048584 positive regulation of response to stimulus 26.4706 4 yes
GO:0006996 organelle organization 26.4706 4 no
GO:0010604 positive regulation of macromolecule metabolic process 26.4706 5 no
GO:0080090 regulation of primary metabolic process 26.4706 4 no
GO:0009889 regulation of biosynthetic process 26.4706 4 no
GO:0031323 regulation of cellular metabolic process 26.4706 4 no
GO:0010647 positive regulation of cell communication 26.4706 5 yes
GO:0023056 positive regulation of signaling 26.4706 4 yes
GO:0060627 regulation of vesicle-mediated transport 23.5294 4 yes
GO:1902531 regulation of intracellular signal transduction 23.5294 5 yes
GO:0015031 protein transport 23.5294 4 no
GO:0050804 modulation of chemical synaptic transmission 23.5294 5 no
GO:0051050 positive regulation of transport 23.5294 4 no
GO:0099177 regulation of trans-synaptic signaling 23.5294 4 no
GO:0010468 regulation of gene expression 23.5294 6 no
GO:0010556 regulation of macromolecule biosynthetic process 23.5294 5 no
GO:0031325 positive regulation of cellular metabolic process 23.5294 5 no
GO:0031326 regulation of cellular biosynthetic process 23.5294 5 no
GO:0048523 negative regulation of cellular process 20.5882 4 yes
GO:0051094 positive regulation of developmental process 20.5882 4 yes
GO:0071310 cellular response to organic substance 20.5882 4 yes
GO:0034762 regulation of transmembrane transport 20.5882 4 no
GO:0006811 monoatomic ion transport 20.5882 4 no
GO:0051246 regulation of protein metabolic process 20.5882 5 no
GO:0009891 positive regulation of biosynthetic process 20.5882 5 no
GO:0051128 regulation of cellular component organization 17.6471 4 yes
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 17.6471 4 yes
GO:0009967 positive regulation of signal transduction 17.6471 5 yes
GO:0030030 cell projection organization 17.6471 4 yes
GO:0032101 regulation of response to external stimulus 17.6471 4 yes
GO:0043067 regulation of programmed cell death 17.6471 4 yes
GO:0051130 positive regulation of cellular component organization 14.7059 5 yes
GO:1901701 cellular response to oxygen-containing compound 14.7059 4 yes
GO:1902533 positive regulation of intracellular signal transduction 14.7059 6 yes
GO:2000145 regulation of cell motility 14.7059 4 yes
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 14.7059 5 yes
GO:0030100 regulation of endocytosis 14.7059 5 yes
GO:0030334 regulation of cell migration 14.7059 5 yes
GO:0042981 regulation of apoptotic process 14.7059 5 yes
GO:0043085 positive regulation of catalytic activity 11.7647 4 yes
GO:0048585 negative regulation of response to stimulus 11.7647 4 yes
GO:0120031 plasma membrane bounded cell projection assembly 11.7647 6 yes
GO:0120036 plasma membrane bounded cell projection organization 11.7647 5 yes
GO:0009968 negative regulation of signal transduction 11.7647 5 yes
GO:0010648 negative regulation of cell communication 11.7647 5 yes
GO:0023057 negative regulation of signaling 11.7647 4 yes
GO:0030031 cell projection assembly 11.7647 5 yes
GO:0032103 positive regulation of response to external stimulus 11.7647 5 yes
GO:0043122 regulation of canonical NF-kappaB signal transduction 8.8235 6 yes
GO:0043123 positive regulation of canonical NF-kappaB signal transduction 8.8235 7 yes
GO:0043408 regulation of MAPK cascade 8.8235 6 yes
GO:0048259 regulation of receptor-mediated endocytosis 8.8235 6 yes
GO:0071396 cellular response to lipid 8.8235 5 yes
GO:1902532 negative regulation of intracellular signal transduction 8.8235 6 yes
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 8.8235 5 yes
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 8.8235 4 yes
GO:0022603 regulation of anatomical structure morphogenesis 8.8235 4 yes
GO:0033993 response to lipid 8.8235 4 yes
GO:0043410 positive regulation of MAPK cascade 5.8824 7 yes
GO:0043949 regulation of cAMP-mediated signaling 5.8824 6 yes
GO:0050920 regulation of chemotaxis 5.8824 4 yes
GO:0050921 positive regulation of chemotaxis 5.8824 5 yes
GO:0051056 regulation of small GTPase mediated signal transduction 5.8824 6 yes
GO:0051057 positive regulation of small GTPase mediated signal transduction 5.8824 7 yes
GO:0051129 negative regulation of cellular component organization 5.8824 5 yes
GO:0051493 regulation of cytoskeleton organization 5.8824 6 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 5.8824 6 yes
GO:2000147 positive regulation of cell motility 5.8824 5 yes
GO:0002090 regulation of receptor internalization 5.8824 7 yes
GO:0010975 regulation of neuron projection development 5.8824 7 yes
GO:0021545 cranial nerve development 5.8824 4 yes
GO:0021554 optic nerve development 5.8824 5 yes
GO:0021782 glial cell development 5.8824 4 yes
GO:0022604 regulation of cell morphogenesis 5.8824 5 yes
GO:0030335 positive regulation of cell migration 5.8824 6 yes
GO:0031344 regulation of cell projection organization 5.8824 5 yes
GO:0032970 regulation of actin filament-based process 5.8824 4 yes
GO:0033043 regulation of organelle organization 5.8824 5 yes
GO:0040017 positive regulation of locomotion 5.8824 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CAR10_HUMAN [view interactions] Low throughput no yes
ARHGB_HUMAN [view interactions] Low throughput no yes
ENPP2_HUMAN [view interactions] Low throughput no yes
ITB4_HUMAN [view entry] [view interactions] Low throughput yes yes
NED4L_HUMAN [view entry] [view interactions] Low throughput yes yes
UBP11_HUMAN [view interactions] Low throughput no yes
CD14_HUMAN [view interactions] Low throughput no no
GIPC1_HUMAN [view entry] [view interactions] Low throughput yes yes
DP13A_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAI1_HUMAN [view entry] [view interactions] Low throughput yes yes
GBB1_HUMAN [view entry] [view interactions] Low throughput yes yes
ARHGC_HUMAN [view interactions] Low throughput no yes
OCAD1_HUMAN [view interactions] High throughput no yes
ELOV2_HUMAN [view interactions] High throughput no no
GPC5B_HUMAN [view entry] [view interactions] High throughput yes no
S39AA_HUMAN [view interactions] High throughput no no
STX8_HUMAN [view interactions] High throughput no yes
MAN1_HUMAN [view interactions] High throughput no yes
CIA30_HUMAN [view interactions] High throughput no yes
ENPP4_HUMAN [view interactions] High throughput no yes
MFSD5_HUMAN [view interactions] High throughput no yes
IPPK_HUMAN [view interactions] High throughput no yes
C3AR_HUMAN [view interactions] High throughput no no
GPR21_HUMAN [view interactions] High throughput no no
LYPD3_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
DRD2_HUMAN [view entry] [view interactions] High throughput yes no
SRSF6_HUMAN [view interactions] High throughput no yes
HNRPK_HUMAN [view entry] [view interactions] High throughput yes yes
MBOA7_HUMAN [view interactions] High throughput no no
PIGO_HUMAN [view interactions] High throughput no no
GOGB1_HUMAN [view entry] [view interactions] High throughput yes yes
GPC5C_HUMAN [view interactions] High throughput no no
KTN1_HUMAN [view entry] [view interactions] High throughput yes yes
GPAA1_HUMAN [view interactions] High throughput no yes
CXG1_HUMAN [view interactions] High throughput no no
MRP4_HUMAN [view interactions] High throughput no no
S35B2_HUMAN [view interactions] High throughput no no
SPP2B_HUMAN [view interactions] High throughput no yes
ZDH17_HUMAN [view entry] [view interactions] High throughput yes yes
REEP5_HUMAN [view entry] [view interactions] High throughput yes yes
STX5_HUMAN [view interactions] High throughput no yes
ZNT5_HUMAN [view interactions] High throughput no yes
HMDH_HUMAN [view interactions] High throughput no yes
TM87B_HUMAN [view interactions] High throughput no yes
PIGU_HUMAN [view interactions] High throughput no no
PGAP4_HUMAN [view interactions] High throughput no no
ZMYM3_HUMAN [view interactions] High throughput no yes
S39A1_HUMAN [view interactions] High throughput no no
EXTL2_HUMAN [view interactions] High throughput no yes
NOP9_HUMAN [view interactions] High throughput no no
GPHRA_HUMAN [view interactions] High throughput no no
ALG6_HUMAN [view interactions] High throughput no no
SEC62_HUMAN [view interactions] High throughput no yes
SC5D_HUMAN [view interactions] High throughput no yes
NU1M_HUMAN [view interactions] High throughput no yes
CD47_HUMAN [view interactions] High throughput no no
ZDHC9_HUMAN [view interactions] High throughput no yes
UQCC1_HUMAN [view interactions] High throughput no yes
LNP_HUMAN [view interactions] High throughput no yes
RTN2_HUMAN [view interactions] High throughput no no
B4GT3_HUMAN [view interactions] High throughput no yes
TMPPE_HUMAN [view interactions] High throughput no yes
NDC1_HUMAN [view interactions] High throughput no yes
ZNT7_HUMAN [view interactions] High throughput no no
AGRE5_HUMAN [view interactions] High throughput no no
ENTP7_HUMAN [view interactions] High throughput no no
CERS5_HUMAN [view interactions] High throughput no yes
LMBR1_HUMAN [view interactions] High throughput no yes
ARV1_HUMAN [view interactions] High throughput no yes
VAMP2_HUMAN [view entry] [view interactions] High throughput yes no
CKLF6_HUMAN [view interactions] High throughput no yes
PRAF2_HUMAN [view entry] [view interactions] High throughput yes yes
CREL1_HUMAN [view interactions] High throughput no yes
LRC8A_HUMAN [view entry] [view interactions] High throughput yes no
ALG3_HUMAN [view interactions] High throughput no yes
GP1BB_HUMAN [view interactions] High throughput no no
TPC1_HUMAN [view interactions] High throughput no yes
AGRL3_HUMAN [view entry] [view interactions] High throughput yes yes
AT2B4_HUMAN [view entry] [view interactions] High throughput yes yes
T161B_HUMAN [view interactions] High throughput no no
MFS12_HUMAN [view interactions] High throughput no yes
CKLF4_HUMAN [view interactions] High throughput no yes
CXCR4_HUMAN [view interactions] High throughput no no
S35F2_HUMAN [view interactions] High throughput no yes
MITOS_HUMAN [view entry] [view interactions] High throughput yes yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
G137A_HUMAN [view interactions] High throughput no no
TTYH3_HUMAN [view interactions] High throughput no yes
ADCY6_HUMAN [view interactions] High throughput no yes
ZDH13_HUMAN [view interactions] High throughput no no
VMA21_HUMAN [view interactions] High throughput no no
EMC6_HUMAN [view interactions] High throughput no yes
PIGW_HUMAN [view interactions] High throughput no no
SEC20_HUMAN [view interactions] High throughput no yes
TSN15_HUMAN [view interactions] High throughput no yes
CTLA4_HUMAN [view interactions] High throughput no no
TNF18_HUMAN [view interactions] High throughput no no
PCD19_HUMAN [view interactions] High throughput no yes
TTYH1_HUMAN [view entry] [view interactions] High throughput yes no
GAMT_HUMAN [view interactions] High throughput no no
STX4_HUMAN [view entry] [view interactions] High throughput yes no
SNX14_HUMAN [view entry] [view interactions] High throughput yes yes
AT2A1_HUMAN [view entry] [view interactions] High throughput yes no
SNX13_HUMAN [view interactions] High throughput no no
SYPH_HUMAN [view entry] [view interactions] High throughput yes yes
DERL2_HUMAN [view interactions] High throughput no yes
TR10C_HUMAN [view interactions] High throughput no no
UFO_HUMAN [view interactions] High throughput no no
AGRE2_HUMAN [view interactions] High throughput no no
LRC8E_HUMAN [view interactions] High throughput no no
STR3N_HUMAN [view interactions] High throughput no yes
ERMP1_HUMAN [view interactions] High throughput no no
TR10B_HUMAN [view interactions] High throughput no no
ERGI3_HUMAN [view interactions] High throughput no yes
GPAT4_HUMAN [view interactions] High throughput no yes
TPSN_HUMAN [view interactions] High throughput no yes
AGRG6_HUMAN [view interactions] High throughput no no
EMC5_HUMAN [view interactions] High throughput no yes
SPTC2_HUMAN [view interactions] High throughput no no
GPI8_HUMAN [view entry] [view interactions] High throughput yes no
DHC24_HUMAN [view interactions] High throughput no yes
PTSS2_HUMAN [view interactions] High throughput no yes
MSMO1_HUMAN [view interactions] High throughput no yes
T126A_HUMAN [view entry] [view interactions] High throughput yes yes
FA8A1_HUMAN [view interactions] High throughput no yes
ALG11_HUMAN [view interactions] High throughput no yes
GOSR2_HUMAN [view interactions] High throughput no yes
SGMR1_HUMAN [view entry] [view interactions] High throughput yes yes
PLCD_HUMAN [view interactions] High throughput no yes
OXA1L_HUMAN [view interactions] High throughput no yes
TM9S1_HUMAN [view interactions] High throughput no yes
TM9S4_HUMAN [view interactions] High throughput no yes
TMEM9_HUMAN [view interactions] High throughput no no
YIPF6_HUMAN [view interactions] High throughput no yes
TM9S2_HUMAN [view interactions] High throughput no yes
KDSR_HUMAN [view interactions] High throughput no yes
ACAD9_HUMAN [view interactions] High throughput no yes
SCAM3_HUMAN [view interactions] High throughput no no
PIGT_HUMAN [view interactions] High throughput no no
K2013_HUMAN [view interactions] High throughput no yes
T106B_HUMAN [view interactions] High throughput no yes
STOM_HUMAN [view entry] [view interactions] High throughput yes yes
EMC2_HUMAN [view interactions] High throughput no yes
AR6P6_HUMAN [view interactions] High throughput no yes
P4HTM_HUMAN [view interactions] High throughput no yes
PIGS_HUMAN [view interactions] High throughput no yes
TM9S3_HUMAN [view interactions] High throughput no yes
TM223_HUMAN [view interactions] High throughput no yes
T120B_HUMAN [view interactions] High throughput no yes
SCAM2_HUMAN [view interactions] High throughput no no
MIA2_HUMAN [view interactions] High throughput no yes
EMC8_HUMAN [view interactions] High throughput no no
NDUB5_HUMAN [view interactions] High throughput no yes
NDUB3_HUMAN [view interactions] High throughput no yes
EXTL3_HUMAN [view interactions] High throughput no yes
TSN3_HUMAN [view interactions] High throughput no yes
S19A2_HUMAN [view interactions] High throughput no yes
XYLK_HUMAN [view interactions] High throughput no yes
ATP9A_HUMAN [view interactions] High throughput no yes
PRAF3_HUMAN [view interactions] High throughput no yes
S1PR2_HUMAN [view entry] [view interactions] High throughput yes no
COX3_HUMAN [view interactions] High throughput no yes
CO1A1_HUMAN [view interactions] High throughput no yes
NU4M_HUMAN [view interactions] High throughput no yes
ATP8_HUMAN [view interactions] High throughput no no
PPAL_HUMAN [view interactions] High throughput no no
TMM11_HUMAN [view interactions] High throughput no no
LEG3_HUMAN [view interactions] High throughput no yes
SL9A1_HUMAN [view interactions] High throughput no no
AT5F1_HUMAN [view interactions] High throughput no yes
SELT_HUMAN [view interactions] High throughput no yes
TYRO3_HUMAN [view interactions] High throughput no yes
CKAP4_HUMAN [view entry] [view interactions] High throughput yes yes
SCAP_HUMAN [view interactions] High throughput no yes
MTR1L_HUMAN [view interactions] High throughput no no
ITPR2_HUMAN [view interactions] High throughput no yes
AG10A_HUMAN [view interactions] High throughput no yes
COL12_HUMAN [view interactions] High throughput no no
TM164_HUMAN [view interactions] High throughput no yes
MBOA5_HUMAN [view interactions] High throughput no no
HACD2_HUMAN [view interactions] High throughput no yes
CERS6_HUMAN [view interactions] High throughput no yes
RETR3_HUMAN [view interactions] High throughput no yes
CGAT2_HUMAN [view interactions] High throughput no yes
FITM2_HUMAN [view interactions] High throughput no no
F241A_HUMAN [view interactions] High throughput no yes
ARL10_HUMAN [view interactions] High throughput no yes
TM87A_HUMAN [view interactions] High throughput no yes
MFSD8_HUMAN [view interactions] High throughput no yes
GOGA5_HUMAN [view interactions] High throughput no yes
CTR3_HUMAN [view interactions] High throughput no no
BRI3B_HUMAN [view interactions] High throughput no yes
PEX13_HUMAN [view interactions] High throughput no yes
TM186_HUMAN [view interactions] High throughput no no
CHP3_HUMAN [view interactions] High throughput no yes
F241B_HUMAN [view interactions] High throughput no yes
CERS2_HUMAN [view interactions] High throughput no no
REEP6_HUMAN [view interactions] High throughput no no
RN170_HUMAN [view interactions] High throughput no yes
F210B_HUMAN [view interactions] High throughput no yes
ERGI2_HUMAN [view interactions] High throughput no yes
ECSIT_HUMAN [view interactions] High throughput no yes
XYLT2_HUMAN [view interactions] High throughput no no
SG196_HUMAN [view interactions] High throughput no yes
REEP4_HUMAN [view interactions] High throughput no no
RN121_HUMAN [view interactions] High throughput no yes
CERS4_HUMAN [view interactions] High throughput no yes
MRS2_HUMAN [view interactions] High throughput no no
SERC1_HUMAN [view interactions] High throughput no yes
SAC1_HUMAN [view entry] [view interactions] High throughput yes yes
ZDH18_HUMAN [view interactions] High throughput no yes
RMND1_HUMAN [view interactions] High throughput no yes