KCNC4_HUMAN
Evidence for PS localization
Functions
This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KCNC4_HUMAN |
|---|---|---|---|---|
| GO:0022832 | voltage-gated channel activity | 30.7692 | 6 | yes |
| GO:0022836 | gated channel activity | 30.7692 | 5 | yes |
| GO:0022843 | voltage-gated cation channel activity | 30.7692 | 5 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 30.7692 | 4 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 30.7692 | 5 | yes |
| GO:0017076 | purine nucleotide binding | 30.7692 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 30.7692 | 5 | no |
| GO:0005216 | ion channel activity | 30.7692 | 4 | yes |
| GO:0005244 | voltage-gated ion channel activity | 30.7692 | 4 | yes |
| GO:0005249 | voltage-gated potassium channel activity | 30.7692 | 6 | yes |
| GO:0005261 | cation channel activity | 30.7692 | 5 | yes |
| GO:0005267 | potassium channel activity | 30.7692 | 6 | yes |
| GO:0008324 | cation transmembrane transporter activity | 30.7692 | 4 | yes |
| GO:0015079 | potassium ion transmembrane transporter activity | 30.7692 | 6 | yes |
| GO:0015267 | channel activity | 30.7692 | 4 | yes |
| GO:0046872 | metal ion binding | 23.0769 | 4 | no |
| GO:0005524 | ATP binding | 23.0769 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 23.0769 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 23.0769 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 23.0769 | 4 | no |
| GO:0031625 | ubiquitin protein ligase binding | 23.0769 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 23.0769 | 4 | no |
| GO:0005251 | delayed rectifier potassium channel activity | 23.0769 | 7 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KCNC4_HUMAN |
|---|---|---|---|---|
| GO:0051049 | regulation of transport | 61.5385 | 4 | yes |
| GO:0034762 | regulation of transmembrane transport | 46.1538 | 4 | yes |
| GO:0034765 | regulation of ion transmembrane transport | 46.1538 | 5 | yes |
| GO:0043269 | regulation of ion transport | 46.1538 | 5 | yes |
| GO:0031323 | regulation of cellular metabolic process | 46.1538 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 46.1538 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 46.1538 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 46.1538 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 46.1538 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 46.1538 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 46.1538 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 46.1538 | 4 | no |
| GO:0043933 | protein-containing complex organization | 30.7692 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 30.7692 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 30.7692 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 30.7692 | 5 | no |
| GO:0010959 | regulation of metal ion transport | 30.7692 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 30.7692 | 5 | no |
| GO:0031399 | regulation of protein modification process | 30.7692 | 6 | no |
| GO:0032880 | regulation of protein localization | 30.7692 | 5 | no |
| GO:0051050 | positive regulation of transport | 30.7692 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 30.7692 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 30.7692 | 5 | no |
| GO:0060341 | regulation of cellular localization | 30.7692 | 4 | no |
| GO:0071310 | cellular response to organic substance | 30.7692 | 4 | no |
| GO:1904062 | regulation of cation transmembrane transport | 30.7692 | 6 | no |
| GO:0051129 | negative regulation of cellular component organization | 30.7692 | 5 | no |
| GO:0006986 | response to unfolded protein | 30.7692 | 4 | no |
| GO:0051084 | de novo post-translational protein folding | 30.7692 | 4 | no |
| GO:0051085 | chaperone cofactor-dependent protein refolding | 30.7692 | 4 | no |
| GO:0006811 | ion transport | 23.0769 | 4 | yes |
| GO:0006812 | cation transport | 23.0769 | 5 | yes |
| GO:0006813 | potassium ion transport | 23.0769 | 7 | yes |
| GO:0022607 | cellular component assembly | 23.0769 | 4 | yes |
| GO:0030001 | metal ion transport | 23.0769 | 6 | yes |
| GO:0051259 | protein complex oligomerization | 23.0769 | 6 | yes |
| GO:0051260 | protein homooligomerization | 23.0769 | 7 | yes |
| GO:0065003 | protein-containing complex assembly | 23.0769 | 5 | yes |
| GO:0071805 | potassium ion transmembrane transport | 23.0769 | 6 | yes |
| GO:0098655 | cation transmembrane transport | 23.0769 | 4 | yes |
| GO:0098660 | inorganic ion transmembrane transport | 23.0769 | 4 | yes |
| GO:0098662 | inorganic cation transmembrane transport | 23.0769 | 5 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 23.0769 | 4 | no |
| GO:0009894 | regulation of catabolic process | 23.0769 | 4 | no |
| GO:0009966 | regulation of signal transduction | 23.0769 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 23.0769 | 4 | no |
| GO:0010646 | regulation of cell communication | 23.0769 | 4 | no |
| GO:0022898 | regulation of transmembrane transporter activity | 23.0769 | 4 | no |
| GO:0031396 | regulation of protein ubiquitination | 23.0769 | 8 | no |
| GO:0032412 | regulation of ion transmembrane transporter activity | 23.0769 | 5 | no |
| GO:0036211 | protein modification process | 23.0769 | 4 | no |
| GO:0043254 | regulation of protein-containing complex assembly | 23.0769 | 5 | no |
| GO:0043412 | macromolecule modification | 23.0769 | 4 | no |
| GO:0051223 | regulation of protein transport | 23.0769 | 5 | no |
| GO:0051726 | regulation of cell cycle | 23.0769 | 4 | no |
| GO:0070201 | regulation of establishment of protein localization | 23.0769 | 6 | no |
| GO:0080134 | regulation of response to stress | 23.0769 | 4 | no |
| GO:1903320 | regulation of protein modification by small protein conjugation or removal | 23.0769 | 7 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 23.0769 | 5 | no |
| GO:0090083 | regulation of inclusion body assembly | 23.0769 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 23.0769 | 5 | no |
| GO:0035967 | cellular response to topologically incorrect protein | 23.0769 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 23.0769 | 5 | no |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in KCNC4_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 15.3846 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| BACE1_HUMAN | [view interactions] | Low throughput | no | yes |
| KPCE_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| MKS3_HUMAN | [view interactions] | High throughput | no | no |
| KCNC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCNC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJB5_HUMAN | [view interactions] | High throughput | no | yes |
| S2551_HUMAN | [view interactions] | High throughput | no | no |
| PLD6_HUMAN | [view interactions] | High throughput | no | yes |
| NSMA_HUMAN | [view interactions] | High throughput | no | yes |
| DNJB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHBL4_HUMAN | [view interactions] | High throughput | no | no |
| RN215_HUMAN | [view interactions] | High throughput | no | yes |
| TYW1_HUMAN | [view interactions] | High throughput | no | yes |
| AMFR_HUMAN | [view interactions] | High throughput | no | yes |
| ABCBA_HUMAN | [view interactions] | High throughput | no | yes |
| DNJB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDZD8_HUMAN | [view interactions] | High throughput | no | yes |
| BAG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NGBR_HUMAN | [view interactions] | High throughput | no | no |
| HERC3_HUMAN | [view interactions] | High throughput | no | yes |
| PDE3B_HUMAN | [view interactions] | High throughput | no | no |
| LEMD2_HUMAN | [view interactions] | High throughput | no | yes |
| ESYT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GXLT2_HUMAN | [view interactions] | High throughput | no | no |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPL4_HUMAN | [view interactions] | High throughput | no | yes |
| BRAF_HUMAN | [view interactions] | High throughput | no | yes |
| B3GA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAT14_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| TBL2_HUMAN | [view interactions] | High throughput | no | no |
| HSP72_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBAC2_HUMAN | [view interactions] | High throughput | no | yes |
| KCAB2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KCAB1_HUMAN | [view interactions] | Computational | no | no |
| KCNH2_HUMAN | [view interactions] | Computational | no | no |
| KCNE3_HUMAN | [view interactions] | Computational | no | yes |
| KCAB3_HUMAN | [view interactions] | Computational | no | no |