Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AGRB3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity . Promotes myoblast fusion through ELMO/DOCK1 (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in AGRB3_HUMAN
GO:0005096 GTPase activator activity 14.2857 4 yes
GO:0030695 GTPase regulator activity 14.2857 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in AGRB3_HUMAN
GO:0051128 regulation of cellular component organization 64.2857 4 yes
GO:0022603 regulation of anatomical structure morphogenesis 50.0000 4 yes
GO:0031344 regulation of cell projection organization 50.0000 5 yes
GO:0010975 regulation of neuron projection development 42.8571 7 yes
GO:0050807 regulation of synapse organization 42.8571 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 42.8571 6 yes
GO:0010646 regulation of cell communication 42.8571 4 no
GO:0050804 modulation of chemical synaptic transmission 42.8571 5 no
GO:0099177 regulation of trans-synaptic signaling 42.8571 4 no
GO:0006996 organelle organization 42.8571 4 no
GO:0048522 positive regulation of cellular process 35.7143 4 yes
GO:0007612 learning 28.5714 4 yes
GO:0050890 cognition 28.5714 4 yes
GO:0051094 positive regulation of developmental process 28.5714 4 yes
GO:0051130 positive regulation of cellular component organization 28.5714 5 yes
GO:0051960 regulation of nervous system development 28.5714 5 yes
GO:2000026 regulation of multicellular organismal development 28.5714 4 yes
GO:0099536 synaptic signaling 28.5714 4 no
GO:0099537 trans-synaptic signaling 28.5714 5 no
GO:0008104 protein localization 28.5714 4 no
GO:0031399 regulation of protein modification process 28.5714 6 no
GO:0048523 negative regulation of cellular process 28.5714 4 no
GO:0051246 regulation of protein metabolic process 28.5714 5 no
GO:0060255 regulation of macromolecule metabolic process 28.5714 4 no
GO:0072657 protein localization to membrane 28.5714 4 no
GO:0080090 regulation of primary metabolic process 28.5714 4 no
GO:0050770 regulation of axonogenesis 28.5714 5 no
GO:0034330 cell junction organization 21.4286 4 yes
GO:0044087 regulation of cellular component biogenesis 21.4286 4 yes
GO:0050808 synapse organization 21.4286 5 yes
GO:0051240 positive regulation of multicellular organismal process 21.4286 4 yes
GO:0051962 positive regulation of nervous system development 21.4286 5 yes
GO:0007268 chemical synaptic transmission 21.4286 7 no
GO:0098916 anterograde trans-synaptic signaling 21.4286 6 no
GO:0001932 regulation of protein phosphorylation 21.4286 7 no
GO:0001934 positive regulation of protein phosphorylation 21.4286 8 no
GO:0009893 positive regulation of metabolic process 21.4286 4 no
GO:0009966 regulation of signal transduction 21.4286 4 no
GO:0010562 positive regulation of phosphorus metabolic process 21.4286 6 no
GO:0010604 positive regulation of macromolecule metabolic process 21.4286 5 no
GO:0019220 regulation of phosphate metabolic process 21.4286 6 no
GO:0022607 cellular component assembly 21.4286 4 no
GO:0031323 regulation of cellular metabolic process 21.4286 4 no
GO:0031325 positive regulation of cellular metabolic process 21.4286 5 no
GO:0031346 positive regulation of cell projection organization 21.4286 6 no
GO:0031401 positive regulation of protein modification process 21.4286 7 no
GO:0033365 protein localization to organelle 21.4286 5 no
GO:0035418 protein localization to synapse 21.4286 6 no
GO:0042325 regulation of phosphorylation 21.4286 7 no
GO:0042327 positive regulation of phosphorylation 21.4286 8 no
GO:0043085 positive regulation of catalytic activity 21.4286 4 no
GO:0045937 positive regulation of phosphate metabolic process 21.4286 7 no
GO:0051174 regulation of phosphorus metabolic process 21.4286 5 no
GO:0051247 positive regulation of protein metabolic process 21.4286 6 no
GO:0062237 protein localization to postsynapse 21.4286 7 no
GO:0099633 protein localization to postsynaptic specialization membrane 21.4286 6 no
GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane 21.4286 4 no
GO:1902414 protein localization to cell junction 21.4286 5 no
GO:1903539 protein localization to postsynaptic membrane 21.4286 5 no
GO:1990778 protein localization to cell periphery 21.4286 5 no
GO:0009892 negative regulation of metabolic process 21.4286 4 no
GO:0010605 negative regulation of macromolecule metabolic process 21.4286 5 no
GO:0051248 negative regulation of protein metabolic process 21.4286 6 no
GO:0045595 regulation of cell differentiation 21.4286 4 no
GO:0050767 regulation of neurogenesis 21.4286 6 no
GO:0060284 regulation of cell development 21.4286 5 no
GO:0097106 postsynaptic density organization 21.4286 6 no
GO:0099084 postsynaptic specialization organization 21.4286 5 no
GO:0034331 cell junction maintenance 14.2857 5 yes
GO:0043954 cellular component maintenance 14.2857 4 yes
GO:0044089 positive regulation of cellular component biogenesis 14.2857 5 yes
GO:0048814 regulation of dendrite morphogenesis 14.2857 5 yes
GO:0050773 regulation of dendrite development 14.2857 4 yes
GO:0051093 negative regulation of developmental process 14.2857 4 yes
GO:0051241 negative regulation of multicellular organismal process 14.2857 4 yes
GO:0051963 regulation of synapse assembly 14.2857 6 yes
GO:0051965 positive regulation of synapse assembly 14.2857 6 yes
GO:0090128 regulation of synapse maturation 14.2857 4 yes
GO:0099558 maintenance of synapse structure 14.2857 6 yes
GO:1901888 regulation of cell junction assembly 14.2857 5 yes
GO:1901890 positive regulation of cell junction assembly 14.2857 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
C1QL3_HUMAN [view entry] [view interactions] Low throughput yes no
C1QL2_HUMAN [view entry] [view interactions] Low throughput yes no
ELMO1_HUMAN [view entry] [view interactions] Low throughput yes no
SCOT1_HUMAN [view entry] [view interactions] High throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
HDAC4_HUMAN [view interactions] High throughput no yes
GPT11_HUMAN [view interactions] High throughput no no
G37L1_HUMAN [view interactions] High throughput no yes
CTR1_HUMAN [view interactions] High throughput no no
TLCD4_HUMAN [view interactions] High throughput no no
DSCR9_HUMAN [view interactions] High throughput no no
ZNF24_HUMAN [view interactions] High throughput no yes
MUC1_HUMAN [view interactions] High throughput no no
S100P_HUMAN [view interactions] High throughput no no
OTU7A_HUMAN [view interactions] High throughput no no
SNTA1_HUMAN [view entry] [view interactions] High throughput yes no
CDKL5_HUMAN [view entry] [view interactions] High throughput yes yes
GRIA2_HUMAN [view entry] [view interactions] High throughput yes yes
LRC4C_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK2_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes