Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

KCNC3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. The channel displays rapid activation and inactivation kinetics (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). It plays a role in the regulation of the frequency, shape and duration of action potentials in Purkinje cells. Required for normal survival of cerebellar neurons, probably via its role in regulating the duration and frequency of action potentials that in turn regulate the activity of voltage-gated Ca(2+) channels and cellular Ca(2+) homeostasis . Required for normal motor function (PubMed, PubMed, PubMed, PubMed, PubMed). Plays a role in the reorganization of the cortical actin cytoskeleton and the formation of actin veil structures in neuronal growth cones via its interaction with HAX1 and the Arp2/3 complex (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
420 Arg His Spinocerebellarataxia13(SCA13) -
448 Phe Leu Spinocerebellarataxia13(SCA13) -
423 Arg His Spinocerebellarataxia13(SCA13) -
535 Val Met Spinocerebellarataxia13(SCA13) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in KCNC3_HUMAN
GO:0008324 monoatomic cation transmembrane transporter activity 50.0000 4 yes
GO:0015079 potassium ion transmembrane transporter activity 50.0000 6 yes
GO:0015267 channel activity 50.0000 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 50.0000 4 yes
GO:0046873 metal ion transmembrane transporter activity 50.0000 5 yes
GO:0005216 monoatomic ion channel activity 37.5000 4 yes
GO:0005244 voltage-gated monoatomic ion channel activity 37.5000 5 yes
GO:0005249 voltage-gated potassium channel activity 37.5000 7 yes
GO:0005251 delayed rectifier potassium channel activity 37.5000 8 yes
GO:0005261 monoatomic cation channel activity 37.5000 5 yes
GO:0005267 potassium channel activity 37.5000 6 yes
GO:0022832 voltage-gated channel activity 37.5000 6 yes
GO:0022836 gated channel activity 37.5000 5 yes
GO:0022843 voltage-gated monoatomic cation channel activity 37.5000 6 yes
GO:0004725 protein tyrosine phosphatase activity 25.0000 4 no
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 25.0000 5 no
GO:0016791 phosphatase activity 25.0000 5 no
GO:0019198 transmembrane receptor protein phosphatase activity 25.0000 4 no
GO:0042578 phosphoric ester hydrolase activity 25.0000 4 no
GO:0000166 nucleotide binding 25.0000 4 no
GO:0004713 protein tyrosine kinase activity 25.0000 4 no
GO:0005524 ATP binding 25.0000 5 no
GO:0016301 kinase activity 25.0000 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 25.0000 4 no
GO:0017076 purine nucleotide binding 25.0000 5 no
GO:0030554 adenyl nucleotide binding 25.0000 6 no
GO:0032555 purine ribonucleotide binding 25.0000 4 no
GO:0032559 adenyl ribonucleotide binding 25.0000 5 no
GO:0035639 purine ribonucleoside triphosphate binding 25.0000 4 no
GO:0043168 anion binding 25.0000 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in KCNC3_HUMAN
GO:0006811 monoatomic ion transport 62.5000 4 yes
GO:0006812 monoatomic cation transport 62.5000 5 yes
GO:0022607 cellular component assembly 62.5000 4 yes
GO:0030001 metal ion transport 62.5000 6 yes
GO:0048522 positive regulation of cellular process 62.5000 4 no
GO:0006813 potassium ion transport 50.0000 7 yes
GO:0071805 potassium ion transmembrane transport 50.0000 5 yes
GO:0098655 monoatomic cation transmembrane transport 50.0000 4 yes
GO:0098662 inorganic cation transmembrane transport 50.0000 4 yes
GO:0051049 regulation of transport 50.0000 4 no
GO:0006796 phosphate-containing compound metabolic process 50.0000 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 50.0000 4 no
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0010975 regulation of neuron projection development 50.0000 7 no
GO:0022603 regulation of anatomical structure morphogenesis 50.0000 4 no
GO:0031344 regulation of cell projection organization 50.0000 5 no
GO:0036211 protein modification process 50.0000 4 no
GO:0043412 macromolecule modification 50.0000 4 no
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 50.0000 6 no
GO:0032101 regulation of response to external stimulus 50.0000 4 no
GO:0043933 protein-containing complex organization 37.5000 4 yes
GO:0051259 protein complex oligomerization 37.5000 6 yes
GO:0051260 protein homooligomerization 37.5000 7 yes
GO:0065003 protein-containing complex assembly 37.5000 5 yes
GO:0051050 positive regulation of transport 37.5000 4 no
GO:0009966 regulation of signal transduction 37.5000 4 no
GO:0031346 positive regulation of cell projection organization 37.5000 6 no
GO:0048523 negative regulation of cellular process 37.5000 4 no
GO:0048585 negative regulation of response to stimulus 37.5000 4 no
GO:0050804 modulation of chemical synaptic transmission 37.5000 5 no
GO:0051130 positive regulation of cellular component organization 37.5000 5 no
GO:0051240 positive regulation of multicellular organismal process 37.5000 4 no
GO:0099177 regulation of trans-synaptic signaling 37.5000 4 no
GO:2000026 regulation of multicellular organismal development 37.5000 4 no
GO:0080134 regulation of response to stress 37.5000 4 no
GO:0030030 cell projection organization 37.5000 4 no
GO:0031175 neuron projection development 37.5000 6 no
GO:0120036 plasma membrane bounded cell projection organization 37.5000 5 no
GO:0051262 protein tetramerization 25.0000 7 yes
GO:0010038 response to metal ion 25.0000 4 no
GO:0010243 response to organonitrogen compound 25.0000 4 no
GO:0010959 regulation of metal ion transport 25.0000 6 no
GO:0034762 regulation of transmembrane transport 25.0000 4 no
GO:0034765 regulation of monoatomic ion transmembrane transport 25.0000 5 no
GO:0035864 response to potassium ion 25.0000 5 no
GO:0043269 regulation of monoatomic ion transport 25.0000 5 no
GO:1904062 regulation of monoatomic cation transmembrane transport 25.0000 6 no
GO:0006470 protein dephosphorylation 25.0000 5 no
GO:0007185 cell surface receptor protein tyrosine phosphatase signaling pathway 25.0000 5 no
GO:0009968 negative regulation of signal transduction 25.0000 5 no
GO:0010648 negative regulation of cell communication 25.0000 5 no
GO:0016311 dephosphorylation 25.0000 5 no
GO:0022604 regulation of cell morphogenesis 25.0000 5 no
GO:0023057 negative regulation of signaling 25.0000 4 no
GO:0045595 regulation of cell differentiation 25.0000 4 no
GO:0045597 positive regulation of cell differentiation 25.0000 5 no
GO:0050776 regulation of immune response 25.0000 4 no
GO:0050807 regulation of synapse organization 25.0000 5 no
GO:0051094 positive regulation of developmental process 25.0000 4 no
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 25.0000 4 no
GO:0099175 regulation of postsynapse organization 25.0000 6 no
GO:0099536 synaptic signaling 25.0000 4 no
GO:0099537 trans-synaptic signaling 25.0000 5 no
GO:0099560 synaptic membrane adhesion 25.0000 5 no
GO:0032102 negative regulation of response to external stimulus 25.0000 5 no
GO:0032880 regulation of protein localization 25.0000 5 no
GO:0051046 regulation of secretion 25.0000 5 no
GO:0051047 positive regulation of secretion 25.0000 5 no
GO:0051241 negative regulation of multicellular organismal process 25.0000 4 no
GO:0055080 monoatomic cation homeostasis 25.0000 4 no
GO:0060341 regulation of cellular localization 25.0000 4 no
GO:0070201 regulation of establishment of protein localization 25.0000 6 no
GO:0071310 cellular response to organic substance 25.0000 4 no
GO:1903034 regulation of response to wounding 25.0000 5 no
GO:1903530 regulation of secretion by cell 25.0000 4 no
GO:1903532 positive regulation of secretion by cell 25.0000 5 no
GO:0001764 neuron migration 25.0000 4 no
GO:0001932 regulation of protein phosphorylation 25.0000 7 no
GO:0001934 positive regulation of protein phosphorylation 25.0000 8 no
GO:0006468 protein phosphorylation 25.0000 5 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 25.0000 5 no
GO:0009889 regulation of biosynthetic process 25.0000 4 no
GO:0009890 negative regulation of biosynthetic process 25.0000 5 no
GO:0009892 negative regulation of metabolic process 25.0000 4 no
GO:0009893 positive regulation of metabolic process 25.0000 4 no
GO:0009967 positive regulation of signal transduction 25.0000 5 no
GO:0010468 regulation of gene expression 25.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0010562 positive regulation of phosphorus metabolic process 25.0000 6 no
GO:0010604 positive regulation of macromolecule metabolic process 25.0000 5 no
GO:0010605 negative regulation of macromolecule metabolic process 25.0000 5 no
GO:0010629 negative regulation of gene expression 25.0000 7 no
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0010976 positive regulation of neuron projection development 25.0000 7 no
GO:0016310 phosphorylation 25.0000 5 no
GO:0018108 peptidyl-tyrosine phosphorylation 25.0000 6 no
GO:0018193 peptidyl-amino acid modification 25.0000 5 no
GO:0018212 peptidyl-tyrosine modification 25.0000 6 no
GO:0019220 regulation of phosphate metabolic process 25.0000 6 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:0031323 regulation of cellular metabolic process 25.0000 4 no
GO:0031324 negative regulation of cellular metabolic process 25.0000 5 no
GO:0031325 positive regulation of cellular metabolic process 25.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0031327 negative regulation of cellular biosynthetic process 25.0000 6 no
GO:0031399 regulation of protein modification process 25.0000 6 no
GO:0031401 positive regulation of protein modification process 25.0000 7 no
GO:0032103 positive regulation of response to external stimulus 25.0000 5 no
GO:0042325 regulation of phosphorylation 25.0000 7 no
GO:0042327 positive regulation of phosphorylation 25.0000 8 no
GO:0042981 regulation of apoptotic process 25.0000 5 no
GO:0043067 regulation of programmed cell death 25.0000 4 no
GO:0043085 positive regulation of catalytic activity 25.0000 4 no
GO:0045937 positive regulation of phosphate metabolic process 25.0000 7 no
GO:0048584 positive regulation of response to stimulus 25.0000 4 no
GO:0051174 regulation of phosphorus metabolic process 25.0000 5 no
GO:0051246 regulation of protein metabolic process 25.0000 5 no
GO:0051247 positive regulation of protein metabolic process 25.0000 6 no
GO:0051336 regulation of hydrolase activity 25.0000 4 no
GO:0051345 positive regulation of hydrolase activity 25.0000 5 no
GO:0060255 regulation of macromolecule metabolic process 25.0000 4 no
GO:0080090 regulation of primary metabolic process 25.0000 4 no
GO:0141124 intracellular signaling cassette 25.0000 4 no
GO:1902531 regulation of intracellular signal transduction 25.0000 5 no
GO:1902533 positive regulation of intracellular signal transduction 25.0000 6 no
GO:2001233 regulation of apoptotic signaling pathway 25.0000 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KCNC4_HUMAN [view entry] [view interactions] High throughput yes no
RHBD3_HUMAN [view interactions] High throughput no yes
ATF6B_HUMAN [view interactions] High throughput no yes
NFIP1_HUMAN [view interactions] High throughput no yes
ATF6A_HUMAN [view interactions] High throughput no yes
FP100_HUMAN [view interactions] High throughput no yes
PAX6_HUMAN [view interactions] High throughput no no
KCNC1_HUMAN [view entry] [view interactions] High throughput yes yes
PTPRF_HUMAN [view entry] [view interactions] High throughput yes yes
FYN_HUMAN [view entry] [view interactions] High throughput yes no
HYEP_HUMAN [view interactions] High throughput no no
ERD21_HUMAN [view interactions] High throughput no yes
TENS1_HUMAN [view interactions] High throughput no no
OSMR_HUMAN [view interactions] High throughput no yes
P4HA1_HUMAN [view interactions] High throughput no yes
BMR1A_HUMAN [view interactions] High throughput no no
PKHH3_HUMAN [view interactions] High throughput no no
UFO_HUMAN [view interactions] High throughput no no
S20A1_HUMAN [view interactions] High throughput no yes
JAK1_HUMAN [view interactions] High throughput no yes
FGFR1_HUMAN [view entry] [view interactions] High throughput yes yes
PTPRD_HUMAN [view entry] [view interactions] High throughput yes no
PCX3_HUMAN [view interactions] High throughput no no
VRK2_HUMAN [view interactions] High throughput no no
DDR1_HUMAN [view interactions] High throughput no yes
S12A2_HUMAN [view entry] [view interactions] High throughput yes yes
KC1G2_HUMAN [view interactions] High throughput no yes
RIT1_HUMAN [view interactions] High throughput no yes