Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

KCNC3_HUMAN

Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. The channel displays rapid activation and inactivation kinetics (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). It plays a role in the regulation of the frequency, shape and duration of action potentials in Purkinje cells. Required for normal survival of cerebellar neurons, probably via its role in regulating the duration and frequency of action potentials that in turn regulate the activity of voltage-gated Ca(2+) channels and cellular Ca(2+) homeostasis . Required for normal motor function (PubMed, PubMed, PubMed, PubMed, PubMed). Plays a role in the reorganization of the cortical actin cytoskeleton and the formation of actin veil structures in neuronal growth cones via its interaction with HAX1 and the Arp2/3 complex (PubMed). [View more on UniProt]

0100200300400500600700
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 82%

Interacting region for partners were not defined.

KCNC3_HUMAN has binary interactions with 7 proteins

KCNC3_HUMANS12A2_HUMANKCNC1_HUMANKCNC4_HUMANPTPRF_HUMANFGFR1_HUMANPTPRD_HUMANFYN_HUMANKCNC3_HUMANS12A2_HUMANKCNC1_HUMANKCNC4_HUMANPTPRF_HUMANFGFR1_HUMANPTPRD_HUMANFYN_HUMAN
Download full PS network for entry.
0100200300400500600700
Interacting regions
Canonical [KCNC3_HUMAN]
Isoform [E7ETH1] alignment
Isoform [A0A590UJ62] alignment
Isoform [E9PQY4] alignment
LOADING 89%
Position Amino acid Mutation Disease Overlap with binding region
420 Arg His Spinocerebellarataxia13(SCA13) -
448 Phe Leu Spinocerebellarataxia13(SCA13) -
423 Arg His Spinocerebellarataxia13(SCA13) -
535 Val Met Spinocerebellarataxia13(SCA13) -

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Biological process

Disease

No data found.

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