Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

KCNC1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient (PubMed). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
320 Arg His Epilepsy,progressivemyoclonic7(EPM7) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in KCNC1_HUMAN
GO:0005216 monoatomic ion channel activity 54.5455 4 yes
GO:0005244 voltage-gated monoatomic ion channel activity 54.5455 5 yes
GO:0005249 voltage-gated potassium channel activity 54.5455 7 yes
GO:0005251 delayed rectifier potassium channel activity 54.5455 8 yes
GO:0005261 monoatomic cation channel activity 54.5455 5 yes
GO:0005267 potassium channel activity 54.5455 6 yes
GO:0008324 monoatomic cation transmembrane transporter activity 54.5455 4 yes
GO:0015079 potassium ion transmembrane transporter activity 54.5455 6 yes
GO:0015267 channel activity 54.5455 4 yes
GO:0022832 voltage-gated channel activity 54.5455 6 yes
GO:0022836 gated channel activity 54.5455 5 yes
GO:0022843 voltage-gated monoatomic cation channel activity 54.5455 6 yes
GO:0022890 inorganic cation transmembrane transporter activity 54.5455 4 yes
GO:0046873 metal ion transmembrane transporter activity 54.5455 5 yes
GO:0019894 kinesin binding 27.2727 4 yes
GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 27.2727 6 yes
GO:0045296 cadherin binding 27.2727 4 no
GO:0000166 nucleotide binding 27.2727 4 no
GO:0005524 ATP binding 27.2727 5 no
GO:0017076 purine nucleotide binding 27.2727 5 no
GO:0030554 adenyl nucleotide binding 27.2727 6 no
GO:0032555 purine ribonucleotide binding 27.2727 4 no
GO:0032559 adenyl ribonucleotide binding 27.2727 5 no
GO:0035639 purine ribonucleoside triphosphate binding 27.2727 4 no
GO:0043168 anion binding 27.2727 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in KCNC1_HUMAN
GO:0006811 monoatomic ion transport 63.6364 4 yes
GO:0006812 monoatomic cation transport 63.6364 5 yes
GO:0010959 regulation of metal ion transport 63.6364 6 yes
GO:0022607 cellular component assembly 63.6364 4 yes
GO:0030001 metal ion transport 63.6364 6 yes
GO:0043269 regulation of monoatomic ion transport 63.6364 5 yes
GO:0043270 positive regulation of monoatomic ion transport 63.6364 5 yes
GO:0043933 protein-containing complex organization 63.6364 4 yes
GO:0048522 positive regulation of cellular process 63.6364 4 yes
GO:0051049 regulation of transport 63.6364 4 yes
GO:0051050 positive regulation of transport 63.6364 4 yes
GO:0006813 potassium ion transport 54.5455 7 yes
GO:0043266 regulation of potassium ion transport 54.5455 7 yes
GO:0065003 protein-containing complex assembly 54.5455 5 yes
GO:0071805 potassium ion transmembrane transport 54.5455 5 yes
GO:0098655 monoatomic cation transmembrane transport 54.5455 4 yes
GO:0098662 inorganic cation transmembrane transport 54.5455 4 yes
GO:0010038 response to metal ion 45.4545 4 yes
GO:0034762 regulation of transmembrane transport 45.4545 4 yes
GO:0034765 regulation of monoatomic ion transmembrane transport 45.4545 5 yes
GO:0043268 positive regulation of potassium ion transport 45.4545 6 yes
GO:0051259 protein complex oligomerization 45.4545 6 yes
GO:0051260 protein homooligomerization 45.4545 7 yes
GO:1901379 regulation of potassium ion transmembrane transport 45.4545 7 yes
GO:1904062 regulation of monoatomic cation transmembrane transport 45.4545 6 yes
GO:0034764 positive regulation of transmembrane transport 36.3636 5 yes
GO:0034767 positive regulation of monoatomic ion transmembrane transport 36.3636 6 yes
GO:1904064 positive regulation of cation transmembrane transport 36.3636 7 yes
GO:0008104 protein localization 36.3636 4 no
GO:0010646 regulation of cell communication 36.3636 4 no
GO:0031323 regulation of cellular metabolic process 27.2727 4 no
GO:0031326 regulation of cellular biosynthetic process 27.2727 5 no
GO:0032880 regulation of protein localization 27.2727 5 no
GO:0035418 protein localization to synapse 27.2727 6 no
GO:0060255 regulation of macromolecule metabolic process 27.2727 4 no
GO:0060341 regulation of cellular localization 27.2727 4 no
GO:0061024 membrane organization 27.2727 4 no
GO:0098916 anterograde trans-synaptic signaling 27.2727 6 no
GO:0099536 synaptic signaling 27.2727 4 no
GO:0099537 trans-synaptic signaling 27.2727 5 no
GO:1902414 protein localization to cell junction 27.2727 5 no
GO:1903829 positive regulation of protein localization 27.2727 5 no
GO:1905475 regulation of protein localization to membrane 27.2727 6 no
GO:1905477 positive regulation of protein localization to membrane 27.2727 6 no
GO:0071241 cellular response to inorganic substance 27.2727 4 no
GO:0010647 positive regulation of cell communication 27.2727 5 no
GO:0015031 protein transport 27.2727 4 no
GO:0030030 cell projection organization 27.2727 4 no
GO:0071702 organic substance transport 27.2727 4 no
GO:0071705 nitrogen compound transport 27.2727 4 no
GO:0009416 response to light stimulus 27.2727 4 yes
GO:0009642 response to light intensity 27.2727 5 yes
GO:0010243 response to organonitrogen compound 27.2727 4 yes
GO:0014075 response to amine 27.2727 5 yes
GO:0021545 cranial nerve development 27.2727 4 yes
GO:0021554 optic nerve development 27.2727 5 yes
GO:0021759 globus pallidus development 27.2727 4 yes
GO:0051262 protein tetramerization 27.2727 7 yes
GO:1901381 positive regulation of potassium ion transmembrane transport 27.2727 7 yes
GO:1990089 response to nerve growth factor 27.2727 4 yes
GO:0006996 organelle organization 27.2727 4 no
GO:0007268 chemical synaptic transmission 27.2727 7 no
GO:0009889 regulation of biosynthetic process 27.2727 4 no
GO:0010468 regulation of gene expression 27.2727 6 no
GO:0010556 regulation of macromolecule biosynthetic process 27.2727 5 no
GO:0010996 response to auditory stimulus 18.1818 4 yes
GO:0035864 response to potassium ion 18.1818 5 yes
GO:0071466 cellular response to xenobiotic stimulus 18.1818 4 yes
GO:0071774 response to fibroblast growth factor 18.1818 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KCNG3_HUMAN [view interactions] Low throughput no no
KCNH1_HUMAN [view entry] [view interactions] Low throughput yes yes
KCNV2_HUMAN [view interactions] Low throughput no no
KCNC2_HUMAN [view entry] [view interactions] Low throughput yes no
ANK3_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG1_HUMAN [view entry] [view interactions] Low throughput yes yes
KCC2A_HUMAN [view entry] [view interactions] Low throughput yes yes
KIF5A_HUMAN [view entry] [view interactions] Low throughput yes yes
KCNC1_HUMAN [view entry] [view interactions] Low throughput yes yes
KINH_HUMAN [view entry] [view interactions] Low throughput yes no
LPAR3_HUMAN [view interactions] High throughput no no
BI1_HUMAN [view interactions] High throughput no yes
TARG1_HUMAN [view interactions] High throughput no no
KCNC4_HUMAN [view entry] [view interactions] High throughput yes no
KCNC3_HUMAN [view entry] [view interactions] High throughput yes yes
SPPL3_HUMAN [view interactions] High throughput no no