Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ELMO2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ELMO2_HUMAN
GO:0019900 kinase binding 50.0000 4 yes
GO:0019901 protein kinase binding 50.0000 5 yes
GO:0030695 GTPase regulator activity 31.8182 4 no
GO:0017124 SH3 domain binding 27.2727 4 yes
GO:0017076 purine nucleotide binding 22.7273 4 no
GO:0032555 purine ribonucleotide binding 22.7273 4 no
GO:0035639 purine ribonucleoside triphosphate binding 22.7273 4 no
GO:0003924 GTPase activity 22.7273 7 no
GO:0016462 pyrophosphatase activity 22.7273 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 22.7273 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 22.7273 6 no
GO:0005085 guanyl-nucleotide exchange factor activity 22.7273 5 no
GO:0030971 receptor tyrosine kinase binding 18.1818 4 yes
GO:1990782 protein tyrosine kinase binding 18.1818 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ELMO2_HUMAN
GO:0048522 positive regulation of cellular process 81.8182 4 no
GO:0031323 regulation of cellular metabolic process 59.0909 4 no
GO:0051128 regulation of cellular component organization 54.5455 4 no
GO:0007264 small GTPase mediated signal transduction 50.0000 4 no
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 50.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0006996 organelle organization 50.0000 4 no
GO:0009893 positive regulation of metabolic process 45.4545 4 no
GO:0009966 regulation of signal transduction 45.4545 4 no
GO:0031325 positive regulation of cellular metabolic process 45.4545 5 no
GO:0022603 regulation of anatomical structure morphogenesis 45.4545 4 no
GO:0030334 regulation of cell migration 45.4545 5 no
GO:2000145 regulation of cell motility 45.4545 4 no
GO:0007010 cytoskeleton organization 45.4545 5 no
GO:0022607 cellular component assembly 40.9091 4 no
GO:0051246 regulation of protein metabolic process 40.9091 5 no
GO:0048523 negative regulation of cellular process 40.9091 4 no
GO:1902531 regulation of intracellular signal transduction 40.9091 5 no
GO:0022604 regulation of cell morphogenesis 36.3636 5 no
GO:0033043 regulation of organelle organization 36.3636 5 no
GO:0051493 regulation of cytoskeleton organization 36.3636 6 no
GO:0009889 regulation of biosynthetic process 36.3636 4 no
GO:0010468 regulation of gene expression 36.3636 5 no
GO:0010604 positive regulation of macromolecule metabolic process 36.3636 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 36.3636 5 no
GO:0030030 cell projection organization 36.3636 4 no
GO:0030335 positive regulation of cell migration 36.3636 6 no
GO:0040017 positive regulation of locomotion 36.3636 4 no
GO:0045595 regulation of cell differentiation 36.3636 4 no
GO:0060284 regulation of cell development 36.3636 5 no
GO:2000147 positive regulation of cell motility 36.3636 5 no
GO:0031399 regulation of protein modification process 36.3636 6 no
GO:0051094 positive regulation of developmental process 36.3636 4 no
GO:0051174 regulation of phosphorus metabolic process 31.8182 5 no
GO:0010810 regulation of cell-substrate adhesion 31.8182 5 no
GO:0030155 regulation of cell adhesion 31.8182 4 no
GO:0044087 regulation of cellular component biogenesis 31.8182 4 no
GO:0097435 supramolecular fiber organization 31.8182 4 yes
GO:0031326 regulation of cellular biosynthetic process 31.8182 5 no
GO:0051247 positive regulation of protein metabolic process 31.8182 6 no
GO:0031175 neuron projection development 31.8182 6 no
GO:0120036 plasma membrane bounded cell projection organization 31.8182 5 no
GO:0001932 regulation of protein phosphorylation 31.8182 7 no
GO:0010720 positive regulation of cell development 31.8182 6 no
GO:0019220 regulation of phosphate metabolic process 31.8182 6 no
GO:0042325 regulation of phosphorylation 31.8182 7 no
GO:0045597 positive regulation of cell differentiation 31.8182 5 no
GO:0032956 regulation of actin cytoskeleton organization 27.2727 5 no
GO:0032970 regulation of actin filament-based process 27.2727 4 no
GO:0051130 positive regulation of cellular component organization 27.2727 5 no
GO:0061024 membrane organization 27.2727 4 no
GO:0010769 regulation of cell morphogenesis involved in differentiation 27.2727 6 no
GO:0010770 positive regulation of cell morphogenesis involved in differentiation 27.2727 7 no
GO:0010811 positive regulation of cell-substrate adhesion 27.2727 6 no
GO:0045785 positive regulation of cell adhesion 27.2727 5 no
GO:1900024 regulation of substrate adhesion-dependent cell spreading 27.2727 6 no
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 27.2727 7 no
GO:0007015 actin filament organization 27.2727 5 yes
GO:0006355 regulation of DNA-templated transcription 27.2727 6 no
GO:0010556 regulation of macromolecule biosynthetic process 27.2727 5 no
GO:0010647 positive regulation of cell communication 27.2727 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 27.2727 5 no
GO:0023056 positive regulation of signaling 27.2727 4 no
GO:0043085 positive regulation of catalytic activity 27.2727 4 no
GO:0048584 positive regulation of response to stimulus 27.2727 4 no
GO:0051049 regulation of transport 27.2727 4 no
GO:0051252 regulation of RNA metabolic process 27.2727 5 no
GO:0051336 regulation of hydrolase activity 27.2727 4 no
GO:1903506 regulation of nucleic acid-templated transcription 27.2727 7 no
GO:2001141 regulation of RNA biosynthetic process 27.2727 6 no
GO:0031344 regulation of cell projection organization 27.2727 5 no
GO:0051241 negative regulation of multicellular organismal process 27.2727 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 27.2727 6 no
GO:0009892 negative regulation of metabolic process 27.2727 4 no
GO:0010605 negative regulation of macromolecule metabolic process 27.2727 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 22.7273 5 no
GO:0051248 negative regulation of protein metabolic process 22.7273 6 no
GO:0002685 regulation of leukocyte migration 22.7273 4 no
GO:0006911 phagocytosis, engulfment 22.7273 7 no
GO:0007265 Ras protein signal transduction 22.7273 5 no
GO:0008360 regulation of cell shape 22.7273 6 no
GO:0010324 membrane invagination 22.7273 5 no
GO:0042127 regulation of cell population proliferation 22.7273 4 no
GO:0060627 regulation of vesicle-mediated transport 22.7273 4 no
GO:0099024 plasma membrane invagination 22.7273 6 no
GO:0001934 positive regulation of protein phosphorylation 22.7273 8 no
GO:0010562 positive regulation of phosphorus metabolic process 22.7273 6 no
GO:0031401 positive regulation of protein modification process 22.7273 7 no
GO:0042327 positive regulation of phosphorylation 22.7273 8 no
GO:0045937 positive regulation of phosphate metabolic process 22.7273 7 no
GO:0051056 regulation of small GTPase mediated signal transduction 22.7273 6 no
GO:0016192 vesicle-mediated transport 22.7273 4 yes
GO:0060326 cell chemotaxis 22.7273 4 yes
GO:0009891 positive regulation of biosynthetic process 22.7273 5 no
GO:0009967 positive regulation of signal transduction 22.7273 5 no
GO:0051050 positive regulation of transport 22.7273 4 no
GO:0051345 positive regulation of hydrolase activity 22.7273 5 no
GO:0060341 regulation of cellular localization 22.7273 4 no
GO:2000377 regulation of reactive oxygen species metabolic process 22.7273 5 no
GO:0043408 regulation of MAPK cascade 22.7273 6 no
GO:0007167 enzyme-linked receptor protein signaling pathway 22.7273 4 no
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 22.7273 5 no
GO:0031400 negative regulation of protein modification process 22.7273 7 no
GO:0006915 apoptotic process 13.6364 4 yes
GO:0006909 phagocytosis 9.0909 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in ELMO2_HUMAN
DOID:0111962 combined immunodeficiency 9.0909 4 no
DOID:612 primary immunodeficiency disease 9.0909 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ARL4A_HUMAN [view interactions] Low throughput no no
CDC27_HUMAN [view interactions] Low throughput no yes
RHOG_HUMAN [view entry] [view interactions] Low throughput yes no
AGRB1_HUMAN [view entry] [view interactions] Low throughput yes no
DOCK1_HUMAN [view entry] [view interactions] High throughput yes yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
EPHA1_HUMAN [view interactions] High throughput no yes
ERMAP_HUMAN [view interactions] High throughput no yes
ELMO1_HUMAN [view interactions] High throughput no no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
CRK_HUMAN [view entry] [view interactions] High throughput yes no
DOCK5_HUMAN [view entry] [view interactions] High throughput yes no
DOCK3_HUMAN [view entry] [view interactions] High throughput yes yes
DOCK4_HUMAN [view entry] [view interactions] High throughput yes no
NPM_HUMAN [view entry] [view interactions] High throughput yes yes
FBW1B_HUMAN [view interactions] High throughput no yes
FBW1A_HUMAN [view interactions] High throughput no yes
CRKL_HUMAN [view entry] [view interactions] High throughput yes yes
MLH1_HUMAN [view interactions] High throughput no yes
CP135_HUMAN [view interactions] High throughput no no
ELMO3_HUMAN [view interactions] High throughput no yes
ARRB1_HUMAN [view entry] [view interactions] High throughput yes yes
SNAI1_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA4_HUMAN [view interactions] High throughput no yes
RHGBB_HUMAN [view interactions] High throughput no no
CHIO_HUMAN [view interactions] High throughput no yes
DOCK2_HUMAN [view entry] [view interactions] High throughput yes no
RGAP1_HUMAN [view interactions] High throughput no no
L2GL2_HUMAN [view interactions] High throughput no yes
CC167_HUMAN [view interactions] High throughput no yes
SEM4C_HUMAN [view entry] [view interactions] High throughput yes no
IDD_HUMAN [view interactions] High throughput no no
CC018_HUMAN [view interactions] High throughput no yes
NMDZ1_HUMAN [view entry] [view interactions] High throughput yes yes
NUAK1_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
DRG1_HUMAN [view interactions] High throughput no yes
ACACA_HUMAN [view entry] [view interactions] High throughput yes yes
KS6A2_HUMAN [view interactions] High throughput no yes
DC1I2_HUMAN [view entry] [view interactions] High throughput yes yes
ILK_HUMAN [view interactions] Computational no no
RAC3_HUMAN [view entry] [view interactions] Computational yes no
GULP1_HUMAN [view interactions] Computational no no
UFO_HUMAN [view interactions] Computational no no
CLIP3_HUMAN [view entry] [view interactions] Computational yes no
BCAR1_HUMAN [view interactions] Computational no yes
WDR35_HUMAN [view interactions] Computational no yes