MITOS_HUMAN
Evidence for PS localization
Functions
ATP-binding subunit of the mitochondrial potassium channel located in the mitochondrial inner membrane (PubMed). Together with CCDC51/MITOK, forms a protein complex localized in the mitochondria that mediates ATP-dependent potassium currents across the inner membrane (that is, mitoK(ATP) channel) (PubMed). Plays a role in mitochondrial iron transport (PubMed). Required for maintenance of normal cardiac function, possibly by influencing mitochondrial iron export and regulating the maturation of cytosolic iron sulfur cluster-containing enzymes . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MITOS_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 44.4444 | 4 | yes |
| GO:0000166 | nucleotide binding | 33.3333 | 4 | yes |
| GO:0005524 | ATP binding | 33.3333 | 5 | yes |
| GO:0015399 | primary active transmembrane transporter activity | 33.3333 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 33.3333 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 33.3333 | 4 | yes |
| GO:0016887 | ATP hydrolysis activity | 33.3333 | 7 | yes |
| GO:0017076 | purine nucleotide binding | 33.3333 | 5 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 33.3333 | 6 | yes |
| GO:0030554 | adenyl nucleotide binding | 33.3333 | 6 | yes |
| GO:0032555 | purine ribonucleotide binding | 33.3333 | 4 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 33.3333 | 5 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 33.3333 | 4 | yes |
| GO:0015440 | ABC-type peptide transporter activity | 22.2222 | 4 | yes |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 22.2222 | 4 | no |
| GO:0022853 | active monoatomic ion transmembrane transporter activity | 22.2222 | 4 | no |
| GO:0022890 | inorganic cation transmembrane transporter activity | 22.2222 | 4 | no |
| GO:0043169 | cation binding | 22.2222 | 4 | no |
| GO:0046872 | metal ion binding | 22.2222 | 5 | no |
| GO:0046873 | metal ion transmembrane transporter activity | 22.2222 | 5 | no |
| GO:0008509 | monoatomic anion transmembrane transporter activity | 22.2222 | 4 | no |
| GO:0015103 | inorganic anion transmembrane transporter activity | 22.2222 | 4 | no |
| GO:0015108 | chloride transmembrane transporter activity | 22.2222 | 5 | no |
| GO:0031267 | small GTPase binding | 22.2222 | 5 | no |
| GO:0051020 | GTPase binding | 22.2222 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MITOS_HUMAN |
|---|---|---|---|---|
| GO:0051049 | regulation of transport | 55.5556 | 4 | no |
| GO:0006811 | monoatomic ion transport | 44.4444 | 4 | yes |
| GO:0006812 | monoatomic cation transport | 33.3333 | 5 | yes |
| GO:0030001 | metal ion transport | 33.3333 | 6 | yes |
| GO:0098655 | monoatomic cation transmembrane transport | 33.3333 | 4 | yes |
| GO:0098662 | inorganic cation transmembrane transport | 33.3333 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 33.3333 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 33.3333 | 4 | no |
| GO:0060341 | regulation of cellular localization | 33.3333 | 4 | no |
| GO:0006813 | potassium ion transport | 22.2222 | 7 | yes |
| GO:0006839 | mitochondrial transport | 22.2222 | 4 | yes |
| GO:0008361 | regulation of cell size | 22.2222 | 5 | yes |
| GO:0032535 | regulation of cellular component size | 22.2222 | 4 | yes |
| GO:0071805 | potassium ion transmembrane transport | 22.2222 | 5 | yes |
| GO:0140141 | mitochondrial potassium ion transmembrane transport | 22.2222 | 4 | yes |
| GO:0010646 | regulation of cell communication | 22.2222 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 22.2222 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 22.2222 | 4 | no |
| GO:0022604 | regulation of cell morphogenesis | 22.2222 | 5 | no |
| GO:0023057 | negative regulation of signaling | 22.2222 | 4 | no |
| GO:0032970 | regulation of actin filament-based process | 22.2222 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 22.2222 | 4 | no |
| GO:0006996 | organelle organization | 22.2222 | 4 | no |
| GO:0032386 | regulation of intracellular transport | 22.2222 | 5 | no |
| GO:0032388 | positive regulation of intracellular transport | 22.2222 | 5 | no |
| GO:0043269 | regulation of monoatomic ion transport | 22.2222 | 5 | no |
| GO:0051050 | positive regulation of transport | 22.2222 | 4 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 22.2222 | 4 | no |
| GO:0032880 | regulation of protein localization | 22.2222 | 5 | no |
| GO:0051223 | regulation of protein transport | 22.2222 | 5 | no |
| GO:0070201 | regulation of establishment of protein localization | 22.2222 | 6 | no |
| GO:0007268 | chemical synaptic transmission | 22.2222 | 7 | no |
| GO:0009914 | hormone transport | 22.2222 | 4 | no |
| GO:0023061 | signal release | 22.2222 | 4 | no |
| GO:0046879 | hormone secretion | 22.2222 | 5 | no |
| GO:0046903 | secretion | 22.2222 | 4 | no |
| GO:0071702 | organic substance transport | 22.2222 | 4 | no |
| GO:0071705 | nitrogen compound transport | 22.2222 | 4 | no |
| GO:0098916 | anterograde trans-synaptic signaling | 22.2222 | 6 | no |
| GO:0099536 | synaptic signaling | 22.2222 | 4 | no |
| GO:0099537 | trans-synaptic signaling | 22.2222 | 5 | no |
| GO:0051051 | negative regulation of transport | 22.2222 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MITOK_HUMAN | [view interactions] | Low throughput | no | yes |
| MITOS_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| SAT1_HUMAN | [view interactions] | High throughput | no | yes |
| NOA1_HUMAN | [view interactions] | High throughput | no | yes |
| OMA1_HUMAN | [view interactions] | High throughput | no | no |
| FMNL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TM171_HUMAN | [view interactions] | High throughput | no | yes |
| GBRE_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LPAR6_HUMAN | [view interactions] | High throughput | no | no |
| CLC2D_HUMAN | [view interactions] | High throughput | no | yes |
| SPP2B_HUMAN | [view interactions] | High throughput | no | yes |
| GTR12_HUMAN | [view interactions] | High throughput | no | yes |
| LPAR1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VSIG1_HUMAN | [view interactions] | High throughput | no | no |
| S39A9_HUMAN | [view interactions] | High throughput | no | yes |
| STS_HUMAN | [view interactions] | High throughput | no | no |
| SCN3B_HUMAN | [view interactions] | High throughput | no | no |
| NR3L1_HUMAN | [view interactions] | High throughput | no | no |
| GPR37_HUMAN | [view interactions] | High throughput | no | no |
| S15A1_HUMAN | [view interactions] | High throughput | no | no |
| AGRG5_HUMAN | [view interactions] | High throughput | no | no |
| AAAT_HUMAN | [view interactions] | High throughput | no | no |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| CD80_HUMAN | [view interactions] | High throughput | no | no |
| NKG2D_HUMAN | [view interactions] | High throughput | no | no |
| GPR17_HUMAN | [view interactions] | High throughput | no | no |
| LRCH1_HUMAN | [view interactions] | High throughput | no | yes |
| NK3R_HUMAN | [view interactions] | High throughput | no | no |
| CKLF5_HUMAN | [view interactions] | High throughput | no | yes |
| HIDE1_HUMAN | [view interactions] | High throughput | no | no |
| S22A2_HUMAN | [view interactions] | High throughput | no | no |
| NIPA3_HUMAN | [view interactions] | High throughput | no | no |
| CXCR4_HUMAN | [view interactions] | High throughput | no | no |
| VMAT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| V2R_HUMAN | [view interactions] | High throughput | no | no |
| TSN15_HUMAN | [view interactions] | High throughput | no | yes |
| COPT1_HUMAN | [view interactions] | High throughput | no | no |
| AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| S22A4_HUMAN | [view interactions] | High throughput | no | yes |
| AQP3_HUMAN | [view interactions] | High throughput | no | no |
| GPR12_HUMAN | [view interactions] | High throughput | no | no |
| S26A6_HUMAN | [view interactions] | High throughput | no | yes |
| SO4C1_HUMAN | [view interactions] | High throughput | no | no |
| FPR1_HUMAN | [view interactions] | High throughput | no | no |
| SC5A4_HUMAN | [view interactions] | High throughput | no | no |
| P2RY8_HUMAN | [view interactions] | High throughput | no | no |
| HS2ST_HUMAN | [view interactions] | High throughput | no | yes |
| VIPR2_HUMAN | [view interactions] | High throughput | no | no |
| S22A9_HUMAN | [view interactions] | High throughput | no | no |
| B3GA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPR45_HUMAN | [view interactions] | High throughput | no | no |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| VIPR1_HUMAN | [view interactions] | High throughput | no | yes |
| RFIP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADPGK_HUMAN | [view interactions] | High throughput | no | no |
| GRP1_HUMAN | [view interactions] | High throughput | no | no |
| MTEF3_HUMAN | [view interactions] | High throughput | no | no |
| LDH6B_HUMAN | [view interactions] | High throughput | no | no |
| EPCR_HUMAN | [view interactions] | High throughput | no | yes |
| IMPA3_HUMAN | [view interactions] | High throughput | no | yes |