Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

KCNC3_HUMAN

Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. The channel displays rapid activation and inactivation kinetics (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). It plays a role in the regulation of the frequency, shape and duration of action potentials in Purkinje cells. Required for normal survival of cerebellar neurons, probably via its role in regulating the duration and frequency of action potentials that in turn regulate the activity of voltage-gated Ca(2+) channels and cellular Ca(2+) homeostasis . Required for normal motor function (PubMed, PubMed, PubMed, PubMed, PubMed). Plays a role in the reorganization of the cortical actin cytoskeleton and the formation of actin veil structures in neuronal growth cones via its interaction with HAX1 and the Arp2/3 complex (PubMed). [View more on UniProt]

Interacting region for partners were not defined.

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Position Amino acid Mutation Disease Overlap with binding region
420 Arg His Spinocerebellarataxia13(SCA13) -
448 Phe Leu Spinocerebellarataxia13(SCA13) -
423 Arg His Spinocerebellarataxia13(SCA13) -
535 Val Met Spinocerebellarataxia13(SCA13) -

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in KCNC3_HUMAN
GO:0005216 ion channel activity 62.5000 4 yes
GO:0005261 cation channel activity 62.5000 5 yes
GO:0008324 cation transmembrane transporter activity 62.5000 4 yes
GO:0015079 potassium ion transmembrane transporter activity 62.5000 6 yes
GO:0015267 channel activity 62.5000 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 62.5000 4 yes
GO:0046873 metal ion transmembrane transporter activity 62.5000 5 yes
GO:0005244 voltage-gated ion channel activity 50.0000 4 yes
GO:0005249 voltage-gated potassium channel activity 50.0000 6 yes
GO:0005267 potassium channel activity 50.0000 6 yes
GO:0022832 voltage-gated channel activity 50.0000 6 yes
GO:0022836 gated channel activity 50.0000 5 yes
GO:0022843 voltage-gated cation channel activity 50.0000 5 yes
GO:0005251 delayed rectifier potassium channel activity 37.5000 7 yes
GO:0004725 protein tyrosine phosphatase activity 25.0000 4 no
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 25.0000 5 no
GO:0016791 phosphatase activity 25.0000 5 no
GO:0019198 transmembrane receptor protein phosphatase activity 25.0000 4 no
GO:0042578 phosphoric ester hydrolase activity 25.0000 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in KCNC3_HUMAN
GO:0043269 regulation of ion transport 75.0000 5 yes
GO:0051049 regulation of transport 75.0000 4 yes
GO:0006811 ion transport 62.5000 4 yes
GO:0006812 cation transport 62.5000 5 yes
GO:0030001 metal ion transport 62.5000 6 yes
GO:0034762 regulation of transmembrane transport 62.5000 4 yes
GO:0034765 regulation of ion transmembrane transport 62.5000 5 yes
GO:0006813 potassium ion transport 50.0000 7 yes
GO:0022607 cellular component assembly 50.0000 4 yes
GO:0071805 potassium ion transmembrane transport 50.0000 6 yes
GO:0098655 cation transmembrane transport 50.0000 4 yes
GO:0098660 inorganic ion transmembrane transport 50.0000 4 yes
GO:0098662 inorganic cation transmembrane transport 50.0000 5 yes
GO:0048522 positive regulation of cellular process 50.0000 4 no
GO:0006796 phosphate-containing compound metabolic process 50.0000 4 no
GO:0043933 protein-containing complex organization 37.5000 4 yes
GO:0051259 protein complex oligomerization 37.5000 6 yes
GO:0051260 protein homooligomerization 37.5000 7 yes
GO:0065003 protein-containing complex assembly 37.5000 5 yes
GO:0010646 regulation of cell communication 37.5000 4 no
GO:0022603 regulation of anatomical structure morphogenesis 37.5000 4 no
GO:0032101 regulation of response to external stimulus 37.5000 4 no
GO:0032880 regulation of protein localization 37.5000 5 no
GO:0048585 negative regulation of response to stimulus 37.5000 4 no
GO:0050804 modulation of chemical synaptic transmission 37.5000 5 no
GO:0051050 positive regulation of transport 37.5000 4 no
GO:0060341 regulation of cellular localization 37.5000 4 no
GO:0080134 regulation of response to stress 37.5000 4 no
GO:0099177 regulation of trans-synaptic signaling 37.5000 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 37.5000 4 no
GO:0010975 regulation of neuron projection development 37.5000 7 no
GO:0031344 regulation of cell projection organization 37.5000 5 no
GO:0036211 protein modification process 37.5000 4 no
GO:0043412 macromolecule modification 37.5000 4 no
GO:0051128 regulation of cellular component organization 37.5000 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 37.5000 6 no
GO:0010959 regulation of metal ion transport 37.5000 6 no
GO:1904062 regulation of cation transmembrane transport 37.5000 6 no
GO:0051262 protein tetramerization 25.0000 7 yes
GO:0010038 response to metal ion 25.0000 4 no
GO:0032102 negative regulation of response to external stimulus 25.0000 5 no
GO:0035864 response to potassium ion 25.0000 5 no
GO:0043270 positive regulation of ion transport 25.0000 5 no
GO:0051223 regulation of protein transport 25.0000 5 no
GO:0070201 regulation of establishment of protein localization 25.0000 6 no
GO:0071310 cellular response to organic substance 25.0000 4 no
GO:1903034 regulation of response to wounding 25.0000 5 no
GO:2000026 regulation of multicellular organismal development 25.0000 4 no
GO:0006470 protein dephosphorylation 25.0000 5 no
GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway 25.0000 5 no
GO:0009966 regulation of signal transduction 25.0000 4 no
GO:0016311 dephosphorylation 25.0000 5 no
GO:0022604 regulation of cell morphogenesis 25.0000 5 no
GO:0031346 positive regulation of cell projection organization 25.0000 6 no
GO:0048523 negative regulation of cellular process 25.0000 4 no
GO:0050776 regulation of immune response 25.0000 4 no
GO:0050807 regulation of synapse organization 25.0000 5 no
GO:0051130 positive regulation of cellular component organization 25.0000 5 no
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 25.0000 4 no
GO:0099175 regulation of postsynapse organization 25.0000 6 no
GO:0099537 trans-synaptic signaling 25.0000 4 no
GO:0099560 synaptic membrane adhesion 25.0000 5 no
GO:0010243 response to organonitrogen compound 25.0000 4 no
GO:0043266 regulation of potassium ion transport 25.0000 7 no
GO:0070848 response to growth factor 25.0000 4 no
GO:1901379 regulation of potassium ion transmembrane transport 25.0000 7 no
GO:0030030 cell projection organization 25.0000 4 no
GO:0031175 neuron projection development 25.0000 6 no
GO:0080135 regulation of cellular response to stress 25.0000 4 no
GO:0120036 plasma membrane bounded cell projection organization 25.0000 5 no

Disease

Term Name % Distance from top the of the tree Annotated in KCNC3_HUMAN
DOID:331 central nervous system disease 25.0000 3 yes
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KCNC4_HUMAN [view entry] [view interactions] High throughput yes no
RHBD3_HUMAN [view interactions] High throughput no yes
ATF6B_HUMAN [view interactions] High throughput no yes
NFIP1_HUMAN [view interactions] High throughput no yes
ATF6A_HUMAN [view interactions] High throughput no yes
FP100_HUMAN [view interactions] High throughput no yes
PAX6_HUMAN [view interactions] High throughput no no
KCNC1_HUMAN [view entry] [view interactions] High throughput yes yes
PTPRF_HUMAN [view entry] [view interactions] High throughput yes yes
FYN_HUMAN [view entry] [view interactions] High throughput yes no
HYEP_HUMAN [view interactions] High throughput no no
ERD21_HUMAN [view interactions] High throughput no yes
TENS1_HUMAN [view interactions] High throughput no no
OSMR_HUMAN [view interactions] High throughput no yes
P4HA1_HUMAN [view interactions] High throughput no yes
BMR1A_HUMAN [view interactions] High throughput no no
PKHH3_HUMAN [view interactions] High throughput no no
UFO_HUMAN [view interactions] High throughput no no
S20A1_HUMAN [view interactions] High throughput no yes
JAK1_HUMAN [view interactions] High throughput no yes
FGFR1_HUMAN [view interactions] High throughput no yes
PTPRD_HUMAN [view entry] [view interactions] High throughput yes no
PCX3_HUMAN [view interactions] High throughput no no
VRK2_HUMAN [view interactions] High throughput no no
DDR1_HUMAN [view interactions] High throughput no yes
S12A2_HUMAN [view entry] [view interactions] High throughput yes yes
KC1G2_HUMAN [view interactions] High throughput no yes
RIT1_HUMAN [view interactions] High throughput no yes
KCAB3_HUMAN [view interactions] Computational no no
KCAB2_HUMAN [view entry] [view interactions] Computational yes yes
KCAB1_HUMAN [view interactions] Computational no no