Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

KCNC2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. Homotetramer channels mediate delayed-rectifier voltage-dependent potassium currents that activate rapidly at high-threshold voltages and inactivate slowly. Forms tetrameric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNC1, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel. Channel properties may be modulated either by the association with ancillary subunits, such as KCNE1, KCNE2 or KCNE3 or indirectly by nitric oxide (NO) through a cGMP- and PKG-mediated signaling cascade, slowing channel activation and deactivation of delayed rectifier potassium channels . Contributes to fire sustained trains of very brief action potentials at high frequency in retinal ganglion cells, thalamocortical and suprachiasmatic nucleus (SCN) neurons and in hippocampal and neocortical interneurons (PubMed). Sustained maximal action potential firing frequency in inhibitory hippocampal interneurons is negatively modulated by histamine H2 receptor activation in a cAMP- and protein kinase (PKA) phosphorylation-dependent manner. Plays a role in maintaining the fidelity of synaptic transmission in neocortical GABAergic interneurons by generating action potential (AP) repolarization at nerve terminals, thus reducing spike-evoked calcium influx and GABA neurotransmitter release. Required for long-range synchronization of gamma oscillations over distance in the neocortex. Contributes to the modulation of the circadian rhythm of spontaneous action potential firing in suprachiasmatic nucleus (SCN) neurons in a light-dependent manner . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in KCNC2_HUMAN
GO:0005216 ion channel activity 50.0000 4 yes
GO:0005244 voltage-gated ion channel activity 50.0000 4 yes
GO:0005249 voltage-gated potassium channel activity 50.0000 6 yes
GO:0005261 cation channel activity 50.0000 5 yes
GO:0005267 potassium channel activity 50.0000 6 yes
GO:0008324 cation transmembrane transporter activity 50.0000 4 yes
GO:0015079 potassium ion transmembrane transporter activity 50.0000 6 yes
GO:0015267 channel activity 50.0000 4 yes
GO:0022832 voltage-gated channel activity 50.0000 6 yes
GO:0022836 gated channel activity 50.0000 5 yes
GO:0022843 voltage-gated cation channel activity 50.0000 5 yes
GO:0022890 inorganic cation transmembrane transporter activity 50.0000 4 yes
GO:0046873 metal ion transmembrane transporter activity 50.0000 5 yes
GO:0031625 ubiquitin protein ligase binding 50.0000 5 no
GO:0044389 ubiquitin-like protein ligase binding 50.0000 4 no
GO:0005251 delayed rectifier potassium channel activity 33.3333 7 yes
GO:0099508 voltage-gated ion channel activity involved in regulation of presynaptic membrane potential 33.3333 5 yes
GO:0000287 magnesium ion binding 33.3333 5 no
GO:0004674 protein serine/threonine kinase activity 33.3333 4 no
GO:0004679 AMP-activated protein kinase activity 33.3333 5 no
GO:0004690 cyclic nucleotide-dependent protein kinase activity 33.3333 5 no
GO:0004691 cAMP-dependent protein kinase activity 33.3333 6 no
GO:0004712 protein serine/threonine/tyrosine kinase activity 33.3333 4 no
GO:0005524 ATP binding 33.3333 5 no
GO:0016301 kinase activity 33.3333 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 33.3333 4 no
GO:0017076 purine nucleotide binding 33.3333 4 no
GO:0030554 adenyl nucleotide binding 33.3333 5 no
GO:0032555 purine ribonucleotide binding 33.3333 4 no
GO:0032559 adenyl ribonucleotide binding 33.3333 5 no
GO:0035639 purine ribonucleoside triphosphate binding 33.3333 4 no
GO:0046872 metal ion binding 33.3333 4 no
GO:0106310 protein serine kinase activity 33.3333 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in KCNC2_HUMAN
GO:0010959 regulation of metal ion transport 66.6667 6 yes
GO:0022607 cellular component assembly 66.6667 4 yes
GO:0034762 regulation of transmembrane transport 66.6667 4 yes
GO:0034765 regulation of ion transmembrane transport 66.6667 5 yes
GO:0043269 regulation of ion transport 66.6667 5 yes
GO:0043933 protein-containing complex organization 66.6667 4 yes
GO:0051049 regulation of transport 66.6667 4 yes
GO:0065003 protein-containing complex assembly 66.6667 5 yes
GO:1904062 regulation of cation transmembrane transport 66.6667 6 yes
GO:0010243 response to organonitrogen compound 50.0000 4 yes
GO:0022898 regulation of transmembrane transporter activity 50.0000 4 yes
GO:0032412 regulation of ion transmembrane transporter activity 50.0000 5 yes
GO:0043266 regulation of potassium ion transport 50.0000 7 yes
GO:0048522 positive regulation of cellular process 50.0000 4 yes
GO:0051050 positive regulation of transport 50.0000 4 yes
GO:1901379 regulation of potassium ion transmembrane transport 50.0000 7 yes
GO:2001257 regulation of cation channel activity 50.0000 6 yes
GO:0036211 protein modification process 50.0000 4 no
GO:0043412 macromolecule modification 50.0000 4 no
GO:0006796 phosphate-containing compound metabolic process 50.0000 4 no
GO:0006811 ion transport 33.3333 4 yes
GO:0006812 cation transport 33.3333 5 yes
GO:0006813 potassium ion transport 33.3333 7 yes
GO:0009416 response to light stimulus 33.3333 4 yes
GO:0009642 response to light intensity 33.3333 5 yes
GO:0010038 response to metal ion 33.3333 4 yes
GO:0014070 response to organic cyclic compound 33.3333 4 yes
GO:0014075 response to amine 33.3333 5 yes
GO:0019932 second-messenger-mediated signaling 33.3333 4 yes
GO:0021759 globus pallidus development 33.3333 4 yes
GO:0030001 metal ion transport 33.3333 6 yes
GO:0032411 positive regulation of transporter activity 33.3333 4 yes
GO:0032414 positive regulation of ion transmembrane transporter activity 33.3333 5 yes
GO:0034764 positive regulation of transmembrane transport 33.3333 5 yes
GO:0034767 positive regulation of ion transmembrane transport 33.3333 6 yes
GO:0043268 positive regulation of potassium ion transport 33.3333 6 yes
GO:0043270 positive regulation of ion transport 33.3333 5 yes
GO:0051259 protein complex oligomerization 33.3333 6 yes
GO:0051260 protein homooligomerization 33.3333 7 yes
GO:0070848 response to growth factor 33.3333 4 yes
GO:0071805 potassium ion transmembrane transport 33.3333 6 yes
GO:0098655 cation transmembrane transport 33.3333 4 yes
GO:0098660 inorganic ion transmembrane transport 33.3333 4 yes
GO:0098662 inorganic cation transmembrane transport 33.3333 5 yes
GO:1901016 regulation of potassium ion transmembrane transporter activity 33.3333 6 yes
GO:1901018 positive regulation of potassium ion transmembrane transporter activity 33.3333 6 yes
GO:1901381 positive regulation of potassium ion transmembrane transport 33.3333 7 yes
GO:1901699 cellular response to nitrogen compound 33.3333 4 yes
GO:1901701 cellular response to oxygen-containing compound 33.3333 4 yes
GO:1903818 positive regulation of voltage-gated potassium channel activity 33.3333 7 yes
GO:1904064 positive regulation of cation transmembrane transport 33.3333 7 yes
GO:2001259 positive regulation of cation channel activity 33.3333 6 yes
GO:0001843 neural tube closure 33.3333 5 no
GO:0003091 renal water homeostasis 33.3333 4 no
GO:0006468 protein phosphorylation 33.3333 5 no
GO:0008589 regulation of smoothened signaling pathway 33.3333 5 no
GO:0009966 regulation of signal transduction 33.3333 4 no
GO:0009968 negative regulation of signal transduction 33.3333 5 no
GO:0010468 regulation of gene expression 33.3333 5 no
GO:0010646 regulation of cell communication 33.3333 4 no
GO:0010648 negative regulation of cell communication 33.3333 5 no
GO:0010737 protein kinase A signaling 33.3333 4 no
GO:0016310 phosphorylation 33.3333 5 no
GO:0023057 negative regulation of signaling 33.3333 4 no
GO:0030104 water homeostasis 33.3333 5 no
GO:0030162 regulation of proteolysis 33.3333 6 no
GO:0034380 high-density lipoprotein particle assembly 33.3333 4 no
GO:0045879 negative regulation of smoothened signaling pathway 33.3333 6 no
GO:0048523 negative regulation of cellular process 33.3333 4 no
GO:0048585 negative regulation of response to stimulus 33.3333 4 no
GO:0048878 chemical homeostasis 33.3333 4 no
GO:0051171 regulation of nitrogen compound metabolic process 33.3333 4 no
GO:0051246 regulation of protein metabolic process 33.3333 5 no
GO:0060255 regulation of macromolecule metabolic process 33.3333 4 no
GO:0060606 tube closure 33.3333 4 no
GO:0065005 protein-lipid complex assembly 33.3333 6 no
GO:0070613 regulation of protein processing 33.3333 7 no
GO:0071825 protein-lipid complex subunit organization 33.3333 5 no
GO:0080090 regulation of primary metabolic process 33.3333 4 no
GO:1901620 regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning 33.3333 6 no
GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning 33.3333 7 no
GO:1903317 regulation of protein maturation 33.3333 6 no
GO:0032880 regulation of protein localization 33.3333 5 no
GO:0060341 regulation of cellular localization 33.3333 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KCNC1_HUMAN [view entry] [view interactions] Low throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
KCAB1_HUMAN [view interactions] Computational no no
KCAB2_HUMAN [view entry] [view interactions] Computational yes yes
KAPCG_HUMAN [view interactions] Computational no no
KCAB3_HUMAN [view interactions] Computational no no
KAPCA_HUMAN [view entry] [view interactions] Computational yes yes
KAPCB_HUMAN [view entry] [view interactions] Computational yes yes