GPI8_HUMAN
Evidence for PS localization
Functions
Mediates GPI anchoring in the endoplasmic reticulum, by replacing a proteins C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GPI8_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 41.1765 | 4 | no |
| GO:0017076 | purine nucleotide binding | 29.4118 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 29.4118 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 29.4118 | 4 | no |
| GO:0003723 | RNA binding | 23.5294 | 4 | no |
| GO:0045296 | cadherin binding | 23.5294 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GPI8_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 70.5882 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 52.9412 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 47.0588 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 47.0588 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 47.0588 | 4 | no |
| GO:0009966 | regulation of signal transduction | 47.0588 | 4 | no |
| GO:0010646 | regulation of cell communication | 47.0588 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 35.2941 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 35.2941 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 35.2941 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 35.2941 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 35.2941 | 5 | no |
| GO:0008104 | protein localization | 35.2941 | 4 | yes |
| GO:0036211 | protein modification process | 35.2941 | 4 | yes |
| GO:0043412 | macromolecule modification | 35.2941 | 4 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 29.4118 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 29.4118 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 29.4118 | 4 | no |
| GO:0010468 | regulation of gene expression | 29.4118 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 29.4118 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 29.4118 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 29.4118 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 29.4118 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 29.4118 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 29.4118 | 5 | no |
| GO:0023056 | positive regulation of signaling | 29.4118 | 4 | no |
| GO:0061024 | membrane organization | 29.4118 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 29.4118 | 5 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 29.4118 | 6 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 29.4118 | 4 | no |
| GO:0006996 | organelle organization | 29.4118 | 4 | no |
| GO:0030335 | positive regulation of cell migration | 23.5294 | 6 | no |
| GO:0031344 | regulation of cell projection organization | 23.5294 | 5 | no |
| GO:0031399 | regulation of protein modification process | 23.5294 | 6 | no |
| GO:0034330 | cell junction organization | 23.5294 | 4 | no |
| GO:0040017 | positive regulation of locomotion | 23.5294 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 23.5294 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 23.5294 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 23.5294 | 4 | no |
| GO:0051049 | regulation of transport | 23.5294 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 23.5294 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 23.5294 | 6 | no |
| GO:2000026 | regulation of multicellular organismal development | 23.5294 | 4 | no |
| GO:2000145 | regulation of cell motility | 23.5294 | 4 | no |
| GO:2000147 | positive regulation of cell motility | 23.5294 | 5 | no |
| GO:0009057 | macromolecule catabolic process | 23.5294 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 23.5294 | 4 | no |
| GO:0030163 | protein catabolic process | 23.5294 | 4 | no |
| GO:0034976 | response to endoplasmic reticulum stress | 23.5294 | 4 | no |
| GO:1901565 | organonitrogen compound catabolic process | 23.5294 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 23.5294 | 6 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 23.5294 | 7 | no |
| GO:0009889 | regulation of biosynthetic process | 23.5294 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 23.5294 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 23.5294 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 23.5294 | 6 | no |
| GO:0010941 | regulation of cell death | 23.5294 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 23.5294 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 23.5294 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 23.5294 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 23.5294 | 6 | no |
| GO:0043066 | negative regulation of apoptotic process | 23.5294 | 7 | no |
| GO:0043067 | regulation of programmed cell death | 23.5294 | 5 | no |
| GO:0043069 | negative regulation of programmed cell death | 23.5294 | 6 | no |
| GO:0060548 | negative regulation of cell death | 23.5294 | 5 | no |
| GO:0071702 | organic substance transport | 23.5294 | 4 | no |
| GO:0071705 | nitrogen compound transport | 23.5294 | 4 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 23.5294 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 23.5294 | 6 | no |
| GO:0016192 | vesicle-mediated transport | 23.5294 | 4 | no |
| GO:1901566 | organonitrogen compound biosynthetic process | 23.5294 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 23.5294 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 23.5294 | 5 | no |
| GO:0010975 | regulation of neuron projection development | 23.5294 | 7 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 23.5294 | 4 | no |
| GO:0022607 | cellular component assembly | 23.5294 | 4 | no |
| GO:0023057 | negative regulation of signaling | 23.5294 | 4 | no |
| GO:0030334 | regulation of cell migration | 23.5294 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PIGS_HUMAN | [view interactions] | Low throughput | no | yes |
| PIGT_HUMAN | [view interactions] | Low throughput | no | no |
| GPAA1_HUMAN | [view interactions] | Low throughput | no | yes |
| PPB1_HUMAN | [view interactions] | Low throughput | no | no |
| PIGU_HUMAN | [view interactions] | Low throughput | no | no |
| CALX_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ULBP2_HUMAN | [view interactions] | Low throughput | no | no |
| HS2ST_HUMAN | [view interactions] | High throughput | no | yes |
| GPIX_HUMAN | [view interactions] | High throughput | no | no |
| VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSN15_HUMAN | [view interactions] | High throughput | no | yes |
| CLC2B_HUMAN | [view interactions] | High throughput | no | yes |
| LPAR1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SIA8E_HUMAN | [view interactions] | High throughput | no | yes |
| P2RX2_HUMAN | [view interactions] | High throughput | no | no |
| CPNE2_HUMAN | [view interactions] | High throughput | no | yes |
| PRG2_HUMAN | [view interactions] | High throughput | no | no |
| FBX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IDS_HUMAN | [view interactions] | High throughput | no | yes |
| NDKB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| B3GA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CST9L_HUMAN | [view interactions] | High throughput | no | no |
| T106A_HUMAN | [view interactions] | High throughput | no | no |
| KLK15_HUMAN | [view interactions] | High throughput | no | no |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| COPE_HUMAN | [view interactions] | High throughput | no | yes |
| PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMEDA_HUMAN | [view interactions] | High throughput | no | yes |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCD47_HUMAN | [view interactions] | High throughput | no | yes |
| ERD21_HUMAN | [view interactions] | High throughput | no | yes |
| PGAP3_HUMAN | [view interactions] | High throughput | no | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALR3_HUMAN | [view interactions] | High throughput | no | no |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDIA4_HUMAN | [view interactions] | High throughput | no | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNE3_HUMAN | [view interactions] | High throughput | no | no |
| T106B_HUMAN | [view interactions] | High throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| MOT11_HUMAN | [view interactions] | High throughput | no | no |
| BST2_HUMAN | [view interactions] | High throughput | no | yes |
| UN93B_HUMAN | [view interactions] | High throughput | no | yes |
| SG196_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| TECT3_HUMAN | [view interactions] | High throughput | no | yes |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| B3GN3_HUMAN | [view interactions] | High throughput | no | no |
| LYPD3_HUMAN | [view interactions] | High throughput | no | no |
| TSP50_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| S15A3_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| FA20C_HUMAN | [view interactions] | High throughput | no | no |
| THY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIGP_HUMAN | [view interactions] | Computational | no | yes |
| UPAR_HUMAN | [view interactions] | Computational | no | yes |
| PIGM_HUMAN | [view interactions] | Computational | no | no |
| PIGV_HUMAN | [view interactions] | Computational | no | no |
| PIGC_HUMAN | [view interactions] | Computational | no | no |
| PIGB_HUMAN | [view interactions] | Computational | no | yes |
| PIGO_HUMAN | [view interactions] | Computational | no | no |
| PGAP1_HUMAN | [view interactions] | Computational | no | no |
| PIGQ_HUMAN | [view interactions] | Computational | no | yes |
| PIGA_HUMAN | [view interactions] | Computational | no | yes |
| PIGL_HUMAN | [view interactions] | Computational | no | yes |