Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

KCNC1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient (PubMed). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
320 Arg His Epilepsy,progressivemyoclonic7(EPM7) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in KCNC1_HUMAN
GO:0005216 ion channel activity 57.1429 4 yes
GO:0005244 voltage-gated ion channel activity 57.1429 4 yes
GO:0005261 cation channel activity 57.1429 5 yes
GO:0008324 cation transmembrane transporter activity 57.1429 4 yes
GO:0015267 channel activity 57.1429 4 yes
GO:0022832 voltage-gated channel activity 57.1429 6 yes
GO:0022836 gated channel activity 57.1429 5 yes
GO:0022843 voltage-gated cation channel activity 57.1429 5 yes
GO:0022890 inorganic cation transmembrane transporter activity 57.1429 4 yes
GO:0046873 metal ion transmembrane transporter activity 57.1429 5 yes
GO:0005249 voltage-gated potassium channel activity 50.0000 6 yes
GO:0005267 potassium channel activity 50.0000 6 yes
GO:0015079 potassium ion transmembrane transporter activity 50.0000 6 yes
GO:0005251 delayed rectifier potassium channel activity 42.8571 7 yes
GO:0019894 kinesin binding 21.4286 4 yes
GO:0099508 voltage-gated ion channel activity involved in regulation of presynaptic membrane potential 21.4286 5 yes
GO:0005524 ATP binding 21.4286 5 no
GO:0017076 purine nucleotide binding 21.4286 4 no
GO:0030554 adenyl nucleotide binding 21.4286 5 no
GO:0032555 purine ribonucleotide binding 21.4286 4 no
GO:0032559 adenyl ribonucleotide binding 21.4286 5 no
GO:0035639 purine ribonucleoside triphosphate binding 21.4286 4 no
GO:0045296 cadherin binding 21.4286 4 no
GO:0015459 potassium channel regulator activity 21.4286 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in KCNC1_HUMAN
GO:0043269 regulation of ion transport 85.7143 5 yes
GO:0051049 regulation of transport 85.7143 4 yes
GO:0034762 regulation of transmembrane transport 71.4286 4 yes
GO:0034765 regulation of ion transmembrane transport 71.4286 5 yes
GO:0010959 regulation of metal ion transport 64.2857 6 yes
GO:0043266 regulation of potassium ion transport 57.1429 7 yes
GO:0006811 ion transport 50.0000 4 yes
GO:0006812 cation transport 50.0000 5 yes
GO:0022607 cellular component assembly 50.0000 4 yes
GO:0030001 metal ion transport 50.0000 6 yes
GO:0043270 positive regulation of ion transport 50.0000 5 yes
GO:0048522 positive regulation of cellular process 50.0000 4 yes
GO:0051050 positive regulation of transport 50.0000 4 yes
GO:1901379 regulation of potassium ion transmembrane transport 50.0000 7 yes
GO:1904062 regulation of cation transmembrane transport 50.0000 6 yes
GO:0006813 potassium ion transport 42.8571 7 yes
GO:0043933 protein-containing complex organization 42.8571 4 yes
GO:0071805 potassium ion transmembrane transport 42.8571 6 yes
GO:0098655 cation transmembrane transport 42.8571 4 yes
GO:0098660 inorganic ion transmembrane transport 42.8571 4 yes
GO:0098662 inorganic cation transmembrane transport 42.8571 5 yes
GO:0010038 response to metal ion 35.7143 4 yes
GO:0022898 regulation of transmembrane transporter activity 35.7143 4 yes
GO:0032412 regulation of ion transmembrane transporter activity 35.7143 5 yes
GO:0043268 positive regulation of potassium ion transport 35.7143 6 yes
GO:0051259 protein complex oligomerization 35.7143 6 yes
GO:0051260 protein homooligomerization 35.7143 7 yes
GO:0065003 protein-containing complex assembly 35.7143 5 yes
GO:1901016 regulation of potassium ion transmembrane transporter activity 35.7143 6 yes
GO:2001257 regulation of cation channel activity 35.7143 6 yes
GO:0008104 protein localization 35.7143 4 no
GO:0032411 positive regulation of transporter activity 28.5714 4 yes
GO:0032414 positive regulation of ion transmembrane transporter activity 28.5714 5 yes
GO:0034764 positive regulation of transmembrane transport 28.5714 5 yes
GO:0034767 positive regulation of ion transmembrane transport 28.5714 6 yes
GO:1904064 positive regulation of cation transmembrane transport 28.5714 7 yes
GO:2001259 positive regulation of cation channel activity 28.5714 6 yes
GO:0010646 regulation of cell communication 28.5714 4 no
GO:0032880 regulation of protein localization 28.5714 5 no
GO:0060341 regulation of cellular localization 28.5714 4 no
GO:0009416 response to light stimulus 21.4286 4 yes
GO:0009642 response to light intensity 21.4286 5 yes
GO:0010243 response to organonitrogen compound 21.4286 4 yes
GO:0014075 response to amine 21.4286 5 yes
GO:0021759 globus pallidus development 21.4286 4 yes
GO:0051262 protein tetramerization 21.4286 7 yes
GO:0070848 response to growth factor 21.4286 4 yes
GO:1901018 positive regulation of potassium ion transmembrane transporter activity 21.4286 6 yes
GO:1901381 positive regulation of potassium ion transmembrane transport 21.4286 7 yes
GO:1903818 positive regulation of voltage-gated potassium channel activity 21.4286 7 yes
GO:0006996 organelle organization 21.4286 4 no
GO:0015031 protein transport 21.4286 4 no
GO:0030030 cell projection organization 21.4286 4 no
GO:0035418 protein localization to synapse 21.4286 6 no
GO:0071702 organic substance transport 21.4286 4 no
GO:0071705 nitrogen compound transport 21.4286 4 no
GO:1902414 protein localization to cell junction 21.4286 5 no
GO:1903829 positive regulation of protein localization 21.4286 5 no
GO:1905475 regulation of protein localization to membrane 21.4286 6 no
GO:1905477 positive regulation of protein localization to membrane 21.4286 6 no
GO:0072657 protein localization to membrane 21.4286 4 no
GO:0072659 protein localization to plasma membrane 21.4286 5 no
GO:1990778 protein localization to cell periphery 21.4286 5 no
GO:0007268 chemical synaptic transmission 21.4286 6 no
GO:0098916 anterograde trans-synaptic signaling 21.4286 5 no
GO:0099537 trans-synaptic signaling 21.4286 4 no
GO:0010468 regulation of gene expression 21.4286 5 no
GO:0060255 regulation of macromolecule metabolic process 21.4286 4 no
GO:0061024 membrane organization 21.4286 4 no
GO:0071241 cellular response to inorganic substance 21.4286 4 no
GO:0010996 response to auditory stimulus 14.2857 4 yes
GO:0035864 response to potassium ion 14.2857 5 yes
GO:0071466 cellular response to xenobiotic stimulus 14.2857 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in KCNC1_HUMAN
DOID:331 central nervous system disease 28.5714 3 yes
DOID:0050701 electroclinical syndrome 14.2857 6 yes
DOID:0050706 variable age at onset electroclinical syndrome 14.2857 7 yes
DOID:0111447 progressive myoclonus epilepsy 7 14.2857 9 yes
DOID:1826 epilepsy 14.2857 5 yes
DOID:891 progressive myoclonus epilepsy 14.2857 8 yes
DOID:936 brain disease 14.2857 4 yes

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KCNG3_HUMAN [view interactions] Low throughput no no
KCNH1_HUMAN [view entry] [view interactions] Low throughput yes yes
KCNV2_HUMAN [view interactions] Low throughput no no
KCNC2_HUMAN [view entry] [view interactions] Low throughput yes no
ANK3_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG1_HUMAN [view entry] [view interactions] Low throughput yes yes
KCC2A_HUMAN [view entry] [view interactions] Low throughput yes yes
KIF5A_HUMAN [view entry] [view interactions] Low throughput yes yes
KCNC1_HUMAN [view entry] [view interactions] Low throughput yes yes
KINH_HUMAN [view entry] [view interactions] Low throughput yes no
LPAR3_HUMAN [view interactions] High throughput no no
BI1_HUMAN [view interactions] High throughput no yes
TARG1_HUMAN [view interactions] High throughput no no
KCNC4_HUMAN [view entry] [view interactions] High throughput yes no
KCNC3_HUMAN [view entry] [view interactions] High throughput yes yes
NCS1_HUMAN [view entry] [view interactions] Computational yes yes
DPP6_HUMAN [view entry] [view interactions] Computational yes no
CSEN_HUMAN [view interactions] Computational no no
DPP10_HUMAN [view interactions] Computational no yes
KCIP1_HUMAN [view interactions] Computational no yes
CAV3_HUMAN [view interactions] Computational no no
KCAB3_HUMAN [view interactions] Computational no no
KCIP4_HUMAN [view interactions] Computational no no
KCIP2_HUMAN [view interactions] Computational no no
KCNH2_HUMAN [view interactions] Computational no no
KCNH3_HUMAN [view interactions] Computational no no
KCAB1_HUMAN [view interactions] Computational no no
KCAB2_HUMAN [view entry] [view interactions] Computational yes yes