AGRB3_HUMAN
Evidence for PS localization
Functions
Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity . Promotes myoblast fusion through ELMO/DOCK1 (PubMed). [View more on UniProt]
Protein features
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 37%
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
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AGRB3_HUMAN has binary interactions with 13 proteins
Isoforms
Interacting regions
Canonical [AGRB3_HUMAN]
Isoform [J3KMY8] alignment
Isoform [O60242-2] alignment
Isoform [A0A804HJR2] alignment
Isoform [S4R3D0] alignment
Isoform [S4R307] alignment
LOADING 31%
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AGRB3_HUMAN |
|---|---|---|---|---|
| GO:0005096 | GTPase activator activity | 14.2857 | 4 | yes |
| GO:0030695 | GTPase regulator activity | 14.2857 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AGRB3_HUMAN |
|---|---|---|---|---|
| GO:0051128 | regulation of cellular component organization | 64.2857 | 4 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 50.0000 | 4 | yes |
| GO:0031344 | regulation of cell projection organization | 50.0000 | 5 | yes |
| GO:0010975 | regulation of neuron projection development | 42.8571 | 7 | yes |
| GO:0050807 | regulation of synapse organization | 42.8571 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 42.8571 | 6 | yes |
| GO:0010646 | regulation of cell communication | 42.8571 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 42.8571 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 42.8571 | 4 | no |
| GO:0006996 | organelle organization | 42.8571 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 35.7143 | 4 | yes |
| GO:0007612 | learning | 28.5714 | 4 | yes |
| GO:0050890 | cognition | 28.5714 | 4 | yes |
| GO:0051094 | positive regulation of developmental process | 28.5714 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 28.5714 | 5 | yes |
| GO:0051960 | regulation of nervous system development | 28.5714 | 5 | yes |
| GO:2000026 | regulation of multicellular organismal development | 28.5714 | 4 | yes |
| GO:0099536 | synaptic signaling | 28.5714 | 4 | no |
| GO:0099537 | trans-synaptic signaling | 28.5714 | 5 | no |
| GO:0008104 | protein localization | 28.5714 | 4 | no |
| GO:0031399 | regulation of protein modification process | 28.5714 | 6 | no |
| GO:0048523 | negative regulation of cellular process | 28.5714 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 28.5714 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 28.5714 | 4 | no |
| GO:0072657 | protein localization to membrane | 28.5714 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| C1QL2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| C1QL3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CDKL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTR1_HUMAN | [view interactions] | High throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DSCR9_HUMAN | [view interactions] | High throughput | no | no |
| ELMO1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| G37L1_HUMAN | [view interactions] | High throughput | no | yes |
| GPT11_HUMAN | [view interactions] | High throughput | no | no |
| GRIA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| LRC4C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MUC1_HUMAN | [view interactions] | High throughput | no | no |
| NTRK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OTU7A_HUMAN | [view interactions] | High throughput | no | no |
| S100P_HUMAN | [view interactions] | High throughput | no | no |
| SCOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNTA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TLCD4_HUMAN | [view interactions] | High throughput | no | no |
| ZNF24_HUMAN | [view interactions] | High throughput | no | yes |