KCNC3_HUMAN
Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. The channel displays rapid activation and inactivation kinetics (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). It plays a role in the regulation of the frequency, shape and duration of action potentials in Purkinje cells. Required for normal survival of cerebellar neurons, probably via its role in regulating the duration and frequency of action potentials that in turn regulate the activity of voltage-gated Ca(2+) channels and cellular Ca(2+) homeostasis . Required for normal motor function (PubMed, PubMed, PubMed, PubMed, PubMed). Plays a role in the reorganization of the cortical actin cytoskeleton and the formation of actin veil structures in neuronal growth cones via its interaction with HAX1 and the Arp2/3 complex (PubMed). [View more on UniProt]
Interacting region for partners were not defined.
Position | Amino acid | Mutation | Disease | Overlap with binding region |
---|---|---|---|---|
420 | Arg | His | Spinocerebellarataxia13(SCA13) | - |
448 | Phe | Leu | Spinocerebellarataxia13(SCA13) | - |
423 | Arg | His | Spinocerebellarataxia13(SCA13) | - |
535 | Val | Met | Spinocerebellarataxia13(SCA13) | - |
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in KCNC3_HUMAN |
---|---|---|---|---|
GO:0005216 | ion channel activity | 62.5000 | 4 | yes |
GO:0005261 | cation channel activity | 62.5000 | 5 | yes |
GO:0008324 | cation transmembrane transporter activity | 62.5000 | 4 | yes |
GO:0015079 | potassium ion transmembrane transporter activity | 62.5000 | 6 | yes |
GO:0015267 | channel activity | 62.5000 | 4 | yes |
GO:0022890 | inorganic cation transmembrane transporter activity | 62.5000 | 4 | yes |
GO:0046873 | metal ion transmembrane transporter activity | 62.5000 | 5 | yes |
GO:0005244 | voltage-gated ion channel activity | 50.0000 | 4 | yes |
GO:0005249 | voltage-gated potassium channel activity | 50.0000 | 6 | yes |
GO:0005267 | potassium channel activity | 50.0000 | 6 | yes |
GO:0022832 | voltage-gated channel activity | 50.0000 | 6 | yes |
GO:0022836 | gated channel activity | 50.0000 | 5 | yes |
GO:0022843 | voltage-gated cation channel activity | 50.0000 | 5 | yes |
GO:0005251 | delayed rectifier potassium channel activity | 37.5000 | 7 | yes |
GO:0004725 | protein tyrosine phosphatase activity | 25.0000 | 4 | no |
GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity | 25.0000 | 5 | no |
GO:0016791 | phosphatase activity | 25.0000 | 5 | no |
GO:0019198 | transmembrane receptor protein phosphatase activity | 25.0000 | 4 | no |
GO:0042578 | phosphoric ester hydrolase activity | 25.0000 | 4 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in KCNC3_HUMAN |
---|---|---|---|---|
GO:0043269 | regulation of ion transport | 75.0000 | 5 | yes |
GO:0051049 | regulation of transport | 75.0000 | 4 | yes |
GO:0006811 | ion transport | 62.5000 | 4 | yes |
GO:0006812 | cation transport | 62.5000 | 5 | yes |
GO:0030001 | metal ion transport | 62.5000 | 6 | yes |
GO:0034762 | regulation of transmembrane transport | 62.5000 | 4 | yes |
GO:0034765 | regulation of ion transmembrane transport | 62.5000 | 5 | yes |
GO:0006813 | potassium ion transport | 50.0000 | 7 | yes |
GO:0022607 | cellular component assembly | 50.0000 | 4 | yes |
GO:0071805 | potassium ion transmembrane transport | 50.0000 | 6 | yes |
GO:0098655 | cation transmembrane transport | 50.0000 | 4 | yes |
GO:0098660 | inorganic ion transmembrane transport | 50.0000 | 4 | yes |
GO:0098662 | inorganic cation transmembrane transport | 50.0000 | 5 | yes |
GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | no |
GO:0006796 | phosphate-containing compound metabolic process | 50.0000 | 4 | no |
GO:0043933 | protein-containing complex organization | 37.5000 | 4 | yes |
GO:0051259 | protein complex oligomerization | 37.5000 | 6 | yes |
GO:0051260 | protein homooligomerization | 37.5000 | 7 | yes |
GO:0065003 | protein-containing complex assembly | 37.5000 | 5 | yes |
GO:0010646 | regulation of cell communication | 37.5000 | 4 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 37.5000 | 4 | no |
GO:0032101 | regulation of response to external stimulus | 37.5000 | 4 | no |
GO:0032880 | regulation of protein localization | 37.5000 | 5 | no |
GO:0048585 | negative regulation of response to stimulus | 37.5000 | 4 | no |
GO:0050804 | modulation of chemical synaptic transmission | 37.5000 | 5 | no |
GO:0051050 | positive regulation of transport | 37.5000 | 4 | no |
GO:0060341 | regulation of cellular localization | 37.5000 | 4 | no |
GO:0080134 | regulation of response to stress | 37.5000 | 4 | no |
GO:0099177 | regulation of trans-synaptic signaling | 37.5000 | 4 | no |
GO:0007167 | enzyme-linked receptor protein signaling pathway | 37.5000 | 4 | no |
GO:0010975 | regulation of neuron projection development | 37.5000 | 7 | no |
GO:0031344 | regulation of cell projection organization | 37.5000 | 5 | no |
GO:0036211 | protein modification process | 37.5000 | 4 | no |
GO:0043412 | macromolecule modification | 37.5000 | 4 | no |
GO:0051128 | regulation of cellular component organization | 37.5000 | 4 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 37.5000 | 6 | no |
GO:0010959 | regulation of metal ion transport | 37.5000 | 6 | no |
GO:1904062 | regulation of cation transmembrane transport | 37.5000 | 6 | no |
GO:0051262 | protein tetramerization | 25.0000 | 7 | yes |
GO:0010038 | response to metal ion | 25.0000 | 4 | no |
GO:0032102 | negative regulation of response to external stimulus | 25.0000 | 5 | no |
GO:0035864 | response to potassium ion | 25.0000 | 5 | no |
GO:0043270 | positive regulation of ion transport | 25.0000 | 5 | no |
GO:0051223 | regulation of protein transport | 25.0000 | 5 | no |
GO:0070201 | regulation of establishment of protein localization | 25.0000 | 6 | no |
GO:0071310 | cellular response to organic substance | 25.0000 | 4 | no |
GO:1903034 | regulation of response to wounding | 25.0000 | 5 | no |
GO:2000026 | regulation of multicellular organismal development | 25.0000 | 4 | no |
GO:0006470 | protein dephosphorylation | 25.0000 | 5 | no |
GO:0007185 | transmembrane receptor protein tyrosine phosphatase signaling pathway | 25.0000 | 5 | no |
GO:0009966 | regulation of signal transduction | 25.0000 | 4 | no |
GO:0016311 | dephosphorylation | 25.0000 | 5 | no |
GO:0022604 | regulation of cell morphogenesis | 25.0000 | 5 | no |
GO:0031346 | positive regulation of cell projection organization | 25.0000 | 6 | no |
GO:0048523 | negative regulation of cellular process | 25.0000 | 4 | no |
GO:0050776 | regulation of immune response | 25.0000 | 4 | no |
GO:0050807 | regulation of synapse organization | 25.0000 | 5 | no |
GO:0051130 | positive regulation of cellular component organization | 25.0000 | 5 | no |
GO:0098742 | cell-cell adhesion via plasma-membrane adhesion molecules | 25.0000 | 4 | no |
GO:0099175 | regulation of postsynapse organization | 25.0000 | 6 | no |
GO:0099537 | trans-synaptic signaling | 25.0000 | 4 | no |
GO:0099560 | synaptic membrane adhesion | 25.0000 | 5 | no |
GO:0010243 | response to organonitrogen compound | 25.0000 | 4 | no |
GO:0043266 | regulation of potassium ion transport | 25.0000 | 7 | no |
GO:0070848 | response to growth factor | 25.0000 | 4 | no |
GO:1901379 | regulation of potassium ion transmembrane transport | 25.0000 | 7 | no |
GO:0030030 | cell projection organization | 25.0000 | 4 | no |
GO:0031175 | neuron projection development | 25.0000 | 6 | no |
GO:0080135 | regulation of cellular response to stress | 25.0000 | 4 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 25.0000 | 5 | no |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in KCNC3_HUMAN |
---|---|---|---|---|
DOID:331 | central nervous system disease | 25.0000 | 3 | yes |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
KCNC4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHBD3_HUMAN | [view interactions] | High throughput | no | yes |
ATF6B_HUMAN | [view interactions] | High throughput | no | yes |
NFIP1_HUMAN | [view interactions] | High throughput | no | yes |
ATF6A_HUMAN | [view interactions] | High throughput | no | yes |
FP100_HUMAN | [view interactions] | High throughput | no | yes |
PAX6_HUMAN | [view interactions] | High throughput | no | no |
KCNC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PTPRF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HYEP_HUMAN | [view interactions] | High throughput | no | no |
ERD21_HUMAN | [view interactions] | High throughput | no | yes |
TENS1_HUMAN | [view interactions] | High throughput | no | no |
OSMR_HUMAN | [view interactions] | High throughput | no | yes |
P4HA1_HUMAN | [view interactions] | High throughput | no | yes |
BMR1A_HUMAN | [view interactions] | High throughput | no | no |
PKHH3_HUMAN | [view interactions] | High throughput | no | no |
UFO_HUMAN | [view interactions] | High throughput | no | no |
S20A1_HUMAN | [view interactions] | High throughput | no | yes |
JAK1_HUMAN | [view interactions] | High throughput | no | yes |
FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
PTPRD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PCX3_HUMAN | [view interactions] | High throughput | no | no |
VRK2_HUMAN | [view interactions] | High throughput | no | no |
DDR1_HUMAN | [view interactions] | High throughput | no | yes |
S12A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KC1G2_HUMAN | [view interactions] | High throughput | no | yes |
RIT1_HUMAN | [view interactions] | High throughput | no | yes |
KCAB3_HUMAN | [view interactions] | Computational | no | no |
KCAB2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
KCAB1_HUMAN | [view interactions] | Computational | no | no |