B3GA3_HUMAN
Evidence for PS localization
Functions
Glycosaminoglycans biosynthesis (PubMed). Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate. Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4-Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans. Can also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins. Shows strict specificity for Gal-beta-1,3-Gal-beta-1,4-Xyl, exhibiting negligible incorporation into other galactoside substrates including Galbeta1-3Gal beta1-O-benzyl, Galbeta1-4GlcNAc and Galbeta1-4Glc. Stimulates 2-phosphoxylose phosphatase activity of PXYLP1 in presence of uridine diphosphate-glucuronic acid (UDP-GlcUA) during completion of linkage region formation (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in B3GA3_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 20.0000 | 4 | yes |
| GO:0046872 | metal ion binding | 20.0000 | 5 | yes |
| GO:0008194 | UDP-glycosyltransferase activity | 10.0000 | 4 | yes |
| GO:0015018 | galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity | 10.0000 | 6 | yes |
| GO:0015020 | glucuronosyltransferase activity | 10.0000 | 5 | yes |
| GO:0016758 | hexosyltransferase activity | 10.0000 | 4 | yes |
| GO:0019211 | phosphatase activator activity | 10.0000 | 4 | yes |
| GO:0019888 | protein phosphatase regulator activity | 10.0000 | 4 | yes |
| GO:0072542 | protein phosphatase activator activity | 10.0000 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in B3GA3_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 45.0000 | 4 | no |
| GO:0051049 | regulation of transport | 40.0000 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 40.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 35.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 35.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 35.0000 | 4 | no |
| GO:0051050 | positive regulation of transport | 30.0000 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 30.0000 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 30.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 30.0000 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.0000 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 30.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 30.0000 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 30.0000 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 30.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 30.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 30.0000 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 30.0000 | 5 | no |
| GO:0051046 | regulation of secretion | 30.0000 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 30.0000 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 30.0000 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 30.0000 | 5 | no |
| GO:0036211 | protein modification process | 25.0000 | 4 | yes |
| GO:0043412 | macromolecule modification | 25.0000 | 4 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 25.0000 | 7 | no |
| GO:0009967 | positive regulation of signal transduction | 25.0000 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 25.0000 | 5 | no |
| GO:0051253 | negative regulation of RNA metabolic process | 25.0000 | 6 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 25.0000 | 6 | no |
| GO:0061024 | membrane organization | 25.0000 | 4 | no |
| GO:0071310 | cellular response to organic substance | 25.0000 | 4 | no |
| GO:1903530 | regulation of secretion by cell | 25.0000 | 4 | no |
| GO:0033043 | regulation of organelle organization | 25.0000 | 5 | no |
| GO:0008104 | protein localization | 25.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 25.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0009059 | macromolecule biosynthetic process | 20.0000 | 4 | yes |
| GO:0032880 | regulation of protein localization | 20.0000 | 5 | yes |
| GO:0043085 | positive regulation of catalytic activity | 20.0000 | 4 | yes |
| GO:0051223 | regulation of protein transport | 20.0000 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 20.0000 | 4 | yes |
| GO:0070201 | regulation of establishment of protein localization | 20.0000 | 6 | yes |
| GO:1903829 | positive regulation of protein localization | 20.0000 | 5 | yes |
| GO:0032386 | regulation of intracellular transport | 15.0000 | 5 | yes |
| GO:0032388 | positive regulation of intracellular transport | 15.0000 | 5 | yes |
| GO:0051222 | positive regulation of protein transport | 15.0000 | 5 | yes |
| GO:1904951 | positive regulation of establishment of protein localization | 15.0000 | 6 | yes |
| GO:0006022 | aminoglycan metabolic process | 10.0000 | 4 | yes |
| GO:0006023 | aminoglycan biosynthetic process | 10.0000 | 5 | yes |
| GO:0006024 | glycosaminoglycan biosynthetic process | 10.0000 | 6 | yes |
| GO:0006029 | proteoglycan metabolic process | 10.0000 | 5 | yes |
| GO:0006486 | protein glycosylation | 10.0000 | 4 | yes |
| GO:0009100 | glycoprotein metabolic process | 10.0000 | 4 | yes |
| GO:0009101 | glycoprotein biosynthetic process | 10.0000 | 5 | yes |
| GO:0015012 | heparan sulfate proteoglycan biosynthetic process | 10.0000 | 5 | yes |
| GO:0030166 | proteoglycan biosynthetic process | 10.0000 | 6 | yes |
| GO:0030203 | glycosaminoglycan metabolic process | 10.0000 | 5 | yes |
| GO:0033157 | regulation of intracellular protein transport | 10.0000 | 6 | yes |
| GO:0044272 | sulfur compound biosynthetic process | 10.0000 | 4 | yes |
| GO:0050650 | chondroitin sulfate proteoglycan biosynthetic process | 10.0000 | 7 | yes |
| GO:0050651 | dermatan sulfate proteoglycan biosynthetic process | 10.0000 | 7 | yes |
| GO:0050654 | chondroitin sulfate proteoglycan metabolic process | 10.0000 | 6 | yes |
| GO:0050655 | dermatan sulfate proteoglycan metabolic process | 10.0000 | 6 | yes |
| GO:0090316 | positive regulation of intracellular protein transport | 10.0000 | 6 | yes |
| GO:1901137 | carbohydrate derivative biosynthetic process | 10.0000 | 4 | yes |
| GO:1901566 | organonitrogen compound biosynthetic process | 10.0000 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| B3GA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SG196_HUMAN | [view interactions] | Low throughput | no | yes |
| CLC2D_HUMAN | [view interactions] | High throughput | no | yes |
| XYLT2_HUMAN | [view interactions] | High throughput | no | no |
| P2RY8_HUMAN | [view interactions] | High throughput | no | no |
| GP108_HUMAN | [view interactions] | High throughput | no | yes |
| EXTL3_HUMAN | [view interactions] | High throughput | no | yes |
| RAMP3_HUMAN | [view interactions] | High throughput | no | no |
| ZNT7_HUMAN | [view interactions] | High throughput | no | no |
| GPX8_HUMAN | [view interactions] | High throughput | no | no |
| LRAD1_HUMAN | [view interactions] | High throughput | no | no |
| PSPC_HUMAN | [view interactions] | High throughput | no | no |
| TM160_HUMAN | [view interactions] | High throughput | no | no |
| T106A_HUMAN | [view interactions] | High throughput | no | no |
| SAAL1_HUMAN | [view interactions] | High throughput | no | yes |
| MGAT1_HUMAN | [view interactions] | High throughput | no | yes |
| TMM79_HUMAN | [view interactions] | High throughput | no | no |
| K2013_HUMAN | [view interactions] | High throughput | no | yes |
| KCNKG_HUMAN | [view interactions] | High throughput | no | no |
| ZDH12_HUMAN | [view interactions] | High throughput | no | yes |
| CND3_HUMAN | [view interactions] | High throughput | no | yes |
| TSN15_HUMAN | [view interactions] | High throughput | no | yes |
| RN185_HUMAN | [view interactions] | High throughput | no | no |
| NRG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DYM_HUMAN | [view interactions] | High throughput | no | yes |
| SGCA_HUMAN | [view interactions] | High throughput | no | yes |
| SETX_HUMAN | [view interactions] | High throughput | no | yes |
| AGRE5_HUMAN | [view interactions] | High throughput | no | no |
| T106B_HUMAN | [view interactions] | High throughput | no | yes |
| HMOX1_HUMAN | [view interactions] | High throughput | no | no |
| ARMC6_HUMAN | [view interactions] | High throughput | no | yes |
| AA2BR_HUMAN | [view interactions] | High throughput | no | no |
| XPO4_HUMAN | [view interactions] | High throughput | no | no |
| SIA8C_HUMAN | [view interactions] | High throughput | no | yes |
| KLRG2_HUMAN | [view interactions] | High throughput | no | no |
| SNG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F174A_HUMAN | [view interactions] | High throughput | no | yes |
| S39A4_HUMAN | [view interactions] | High throughput | no | no |
| MBRL_HUMAN | [view interactions] | High throughput | no | yes |
| S1PR4_HUMAN | [view interactions] | High throughput | no | no |
| TMM59_HUMAN | [view interactions] | High throughput | no | yes |
| HYAL2_HUMAN | [view interactions] | High throughput | no | no |
| CHSTC_HUMAN | [view interactions] | High throughput | no | yes |
| GPI8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NMU_HUMAN | [view interactions] | High throughput | no | no |
| CD70_HUMAN | [view interactions] | High throughput | no | no |
| ATPG_HUMAN | [view interactions] | High throughput | no | yes |
| NK1R_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CIAO1_HUMAN | [view interactions] | High throughput | no | yes |
| AT133_HUMAN | [view interactions] | High throughput | no | yes |
| TMM95_HUMAN | [view interactions] | High throughput | no | no |
| TM171_HUMAN | [view interactions] | High throughput | no | yes |
| MITOS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| NDST3_HUMAN | [view interactions] | High throughput | no | yes |
| ZDH13_HUMAN | [view interactions] | High throughput | no | no |
| PIGG_HUMAN | [view interactions] | High throughput | no | yes |
| PDE2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLD4_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| S22A9_HUMAN | [view interactions] | High throughput | no | no |
| CGAT2_HUMAN | [view interactions] | High throughput | no | yes |
| GOLI4_HUMAN | [view interactions] | High throughput | no | yes |
| CKAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COL12_HUMAN | [view interactions] | High throughput | no | no |
| HEAT3_HUMAN | [view interactions] | High throughput | no | yes |
| DAAF5_HUMAN | [view interactions] | High throughput | no | no |
| NLGN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR13_HUMAN | [view interactions] | High throughput | no | yes |
| LYAG_HUMAN | [view interactions] | High throughput | no | yes |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| SC22B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CCR2_HUMAN | [view interactions] | High throughput | no | yes |
| CCR4_HUMAN | [view interactions] | High throughput | no | yes |
| GPR35_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| HNRPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RELCH_HUMAN | [view interactions] | High throughput | no | yes |
| JPH1_HUMAN | [view interactions] | High throughput | no | no |
| MAN1_HUMAN | [view interactions] | High throughput | no | yes |
| PBIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HMDH_HUMAN | [view interactions] | High throughput | no | yes |
| SEC62_HUMAN | [view interactions] | High throughput | no | yes |
| HAUS7_HUMAN | [view interactions] | High throughput | no | no |
| NOP9_HUMAN | [view interactions] | High throughput | no | no |
| PTPRO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NLGN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCNC4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| GFRA3_HUMAN | [view interactions] | High throughput | no | yes |
| COPT1_HUMAN | [view interactions] | High throughput | no | no |