Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ELMO1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ELMO1_HUMAN
GO:0017124 SH3 domain binding 33.3333 4 yes
GO:0019900 kinase binding 33.3333 4 no
GO:0019901 protein kinase binding 29.1667 5 no
GO:0051020 GTPase binding 29.1667 4 no
GO:0043168 anion binding 25.0000 4 no
GO:0005096 GTPase activator activity 25.0000 4 no
GO:0030695 GTPase regulator activity 25.0000 4 no
GO:0005085 guanyl-nucleotide exchange factor activity 20.8333 5 no
GO:0031267 small GTPase binding 20.8333 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in ELMO1_HUMAN
GO:0048522 positive regulation of cellular process 79.1667 4 no
GO:0006996 organelle organization 58.3333 4 yes
GO:0031323 regulation of cellular metabolic process 58.3333 4 no
GO:0051128 regulation of cellular component organization 54.1667 4 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0141124 intracellular signaling cassette 45.8333 4 yes
GO:0009889 regulation of biosynthetic process 45.8333 4 no
GO:0009893 positive regulation of metabolic process 45.8333 4 no
GO:0031325 positive regulation of cellular metabolic process 45.8333 5 no
GO:0048523 negative regulation of cellular process 45.8333 4 no
GO:0007264 small GTPase-mediated signal transduction 41.6667 5 yes
GO:0010468 regulation of gene expression 41.6667 6 no
GO:0010556 regulation of macromolecule biosynthetic process 41.6667 5 no
GO:0010646 regulation of cell communication 41.6667 4 no
GO:0022607 cellular component assembly 41.6667 4 no
GO:0031326 regulation of cellular biosynthetic process 41.6667 5 no
GO:0051130 positive regulation of cellular component organization 41.6667 5 no
GO:0009966 regulation of signal transduction 37.5000 4 no
GO:0031344 regulation of cell projection organization 37.5000 5 no
GO:0051049 regulation of transport 37.5000 4 no
GO:0060341 regulation of cellular localization 37.5000 4 no
GO:0006915 apoptotic process 33.3333 4 yes
GO:0007010 cytoskeleton organization 33.3333 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0022603 regulation of anatomical structure morphogenesis 33.3333 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 33.3333 6 no
GO:0061024 membrane organization 29.1667 4 yes
GO:0097435 supramolecular fiber organization 29.1667 4 yes
GO:0009892 negative regulation of metabolic process 29.1667 4 no
GO:0010605 negative regulation of macromolecule metabolic process 29.1667 5 no
GO:0023056 positive regulation of signaling 29.1667 4 no
GO:0030030 cell projection organization 29.1667 4 no
GO:0030334 regulation of cell migration 29.1667 5 no
GO:0033043 regulation of organelle organization 29.1667 5 no
GO:0043933 protein-containing complex organization 29.1667 4 no
GO:0044087 regulation of cellular component biogenesis 29.1667 4 no
GO:0048584 positive regulation of response to stimulus 29.1667 4 no
GO:0051246 regulation of protein metabolic process 29.1667 5 no
GO:1902531 regulation of intracellular signal transduction 29.1667 5 no
GO:2000145 regulation of cell motility 29.1667 4 no
GO:0032880 regulation of protein localization 29.1667 5 no
GO:1903829 positive regulation of protein localization 29.1667 5 no
GO:0007167 enzyme-linked receptor protein signaling pathway 25.0000 4 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 25.0000 5 no
GO:0009967 positive regulation of signal transduction 25.0000 5 no
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0030155 regulation of cell adhesion 25.0000 4 no
GO:0030335 positive regulation of cell migration 25.0000 6 no
GO:0031324 negative regulation of cellular metabolic process 25.0000 5 no
GO:0031399 regulation of protein modification process 25.0000 6 no
GO:0040017 positive regulation of locomotion 25.0000 4 no
GO:0044089 positive regulation of cellular component biogenesis 25.0000 5 no
GO:0045785 positive regulation of cell adhesion 25.0000 5 no
GO:0051241 negative regulation of multicellular organismal process 25.0000 4 no
GO:0051493 regulation of cytoskeleton organization 25.0000 6 no
GO:0060326 cell chemotaxis 25.0000 4 no
GO:2000147 positive regulation of cell motility 25.0000 5 no
GO:0009894 regulation of catabolic process 25.0000 4 no
GO:0006355 regulation of DNA-templated transcription 25.0000 7 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0051252 regulation of RNA metabolic process 25.0000 5 no
GO:0070925 organelle assembly 25.0000 5 no
GO:2001141 regulation of RNA biosynthetic process 25.0000 6 no
GO:0006911 phagocytosis, engulfment 20.8333 7 yes
GO:0007015 actin filament organization 20.8333 5 yes
GO:0010324 membrane invagination 20.8333 5 yes
GO:0016601 Rac protein signal transduction 20.8333 6 yes
GO:0099024 plasma membrane invagination 20.8333 6 yes
GO:0009890 negative regulation of biosynthetic process 20.8333 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 20.8333 6 no
GO:0010810 regulation of cell-substrate adhesion 20.8333 5 no
GO:0010811 positive regulation of cell-substrate adhesion 20.8333 6 no
GO:0019220 regulation of phosphate metabolic process 20.8333 6 no
GO:0022604 regulation of cell morphogenesis 20.8333 5 no
GO:0030100 regulation of endocytosis 20.8333 5 no
GO:0031175 neuron projection development 20.8333 6 no
GO:0031327 negative regulation of cellular biosynthetic process 20.8333 6 no
GO:0031346 positive regulation of cell projection organization 20.8333 6 no
GO:0032956 regulation of actin cytoskeleton organization 20.8333 5 no
GO:0032970 regulation of actin filament-based process 20.8333 4 no
GO:0042325 regulation of phosphorylation 20.8333 7 no
GO:0051056 regulation of small GTPase mediated signal transduction 20.8333 6 no
GO:0051129 negative regulation of cellular component organization 20.8333 5 no
GO:0051174 regulation of phosphorus metabolic process 20.8333 5 no
GO:0051247 positive regulation of protein metabolic process 20.8333 6 no
GO:0060627 regulation of vesicle-mediated transport 20.8333 4 no
GO:0065003 protein-containing complex assembly 20.8333 5 no
GO:0120036 plasma membrane bounded cell projection organization 20.8333 5 no
GO:1900024 regulation of substrate adhesion-dependent cell spreading 20.8333 6 no
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 20.8333 7 no
GO:0031329 regulation of cellular catabolic process 20.8333 5 no
GO:0042127 regulation of cell population proliferation 20.8333 4 no
GO:0051240 positive regulation of multicellular organismal process 20.8333 4 no
GO:0009891 positive regulation of biosynthetic process 20.8333 5 no
GO:0010975 regulation of neuron projection development 20.8333 7 no
GO:0051050 positive regulation of transport 20.8333 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DOCK1_HUMAN [view entry] [view interactions] Low throughput yes yes
DOCK2_HUMAN [view entry] [view interactions] Low throughput yes no
AGRB1_HUMAN [view entry] [view interactions] Low throughput yes no
RHOG_HUMAN [view entry] [view interactions] Low throughput yes no
DOCK3_HUMAN [view entry] [view interactions] Low throughput yes yes
DOCK5_HUMAN [view entry] [view interactions] Low throughput yes no
ANXA2_HUMAN [view entry] [view interactions] Low throughput yes no
HCK_HUMAN [view entry] [view interactions] Low throughput yes no
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
DOCK4_HUMAN [view entry] [view interactions] Low throughput yes no
AGRB3_HUMAN [view entry] [view interactions] Low throughput yes no
ARL4A_HUMAN [view interactions] Low throughput no no
CDC27_HUMAN [view interactions] Low throughput no yes
APBB1_HUMAN [view entry] [view interactions] Low throughput yes yes
PGH2_HUMAN [view interactions] Low throughput no no
ARHGG_HUMAN [view interactions] Low throughput no yes
ELMO1_HUMAN [view entry] [view interactions] Low throughput yes no
CALL3_HUMAN [view interactions] High throughput no yes
ZN398_HUMAN [view interactions] High throughput no no
ELMO2_HUMAN [view entry] [view interactions] High throughput yes no
MED31_HUMAN [view interactions] High throughput no yes
CDC73_HUMAN [view interactions] High throughput no yes
PK3CA_HUMAN [view entry] [view interactions] High throughput yes yes
GBB2_HUMAN [view entry] [view interactions] High throughput yes yes
PHAG1_HUMAN [view interactions] High throughput no yes
DYR1A_HUMAN [view interactions] High throughput no yes
TRI54_HUMAN [view interactions] High throughput no no
BAG3_HUMAN [view entry] [view interactions] High throughput yes no
UBP4_HUMAN [view interactions] High throughput no no
TTC19_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
ELMO3_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
NUAK1_HUMAN [view interactions] High throughput no no
NMDZ1_HUMAN [view entry] [view interactions] High throughput yes yes
CRKL_HUMAN [view entry] [view interactions] High throughput yes yes
CRK_HUMAN [view entry] [view interactions] High throughput yes no
PMGT2_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
CSK_HUMAN [view interactions] High throughput no yes