Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ELMO2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ELMO2_HUMAN
GO:0019900 kinase binding 45.4545 4 yes
GO:0019901 protein kinase binding 45.4545 5 yes
GO:0030695 GTPase regulator activity 36.3636 4 no
GO:0017124 SH3 domain binding 31.8182 4 yes
GO:0005096 GTPase activator activity 31.8182 4 no
GO:0030971 receptor tyrosine kinase binding 27.2727 4 yes
GO:1990782 protein tyrosine kinase binding 27.2727 6 yes
GO:0043168 anion binding 22.7273 4 no
GO:0005085 guanyl-nucleotide exchange factor activity 22.7273 5 no
GO:0031267 small GTPase binding 22.7273 5 no
GO:0051020 GTPase binding 22.7273 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in ELMO2_HUMAN
GO:0048522 positive regulation of cellular process 72.7273 4 no
GO:0010646 regulation of cell communication 59.0909 4 no
GO:0009966 regulation of signal transduction 54.5455 4 no
GO:0031323 regulation of cellular metabolic process 54.5455 4 no
GO:0006996 organelle organization 50.0000 4 no
GO:0007264 small GTPase-mediated signal transduction 50.0000 5 no
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:0141124 intracellular signaling cassette 50.0000 4 no
GO:1902531 regulation of intracellular signal transduction 50.0000 5 no
GO:0060255 regulation of macromolecule metabolic process 45.4545 4 no
GO:0080090 regulation of primary metabolic process 45.4545 4 no
GO:0022607 cellular component assembly 40.9091 4 no
GO:0030334 regulation of cell migration 40.9091 5 no
GO:0048523 negative regulation of cellular process 40.9091 4 no
GO:2000145 regulation of cell motility 40.9091 4 no
GO:0007010 cytoskeleton organization 36.3636 5 no
GO:0009889 regulation of biosynthetic process 36.3636 4 no
GO:0009893 positive regulation of metabolic process 36.3636 4 no
GO:0030335 positive regulation of cell migration 36.3636 6 no
GO:0031325 positive regulation of cellular metabolic process 36.3636 5 no
GO:0040017 positive regulation of locomotion 36.3636 4 no
GO:0048584 positive regulation of response to stimulus 36.3636 4 no
GO:2000147 positive regulation of cell motility 36.3636 5 no
GO:0009892 negative regulation of metabolic process 31.8182 4 no
GO:0010468 regulation of gene expression 31.8182 6 no
GO:0010556 regulation of macromolecule biosynthetic process 31.8182 5 no
GO:0010605 negative regulation of macromolecule metabolic process 31.8182 5 no
GO:0010647 positive regulation of cell communication 31.8182 5 no
GO:0023056 positive regulation of signaling 31.8182 4 no
GO:0031326 regulation of cellular biosynthetic process 31.8182 5 no
GO:0031399 regulation of protein modification process 31.8182 6 no
GO:0051246 regulation of protein metabolic process 31.8182 5 no
GO:0007015 actin filament organization 27.2727 5 yes
GO:0060326 cell chemotaxis 27.2727 4 yes
GO:0097435 supramolecular fiber organization 27.2727 4 yes
GO:0001932 regulation of protein phosphorylation 27.2727 7 no
GO:0007167 enzyme-linked receptor protein signaling pathway 27.2727 4 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 27.2727 5 no
GO:0009967 positive regulation of signal transduction 27.2727 5 no
GO:0010604 positive regulation of macromolecule metabolic process 27.2727 5 no
GO:0010810 regulation of cell-substrate adhesion 27.2727 5 no
GO:0019220 regulation of phosphate metabolic process 27.2727 6 no
GO:0030030 cell projection organization 27.2727 4 no
GO:0030155 regulation of cell adhesion 27.2727 4 no
GO:0031324 negative regulation of cellular metabolic process 27.2727 5 no
GO:0031344 regulation of cell projection organization 27.2727 5 no
GO:0042325 regulation of phosphorylation 27.2727 7 no
GO:0044087 regulation of cellular component biogenesis 27.2727 4 no
GO:0051056 regulation of small GTPase mediated signal transduction 27.2727 6 no
GO:0051130 positive regulation of cellular component organization 27.2727 5 no
GO:0051174 regulation of phosphorus metabolic process 27.2727 5 no
GO:0051241 negative regulation of multicellular organismal process 27.2727 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 27.2727 6 no
GO:0060341 regulation of cellular localization 27.2727 4 no
GO:0031400 negative regulation of protein modification process 27.2727 7 no
GO:0051248 negative regulation of protein metabolic process 27.2727 6 no
GO:0043408 regulation of MAPK cascade 27.2727 6 no
GO:0098657 import into cell 22.7273 4 yes
GO:0010811 positive regulation of cell-substrate adhesion 22.7273 6 no
GO:0022603 regulation of anatomical structure morphogenesis 22.7273 4 no
GO:0033043 regulation of organelle organization 22.7273 5 no
GO:0043933 protein-containing complex organization 22.7273 4 no
GO:0045785 positive regulation of cell adhesion 22.7273 5 no
GO:0051049 regulation of transport 22.7273 4 no
GO:0051493 regulation of cytoskeleton organization 22.7273 6 no
GO:0061024 membrane organization 22.7273 4 no
GO:0065003 protein-containing complex assembly 22.7273 5 no
GO:1900024 regulation of substrate adhesion-dependent cell spreading 22.7273 6 no
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 22.7273 7 no
GO:1902533 positive regulation of intracellular signal transduction 22.7273 6 no
GO:2000377 regulation of reactive oxygen species metabolic process 22.7273 5 no
GO:0032880 regulation of protein localization 22.7273 5 no
GO:0042127 regulation of cell population proliferation 22.7273 4 no
GO:1903829 positive regulation of protein localization 22.7273 5 no
GO:0009891 positive regulation of biosynthetic process 22.7273 5 no
GO:0048585 negative regulation of response to stimulus 22.7273 4 no
GO:0006355 regulation of DNA-templated transcription 22.7273 7 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 22.7273 5 no
GO:0051252 regulation of RNA metabolic process 22.7273 5 no
GO:2001141 regulation of RNA biosynthetic process 22.7273 6 no
GO:0006915 apoptotic process 18.1818 4 yes
GO:0006909 phagocytosis 9.0909 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ARL4A_HUMAN [view interactions] Low throughput no no
CDC27_HUMAN [view interactions] Low throughput no yes
RHOG_HUMAN [view entry] [view interactions] Low throughput yes no
AGRB1_HUMAN [view entry] [view interactions] Low throughput yes no
FBW1A_HUMAN [view interactions] High throughput no yes
CRKL_HUMAN [view entry] [view interactions] High throughput yes yes
MLH1_HUMAN [view interactions] High throughput no yes
CP135_HUMAN [view interactions] High throughput no no
ELMO3_HUMAN [view interactions] High throughput no yes
ARRB1_HUMAN [view entry] [view interactions] High throughput yes yes
SNAI1_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA4_HUMAN [view interactions] High throughput no yes
RHGBB_HUMAN [view interactions] High throughput no no
CHIO_HUMAN [view interactions] High throughput no yes
DOCK2_HUMAN [view entry] [view interactions] High throughput yes no
RGAP1_HUMAN [view interactions] High throughput no no
L2GL2_HUMAN [view interactions] High throughput no yes
CC167_HUMAN [view interactions] High throughput no yes
SEM4C_HUMAN [view entry] [view interactions] High throughput yes no
IDD_HUMAN [view interactions] High throughput no no
CC018_HUMAN [view interactions] High throughput no yes
NMDZ1_HUMAN [view entry] [view interactions] High throughput yes yes
NUAK1_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
DRG1_HUMAN [view interactions] High throughput no yes
TLS1_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
UBE2H_HUMAN [view interactions] High throughput no yes
ACACA_HUMAN [view entry] [view interactions] High throughput yes yes
RB_HUMAN [view interactions] High throughput no yes
KEAP1_HUMAN [view interactions] High throughput no yes
NQO2_HUMAN [view interactions] High throughput no yes
EFNMT_HUMAN [view interactions] High throughput no yes
KS6A2_HUMAN [view interactions] High throughput no yes
DC1I2_HUMAN [view entry] [view interactions] High throughput yes yes
DET1_HUMAN [view interactions] High throughput no no
RFA1_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
DOCK1_HUMAN [view entry] [view interactions] High throughput yes yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
EPHA1_HUMAN [view interactions] High throughput no yes
ERMAP_HUMAN [view interactions] High throughput no yes
ELMO1_HUMAN [view entry] [view interactions] High throughput yes no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
CRK_HUMAN [view entry] [view interactions] High throughput yes no
DOCK5_HUMAN [view entry] [view interactions] High throughput yes no
DOCK3_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
DOCK4_HUMAN [view entry] [view interactions] High throughput yes no
NPM_HUMAN [view entry] [view interactions] High throughput yes yes
FBW1B_HUMAN [view interactions] High throughput no yes